!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Mus musculus
!gene	SIRT1
!cell	Liver
!perturbation	Knockout (Heterozygous)
!disease	Caloric Restriction
!end_metadata
TPMT	0.109052
PBLD	0.108738
TFB1M	0.098846
FMO3	-0.096975
GDPD3	-0.091527
CHAC1	0.084238
CAMK2B	0.076857
HMGXB3	-0.076342
DCT	0.074614
RPS2	0.070248
WDR46	0.067642
SLC38A5	-0.067110
SQLE	-0.063784
NREP	0.062989
CYP4A22	0.059654
CYP17A1	-0.059025
ZNF665	-0.056033
TMEM68	-0.055590
FBXL3	0.054935
GCK	0.054831
SPSB4	0.054762
ENPP5	0.054223
HLA-DRA	-0.052755
HIST1H1C	0.051285
CHRNA4	-0.050263
SAA2-SAA4	0.050107
CYP51A1	-0.048877
NT5E	-0.048771
CBWD1	0.048750
LSS	-0.047999
CFB	0.047969
SLC23A3	-0.047923
SLC51B	-0.047846
ZBTB22	0.047657
NSDHL	-0.047024
DHCR24	-0.046622
SLC15A2	-0.046390
PLEKHB2	-0.045768
CRYM	-0.045710
ACOT1	-0.045552
DBP	0.045523
GALE	-0.045085
NFE2	-0.044817
ACSS2	-0.043695
VCAM1	-0.042725
LARS2	0.042507
FLYWCH2	-0.042112
CYP4A11	-0.042097
CYP7A1	-0.041845
TESK1	0.041775
GDF9	-0.041605
NUDT7	0.041346
SUSD4	0.041045
TTC27	0.041016
HLA-E	0.040511
GLT1D1	-0.040472
LRRC24	-0.040319
PDK4	-0.040088
PPARGC1A	-0.039927
HSD17B6	0.039834
FHIT	0.039471
FGFR1OP2	0.039369
CISH	0.039366
SRD5A1	0.039189
RDH11	-0.038513
FKBP11	-0.038450
RCAN2	-0.038365
ELOVL3	0.038132
GBP3	-0.038013
FDPS	-0.037826
PHLDA1	0.037736
ALDOC	-0.037568
PMVK	-0.037552
SLC30A10	-0.037081
SGK1	-0.036899
HBB	0.036800
CA3	0.036797
ENPP6	-0.036788
SLC35G1	-0.035676
BCL6	-0.035079
TGFBR2	-0.035025
GNA14	0.034811
XBP1	0.034305
ACOT4	-0.034173
GMDS	-0.033859
DDIT4	-0.033671
WFDC2	0.033557
INHBE	0.033420
FFAR4	-0.033345
IGFBP3	-0.033319
VPREB3	0.033174
EPPK1	0.033043
PER3	0.032999
MSMO1	-0.032944
TPO	0.032940
CTGF	-0.032326
HEXIM1	-0.032203
OSGIN1	0.032026
OVOS2	-0.031995
CDKN1A	-0.031840
LYVE1	-0.031838
MVD	-0.031675
TNFRSF11B	-0.031630
DDC	0.031554
ST3GAL6	0.031533
ADH4	0.031519
RND2	-0.031463
B3GALT6	0.031256
HIST4H4	0.031178
CLDN2	0.031058
SLC47A1	-0.031049
ZNF24	0.031037
LCN2	0.030948
TMEM25	-0.030927
IRS2	-0.030407
HJURP	0.030359
KIAA0319	-0.030285
MRPL10	0.030184
YIPF4	-0.030053
ZNF91	0.029940
FAM110C	0.029889
RALGAPA2	-0.029881
SAE1	0.029794
FMO4	-0.029788
NHLRC1	0.029694
AQP8	-0.029603
IGFALS	0.029572
ABCC3	0.029425
NCMAP	0.029365
PRR18	-0.029258
AQP4	-0.029244
LBP	0.029204
SLC25A30	0.029117
IRGM	0.029095
NUPR1	-0.029083
TTC39C	0.029067
PNPO	0.029021
SCRN2	0.028970
PCDH20	-0.028875
MEGF9	-0.028870
AXIN2	-0.028620
HLA-DQA1	0.028159
RUSC2	0.028081
PLIN4	-0.028079
DHCR7	-0.028012
P2RY13	-0.027644
BUD13	-0.027625
NRG4	-0.027523
JAZF1	-0.027510
LRIT1	0.027486
POP4	0.027433
RGS5	-0.027431
C1orf210	0.027329
POLD2	-0.027270
SAP130	-0.027250
C8A	0.027239
SLC17A8	0.027190
HMGCS1	-0.027172
DNAJC3	-0.027101
CPEB2	-0.027054
NMRAL1	-0.027004
LACC1	-0.026946
SUGCT	-0.026784
ERO1LB	-0.026716
ALAS2	0.026667
STBD1	-0.026627
BSDC1	0.026624
ABCD2	-0.026604
SDR42E1	0.026599
VSIG4	-0.026593
SLC25A3	0.026573
ALDOB	-0.026534
CLCN7	-0.026504
GRB10	-0.026473
FBXO21	-0.026454
UGT1A3	-0.026443
IGFBP1	-0.026375
CELA1	0.026370
SCARA5	0.026364
KLF3	-0.026303
ALAS1	0.026262
RASSF3	0.026198
BMPER	-0.026007
FAM199X	-0.025942
CDC42EP5	-0.025908
QPCT	-0.025768
MAP3K1	-0.025676
TCEA3	0.025581
TMEM150A	0.025578
FKBP14	-0.025557
GDPD1	-0.025500
ABCG8	0.025352
C1QC	-0.025347
FXYD6	0.025338
LRAT	-0.025260
XKR9	-0.025230
GRPEL2	-0.025090
PDZK1IP1	-0.025084
SLCO2A1	-0.024954
FNDC3B	-0.024841
SLC13A2	-0.024823
GPC3	-0.024698
CCDC68	0.024684
RASL11B	-0.024668
SLC39A4	0.024653
FRAT2	-0.024639
ASPDH	0.024636
ASIC5	0.024549
GCLM	0.024523
PSAT1	-0.024467
PPP1R3C	-0.024458
EHD3	-0.024456
SEC61A1	-0.024376
TBC1D2B	-0.024280
TGM1	0.024243
TFF3	-0.024172
LRRC59	-0.024119
CYP1A2	0.024087
FADS6	-0.024067
INHBB	0.024053
PPTC7	-0.024048
LUM	-0.024044
USP2	-0.024043
TMEM203	0.024034
SRD5A2	-0.024003
CD74	-0.023990
GDF2	0.023930
CYP7B1	0.023917
COG8	0.023903
TMEM98	-0.023901
LPIN2	-0.023892
FOLR2	-0.023883
WSB1	-0.023873
PRCP	-0.023802
HIST1H2BK	0.023792
CORIN	-0.023769
RBM15	-0.023718
YOD1	-0.023706
NECAB1	-0.023684
HIST1H2BM	0.023673
SEL1L3	-0.023647
GAL3ST1	0.023557
NPR2	0.023550
CLIP4	0.023545
C6	0.023497
TP53INP1	-0.023441
TMTC2	-0.023423
CALR	-0.023409
C3orf58	0.023366
GNGT2	-0.023328
UBIAD1	-0.023327
NTN4	-0.023325
POU6F1	0.023312
ENC1	-0.023304
OLIG1	-0.023298
LEPROTL1	0.023292
GRHPR	0.023213
IMPA2	-0.023184
BBS7	-0.023161
GALNT11	-0.023157
EHHADH	-0.023136
PANK3	-0.023123
QPRT	0.023088
OXLD1	0.023052
CCDC107	0.022977
PREP	0.022954
SREBF1	0.022936
APOC2	0.022918
NID2	0.022908
ADRB2	-0.022891
WASF1	-0.022850
HIST1H2BL	0.022759
SLC38A4	0.022744
RAPGEF5	-0.022707
GLO1	0.022643
GBP4	-0.022616
MICAL3	-0.022605
FNIP1	-0.022585
CYP2U1	0.022575
ATP5G2	-0.022531
RAB27A	0.022488
SMIM15	-0.022481
CLU	0.022464
MPP4	-0.022439
HMHA1	-0.022382
SIRT1	-0.022367
COMMD10	-0.022333
PIP4K2A	-0.022280
C9	0.022254
CXCL2	0.022224
KAT7	0.022222
PXMP2	0.022218
C11orf24	-0.022214
HIST1H4J	0.022206
MRC1	-0.022183
KLC4	-0.022134
AXL	-0.022128
KIAA0753	-0.022102
FBXO44	0.022094
PTPN21	-0.022065
AACS	0.022054
C1QB	-0.022036
TWISTNB	0.022012
SLC39A6	-0.022006
HTR1D	-0.021982
METTL20	-0.021977
AAMDC	0.021937
ETNK2	0.021906
ACADSB	0.021891
FST	-0.021852
PPAPDC1B	-0.021844
RSAD1	-0.021840
COX6B2	0.021814
C17orf96	-0.021736
SPATA24	-0.021721
FZD7	-0.021716
MSN	-0.021670
SUPV3L1	0.021636
IL6R	-0.021628
RAB8B	-0.021602
GPC4	0.021592
SNX16	-0.021515
CTSV	-0.021470
ZNF131	-0.021454
PSMG2	0.021390
HN1L	-0.021389
CYP39A1	-0.021369
CRY2	-0.021362
TMEM125	0.021351
MS4A6A	-0.021341
HSD17B7	-0.021269
C2orf76	0.021252
PRR15L	0.021200
LY6E	0.021194
SLC25A10	0.021190
ACSM5	0.021184
VLDLR	-0.021175
IL13RA1	0.021174
CD207	-0.021151
FAM129B	0.021131
BHLHB9	-0.021111
IL18R1	-0.021077
TIA1	-0.021051
S100A13	-0.020921
ALDH16A1	0.020883
CISD1	0.020855
NAT8B	0.020836
TMC5	-0.020812
F2R	0.020757
TMIE	-0.020715
VPS72	0.020686
WNT2	-0.020591
ERLEC1	-0.020541
DAP	0.020522
DYNLL1	-0.020518
FMN2	-0.020514
FAM180A	-0.020454
DVL1	-0.020438
INSC	0.020417
FGFRL1	-0.020384
MBNL2	-0.020383
ODF3B	0.020346
PLEKHB1	0.020345
SLC38A3	0.020343
SCCPDH	-0.020336
CES3	0.020328
ZHX2	0.020323
HACE1	0.020316
HIST1H3C	0.020278
PPL	-0.020276
MYADM	-0.020265
SATB1	-0.020256
F8	-0.020208
GSTM4	-0.020208
BAG3	0.020198
NDRG2	0.020189
TCEAL8	-0.020178
GCGR	0.020147
GJB1	0.020142
ADCK4	0.020128
FNDC5	-0.020126
FLCN	-0.020113
B4GALT1	0.020080
IPPK	-0.020072
NID1	-0.020035
SEC61B	-0.020030
FCGRT	0.020022
AKAP12	-0.020008
DDB1	-0.019965
ABCG5	0.019950
FIGN	-0.019944
PIH1D1	0.019943
GLB1	0.019932
HIST2H2AC	0.019905
CUL4B	-0.019900
NAB2	-0.019898
ATP1B1	-0.019878
MTDH	-0.019849
CDHR5	0.019833
CYP4B1	-0.019805
CENPT	-0.019788
MMP15	0.019773
KIAA0513	-0.019768
RBMS3	-0.019728
GIMAP8	-0.019724
CPN2	0.019709
SULT1C2	-0.019696
FAM83A	-0.019613
REEP1	-0.019609
PPP1R15A	-0.019569
FAM160B1	-0.019554
RNPEPL1	0.019546
SYTL5	-0.019536
VAMP5	0.019530
SDF4	-0.019463
APOA4	0.019457
NPR3	0.019453
TNFRSF11A	-0.019445
SLC22A5	-0.019421
CENPL	0.019412
TCF21	-0.019402
CTSE	-0.019401
OARD1	0.019395
HMGCS2	0.019385
LMO4	-0.019378
CD3G	-0.019338
PLTP	-0.019320
HIST1H4K	0.019300
PCSK9	-0.019298
MSRB1	0.019273
SNTB2	-0.019259
C7orf57	-0.019257
PRTN3	-0.019224
XKR8	-0.019206
KDELR2	-0.019174
HLA-G	-0.019169
CALU	-0.019134
ACVR1C	-0.019133
HLA-DMA	-0.019088
SHH	0.019080
STEAP2	-0.019070
FHL1	-0.019059
TGFBI	-0.019052
HLA-A	0.019024
MID1IP1	0.019012
EGR1	-0.019008
ELL3	0.018972
MLXIPL	0.018963
SDHAF1	0.018949
ALDOA	-0.018925
DIO1	-0.018913
UBC	0.018911
CYP4F3	0.018878
TMEM65	-0.018870
ARSA	0.018819
PDE1B	-0.018809
SDC3	-0.018803
RNASEH2C	0.018791
SERPINE2	0.018773
SLC45A3	-0.018759
TMEM64	-0.018753
NME6	-0.018745
HSD3B1	0.018738
BAZ2A	-0.018732
ASPG	0.018711
ADCK5	0.018691
CYP4V2	0.018683
PFKFB2	-0.018682
SERPINB6	-0.018661
C17orf62	-0.018632
PPAT	-0.018623
GPR135	-0.018616
GLYAT	0.018569
HIST1H4I	0.018565
KTI12	0.018548
MTL5	-0.018537
IGFBP2	-0.018493
FADS2	-0.018484
PRPF38B	-0.018462
PDLIM7	-0.018452
HOXB7	-0.018432
PLEKHF2	-0.018429
RAD51C	-0.018363
MTUS2	0.018361
IL18	-0.018361
EEPD1	0.018356
AFF4	-0.018356
SH3TC2	-0.018343
CSRP3	0.018342
FKBP5	-0.018319
USP54	-0.018313
DERA	0.018292
TTC39A	0.018288
CLTB	-0.018278
ZNF717	0.018270
NR5A2	-0.018253
PPARGC1B	-0.018249
ZDHHC4	0.018245
WAS	-0.018216
ID1	-0.018212