!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!drug_name	Methotrexate
!smiles	CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
!drugbank_id	DB00563
!pubchem_cid	126941
!cell_type	HT29
!organism	human
!end_metadata
HAPLN1	0.269591
S100A4	0.226563
TMEM167A	0.216142
DHFR	0.202119
TM4SF4	-0.156708
AKR1B10	0.151277
IFI27	-0.138292
ALDH1A1	-0.137439
DKK1	0.122934
HLA-C	-0.114002
B2M	-0.113323
AKR1C2	0.111473
HLA-B	-0.102189
ZCCHC9	0.101051
AKR1C3	0.098867
VBP1	-0.092160
HLA-A	-0.090784
TSPAN8	-0.090059
SSR4	-0.089542
UQCRFS1	0.086835
MMP7	-0.086327
TMSB10	0.083509
SLC25A6	0.083390
CD24	-0.077845
FDFT1	0.077253
COX6B1	0.077242
EDIL3	0.075325
AKR1C1	0.072409
GPI	0.071511
IFITM2	-0.070942
BCAP31	-0.070407
CCNG1	0.069397
NDUFS6	0.067548
RPL30	-0.066667
IFITM3	-0.065927
ECHS1	0.064651
PODXL	0.061728
IRAK1	-0.061510
OAT	0.059777
EIF3H	-0.059733
RRM2	-0.059484
CAPNS1	0.058271
DKC1	-0.058120
PABPC3	-0.056392
MRPL13	-0.055806
USMG5	0.055621
DNAJA1	-0.055602
LYZ	-0.054505
OCIAD2	0.053580
YWHAZ	-0.053527
RPL8	-0.053525
GSTO1	0.052881
EEF1A2	0.049745
NOP10	-0.049650
RPS14P3	0.049549
TSPAN13	0.048796
KRT8	-0.048785
KLK6	-0.048755
PGAM1	0.048365
BZW2	0.047323
UBE2C	-0.046812
PTMA	-0.046287
KRT18	-0.046057
RPN2	-0.045916
ZWINT	-0.045698
HLA-G	-0.045628
HMGN1	-0.045493
COX2	-0.045447
EIF6	-0.044499
ISG15	-0.044306
RPS6	-0.044120
S100A11	0.044013
ALDOA	0.043923
TMED7	0.043715
NDUFA4	0.043478
DSTN	0.043395
UBE2S	-0.043258
LGALS4	-0.042967
EIF3E	-0.042945
TAF7	0.041365
CDH1	-0.041065
CRABP2	-0.040928
MT1E	-0.040909
GTF3C6	-0.040458
XRCC4	0.039443
PSME2	-0.039346
RAN	-0.038947
RPL12	0.038808
CHMP2A	0.038177
FAM96A	-0.037942
ACTN4	-0.037668
MSN	0.037657
HSPE1	-0.037613
PTGES3	-0.037207
RPL4	-0.036996
PROM1	-0.036825
SEPW1	-0.036677
SNHG6	-0.036462
BST2	-0.036148
LAPTM4B	-0.036101
KRT20	-0.036011
LCN2	-0.035865
LAP3	-0.035835
SPINK1	0.035429
CLPTM1L	0.035107
CTSH	-0.034992
HSPH1	-0.034883
MAPRE1	-0.034775
PSMD2	0.034774
CD55	0.034492
LGALS3BP	-0.034301
HSPA8	-0.034038
GINS1	-0.034008
PRDX5	0.033780
NMI	-0.033738
RPF2	-0.033663
C14orf2	0.033594
HMGN2	-0.033331
FAM60A	-0.033262
YBX1	-0.033016
FABP5	-0.032855
MAL2	-0.032813
ID1	0.032727
SSR2	0.032725
CD164	-0.032594
MRPL36	0.032511
PTPLAD1	-0.032505
TXNIP	-0.032464
HEBP2	-0.032445
PLSCR1	-0.032269
CMBL	0.032169
CLDN2	0.031828
AP2S1	0.031739
SNRPD2	0.031470
ITM2B	0.031418
KIAA0101	-0.031357
CRIP2	0.031295
RGS2	0.031269
RPA3	0.031263
TOMM20	0.031029
SMNDC1	0.030975
MRPS21	-0.030926
WDR54	0.030535
OST4	0.030524
PLS1	-0.030397
MRPS30	0.030309
HIST1H2BK	0.029972
TOMM5	-0.029927
TATDN1	-0.029891
ATF4	0.029757
EIF3J	-0.029684
DYNLL1	-0.029611
VAMP7	-0.029608
RPL10	-0.029601
EPHX1	0.029555
PPIB	-0.029505
NGRN	-0.029205
NDUFV2	0.028844
UFD1L	0.028777
HDAC1	-0.028774
COX5A	-0.028752
IARS2	0.028530
ANXA5	0.028491
P4HB	0.028414
RPS4X	0.028386
LDHB	-0.028238
CALB2	0.028143
ANXA4	-0.028132
ANXA13	-0.028067
LY6E	-0.028027
ALYREF	-0.028017
CRIP1	0.027770
PDIA6	0.027663
FXYD3	0.027663
S100A6	-0.027659
CSE1L	-0.027630
HSP90AB1	-0.027509
FMR1	-0.027269
SUMO2	-0.027264
DHX32	0.027236
IPO7	-0.027203
CD99	0.027189
NDUFB9	-0.027182
STIP1	-0.027052
PSMA4	-0.027000
CAPN2	0.026979
PTS	-0.026876
RAD21	-0.026844
AURKA	-0.026760
NDUFB5	0.026699
PRR13	-0.026682
CKMT2-AS1	0.026514
HMGN3	-0.026292
RPL3	0.026014
CCT3	-0.025980
RPS23	0.025947
CYC1	-0.025885
CAV1	0.025876
PABPC1	-0.025659
ETFB	0.025657
NUSAP1	-0.025596
VIMP	-0.025584
NOP58	-0.025562
NME7	0.025411
SNRPB	0.025198
ENOPH1	-0.024975
ADAM9	0.024848
PRC1	-0.024830
ANP32B	-0.024818
PTDSS1	-0.024734
UBA2	0.024693
DAP	0.024636
ATP6AP1	-0.024595
MRPL17	-0.024470
BRCC3	-0.024464
FAM84B	-0.024424
LASP1	0.024418
FXYD5	0.024418
UBB	-0.024387
ANKRD27	0.024382
ATAD2	-0.024367
MT1HL1	-0.024353
AGPAT5	0.024297
ASUN	-0.024268
MRPL3	0.024249
CDK1	-0.024235
NELFCD	-0.024188
ZDHHC6	0.024178
TYMS	0.024088
MRPL15	-0.024024
PPP1R1B	0.024024
UHRF1	-0.023932
LTA4H	0.023589
RPS20	-0.023522
GNL3	-0.023513
ATP1B1	0.023436
COX6C	-0.023355
LAMP1	-0.023143
MEST	-0.023129
MORC4	0.023079
IMPA1	-0.023023
MAPK6	-0.023018
TPX2	-0.022992
MT2A	-0.022963
PSMA7	-0.022943
LAPTM4A	0.022917
COTL1	0.022910
GTF3A	-0.022807
YWHAB	-0.022770
LYPLA1	-0.022669
RRM1	-0.022586
SNRPA1	-0.022559
S100A16	0.022556
EIF2A	0.022547
IFITM1	-0.022517
HIF1A	0.022495
COPS5	-0.022377
PAM	0.022350
NSA2	-0.022329
HPRT1	-0.022326
CKB	0.022317
KNSTRN	-0.022291
OIP5	-0.022253
PHB2	0.022211
OSTC	0.022031
TRMT5	-0.021891
TWSG1	0.021873
GPX1	-0.021855
IER3	-0.021811
ATRAID	0.021782
PTTG1	0.021688
MRPS35	-0.021680
ADRM1	-0.021659
CTPS1	-0.021639
AQP3	-0.021538
ANLN	-0.021501
CTNNAL1	-0.021461
MORF4L1	-0.021431
HLA-F	-0.021415
ID2	0.021411
C12orf57	0.021326
EPB41L4A-AS1	0.021319
PSMB8	-0.021233
EIF2S2	-0.021109
SLC25A32	-0.021082
TCEAL4	0.021066
KPNA2	0.021033
SLK	0.020955
HPCAL1	0.020923
RFK	-0.020844
BUB1B	-0.020793
C1QBP	-0.020694
UBE2T	-0.020682
UPF2	0.020670
BCCIP	0.020650
FBL	-0.020615
RAB25	0.020550
ZDHHC16	0.020514
PPIF	-0.020463
DDX39A	-0.020443
SRP14	-0.020391
SLIRP	-0.020386
MTHFD1	-0.020256
FAM122B	-0.020219
AHSA1	-0.020140
LYSMD2	-0.020075
PAICS	-0.020057
FUNDC2	-0.019995
CXorf40A	-0.019958
CCT2	-0.019950
GDI2	-0.019949
GLRX3	0.019939
RPS7	0.019934
UQCR10	0.019909
ANP32A	-0.019873
IFI6	-0.019819
PLOD2	0.019803
ESRP1	-0.019751
IDH3G	-0.019749
PGM1	0.019690
SERPINA1	-0.019631
NCAPG2	-0.019631
FANCI	-0.019578
MRPL33	0.019570
SORD	-0.019564
MRPL27	-0.019506
ARL6IP1	0.019432
PNRC2	-0.019420
KLK11	-0.019370
PSMD11	0.019345
CXorf40B	-0.019296
CENPW	-0.019227
GCNT3	-0.019179
EIF1AX	0.019055
CKS1B	-0.019031
AFG3L2	0.018972
KIAA1191	0.018922
AP2M1	0.018918
TRIM28	0.018865
CAV2	0.018846
NDUFAB1	-0.018836
RPS2	0.018822
KIAA1598	0.018804
CBWD1	0.018803
KIF5B	-0.018773
GMDS	-0.018758
UCHL3	-0.018742
ZNF706	-0.018733
SPINT2	0.018693
PITPNB	-0.018651
TCEB1	-0.018588
DYNLRB1	-0.018565
S100A10	0.018495
IARS	-0.018437
SGK223	0.018391
RPL9	-0.018375
TMEM54	-0.018374
ABLIM1	0.018322
CD59	0.018243
CETN2	-0.018240
VDAC3	0.018180
CYFIP1	-0.018148
SEC61G	0.018143
MXI1	0.018139
TUBA4A	-0.018131
ALDH3A2	0.018114
SIGMAR1	-0.018048
ANXA10	0.018039
ZNF511	0.018036
RAB11A	-0.018025
EEF1A1	-0.018012
ETFA	-0.017993
ZWILCH	-0.017989
EEF1D	-0.017988
POLR2K	-0.017951
EREG	-0.017934
PTPRK	-0.017913
CYP3A5	0.017861
TUBA1C	-0.017758
KARS	-0.017748
NAE1	-0.017740
H2AFZ	-0.017736
LACTB2	-0.017724
SLC1A1	-0.017723
PSMA1	-0.017720
TUBB2A	0.017719
SYT13	0.017692
NDUFB2	-0.017627
PRSS2	-0.017568
YES1	0.017530
ALDH3A1	0.017521
OAZ1	-0.017507
PLEK2	0.017503
CBFB	-0.017499
EMC4	-0.017479
MSH3	0.017428
MRPL42	-0.017384
IGFBP7	0.017363
NPTN	-0.017328
IFNGR1	-0.017325
SNX3	-0.017305
UGDH	0.017219
PSME1	-0.017191
LINC00493	0.017173
TAF1D	-0.017155
ATIC	-0.017143
TMEM258	0.017139
TUBA1B	-0.017114
DSCC1	-0.016947
RPS27L	-0.016942
RUVBL2	-0.016941
PCBP1	0.016930
EZH2	-0.016902
ATP6V0B	-0.016899
EIF3A	0.016885
TSPAN1	0.016865
PPP1CB	0.016862
ACADM	0.016860
NEK7	0.016849
CDKN2A	-0.016834
REPIN1	-0.016819
CYSTM1	-0.016805
TSC22D1	0.016802
PRPS1	-0.016764
EIF2S3	0.016754
BANF1	-0.016733
CHORDC1	-0.016612
ARPC1B	-0.016611
RPL24	-0.016609
COPB1	0.016608
USP14	0.016573
MRPL16	-0.016507
RNF139	-0.016489
MDH1	0.016459
SFXN3	0.016449
ODC1	0.016421
C12orf75	-0.016403
DCTPP1	-0.016383
PSMG1	0.016340
ARHGAP18	-0.016325
ARMCX6	0.016325
ATP5I	0.016324
H3F3B	-0.016256
GAPDH	0.016232
RPS12	-0.016230
ANXA2R	0.016230
LBR	-0.016188
CIRH1A	-0.016176
VMA21	-0.016168
PFDN2	-0.016162
PTTG1IP	-0.016135
NHP2	0.016121
FAM91A1	-0.016107
CHCHD3	-0.016095
AMIGO2	0.016088
RPL23	0.016070
EIF1	0.016068
TPD52L2	-0.016057
TPT1	0.016001
TSG101	-0.015992
MTIF2	0.015983
PLP2	-0.015918
SH3KBP1	0.015898
NEAT1	0.015895
SRSF2	-0.015887
RPLP0	0.015884
QPCT	0.015867
SOD1	-0.015854
CFL1	-0.015844
HEXB	-0.015833
CCNI	0.015829
ENC1	-0.015816
CKS2	-0.015802
MELK	-0.015798
TM9SF3	0.015783
CDCA7	-0.015768
TOB1	0.015758
EIF5	0.015745
RTN4	0.015745
HMGB3	-0.015739
PIGP	-0.015737
PFN2	0.015704
MCM7	-0.015692
MTHFD2	0.015611
TRMT11	-0.015586
YWHAQ	0.015581
RBBP7	0.015507
HSP90AA1	-0.015490
SEC11A	-0.015480
NMB	-0.015465
SLC25A1	0.015422
SERPINB1	-0.015400
CEACAM6	-0.015379
GGCT	-0.015343
MUC13	-0.015341
HERPUD1	0.015257
RBMX	-0.015246
ERMP1	-0.015190
COX3	0.015160
CCT6A	-0.015131