!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	human
!drug_name	NICKEL
!smiles	[Ni]
!pubchem_cid	935
!cell_type	HepG2 - liver carcinoma cells
!organism	human
!end_metadata
DUSP1	0.251870
AKR1B1	-0.198715
IER3	0.179379
A2M	-0.150109
PGC	-0.146720
MT2A	0.137434
HSPA8	0.136402
HMOX1	0.119505
RPS9	0.107994
CCL20	0.107201
C20orf24	0.104264
DNAJB1	0.101878
RPS17	0.096749
EIF4A1	0.096614
ATF3	0.093966
RPS29	0.093897
PRDX1	0.089422
UBB	0.088184
RPS15	0.087439
HSP90AB1	0.087198
PEBP1	-0.086930
TF	-0.085810
RPS27A	0.085496
IER2	0.085323
AKR1B10	-0.085244
SPP1	0.082489
HSPD1	0.082313
RPL10A	0.082058
TMSB10	0.080712
MT1X	0.080462
AMBP	-0.079153
RPS4Y1	0.079079
TRIB3	0.078352
RPS7	0.077893
FTH1	0.076089
RPS3	0.075570
HSP90AA1	0.075380
TXNRD1	0.075223
APOH	-0.074393
MANF	-0.073597
RHOB	0.072423
APOB	-0.070574
RPL14	0.070519
RPL9	0.069511
HYOU1	-0.068055
EIF3E	0.067917
RPL13	0.066819
SAA4	-0.066314
CTGF	0.066305
ITIH2	0.065569
RPL22	0.064148
RPS6	0.063049
RBM39	0.061288
RPS5	0.061231
ATP1B1	-0.060923
RPL24	0.059915
RPL11	0.059711
ADM	0.059343
TRIB1	0.059077
RPS10	0.058709
RPL23	0.057949
ID1	-0.057813
ITIH3	-0.057111
EIF1	0.056968
CFL1	0.056560
GADD45B	0.056292
GADD45A	0.056164
SLC25A3	0.055555
HSPH1	0.055430
RPS24	0.053821
SERPINA3	0.053747
RPS19	0.053646
RPL5	0.053240
RPL27	0.053149
CPB2	0.052669
H2AFZ	0.052612
MT1H	0.052461
RBP4	-0.051724
FDFT1	-0.051456
RAN	0.051116
RPL17	0.051006
MTHFD2	0.050807
APOC3	-0.050529
HNRNPA1	0.050454
RAB17	-0.050152
AHSG	-0.049884
RPL30	0.049509
RPL29	0.049289
ODC1	0.048667
CYR61	0.048497
CANX	-0.048353
CALM2	0.048172
JUND	0.047620
POLR1D	0.047590
PPP1R15A	0.047559
PLIN2	0.047442
APOA1	-0.047328
RPS16	0.047205
RPS3A	0.047089
ACTB	0.047033
SERPINA1	-0.046871
RPL21	0.046854
SF3B1	0.046688
FOS	0.046483
RPL4	0.046328
RBMX	0.046181
ALB	-0.046158
RPL13A	0.045925
MYL6	0.045607
RPS8	0.045170
SERPINE1	0.045033
LDLR	0.044913
RPL6	0.044699
RPL18	0.044694
PPA1	0.044131
RPS13	0.044085
APOE	-0.043948
AKR1C3	0.043751
TUBB4B	0.043458
RPS23	0.043332
GDI2	0.043262
SLC38A2	0.042868
RPS14	0.042716
RPL23A	0.042694
NPM1	0.042692
GAPDH	0.042526
DHRS2	0.042161
ASNS	0.042031
IKBKAP	0.041934
CKS2	0.041610
RPL34	0.041599
EIF4A2	0.041125
TPT1	0.040895
GPX3	-0.040853
LIPA	-0.040500
PDIA6	-0.040399
BAG3	0.040301
CTSB	-0.040120
ID2	0.040009
DLK1	0.039837
SLC5A3	-0.039808
EPHA2	0.039584
AARS	-0.039579
ITM2B	-0.039570
EEF2	0.039521
AKR1C1	-0.039473
SUB1	0.039409
SCD	-0.039353
RPL27A	0.038907
PHB2	0.038243
ETNPPL	-0.038220
SDF2L1	-0.038062
PPP1CC	0.037713
RPS4X	0.037695
SLC25A5	0.037558
TMED9	-0.037204
IDH1	-0.036903
GC	-0.036792
PABPC3	0.036727
SEL1L	-0.036703
SRSF2	0.036632
EIF3F	0.036459
RSRC2	0.036412
SOX9	-0.035812
ERLIN1	-0.035736
SERPINA5	-0.035648
GPX2	-0.035392
GSTA1	-0.035159
ACTG1	0.035113
PPIB	-0.034976
RPL8	0.034963
ETFB	0.034653
AHCY	0.034422
SERPINC1	-0.034392
HNRNPA2B1	0.034392
RPS27	0.034292
RPL36A	0.034225
GSN	-0.033961
CNBP	0.033738
DDX5	0.033523
RSL24D1	0.033091
SLC35B1	-0.033027
TM4SF5	-0.032976
ATP5A1	0.032909
PTGES3	0.032730
CYCS	0.032660
RPL12	0.032565
BTF3	0.032549
EIF4B	0.032549
PSMB5	0.032281
CNPY2	-0.032228
CCNL1	0.031853
CSTB	-0.031814
VTN	-0.031813
PDIA3	-0.031717
COX7A2L	0.031670
S100P	0.031475
ZFAND5	0.031367
QARS	0.031295
TGFBI	0.031265
RPS15A	0.031183
H1F0	-0.031137
COMT	-0.030869
ZNF207	0.030831
RPL39	0.030775
SERPINA7	0.030597
MYL12B	0.030582
MMD	-0.030332
PSMB3	0.030260
UBE2D3	0.030207
PDIA4	-0.030195
GLUD2	0.030100
KCMF1	0.030093
TRAM1	-0.029943
PPIF	0.029835
IP6K2	0.029722
GLRX	0.029387
HLF	-0.029378
B2M	0.029219
CIDEB	-0.029091
RPS25	0.029080
RPL37	-0.028903
RPL28	0.028546
MDH1	0.028545
KLF6	0.028503
CYP1A1	-0.028379
RPS21	0.028191
DNAJA1	0.027778
GOT1	0.027188
CEBPB	0.027186
TARS	0.027058
H3F3B	0.026999
AGT	-0.026914
GLUD1	0.026831
MAFF	0.026691
SOD1	0.026649
SSR1	-0.026439
RGS2	0.026433
CCNG1	0.026361
TXN	0.026145
IL17RB	-0.025876
XRCC6	0.025727
RPL15	0.025691
SEPT2	-0.025670
FNTA	0.025489
ATF4	0.025411
CCT4	0.025400
EIF3H	0.025397
IARS	-0.025394
TOMM20	0.025170
KARS	0.025125
TFRC	0.025075
SARS	0.025064
AFP	0.024996
UQCR10	0.024929
EEF1A1	0.024901
APEX1	0.024892
TNFRSF12A	0.024642
GSTO1	-0.024442
ALDH18A1	-0.024207
CCT2	0.024174
ALDOA	-0.024094
PSME1	0.023765
CCT8	0.023679
SAT1	0.023598
SFN	0.023594
GNB2L1	0.023552
KLHDC2	-0.023547
LGALS1	0.023415
CST3	-0.023372
VAMP8	-0.023339
UBE2S	0.023192
HSD17B12	-0.023158
ILF2	0.023147
CARS	0.023015
NONO	0.022985
TST	-0.022981
TMEM59	-0.022953
PPP2CA	0.022914
PCBP1	-0.022752
PTPRK	-0.022694
SRSF5	-0.022564
DBI	0.022532
IMPDH2	0.022470
NIPSNAP1	-0.022450
ATP2A2	-0.022340
TPI1	0.022255
PPIA	0.022225
DYNLL1	0.022098
CCT3	0.022058
UGP2	-0.021995
SNRPG	0.021986
HSP90B1	-0.021921
WARS	-0.021908
PRMT1	0.021899
TGFBR2	-0.021858
LITAF	-0.021769
KLF10	0.021733
SULT1A2	-0.021704
GCLM	0.021687
RPL36AL	0.021628
MIF	0.021542
TKT	0.021540
RPL7A	0.021494
SC5D	-0.021410
RCAN1	0.021405
HSD17B2	-0.021312
SNRPB	0.021238
SNRPE	0.021083
HIST1H4C	0.021031
VAPA	-0.021026
CHCHD2	0.021009
GLTSCR2	0.021007
TACC1	-0.020930
KRT18	0.020924
C4BPA	-0.020851
RPS28	0.020737
SERPINA6	-0.020590
P4HB	-0.020567
PTTG1	0.020538
TXNL1	0.020281
SQLE	-0.020214
CCNB1IP1	0.020203
PFN1	0.020202
DDX21	0.020155
DDX3X	0.020150
DUSP9	-0.020130
GLA	0.020041
NME1	0.020040
HSPB1	0.020015
EGR1	0.020010
SEC61A1	-0.020008
TALDO1	0.019944
RPL35	0.019912
RPS11	0.019814
ANXA4	-0.019803
CLTA	0.019719
AKR1C2	-0.019646
RARRES2	-0.019605
GNG5	-0.019591
NHP2L1	0.019537
FABP1	-0.019485
RPL37A	-0.019346
SULT1A1	-0.019317
MAN1A1	-0.019313
UQCRH	0.019312
CAT	-0.019300
DSTN	-0.019276
RPS6KA3	-0.019243
COPS2	0.019219
F2	-0.019184
PABPC1	0.019153
CERS2	-0.019084
LAMP1	-0.019036
CHORDC1	0.018922
SNX5	0.018897
SEPP1	0.018832
NUP153	0.018764
CYP3A7	-0.018757
ICAM1	0.018710
IDI1	-0.018667
RPN2	-0.018590
TUBB3	0.018585
SCAND1	-0.018541
GMNN	0.018532
GPC3	-0.018517
RANBP1	0.018405
PSAT1	0.018317
VIL1	-0.018188
OXA1L	0.018187
FBXO2	-0.018148
TNS3	-0.018079
ARFGEF2	-0.018033
MCL1	0.018022
CDK7	0.017963
SNX6	0.017934
CDIPT	-0.017907
CHPT1	-0.017899
ATP1A1	-0.017818
SERINC3	-0.017803
NCL	0.017705
CYB5R3	-0.017692
ASGR2	-0.017678
EIF1B	0.017602
C3	-0.017574
DPP4	-0.017461
UBE2C	0.017428
ABCC6	-0.017409
CHKA	0.017399
MPST	-0.017206
RAB1A	-0.017199
GARS	0.017172
TMEM50B	-0.017128
CLU	-0.017085
EEF1B2	0.017067
FAM60A	0.017043
CKS1B	0.017028
HEBP1	-0.016985
IPO5	0.016944
XPOT	-0.016935
PMPCB	0.016892
CFB	-0.016879
SLC20A1	0.016841
RPS18	0.016834
ANG	0.016832
TOP1	0.016811
NXT1	0.016790
DNAJB4	0.016789
EML4	-0.016740
SLC7A5	0.016734
SAP18	0.016728
CFAP20	0.016715
ADAR	-0.016566
ROCK2	-0.016539
EIF5	-0.016534
RPL7	0.016527
SPINK1	-0.016513
ATP5O	0.016455
POLR2B	-0.016440
DDX39A	0.016389
PSMB1	0.016380
SNRPD2	0.016347
PSMD12	0.016292
EFNA1	-0.016283
PCK2	-0.016272
UBE2I	0.016237
TMBIM6	-0.016220
IFITM3	0.016216
CADM1	0.016180
APOA2	-0.016121
CFI	0.016050
PGAM1	0.015952
BNIP3L	-0.015927
BRD2	0.015911
SSR4	-0.015888
JAG1	0.015785
GOLGA5	-0.015757
UQCRQ	-0.015739
ADSL	0.015733
EPHX1	-0.015666
CP	0.015665
SLC3A2	0.015664
DHCR24	-0.015552
GGH	-0.015481
EPAS1	-0.015458
PHB	0.015457
GFPT1	-0.015425
MSMO1	-0.015389
GHITM	-0.015374
SFPQ	0.015369
ATP5B	0.015228
SEPHS2	-0.015192
PHLDA1	0.015172
COASY	-0.015170
PSMD14	0.015155
NR1H4	-0.015096
PSMB7	0.015095
PSMA1	0.015063
HOXD1	-0.015003
TXNIP	0.015000
FXYD2	-0.014957
PHGDH	0.014942
PSMA5	-0.014862
MATR3	0.014787
TCEB1	0.014745
SLC9A3R1	-0.014716
TFR2	-0.014624
TMED2	-0.014589
UQCRC2	0.014567
MAPRE1	0.014543
FST	-0.014536
DUSP14	0.014489
MPC1	-0.014484
SEC61B	-0.014481
ERBB3	-0.014350
ATXN10	-0.014285
USO1	-0.014281
MGAT2	-0.014275
HYAL1	-0.014249
HSD17B11	0.014164
CNN3	0.014157
TTR	-0.014077
PPP4C	-0.014075
EEF1D	0.014071
STARD7	-0.014058
NR0B2	-0.014052
IGBP1	0.013978
FAU	0.013947
BLCAP	-0.013935
HMGB1	0.013927
GSPT1	0.013874
NUDC	-0.013860
LTA4H	0.013846
NFKBIA	-0.013844
YBX1	0.013836
MARCKSL1	-0.013755
C14orf2	0.013728
RNASE4	-0.013707
ASPSCR1	0.013596
AKAP1	-0.013570