!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!cell	Locus coeruleus
!perturbation	Braak stage 4
!disease	PD
!end_metadata
GAL	-0.074458
CHODL	-0.071875
GPR153	-0.063964
DLK1	-0.063533
PDIA3	0.061690
FLJ30901	-0.059571
CYB561	-0.058785
ACTA2	0.055451
IRX3	-0.055274
GDNF	-0.054104
NAIP	0.052974
NACAP1	0.052254
NEBL	0.052223
LMO1	0.051688
HNRNPL	-0.051458
MET	-0.050273
CHGB	-0.049898
LOC155060	0.049850
KLF16	-0.049641
ZNF710	0.048628
ZSCAN10	-0.047654
OGFRL1	0.047395
SPPL2B	-0.046847
FOLR1	0.046720
TANGO2	0.046611
KRTAP5-8	0.046215
PGM5	0.045684
SSTR2	-0.045410
BHLHE23	-0.045397
CCAR2	-0.045145
ARID3A	0.044273
GNG13	0.044203
ABLIM1	0.043693
GLIS1	0.043629
DLGAP3	-0.043517
NR4A1	0.043459
NFYC-AS1	-0.043253
LINC00626	0.043222
FBRSL1	-0.043040
RNF19A	0.042865
SLC41A1	0.042588
CHIC2	-0.042212
ALDOA	-0.042144
SPAG8	0.041641
IL21R	-0.041505
FNDC3B	-0.041456
RAMP3	-0.041245
LPPR1	0.040968
AKIP1	0.040763
SYN1	-0.040718
CHP2	-0.040641
CSPG4	0.040588
NDFIP2	0.040125
LY6H	-0.040124
SAMD11	-0.040094
NUMB	0.040000
DKK3	0.039898
SDS	-0.039704
CNTNAP1	0.039627
FRZB	0.039591
SV2C	-0.039478
NUP50	0.039383
PDE2A	-0.038839
GJA4	0.038814
ABCB1	0.038672
PARP4	0.038563
FAM71F1	-0.038484
GPR4	0.038483
CASP2	0.037967
NBPF14	0.037848
LOC389831	0.037828
PDCD10	0.037532
NCEH1	0.037459
ZNF492	0.037367
AFAP1L2	0.037271
MAFG-AS1	-0.037245
FN1	0.037244
CLCN3	-0.037177
CRYZ	0.037137
DVL1	-0.037099
RAVER1	-0.037027
NPNT	0.036899
MYOF	0.036537
PCBP1-AS1	0.036454
KIAA1671	0.036258
TIAM1	0.036242
PHPT1	0.036185
QKI	0.036123
NUTF2	-0.036060
DLG4	-0.036055
HTR2A	-0.036019
MARVELD1	0.036004
TINCR	-0.035823
ADAMTS7	-0.035765
PIN1	-0.035559
CTGF	0.035503
ELOVL7	0.035423
SLC22A17	-0.035381
RDH5	0.035357
UGT8	0.035319
GLTSCR2	-0.035303
CTDSPL	0.035247
ENDOG	0.035228
PPP1R11	-0.035188
GIMAP6	0.035171
PSORS1C2	-0.035099
PLAC4	0.035060
LNPEP	-0.034981
PPP1R12C	-0.034946
CCND1	0.034571
TMEM217	0.034468
COL1A2	0.034320
BRD3	-0.034304
MIB2	-0.034172
HBD	0.034151
C1orf61	0.034083
NUBP2	-0.034077
LSM12	-0.034033
AATK	-0.033940
MYO5A	-0.033918
SOX2-OT	0.033838
GNA11	-0.033759
CDC37	-0.033621
TXNDC9	0.033618
IQCD	0.033605
SSU72	-0.033353
CLCN7	-0.033152
POLR2A	0.033101
S100A13	0.033083
SNRNP40	-0.033053
ATXN1	0.033039
SOX17	-0.032951
NKX2-8	-0.032879
LMOD1	0.032832
TNFRSF10B	0.032831
EEF1A2	-0.032778
KIAA0930	-0.032762
DCLK1	-0.032604
LOC100289230	0.032559
MRPL11	0.032531
NTN4	0.032475
PPIEL	0.032428
SBF2	0.032396
SH3GLB2	-0.032294
LPAR1	0.032282
SBF1	-0.032278
CD248	0.032143
LINC00667	0.032093
AGAP7P	0.032090
GAS2L1P2	0.032043
BEST4	0.031952
CTNNA1	0.031899
NDRG3	-0.031898
RDX	0.031838
HNRNPA2B1	0.031803
ALK	-0.031722
FLII	0.031707
TUBGCP2	-0.031697
C5orf27	0.031662
NKD2	-0.031612
CLTB	-0.031482
PSMD2	-0.031395
POU2F1	0.031369
FAM73B	-0.031330
SYNGR3	-0.031313
FYCO1	0.031240
CRIP1	0.031105
ST18	0.031029
MAPT	-0.030991
WSB2	-0.030972
CAMK2N2	-0.030967
MEGF9	0.030919
GLDN	0.030803
OSBPL8	-0.030800
CSAG1	0.030749
BOD1L1	-0.030720
CAV1	0.030598
NFYB	0.030523
PLEKHB1	0.030513
IL27RA	0.030414
PDLIM3	0.030339
ARHGAP17	0.030267
P2RY14	0.030242
TRAP1	-0.030017
ACOT7	-0.029972
SORT1	0.029970
TTC28	0.029947
RRP1B	0.029928
KLF15	0.029891
CBFA2T2	0.029772
CXCL12	0.029714
ZMYM6NB	0.029695
RPL23AP32	0.029626
GSTT2	0.029616
GIPR	-0.029596
METTL9	0.029581
GPR124	0.029567
TMEM63B	-0.029554
MUC5AC	0.029516
CFH	0.029513
LAMP2	0.029503
CSNK1E	-0.029494
CABP1	-0.029467
PLS3	0.029395
CACNA2D2	0.029345
MTCH1	-0.029343
PPAP2B	0.029318
HIST1H2BE	0.029293
PYGM	0.029231
MACF1	0.029132
ARHGDIA	-0.029095
S1PR5	0.029074
CTBP1	-0.028953
PNPLA4	0.028944
RSRP1	0.028938
GPR156	-0.028932
PTPRZ1	0.028924
TMBIM4	0.028913
GNB2	-0.028905
LRIG1	0.028843
LPP	0.028779
MED13L	0.028647
TTC31	0.028615
IFITM4P	0.028604
PDZD8	-0.028590
MRAP2	-0.028588
ZNF157	0.028528
GIPC1	-0.028492
SRGN	0.028484
ZSCAN25	0.028456
FAM162B	0.028436
ZFX	0.028375
CTNNB1	-0.028343
DOHH	-0.028331
ZNF407	0.028325
LINC00665	0.028304
TSC22D2	-0.028166
LRRC1	0.028096
AKAP12	-0.028069
HMGN2	0.028069
LOC286382	0.028055
SETD7	0.028054
SYT1	-0.028050
CMAS	0.028036
MOBP	0.028008
MEGF11	0.027981
NSFL1C	-0.027976
COLEC12	0.027962
MAPK8IP2	-0.027937
LGR6	0.027906
KLHL35	-0.027856
MFI2	0.027811
CRMP1	-0.027772
TBC1D24	0.027725
AMT	0.027680
AES	-0.027678
TSR2	-0.027669
LOC101927181	0.027556
CERS6	-0.027542
DYNLRB2	0.027524
VEGFC	0.027503
LRRC4C	0.027452
PLEKHA5	0.027451
SCAPER	0.027431
ARHGAP39	-0.027418
SMO	0.027407
KXD1	-0.027407
SH3BP2	0.027406
DRAM1	0.027394
HSD17B6	0.027285
RHOU	0.027276
FSTL1	0.027275
TCF12	0.027270
PAN2	0.027266
RNF157-AS1	0.027167
OSBPL11	0.027113
THRA	-0.027109
SLC38A2	0.027083
CYB5R3	-0.027071
POLR2E	-0.027044
LSM3	0.026961
WASH1	-0.026892
SNX10	-0.026882
TM4SF1	0.026863
RASSF8	0.026811
OCLN	0.026799
KMT2C	0.026792
ZDHHC16	0.026715
MANEAL	-0.026706
DLG5	0.026631
LIX1L	0.026629
B4GALT2	0.026597
CCDC146	0.026507
SLMO2	-0.026475
MSI2	0.026445
HSP90AA1	-0.026441
TRPM3	0.026440
CBR1	0.026423
PACS2	-0.026375
DBNL	-0.026337
SLC38A3	0.026305
HES4	-0.026304
PRKACA	-0.026284
LPXN	0.026264
ARTN	-0.026260
DCN	0.026253
MXRA8	0.026219
BHLHE40	0.026188
DOK4	0.026173
DGCR6	-0.026091
SNX29	-0.026077
AHCYL1	0.026050
PAPLN	0.026023
HSP90AB1	-0.026018
GPR37	0.025989
SORBS1	0.025984
ATXN7L3	-0.025975
SCRG1	0.025973
DPY19L1	0.025918
PTBP3	-0.025906
ERG	0.025854
FAM181B	0.025792
PRKAR1B	-0.025769
HDAC1	0.025752
KISS1R	-0.025721
P4HA2	-0.025705
DHX29	0.025691
KCMF1	0.025690
UBXN6	-0.025625
DOCK9	0.025614
LINC01278	-0.025611
KHNYN	0.025586
KIAA1324	-0.025567
NTN1	0.025552
TEK	0.025529
RUVBL2	-0.025494
ANKHD1-EIF4EBP3	0.025474
ITPRIPL2	0.025448
MYLK2	0.025367
TTC17	0.025358
HCN3	0.025330
CPOX	0.025291
ANKRD10	0.025275
MFI2-AS1	0.025264
ABAT	-0.025263
ACSL6	0.025255
FAIM2	-0.025241
TAF15	0.025227
MAPK8IP1	-0.025222
SEPT6	-0.025215
MKNK2	-0.025207
TMX1	0.025198
CASP5	0.025196
CREB3	-0.025159
CEP192	0.025113
BCL6B	0.025110
CDC34	-0.025089
DIS3L2	-0.025089
NCBP2	0.025058
SPRY2	0.025047
SPACA3	0.025017
PPP2R4	-0.025008
OR4D2	0.025003
FRYL	0.024990
GGT7	0.024972
ELAVL4	-0.024952
HERC2P7	0.024943
TYMS	0.024896
FZD10	0.024893
RNF2	-0.024871
NEURL1B	0.024823
MUTYH	0.024808
CCL21	0.024803
MPDZ	0.024798
SOBP	0.024793
BCL2L11	0.024773
RUNDC1	0.024763
HIST1H3C	0.024729
CLMN	0.024728
EBF1	0.024703
MARK2	-0.024667
INHBA	0.024652
PFKFB3	0.024652
FGF2	0.024638
RGAG4	-0.024634
RFTN1	0.024627
SERPINA3	-0.024603
ANGEL1	0.024581
RPS6KA3	0.024559
CALY	-0.024542
TEX261	0.024536
PPP2CB	0.024534
STAG3L1	0.024503
ITPKA	0.024495
UBE2Z	-0.024477
TMEM98	0.024474
TSNAX	0.024461
KIAA0485	0.024438
HERC2P2	0.024348
PROCR	0.024334
ATP6V0C	-0.024329
UPK3B	0.024318
SYVN1	0.024308
CDH22	-0.024250
PDE8A	0.024248
PPFIBP2	0.024154
NEIL1	0.024145
CCPG1	0.024133
ULK3	-0.024120
TMEM216	0.024119
TXNIP	0.024103
LOC389199	-0.024099
SOX9	0.024092
CYP1A2	0.024062
TRABD2A	0.024050
APBB1	-0.024034
SMARCA4	-0.024031
ZNF525	0.024005
METRN	-0.023997
KRT18	-0.023989
KCNJ10	0.023962
TACC1	-0.023956
FOXC2	-0.023920
TMEM14A	-0.023920
SORCS2	0.023904
FGD5	0.023901
MTUS1	0.023887
C11orf39	0.023862
BTBD16	0.023833
CYFIP1	0.023821
MITF	0.023813
UST	0.023799
USP54	0.023797
NRXN2	-0.023789
GABRG2	-0.023754
GOLGA2P10	0.023750
ARL8B	-0.023695
TUSC1	0.023644
DGKH	0.023626
CHMP2B	0.023625
LAMC3	0.023623
CHST14	0.023619
ACHE	-0.023600
APPL1	-0.023592
ZNF711	0.023589
HPCAL1	-0.023588
COL23A1	0.023568
CHST13	-0.023560
ABHD8	-0.023550
SERPINB6	0.023543
HIBADH	0.023539
HIST1H4C	-0.023523
HNRNPF	0.023517
KRAS	-0.023494
AP3D1	-0.023479
TCF4	0.023456
ANGPTL2	0.023437
PSRC1	0.023418
MAP1LC3A	-0.023398
CLPX	0.023383
ZNF652	-0.023367
RNF14	-0.023365
PUF60	0.023335
PCYT2	-0.023294
CCM2	-0.023279
JADE1	0.023276
RFTN2	0.023267
PDGFRA	0.023263
SLC25A11	-0.023207
DISC1	0.023200
ATP13A2	-0.023181
KANK2	0.023110
IGFBP5	0.023097
MTF2	-0.023064
GRM3	0.023043
RASGRP3	0.022982
GRASP	0.022963
PDK4	0.022947
FBXO3	0.022942
GRAMD3	0.022927
IFI27	-0.022899
E2F1	-0.022889
THEG	0.022873
AMPD3	0.022859
TPM2	0.022856
PGRMC1	0.022852
SMARCD1	0.022825
CBLB	0.022825
CLDN11	0.022816
LRRC59	0.022811
ANK3	-0.022808
LRRC23	0.022797
ATAD2B	0.022794
PPM1H	-0.022790
TFCP2	0.022741
CDK5	-0.022728
THEM6	-0.022726
MAOA	-0.022722
IFI44L	0.022702
ARID5A	0.022668