!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!cell	SKMel28
!perturbation	Trametinib 
!Time	24hrs
!Concentration	10nM
!end_metadata
HIST1H4C	-0.170360
CXCL8	-0.166279
CCND1	-0.163946
CRYAB	0.161529
SLC20A1	-0.157854
NOV	0.137371
MT2A	-0.131721
ANXA2P1	0.130673
SNAR-A1	-0.128841
MARCKS	0.120786
MYL6	0.109529
PLAT	-0.103514
CYR61	0.100063
MT1A	-0.098682
UCN2	-0.096846
IER3	-0.086914
LPIN1	0.086318
AKR1B1	0.085201
BEX1	0.083084
TNS3	0.081326
H2AFZ	-0.079678
VGF	-0.076398
SLC25A5	-0.074268
SH2B3	-0.073451
LPXN	-0.073212
EIF4A1	-0.070397
CD36	0.069297
HSPB1	0.069204
IFNGR2	-0.068874
MMP1	-0.068081
ANXA2	0.067894
GSTO1	-0.067662
TMEM47	0.065789
RPL31	-0.064619
TMEM158	-0.064090
UBB	-0.063530
RPL35A	-0.063221
UQCRQ	0.063217
RPL13AP5	-0.062194
FTH1P3	0.061749
PTPLB	0.060944
PHACTR1	0.060663
FAM98A	0.060569
BAMBI	-0.060536
ACTB	0.060521
SNRPB2	-0.060149
PHGDH	-0.060051
TM4SF1	-0.059405
FTL	0.058680
PRNP	-0.058146
ATP1A1	-0.058025
YWHAQ	0.057874
ACTG1	0.057436
RCAN1	-0.057266
UBC	-0.055449
EMP1	-0.055127
SPARC	0.055083
COX5B	0.053827
CSRP2	0.053375
CTSK	0.052984
RND3	-0.052786
JUND	0.052476
CDH2	0.052049
TYMS	-0.051255
RPL4	-0.051217
ADSL	-0.050969
CDC20	-0.050085
ARPC5	0.048550
ARHGEF2	-0.048527
PTTG1	-0.048331
VIM	-0.048176
SLC16A6	-0.047828
TMEM59	0.047292
CALD1	0.047241
TUBA1C	-0.047135
MYH9	0.046622
TMSB10	0.046552
ID3	0.046368
KRT34	0.045833
TUBA1B	-0.045727
S100A10	0.045428
HSPB3	0.044569
ALDH1A3	-0.044407
CITED2	0.044286
CCL2	0.044003
DKC1	-0.043902
AVPI1	-0.043675
LXN	0.043606
GNB2L1	0.043182
ATP6V0E1	0.043160
SPRY2	-0.042989
RPS27A	0.042937
PMP22	0.042888
ENO1	-0.042766
CTHRC1	-0.042523
ATP5B	-0.042353
TIMP3	-0.042169
C1orf198	0.042111
MORF4L2	-0.042019
HSPA8	-0.041950
PGRMC1	0.041890
PJA2	0.041790
BAIAP2L2	-0.041727
NUDC	-0.041442
CNN3	0.041280
RPS3	-0.041271
PLP1	0.041251
ZNF674	-0.040890
FERMT2	0.040732
IL1B	-0.040573
LGALS1	-0.040492
RPS16	0.040484
RPS20	-0.040335
EGR1	-0.039712
MYLK	0.039653
ATP6V1A	0.039618
SGK1	-0.039530
WDFY1	0.039367
SERPINE2	-0.039359
PINK1	0.039285
RPL3	-0.039214
POLE3	-0.039136
CAP1	0.039046
MCM6	-0.038910
HMOX1	0.038652
FTH1	0.038228
RPL18	0.038184
COX6C	0.038135
FSCN1	0.037869
GARS	-0.037689
NDUFS8	0.037560
SAT1	-0.037539
RHOA	0.037527
NDUFA4	0.037406
TMEM230	0.037352
SPANXA2	0.037299
PDHB	0.037290
MFGE8	0.037280
EBNA1BP2	-0.037037
RHOC	-0.037004
PLSCR3	0.036907
IMP3	-0.036793
OST4	0.036220
RPS8	-0.036212
ACTR2	0.036162
RANBP1	-0.035320
POLR2H	-0.035252
NDUFB2	0.035214
GTF2H5	0.035150
PEBP1	0.035011
NDUFA2	0.034857
PLOD2	0.034820
FKBP1A	-0.034685
HIGD2A	0.034660
DNAJA1	-0.034618
ARID5B	0.034605
TMEM51	-0.034500
DNMT1	-0.034467
MRPL33	0.034379
RPL37A	0.034362
XPNPEP3	0.034141
PTBP1	-0.034117
HNRNPD	-0.033710
ERH	-0.033520
ANXA2P2	-0.033515
ARL6IP5	0.033300
ANKS1A	-0.033258
RCC2	-0.033160
PSAP	0.033148
ETV5	-0.033071
PET100	0.033071
GPNMB	0.033067
MC1R	-0.032974
PSMB6	0.032895
RPL7	0.032711
TXNRD1	0.032674
NDUFB5	0.032518
MYH10	-0.032454
NOP56	-0.032395
LOC644936	0.032390
PPP1CC	-0.032352
RPL9	-0.032317
MYL12A	0.032217
AMY1C	0.032135
ATOX1	-0.032129
WBP2	0.032082
B2M	0.031821
HNRNPA1P33	-0.031732
FMN2	0.031677
MCM3	-0.031673
RPL13AP3	-0.031558
SOD1	0.031465
PSMB7	-0.031360
ERRFI1	-0.031282
RPL19	0.031200
MARCKSL1	-0.031150
DSTN	0.031100
TNC	-0.031082
CCT8	-0.030867
AURKA	-0.030865
PFN1	-0.030807
ROMO1	0.030746
TALDO1	0.030503
RAI14	0.030373
LEF1	-0.030292
RBX1	0.030274
DDOST	0.030273
QPRT	0.030157
RPS13	0.030149
ATP5H	0.030061
LIMA1	0.029981
LY6E	-0.029933
TTL	-0.029931
RPS27	0.029901
DNAJB11	-0.029825
SYNM	0.029749
RPS17	0.029693
C20orf24	-0.029657
BASP1	0.029633
EIF4A2	0.029497
CEBPB	-0.029489
PHLDA1	-0.029260
PRDX1	0.029215
PTTG3P	-0.029138
LDHA	0.029137
HSPA9	-0.029042
ABHD17C	-0.028979
FAM210B	0.028955
PPP1R15A	-0.028953
HPCAL1	-0.028847
SNRPB	-0.028838
GSPT1	-0.028753
SNAI2	0.028719
PRC1	-0.028594
RNF181	0.028248
YPEL5	0.028089
CDC42EP4	0.027943
IMP4	-0.027940
RAB32	0.027761
SLC7A5	-0.027443
ATRAID	0.027378
BOP1	-0.027360
NPC2	0.027348
BTF3	-0.027340
CLIC1	-0.027293
CDCA5	-0.027287
MRPL17	-0.027274
CENPB	-0.027238
CTSD	0.027137
GPX4	0.027076
CSE1L	-0.027076
RPL26	-0.027066
COX7A2	0.027018
RPL41	0.026885
PSMB1	0.026780
RPL6	-0.026663
CKS2	-0.026557
LIPA	0.026427
RN7SL1	0.026419
NCL	-0.026397
CCDC86	-0.026337
COX6B1	0.026319
RPS11	0.026252
IFITM3	0.026195
TUBB	-0.026126
VAMP3	0.026104
JUN	0.026076
MSH3	0.025961
PA2G4	-0.025927
MRPS24	0.025913
NFIX	0.025869
RAMP2-AS1	0.025802
EVA1A	0.025785
SCRG1	0.025717
PSMG1	-0.025619
NARS	-0.025575
FAM129B	-0.025520
DUSP3	0.025447
NBL1	-0.025409
SNX3	0.025274
F2R	0.025250
CAV1	0.025244
NME1	-0.025242
TOMM40	-0.025239
TRIB3	-0.025195
CKS1B	-0.025165
PPM1G	-0.025039
DECR1	0.024901
ANGPTL7	0.024885
CTGF	-0.024801
DCT	0.024779
RALB	-0.024743
CEMIP	-0.024709
TAX1BP3	0.024662
RANGAP1	-0.024512
GYG1	0.024449
RHOB	0.024412
LSM3	0.024402
PGK1	-0.024388
FEZ2	0.024383
ALCAM	0.024353
IGSF3	-0.024337
ALDH7A1	0.024236
ANP32B	-0.024221
NPPB	0.024166
SNRPF	-0.024155
CDK2AP1	-0.024110
DPYSL2	0.023972
CMTM7	-0.023888
TMEM256	0.023842
NDUFS4	0.023795
PTRF	0.023740
DKK1	0.023695
AGPAT9	-0.023635
ENY2	0.023622
DCBLD2	-0.023522
RPL18A	-0.023470
VCL	0.023416
COX8A	0.023331
MSN	-0.023314
DDT	0.023268
MAT2A	-0.023241
CADM1	0.023186
CKLF	-0.023142
ACAT1	0.022941
RAN	-0.022930
PRDX5	0.022928
SPANXA1	0.022906
CARHSP1	-0.022752
ACTA2	0.022700
MANF	-0.022697
CDK2	-0.022694
CTSL	-0.022684
PSMB10	0.022565
SPOCK1	0.022402
LPP	0.022315
NCOA4	0.022240
NDUFB11	0.022206
RPLP1	0.022128
DFNA5	0.022059
SCD	0.022056
SHMT2	-0.022010
NT5E	-0.021934
MATN2	0.021865
GSTK1	0.021830
ATP6AP2	0.021816
COX7B	0.021664
RPL24	-0.021663
POLR2F	-0.021644
TMBIM4	0.021643
CCDC53	0.021642
SRRT	-0.021627
TRNP1	0.021600
HSPD1	-0.021580
TMEM258	0.021576
MEX3C	-0.021437
ATP6V1F	0.021431
CD81	-0.021414
CCND3	-0.021406
AP1S2	-0.021401
FSTL1	0.021373
HNRNPAB	-0.021359
FEN1	-0.021350
HSP90B1	-0.021326
GNS	0.021302
PPCS	0.021245
TUBA1A	-0.021197
ITGAE	0.021178
GBP1	0.021109
C1orf85	0.021084
PIR	0.021081
MGST3	0.021056
YARS	-0.021023
PRDX6	-0.021010
MYL12B	0.021000
CALM2	0.020974
SPANXC	0.020963
TKT	0.020922
PFDN5	0.020865
SERPINB6	0.020861
MMADHC	-0.020848
CRKL	-0.020835
EIF1	-0.020824
LITAF	-0.020794
RPL27A	0.020752
SNRPA1	-0.020719
OLFML2A	0.020664
PELO	0.020538
RPS21	0.020495
ADD3	0.020487
RTFDC1	0.020460
NDUFA3	0.020439
PABPC4	-0.020417
TPST2	0.020407
BTG1	-0.020361
TMED10P1	0.020319
KHSRP	-0.020248
EIF1B	-0.020240
DHX15	-0.020222
NDUFA12	0.020203
PON2	0.020185
CDC45	-0.020113
THOC7	0.020087
MRGBP	-0.020049
CDK1	-0.019985
GYPC	-0.019984
EIF5A	0.019918
FAM83D	-0.019899
PALLD	0.019889
EEF1G	-0.019860
RPS25	-0.019787
AHNAK	0.019743
REEP5	0.019687
RPS2	0.019630
SDF2L1	-0.019629
GLUD1	-0.019626
XBP1	-0.019618
SNHG6	-0.019580
HMGA1	-0.019564
TMEM131	-0.019553
ETS1	0.019537
NREP	0.019519
MMP3	0.019501
HEBP2	0.019435
CCNA2	-0.019406
TGFA	-0.019358
MAGED1	0.019307
AIMP2	-0.019255
COX4I1	0.019182
TRIB1	-0.019162
PCBP1	-0.019075
DDX39A	-0.019036
RRP7B	0.019035
RPA2	-0.019012
RPS14	-0.019008
MTHFD2	-0.018998
STC1	-0.018968
HSPA2	0.018965
CETN2	0.018906
SRSF6	-0.018831
UBE2M	-0.018808
RPL26L1	0.018806
PGRMC2	0.018728
DAD1	0.018684
HCFC1R1	0.018665
PFN2	0.018641
PPP2R1A	0.018598
EPB41L3	0.018502
UBA52	-0.018458
HMGCS1	0.018411
CTNNAL1	0.018382
EIF3B	-0.018379
ATP6V0E2	0.018370
ID2	0.018351
PRR13	-0.018277
PAICS	-0.018269
TMA7	0.018255
RPL13AP6	-0.018253
AKR1C3	0.018242
IAH1	0.018218
CHCHD10	0.018168
HSPH1	-0.018127
DUSP6	-0.018120
LYPD1	0.018091
MRPS30	-0.018090
RPL39	0.018010
RPF2	-0.017998
CSTB	-0.017946
TIMP2	0.017930
AK2	-0.017919
YBX3	-0.017892
PRCP	0.017888
SYNC	0.017885
SLC35F5	0.017858
MPC1	0.017853
FOSL1	-0.017807
MLANA	0.017803
CHSY1	-0.017765
RRM2	-0.017740
WSB2	0.017727
EPDR1	0.017719
MYC	-0.017581
ASNS	-0.017558
ST6GALNAC2	0.017542
RPL10A	-0.017534
PTDSS1	-0.017516
SLC27A3	-0.017512
PRKCA	0.017499
TMSB4X	0.017470
AGK	-0.017459
CRISPLD2	0.017417
RABEPK	-0.017417
FASN	-0.017404
MDH2	-0.017400
ERAP2	0.017344
HINT1	0.017317
POLR3GL	0.017299
ST13	0.017275
ERGIC3	0.017250
HSP90AB1	-0.017166