!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	mouse
!drug_name	Lubiprostone
!smiles	CCCCC(C1(CCC2C(O1)CC(=O)C2CCCCCCC(=O)O)O)(F)F
!drugbank_id	DB01046
!pubchem_cid	656719
!cell_type	NA
!organism	mouse
!end_metadata
TFF2	0.229736
REG3G	0.219943
MGAM	0.162559
ADA	0.149897
ALPP	0.149300
PRAP1	0.137475
ALPI	0.133376
GSDMC	-0.132712
DNASE1	-0.124586
REG3A	0.122650
CTRB2	-0.114967
FABP2	0.109639
ENPEP	0.103521
SEPP1	0.099398
CELA2A	-0.098455
P4HB	0.097935
CELA1	-0.095767
REG1A	0.095143
APOA1	0.094849
LYPD8	0.094000
OAT	-0.093099
GUCA2B	0.092776
SLC40A1	0.089871
ANXA13	0.089119
PIGR	0.083366
PLA2G4C	-0.082551
PLAC8	0.082449
PAPSS2	0.081399
DMBT1	0.078408
PRSS2	-0.077642
SLC4A7	0.077200
CPB1	-0.076777
CPA1	-0.076721
KRT20	0.075995
PNLIP	-0.075817
RPS12	0.075198
RPL38	0.075045
FABP1	0.074489
EEF1A1	0.073107
RPS29	0.072424
CYP3A7	0.071928
RETNLB	-0.071737
RPS28	0.071403
ADH1C	0.071227
RPS27A	0.071214
ZG16	0.070616
RPS11	0.070031
SGK1	0.069330
ALDOB	0.065181
SLC5A1	0.065137
SAA1	0.064569
ARG2	0.064491
GAL3ST2	0.064461
SLC2A2	0.063885
LCT	-0.063087
ANPEP	0.062739
CELA3B	-0.062589
LYZ	0.062457
RPL23	0.062408
GPX2	-0.062254
OLFM4	-0.062067
XDH	0.061383
SLC6A19	0.061153
RPS23	0.060697
RPLP0	0.060348
RPL4	0.060125
HSPA8	-0.059980
ABCG2	0.058705
FTH1	0.058405
RPL28	0.058277
USMG5	-0.058035
SLC9A3R1	0.057682
SLC2A5	0.056461
HIST1H2BI	-0.056423
NAALADL1	-0.054086
RPL18A	0.053203
C15orf48	-0.053006
ATP1A1	0.053000
CLPS	-0.052477
IL18	0.050862
RPL26	0.050731
MEP1B	0.050529
CRIP1	0.050389
KRT8	0.050364
TMBIM6	0.050157
RPL3	0.049674
HINT1	0.049596
COL3A1	-0.049071
SLC26A6	0.048988
CEL	-0.048988
LGALS4	0.048834
RPL13	0.048792
MGST1	0.048668
MARC2	0.048169
RPLP2	0.048040
SLC6A8	0.047950
TMIGD1	0.047314
RPS14	0.047211
HSPD1	-0.046544
RPS8	0.046054
RPS20	0.045594
LGALS3	0.044981
CLCA1	-0.044907
ANXA4	-0.044803
RPL35	0.044096
CTRL	-0.044017
SOCS3	0.043860
TFF3	0.043680
FABP6	0.043146
CYP3A5	0.043044
RPL37A	0.042514
LAD1	0.041946
FBP1	0.041646
MTTP	0.041613
EZR	0.040880
AADAC	-0.040505
RBM3	0.040410
RPL9	0.040386
PNLIPRP2	-0.039906
RPS26	0.039831
EIF4A2	-0.039316
SNX17	0.039264
SERPINB1	0.038719
CREB3L3	0.038716
EPS8L3	0.038331
REG4	-0.038272
HSP90B1	-0.037315
AOC1	-0.037284
TMEM98	0.036896
SPINK4	-0.036443
IGJ	0.036174
RPL14	0.036154
RPS2	0.036055
GGT1	0.036028
IFIT1	0.035976
RPS24	0.035940
SLC51B	0.035853
RPL10A	0.035608
NFKBIA	0.035439
SLC13A1	0.035231
TMEM45B	0.035112
HSP90AA1	-0.034960
KLF4	0.034924
VDAC2	0.034839
GSDMD	0.034367
EIF3F	0.034232
EFHD2	0.033890
RPS7	0.033802
FAU	0.033751
TM4SF5	0.033135
PCNA	-0.033092
ACTG1	0.032979
RPS19	0.032945
ALDH9A1	0.032692
TPT1	0.032535
PMP22	-0.032372
HSPA5	-0.032292
ATP1B1	0.032228
DGAT1	0.032102
RNASE4	0.032073
IFIT1B	0.031917
PTGR1	0.031723
CTSS	0.031601
LPCAT3	-0.031159
NDUFA1	0.030725
CDHR5	0.030586
CUBN	-0.030561
H1F0	0.030527
ATP5G3	0.030413
PSMB7	-0.030249
RPS5	0.030197
CYP2C9	-0.030193
SAR1B	0.030056
RPS18	0.029984
REG1B	-0.029817
CA2	0.029770
ATP6V0C	0.029626
OCIAD2	0.029536
CDHR2	0.029528
MDH2	0.029487
HSPH1	-0.029173
SMAD4	0.029048
SLC13A2	0.028918
TM4SF4	0.028773
NAT8	0.028710
FCGBP	0.028616
RPL11	0.028345
TKT	0.028151
ATP5J	-0.028143
RPS17	0.027832
LASP1	0.027799
PGAM1	-0.027777
OAZ1	0.027539
ITM2B	0.027384
NTS	-0.027330
RPS10	0.027065
PNLIPRP1	-0.027020
RPL27A	0.026965
MANF	-0.026950
ATP2B1	0.026831
ACTB	0.026685
ABCB1	0.026562
ENPP3	0.026521
CHGB	0.026450
REEP6	0.026425
GHITM	-0.026418
MAPK13	0.026273
RFK	-0.026249
RPL10	0.026206
EEF2	0.026132
SMPDL3A	0.026129
HMGCS2	0.025958
SCIN	-0.025932
RPL18	0.025931
PPA1	0.025906
APOA4	0.025693
RPL19	0.025630
CD74	-0.025601
SERP1	-0.025586
CLCA4	0.025505
RPS4Y1	0.025353
RPL21	0.025222
IL33	-0.025169
UCP2	0.024798
RPL24	0.024669
ACAT1	-0.024556
TNIP1	0.024399
GDA	0.024389
CYP4F12	-0.024345
SMPDL3B	0.024313
GMDS	0.024149
SLC26A3	0.024008
CYP4V2	-0.023841
PPIA	-0.023744
ARHGDIA	0.023728
AHCYL1	0.023721
SNX3	-0.023697
AGR2	-0.023673
ATP5B	0.023618
MMP7	0.023473
FBP2	0.023467
ACAA2	0.023464
ADAMDEC1	-0.023393
ECI2	0.023335
ACTG2	-0.023305
ACE2	0.023282
SLC7A9	0.023272
CYP4B1	0.023119
DGAT2	0.023067
RNF128	0.023061
TGFBI	0.022995
MUC13	0.022941
PKM	0.022933
LAP3	-0.022927
CHORDC1	-0.022915
RPSA	0.022915
DDX3X	0.022838
RPS25	0.022565
RPL7	0.022436
SPINT1	0.022410
RPL22	0.022274
LCN2	0.022265
PGD	-0.022242
SLC35G1	0.022141
CYP2C18	-0.022115
AES	0.022021
XBP1	0.021960
RNASE1	-0.021828
TMC4	0.021720
LDHA	-0.021399
RPL15	0.021255
PTPRR	0.021169
DUSP6	-0.021166
TSTD1	0.021062
CLRN3	-0.020932
PGK1	-0.020712
CKB	-0.020673
ACADL	0.020564
IDH1	0.020501
PLS1	-0.020445
CGREF1	-0.020396
CFL1	0.020348
CIRBP	0.020342
APOC2	0.020294
ACSL5	-0.020250
MUC2	-0.020221
CYP2B6	-0.020077
AAMDC	-0.020075
YWHAQ	-0.019895
HSP90AB1	-0.019892
CEACAM1	-0.019881
CTNNB1	-0.019812
ST14	0.019736
EXOC3L4	0.019712
BAG1	0.019659
ABHD4	0.019551
COX7A1	-0.019489
MGAT4C	-0.019452
DNAJA1	-0.019439
CPS1	-0.019336
NDUFV3	-0.019270
RNF5	-0.019261
FAM213A	0.019230
ELF3	-0.019178
APOB	0.019163
GNA11	0.018983
SLC27A4	0.018945
RPS15A	0.018919
SPARC	-0.018881
GPX4	0.018872
LGALS9B	0.018869
DAZAP2	0.018828
TREH	0.018778
PRPSAP1	0.018732
HNF4G	-0.018650
AKR1A1	0.018645
UQCRC1	0.018634
TVP23B	-0.018631
CCNI	0.018595
MINOS1	-0.018594
SLC25A5	0.018578
TUBA1A	-0.018555
CA9	0.018445
HNRNPUL1	0.018433
SLC51A	0.018424
NDUFA9	-0.018406
EIF6	0.018393
SLC27A2	0.018388
BST1	-0.018336
MYO1A	0.018320
C14orf2	-0.018249
CLDN15	-0.018235
KPNA2	-0.018192
ERBB3	0.018168
TPI1	-0.018155
NDUFC1	-0.017990
MME	-0.017953
METTL9	0.017877
PPP4C	-0.017826
LGALS2	-0.017779
TALDO1	-0.017771
RPL8	0.017730
CASP1	-0.017727
BANF1	-0.017704
NDUFS7	-0.017688
ERO1L	-0.017688
CDA	0.017687
SMIM22	0.017634
RAN	-0.017564
SLC25A3	0.017461
GPI	0.017437
ARF1	-0.017378
UBALD2	0.017377
FAM3D	0.017331
ST3GAL4	0.017261
AP3S1	0.017208
NDUFS2	0.017163
DYNLL1	-0.017095
HSPE1	-0.017012
GUCA2A	0.016999
EMG1	-0.016976
VASP	0.016945
GSTK1	-0.016925
NDUFA8	-0.016917
RPL5	0.016845
VCP	0.016826
UQCRFS1	-0.016798
KHK	0.016700
IL13RA1	-0.016688
TMED4	0.016688
TRIM31	-0.016667
NDUFB6	-0.016532
MYL9	-0.016515
DDC	-0.016481
MYH14	0.016476
ME1	-0.016428
TMEM41A	0.016366
ITFG3	0.016342
RPL6	0.016296
FTL	-0.016261
OTOP3	0.016256
AZIN1	-0.016232
TSC22D1	-0.016202
CDH1	0.016189
MAOB	-0.016152
MVP	0.016137
NDUFA2	0.016070
MARCH7	0.016067
SERF2	-0.016044
PITPNA	0.016038
ATP5J2	-0.015970
VIL1	0.015937
JUND	0.015910
MAF	0.015824
PRDX1	-0.015789
RPL13A	0.015752
RPL27	0.015695
ANKRD13A	0.015620
LGALS3BP	0.015604
DDX17	-0.015578
SLC36A1	0.015559
RPS27L	-0.015542
HADHA	0.015531
MIEN1	-0.015529
MEP1A	-0.015529
IMMP1L	-0.015525
RPS21	0.015509
TAX1BP3	-0.015506
ASNS	0.015504
PLBD1	-0.015503
TXNDC17	0.015500
RAB5A	0.015487
CCL25	0.015423
MS4A10	0.015423
PLIN3	0.015396
TMEM208	-0.015318
SH3BGRL3	0.015286
CTSE	0.015245
SKP1	-0.015244
RPS15	0.015241
RETSAT	-0.015227
MAOA	-0.015225
SOWAHB	0.015141
GDPD1	0.015113
SEPW1	0.015038
COL6A3	-0.015011
GIP	-0.014986
ATP6V0E1	-0.014946
CTH	0.014836
COL4A1	-0.014807
PTP4A2	0.014779
PEX11A	0.014774
ARF6	0.014723
C18orf32	-0.014696
H2AFZ	0.014692
CIDEB	0.014627
KDELR1	0.014615
SLC16A9	0.014615
ASAH2	-0.014567
NDUFB5	-0.014444
COPZ1	-0.014407
MPP1	0.014404
EMC2	-0.014399
TAX1BP1	0.014374
RAC1	0.014359
NADK	-0.014302
FAM8A1	0.014295
SLC7A7	-0.014277
NDUFA3	-0.014272
SRSF1	-0.014148
KITLG	-0.014137
PSMB5	-0.014129
DSC2	-0.013987
PDHA1	-0.013985
HNRNPK	0.013880
RHOC	0.013786
LRRC59	0.013778
LGALS1	-0.013746
CASP7	-0.013721
MYO7B	0.013693
REEP3	0.013672
PGRMC1	-0.013656
COA3	-0.013609
SSR3	-0.013572
VIP	0.013565
RPS9	0.013549
CA4	-0.013546
CDC42SE2	0.013535
STK24	0.013521
UBXN2A	0.013513
NPC1L1	0.013490
FAM162A	0.013459
IGSF23	-0.013449
SLC5A12	-0.013441
PCBP2	0.013393
FOS	0.013338
CLINT1	-0.013314
GPX1	-0.013265
ABCC3	0.013265
ELOVL1	0.013256
NSFL1C	-0.013227
C11orf86	-0.013199
NDUFA4	-0.013184
DBI	-0.013162
SCP2	-0.013155
ARHGEF16	0.013151
TOMM20	0.013113
GLTP	0.013111
HLA-DQB1	-0.013050
ZFP36	0.013049
UQCR11	-0.013019
MCFD2	-0.013017
FUCA1	0.013006
MORF4L2	-0.013000
TSPAN13	0.012977
KLHL9	-0.012963
S100A6	0.012955
NDUFS8	-0.012945
GNB2	0.012907
GNAI2	0.012885