!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	human
!drug_name	Morphine
!smiles	CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(C=C4)O
!drugbank_id	DB00295
!pubchem_cid	5288826
!cell_type	Striatum - SWR/J mice - Acute morphine treatment
!organism	mouse
!end_metadata
CCDC14	0.276422
RTN1	-0.103327
PISD	-0.096970
SEPP1	0.095092
SPARCL1	0.089188
PTGDS	0.086336
FAM107A	0.082502
CLU	0.080784
HPCAL4	0.079804
HTRA1	0.079442
MRPL16	-0.074647
CADM4	-0.068031
SYNDIG1L	-0.067352
TMA7	-0.067209
ANKRD63	-0.066421
NDRG2	0.064898
CDH2	-0.064215
OAZ1	0.063493
TRANK1	0.063454
SH3BGRL3	-0.061904
ATP6V0C	0.060197
PBX3	-0.059911
SEC61G	-0.058757
CYGB	-0.058532
DBP	-0.058421
PPIA	0.057969
NCDN	0.057876
ARHGAP32	-0.057790
CTRB2	-0.054023
MBOAT2	-0.053730
APOE	0.053045
RGS7BP	-0.051251
C10orf10	-0.051093
ATOH8	0.049996
CA2	-0.049608
AGO2	-0.049221
AES	-0.048843
FKBP2	-0.048736
PFN1	-0.048489
ACTB	-0.048118
SCN2B	-0.048064
UQCRC2	-0.047811
EGR1	-0.046606
LRRC58	0.046430
SV2A	-0.046366
SGK1	0.046087
YWHAB	-0.045907
MED16	-0.045842
HRAS	-0.044869
LRRC4C	-0.044307
ENO2	0.044253
TSPAN13	-0.043736
RPS11	-0.043435
ATP5B	0.043254
AKAP5	-0.042613
MRFAP1	0.042571
ATP1A3	-0.042543
KCNJ4	-0.042348
TMOD1	-0.041982
ARPC2	-0.041408
RABGGTA	-0.041354
PSD	0.040892
MAT2A	0.040617
BSG	-0.040184
HLF	-0.040137
PKM	0.040084
R3HDM2	-0.039758
NDFIP1	0.039676
GPM6A	0.039663
RPS8	-0.039628
PLTP	-0.039581
UQCR11	-0.039350
GNAZ	-0.039285
ALDOC	0.039268
LDHB	0.038969
HNRNPA2B1	0.038899
CHST1	-0.038733
DLGAP3	-0.038694
APLP1	-0.038509
DFNA5	-0.038303
KIF5A	0.037883
RTN3	0.037624
GAD1	0.037569
PEA15	0.037384
CMTM5	-0.037342
NEDD8	-0.037041
LMO4	-0.036963
LYNX1	-0.036707
COX6A1	0.036642
RPL10A	0.036505
PRNP	0.036243
HNRNPH2	0.036225
PFDN2	-0.035926
NDUFB7	-0.035917
NDUFB10	-0.035904
RPL10	0.035901
MAPT	-0.035831
GJB6	0.035815
EEF1A1	0.035799
ATP2B1	-0.035710
GPRIN3	-0.035592
ATP6AP2	0.035388
PENK	-0.035332
TSPYL4	0.035278
NRSN1	0.035124
GNA11	-0.035037
OGDH	-0.034850
NDUFA6	-0.034658
NELFA	-0.034564
TESC	-0.034537
CLK1	0.034409
TFG	-0.034390
DDX17	0.034279
PSMB7	-0.034255
PXDN	0.034253
IQSEC1	-0.034195
PRMT5	-0.034079
DZANK1	0.034001
COL6A1	0.033997
RPS2	0.033984
PEBP1	0.033968
ZNF575	0.033965
PDAP1	-0.033957
LRRTM2	-0.033602
MYO18A	-0.033536
MORF4L2	0.033435
TIMM13	-0.033421
TTYH3	0.033378
COA3	-0.033320
PPP2R2B	-0.033319
PDE10A	-0.033264
PHPT1	-0.033256
NDUFA5	-0.033159
RGS7	-0.033084
PSMC5	-0.032965
GAD2	0.032926
HNRNPH1	0.032890
CYP46A1	-0.032864
GJA1	0.032863
IMP4	-0.032854
RHOB	-0.032823
CST3	0.032474
VTI1B	-0.032421
SCG5	0.032416
STK32C	-0.032333
PSAP	0.032263
BZRAP1	0.032161
RPL8	0.031982
PKIA	0.031839
FKBP1A	0.031723
KRT78	0.031477
NENF	-0.031457
C15orf59	0.031367
NDUFV2	-0.030919
BRSK1	-0.030919
PGK1	0.030856
TSC22D3	0.030712
PPAP2B	-0.030563
GABRB2	-0.030546
PPP1CA	-0.030394
SCN4B	0.030373
YWHAH	0.030323
ADORA2A	-0.030243
NAP1L5	0.030139
STX16	0.030125
MAPK8IP1	-0.030100
HNRNPUL1	-0.029973
NTM	-0.029951
YWHAE	0.029827
CSNK2B	-0.029816
TMCC3	-0.029813
CRYM	0.029801
SUSD4	-0.029689
CFDP1	-0.029614
CXXC5	-0.029534
RUFY3	-0.029511
GAP43	-0.029489
SEPHS2	-0.029412
TMEM231	0.029273
UBXN2A	-0.029272
DAD1	-0.029246
HAP1	0.029227
WIPF3	0.029213
DTX3	-0.029190
TTR	0.029185
CCT2	-0.029134
GOT1	0.029134
GRINA	0.029119
ARHGDIA	-0.029072
RPL18A	0.029045
NDUFC1	-0.029000
ATP5J	-0.028981
FAM168B	0.028773
FARP1	-0.028658
SNRPF	-0.028629
LRRC4B	-0.028524
ITM2B	0.028512
RAB5C	-0.028337
HECTD1	-0.028251
DDX5	0.028239
UBL7	-0.028229
SLC4A10	0.028223
ATP5G3	0.028189
GLTP	-0.028183
SNRNP27	-0.028118
MAP1LC3A	-0.028091
GRM3	-0.028083
CHCHD2	0.028081
AMER2	-0.028057
ELOVL5	0.027988
COX6B1	-0.027925
JUNB	-0.027894
SESN3	-0.027881
UNC80	0.027840
GABRD	-0.027837
DUSP14	-0.027804
PAK1IP1	-0.027774
MN1	-0.027743
SRM	-0.027657
SNX3	-0.027641
DUSP26	-0.027624
NDUFA10	-0.027544
ST6GALNAC5	-0.027513
LACE1	-0.027485
CDK5R1	-0.027473
PAQR4	-0.027324
DRD1	-0.027295
RPL28	-0.027284
PTGES3	-0.027228
ALCAM	-0.027227
ATP6V1G2	0.027206
TTC9B	-0.027170
TCF7L2	-0.027114
PIN1	-0.027022
SKI	-0.027009
PHYHIP	-0.026995
LXN	-0.026977
CAP1	-0.026964
DNER	0.026898
SEPT4	-0.026858
SARAF	0.026857
PRMT8	-0.026844
EML2	-0.026736
ARPC3	-0.026726
CALN1	-0.026723
RGS2	-0.026645
OXCT1	0.026589
PSMA4	-0.026572
PTCH2	0.026536
GRIK5	-0.026480
LONRF1	-0.026374
SERPINE2	0.026365
CLPTM1L	-0.026347
MAP7D1	-0.026264
BANF1	-0.026222
SULT4A1	-0.026194
CEP170B	-0.026194
NFE2L1	-0.026172
DRAP1	-0.026172
UQCC2	-0.026116
BCL11B	-0.026063
NDUFS3	-0.025952
EIF5A	0.025944
ARPC4	-0.025874
GPR37	-0.025805
ARID1A	-0.025756
WDFY2	0.025714
HNRNPK	0.025688
RPL26	0.025608
GPRASP1	0.025485
RCAN2	0.025385
RABAC1	-0.025348
RPS15	0.025330
CWC15	-0.025300
AP2S1	-0.025292
XKR6	-0.025239
WSCD2	-0.025228
MRPS34	-0.025179
CPE	0.025169
CDC42EP3	-0.025089
PDE1B	-0.025052
C6orf57	-0.024962
PODXL2	-0.024915
PFN2	0.024913
GATA1	0.024896
RASAL1	0.024802
CPLX1	0.024778
NCEH1	-0.024717
NDUFB3	-0.024710
AATK	-0.024663
USP2	-0.024647
DMTN	-0.024611
MINK1	-0.024600
RGMA	-0.024535
CACNG4	-0.024508
DCLK3	-0.024473
C11orf87	-0.024438
MDH1	0.024437
WASF1	-0.024433
ZMIZ2	-0.024420
MAP2	0.024383
RPL36AL	-0.024305
EDAR	0.024294
STARD10	-0.024229
SEPW1	-0.024227
FABP5	-0.024227
OXR1	0.024204
KCNMB4	-0.024168
GNG3	-0.024158
CNP	-0.024072
ARF5	-0.024065
H2AFX	-0.024054
APBA2	-0.024001
CACHD1	-0.023955
DSTN	0.023941
NCOA1	-0.023928
CAMK1G	0.023867
IVNS1ABP	0.023862
NIFK	-0.023820
APOD	0.023809
HCFC1R1	-0.023730
CLSTN3	-0.023684
CHRM1	-0.023670
ARHGEF9	-0.023649
KCTD17	-0.023647
PPP1R37	-0.023622
ZBTB16	0.023622
NDUFA4	0.023591
GALNT2	-0.023585
WNK1	-0.023546
SLIRP	-0.023512
UBALD1	0.023512
AP2M1	-0.023512
MMD	-0.023488
KCTD1	-0.023459
H2AFY	-0.023400
CADPS	0.023356
GABARAP	-0.023345
MARCKSL1	-0.023316
UBA1	0.023243
STXBP2	0.023210
EI24	-0.023200
GNG5	-0.023138
ATP6V1A	0.023103
TMEM132A	-0.023101
MLC1	0.023052
TUBA1B	0.023047
RETN	0.023043
UBC	0.023039
ACOT7	-0.023021
TAC1	0.023001
HSD3B1	-0.022987
RNF149	0.022976
SLC6A1	0.022968
GABRA4	-0.022936
RPL27	-0.022908
DUSP8	-0.022843
BAI2	-0.022827
ARHGAP33	-0.022710
PRKAR2B	-0.022710
MPC1	0.022696
FAM102B	-0.022688
COPS6	-0.022669
KCNJ11	-0.022669
TUBB4A	-0.022626
ATP5A1	0.022610
PLIN4	0.022574
GNPTG	-0.022566
ATP5H	-0.022549
MORF4L1	0.022541
MATK	-0.022527
MFSD2A	0.022515
PSMC3	-0.022496
SCG2	0.022483
PSAT1	0.022478
ARF3	0.022465
SRSF6	0.022421
GSK3B	-0.022411
CLEC2L	0.022373
DNAJC7	0.022359
ARC	-0.022333
SSBP4	-0.022331
NGEF	-0.022328
NDUFA2	-0.022326
PRR18	-0.022319
FBXL5	0.022311
RPL13	0.022302
GLIS1	0.022263
PPM1E	0.022231
CDC34	-0.022213
FAM169A	0.022200
NLK	-0.022197
NBEA	-0.022185
PRKAR1B	0.022152
WDR13	-0.022141
TSC22D4	0.022116
VCP	-0.022073
NDUFS6	-0.022049
HSP90AB1	0.022033
GNMT	0.022004
RPS25	0.021981
ALDOA	-0.021920
SERINC1	0.021879
CACNA2D3	-0.021859
TF	-0.021823
CKB	-0.021820
LPHN1	-0.021817
PCP4	-0.021757
MAG	-0.021737
RPS29	0.021678
EIF4A1	-0.021672
CASP4	0.021646
RUSC2	-0.021643
ANAPC5	0.021555
CASP14	0.021532
NDUFV3	-0.021528
NTSR2	0.021513
B3GNT1	-0.021479
LINGO1	-0.021407
SCAND1	-0.021392
PJA2	-0.021368
MLLT11	0.021319
RPS13	-0.021305
PHYHD1	0.021256
CNTFR	-0.021198
USP54	0.021195
BCR	-0.021191
DHX36	-0.021180
COMT	-0.021170
ITGB1BP1	-0.021127
PSMB3	-0.021119
MAL	-0.021089
ITPKA	-0.021052
UTP14C	0.021046
LZTS3	-0.020968
EIF3E	-0.020902
SLC25A4	0.020833
EIF1B	-0.020753
KIAA1462	-0.020706
CTSS	0.020695
FBXW5	-0.020694
UGT8	-0.020670
NETO1	-0.020665
ATG16L1	-0.020652
RPS19	-0.020652
GABARAPL1	0.020582
FAM110B	-0.020556
SLC24A3	-0.020544
ATP1B3	0.020500
TUBB2B	0.020490
RESP18	-0.020453
RANBP1	-0.020446
C14orf166	-0.020429
PPFIA3	-0.020416
CCNL2	0.020409
IL33	0.020381
HMGCS1	-0.020381
DLGAP2	-0.020379
TSPAN7	0.020365
ARL6	-0.020356
ARL6IP5	-0.020353
WSB1	0.020326
FAM71F1	-0.020323
ETNPPL	0.020311
ITM2A	-0.020273
CACTIN	-0.020261
ENPP5	0.020248
TMEM88B	-0.020245
MAPK4	-0.020240
DOLPP1	0.020163
FAM213B	-0.020153
CELF5	0.020150
TESK1	-0.020133
DMXL2	0.020128
EFNB3	-0.020105
LMBRD1	-0.020048
TMEM50B	0.020031
FRRS1L	-0.020002
LAPTM4B	0.019994
FYN	-0.019977
ATP6V1B2	0.019964
SPARC	-0.019961
SNF8	-0.019946
TCEAL8	-0.019924
NDUFAF4	-0.019917
DAGLA	-0.019894
MRPS18C	-0.019872
RPS24	-0.019852
SEMA6B	-0.019841
RPS5	0.019840
DRD2	-0.019824
CACNG3	-0.019811
RXRG	-0.019800
PLCL2	-0.019791
EIF4G2	0.019782
LGALS2	-0.019775
JUP	0.019759
EEF2	0.019726
CACNB3	-0.019718
CYP4F8	0.019707