!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!ligand_name	estradiol
!ligand_id	CHEBI:23965
!cell_type	MCF-7 cells
!organism	human
!end_metadata
PTGS2	0.108484
COL21A1	0.089368
CXCL10	0.089174
PLAC1	0.083691
CCL2	0.079950
PLAT	0.077015
CXCL8	0.076655
FGB	0.075416
ISG20	0.075307
CGA	0.074556
PRSS23	0.072571
FOS	0.071039
BIRC3	0.070356
MMP13	0.069881
TTR	0.069198
WISP2	0.067729
VTCN1	-0.065736
BLNK	-0.064395
CCL20	0.062707
CXCL2	0.061979
GNE	-0.061572
SGK1	0.061354
CXCL3	0.060696
IL17RB	0.059227
MYBL1	0.059001
LMO3	-0.058882
RAB31	0.058762
CXCL1	0.057893
TSPAN5	0.057681
PLCL1	0.056088
EPB41L3	0.055739
FGG	0.055627
CXCL12	0.054907
NPY1R	0.054823
EGR3	0.054139
NAA15	0.053891
UGT2B15	0.053679
HCAR3	-0.053521
HCRP1	-0.053442
KIAA0226L	0.052565
MMP1	0.052221
TFF2	0.052164
AREG	0.051636
TCN1	0.051188
TNF	0.050651
FBLN5	0.050411
LINC00341	0.049695
UGT2B28	0.049608
SIK1	0.049402
GRB14	-0.049373
LAMB3	0.047907
MMP10	0.047183
DOCK4	0.047021
CAV1	0.046979
CEBPD	0.046585
RNF43	-0.046246
CXCL11	0.046163
FN1	0.045970
MAT1A	0.045777
CALML5	-0.044892
AOX1	0.044784
STON1	-0.044767
TLR2	0.044675
OPN3	0.044335
IRS2	0.044309
CSGALNACT1	0.044106
PMAIP1	0.044006
RAB26	-0.042695
SEC14L2	0.042655
DEPTOR	0.042542
OLFML3	0.042410
SLC19A2	0.042332
TGFB3	-0.042166
WNT4	0.041747
FICD	0.040264
HEY1	-0.040089
ADM	0.039880
MYC	0.039878
SGPP1	0.039544
TSPAN8	-0.039530
TFPI2	0.039482
NEIL1	-0.039390
CLC	-0.039241
GULP1	0.039090
ID1	0.039049
BCL2A1	0.038969
KRT81	-0.038865
PPOX	-0.038649
ENC1	-0.038160
CD83	0.038016
KIF13A	-0.037800
PAPSS2	0.037042
BFSP2	0.036911
ATP6V0A4	-0.036890
BAG2	0.036673
NFE2L3	0.036612
HOXC4	0.036526
ATF3	0.036138
CP	0.035906
C1QTNF3	-0.035862
SERPINA3	0.035746
GRIA2	0.035649
SEC14L5	-0.035641
IRF6	-0.035322
SOD2	0.034974
GATC	0.034880
F5	0.034851
MIS18BP1	0.034760
RCAN2	-0.034709
RAPGEF4	-0.034397
ASB9	-0.034367
ALDH4A1	-0.034313
MYO15B	-0.034200
FBN2	-0.034116
TIPARP	0.034113
SUOX	-0.034091
ZNF124	0.034023
ABCG2	0.033973
TM4SF1	-0.033595
FJX1	0.033517
NR3C1	0.033500
SYCP2	-0.033352
NRIP1	0.033184
ABHD2	0.032987
HOXC6	0.032948
PCP4	0.032910
FKBP14	0.032889
PDZD2	-0.032823
HOPX	-0.032822
RBKS	-0.032787
TNFAIP3	0.032785
PLEKHA1	0.032681
SLC6A16	-0.032639
TPD52L1	0.032589
KCNV1	0.032404
MAN1C1	-0.032319
C8orf4	0.032253
RGS16	0.032216
WNT5A	0.032111
MMP15	-0.032105
MAP3K8	0.032072
CA12	0.032048
IL1R1	-0.032018
CYP4B1	-0.031970
OSMR	0.031944
TBX3	-0.031683
PSMB9	0.031646
C14orf132	0.031534
RHOBTB3	0.031494
AKR1C3	0.031428
FAM189A2	0.031424
TGFBR3	0.031377
ACKR3	-0.031186
ENPP2	0.031176
PSTPIP2	0.031115
KLRC3	0.031037
TBC1D17	-0.030984
RTN1	-0.030980
PGR	0.030961
CREB5	0.030937
FAM134B	-0.030936
GUCY1B2	-0.030928
BAMBI	-0.030923
ZNF211	-0.030882
GCNT1	-0.030860
SLC7A11	0.030837
RASA4	-0.030786
GEM	0.030631
DCAF16	0.030626
ATP7B	-0.030604
BASP1	0.030586
NAIP	-0.030572
DHRS3	-0.030506
BAI2	-0.030430
S100P	0.030411
NELL2	-0.030395
FHL2	0.030395
ROGDI	-0.030264
DZANK1	-0.030216
ODAM	-0.030206
PALMD	-0.030122
PNP	0.029872
NFKB1	0.029839
GPRC5A	0.029827
CRISP3	-0.029818
RPRM	-0.029805
LIF	0.029785
ANGPTL4	-0.029714
HSPB8	0.029556
SERPINE2	0.029556
TRIM45	-0.029528
NR4A2	0.029479
ACP6	-0.029461
CSTA	-0.029387
PLEKHF1	-0.029263
HOXC5	0.029250
ADAMTS1	0.029226
PIK3IP1	-0.029187
HDAC7	-0.029121
BIK	-0.029059
FBP1	-0.028874
KMO	0.028862
WBP2	-0.028851
MBOAT2	-0.028807
APOL1	0.028729
BCAS1	-0.028721
GGT1	-0.028694
FAM46A	0.028657
GAL	0.028656
SAP30L-AS1	-0.028521
ZNF669	0.028516
ATP8A1	-0.028500
AKR1C2	0.028269
MAFF	0.028209
SLC24A3	-0.028162
SELENBP1	-0.028018
LYPD3	-0.028006
BAHCC1	-0.027966
PADI2	-0.027835
FGF13	-0.027834
SYTL2	-0.027792
AIM1	-0.027748
ICAM1	0.027423
ADAM2	-0.027420
GLUL	0.027395
RIN2	-0.027371
PVALB	-0.027371
CYP26B1	0.027361
NAP1L2	0.027334
AGR2	0.027248
DNAJB9	0.027205
ABCC4	-0.027184
ZNF654	0.027137
NEDD4L	-0.027119
COCH	0.027055
FGD6	0.026999
MYRIP	0.026979
ING4	-0.026956
RUNDC3B	-0.026820
HPX	-0.026783
COL4A5	-0.026758
CERK	-0.026718
HELLS	0.026696
SLC7A5	0.026690
UTP20	0.026639
PPIF	0.026636
CTNND2	-0.026603
SGCG	-0.026595
EGF	0.026547
FGGY	-0.026530
CCNG2	-0.026496
VEGFC	-0.026481
KIAA0922	-0.026437
CTSH	-0.026426
ELF5	-0.026426
UGDH	0.026397
EPHB6	0.026385
ALAD	-0.026337
TMEM158	0.026315
MB	-0.026294
SLC2A6	0.026272
SLC12A5	-0.026245
INPP5J	-0.026170
CEACAM6	-0.026048
NDRG1	-0.026043
ACSS3	-0.026035
SOAT2	-0.025969
BMP4	-0.025933
EEA1	0.025929
REEP1	0.025908
GNAI1	-0.025895
AKR1C1	0.025844
IFRD2	0.025768
PMP22	-0.025730
IQSEC1	-0.025701
SLC7A6	0.025701
TENC1	-0.025690
CADPS2	0.025654
CHD3	-0.025630
FNDC3B	0.025558
ELF1	0.025543
DEFB4A	0.025390
MTL5	-0.025335
PPAP2B	0.025329
KIAA0513	-0.025316
VEGFB	-0.025265
SYT17	-0.025191
MAST3	-0.025176
SPIN1	0.025114
P2RY2	-0.025053
CNN2	-0.025029
CRIM1	0.025029
CDK20	-0.025013
CLCA2	-0.025003
GBP1	0.024983
ZNF185	-0.024947
CTSK	-0.024906
TMPRSS3	0.024826
SLC4A2	-0.024752
PROM1	0.024710
OSGIN1	0.024691
CERS4	-0.024688
CAMK2N1	-0.024682
EFHD1	-0.024647
MAP3K3	-0.024608
SIDT1	-0.024603
SPANXC	-0.024583
UBE2W	0.024535
BATF	0.024529
SLC26A2	0.024528
MIR22HG	0.024438
LPHN2	-0.024420
CFD	-0.024376
SLC39A14	0.024372
PPP1R3C	-0.024336
RELB	0.024303
TANK	0.024254
ECI2	-0.024245
CRELD1	-0.024199
INPP4B	-0.024151
NPHS1	0.024137
SNHG3	0.024115
ABCC5	-0.024083
NIP7	0.024080
NOL4	0.024008
RGCC	0.023989
SLCO4A1	0.023966
IFI44L	-0.023911
KCNN2	-0.023885
ANG	0.023884
TBC1D2	-0.023860
PARP1	0.023841
GINS4	0.023822
COL9A2	-0.023818
ACSL4	0.023807
NUDT6	-0.023779
PAK6	-0.023769
SLC4A3	-0.023745
CA8	0.023714
FAM216A	0.023685
SLC16A6	0.023674
PARM1	0.023627
ABCG1	-0.023621
CTDSP1	-0.023611
CHRNA5	0.023606
COA7	0.023572
TMEM135	-0.023564
HSP90B1	0.023471
SSR3	0.023436
GDF15	0.023411
S100A7	0.023405
SASH1	-0.023378
MAN1A1	0.023353
EIF5A	0.023327
CYBRD1	-0.023327
ZNF862	-0.023252
RHBDF2	0.023241
PTK7	-0.023217
PAIP2B	-0.023205
UCK2	0.023181
BBS1	-0.023102
MIPEP	-0.023077
EIF4G1	0.023066
ATP6V0E2	-0.023064
FAM53B	-0.022981
SLC15A2	-0.022964
HILPDA	-0.022951
ZC3H12A	0.022924
ESF1	0.022866
SSBP2	-0.022782
ZNF189	0.022684
ZNF423	-0.022672
DDX10	0.022664
FBXL7	-0.022655
MGAT4A	0.022645
PPP1R9A	0.022637
RAI14	0.022628
AGBL2	-0.022627
MYBPC1	0.022601
ECH1	-0.022590
PPT2	-0.022547
EPHX2	-0.022510
UCP2	-0.022471
HOXC13	0.022426
VPS9D1	-0.022411
PCYOX1	0.022405
APOLD1	-0.022364
IQCG	-0.022363
LINC00597	-0.022352
PALM	-0.022306
RMND1	-0.022280
EPRS	0.022271
SCN11A	-0.022244
WWC2	0.022238
TUBB2A	0.022195
CHML	0.022012
PLOD2	0.021986
ZNF804A	-0.021939
LIMA1	-0.021911
ZBTB38	0.021884
OR7E14P	-0.021876
SF3A2	-0.021842
LRP8	0.021805
STC2	0.021771
LOC155060	-0.021760
GOLGA2P5	-0.021728
LDOC1	-0.021724
JAM2	-0.021695
NME1	0.021666
MGC12488	-0.021608
FST	0.021520
CCDC28A	-0.021516
GPR64	-0.021481
ARID3B	-0.021480
PRODH	-0.021458
AKIRIN1	0.021457
OPA3	0.021390
GLRX	0.021380
ERMP1	-0.021351
SRGAP2	-0.021348
FKBP4	0.021330
MANF	0.021306
CARD14	-0.021288
ATP2A3	-0.021281
IRS1	0.021260
FLVCR2	0.021246
EHD3	-0.021244
TLE2	-0.021233
ZNF137P	-0.021192
FAM169A	0.021154
ZNF133	-0.021152
ENDOD1	0.021133
ITGA5	0.021111
ORAI3	-0.021075
UCHL3	0.021071
TMSB15A	-0.021064
STIP1	0.021062
ZNF551	0.021052
ZNF500	-0.021041
HSPH1	0.021039
MOCOS	0.021003
TXNRD1	0.020969
EGLN3	0.020969
ADCY6	-0.020965
INSIG2	-0.020944
EPN3	-0.020941
MANEA	0.020931
CTSV	0.020894
SLC2A10	-0.020891
CCNO	-0.020887
ETS2	0.020872
CLDN1	0.020864
MOSPD2	-0.020862
MSMB	-0.020861
SLC22A18	-0.020809
KBTBD11	-0.020802
SORL1	-0.020802
GAS1	-0.020769
TMA16	0.020762
AP1S1	0.020759
CTSS	0.020754
PTPN13	-0.020685
FAM57A	0.020674
RASL11B	-0.020651
BRCC3	0.020614
EYA2	-0.020599
TMEM62	-0.020593
POMT1	-0.020564
SGSM2	-0.020554
NFKBIA	0.020538
GREB1	0.020500
C10orf2	0.020482
TGIF2	0.020475
TRIM62	-0.020465
ABCA12	-0.020450
FAM114A1	-0.020429
UCN	-0.020429
CDC6	0.020377
HOOK1	0.020371
ZNF331	0.020369
PPL	-0.020369
BARX2	0.020356
POGK	0.020351
POP1	0.020350
KAL1	-0.020338
UAP1L1	-0.020311
SEMA3E	-0.020307
PROCR	0.020297
RANGRF	-0.020262
PAQR6	-0.020250
ITGB5	0.020234
INHBB	-0.020174
PRSS8	-0.020168
WDR74	0.020164
ATP2C2	-0.020158
SPSB3	-0.020128
CD302	-0.020108
TUBB6	0.020106
REPS2	-0.020094
MRTO4	0.020090