!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	human
!drug_name	Argyrin A
!smiles	CCC1C2=NC(=CS2)C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(=C)C(=O)N(CC(=O)N1)C)C)CC3=CNC4=C3C(=CC=C4)OC)CC5=CNC6=CC=CC=C65
!pubchem_cid	24978550
!cell_type	MCF7 breast adenocarcinoma cells - 24 Hours
!organism	human
!end_metadata
COX1	0.271123
ND2	0.251004
HSP90AA1	-0.141063
ASS1	0.126468
TFF1	-0.122438
TUBA1B	-0.115461
KRT18	-0.105118
RPS13	-0.098206
PKIB	-0.097725
H2AFZ	-0.097031
EEF2	0.096620
RPS26	-0.095026
HIST1H4C	-0.091759
TUBA1C	-0.090370
ZFAS1	0.089018
RRM2	-0.088689
PSMA4	-0.086963
NPY1R	-0.085678
SLIRP	-0.084550
ACTB	-0.083068
ODC1	-0.082589
SNHG8	0.081595
HSPE1	-0.081364
TMA7	-0.080454
SLC25A6	0.080095
RPL27	-0.078382
NHP2	-0.077147
HMGB1	-0.075249
SCD	0.073725
RPSA	-0.072225
GTF3C6	-0.071891
USMG5	-0.070262
SNRPG	-0.069645
HMGN2	-0.068371
PKM	-0.068192
S100P	0.067711
BCAS2	-0.067479
NDUFAB1	-0.066556
RPL39	-0.065453
NME1	-0.064990
SRP9	-0.064979
NDUFB9	-0.064590
KRT8	-0.063729
CFL1	-0.063274
HSPB1	0.062241
CCNG1	0.061479
C20orf24	-0.060382
RPL36A	0.060090
IER3	0.058705
GGCT	-0.058358
SLC7A5	-0.058329
EIF4B	0.058252
RPS10	-0.055934
RAN	-0.055897
ATP5I	-0.055753
SLC26A2	-0.055699
CBWD1	-0.055139
MRFAP1	-0.055068
ESRP1	0.053479
HSPA1A	0.053466
PSMA6	-0.052877
YWHAQ	-0.052758
TUBB4B	-0.052350
S100A16	-0.051880
DYNLL1	-0.051541
ZWINT	-0.051141
PTMA	-0.051090
SOD1	-0.050839
PSMB4	-0.050809
DPM1	-0.050627
RPS25	-0.050134
SNHG5	0.049989
ATP5E	-0.049836
CHCHD1	-0.049755
YBX1	-0.048763
NACA	0.048610
ZNF217	0.048333
PSMC6	-0.048016
MYL12B	-0.047220
DSP	0.047196
ERH	-0.046968
PHGDH	0.046693
RPL29	0.046259
ECHS1	-0.046250
STARD10	-0.046016
TUBB	-0.045587
NEAT1	0.045535
SNRPF	-0.044963
UBE2S	-0.044532
DDIT4	0.043815
FAM102B	0.043773
FAU	-0.043484
PCNA	-0.042996
PRSS23	-0.042775
C3orf14	-0.042454
UBC	0.042319
C1QBP	-0.042139
TRIM28	-0.041536
PSMB1	-0.041505
EPB41L4A-AS1	0.041368
MCM7	-0.040890
SLC25A3	0.040866
ATP6	0.040738
DDX39A	-0.040607
SLC39A6	0.040545
THOC7	-0.040051
SNRPE	-0.039190
PSMC5	-0.039103
NDUFA12	-0.039025
ANXA2P2	-0.038873
EIF3E	0.038717
HIST1H2BK	0.038433
JTB	-0.038419
PGAM1	-0.038305
AREG	-0.037675
EIF1	0.037562
C6orf48	0.037181
HMGN3	-0.037028
CCT2	-0.037020
SNRPD1	-0.036950
SAC3D1	-0.036852
SLC19A2	-0.036226
PSMC3	-0.035838
MSMO1	0.035835
OAZ1	-0.035623
TPT1	-0.035542
LTA4H	0.035329
RPA3	-0.035282
RPL30	-0.035069
ADI1	-0.034971
PEBP1	-0.034841
HMGN1	-0.034772
CERS2	0.034742
LGALS1	0.034741
FTL	0.034362
ATP5G3	-0.034352
SIAH2	-0.034192
LSM5	-0.034024
IDH1	0.033894
RPS14P3	0.033839
SNHG1	0.033801
SSR2	0.033669
EEF1B2	-0.033647
MRPL3	-0.033528
SULF2	0.033487
BANF1	-0.033459
POMP	-0.033413
UNG	-0.033136
GABARAP	0.033056
RPL5	-0.032962
NDUFS6	-0.032741
CYCS	-0.032624
TALDO1	-0.032558
SF3B5	-0.032348
NUPR1	0.032266
ASNS	0.032164
GABARAPL2	0.032099
TRIP13	-0.032091
KPNA2	-0.032071
IFITM3	0.032036
AMIGO2	0.031983
COX6C	0.031889
TRMT5	-0.031821
CDK2AP1	-0.031812
SNRPD3	-0.031754
IRF2BPL	0.031654
RPLP1	-0.031197
PNRC1	0.031092
YWHAZ	0.030966
PSMA7	-0.030912
RPS24	-0.030898
KARS	-0.030687
STRA13	-0.030564
UQCRQ	-0.030440
PPIB	0.030411
TUBB6	-0.030156
SRM	-0.030049
SNRNP25	-0.029940
XRCC6	-0.029918
GTF3A	-0.029824
PARK7	-0.029760
GAS5	0.029752
NPC2	0.029686
CACYBP	-0.029550
POLR1D	0.029508
NDUFV2	-0.029504
NGFRAP1	-0.029376
NAA50	-0.029308
RPS3A	-0.029302
BOLA3	-0.029273
EIF3H	0.029144
ATP5L	-0.029028
KIAA0101	-0.028972
SRSF2	-0.028932
RHOC	0.028909
STUB1	-0.028823
DDX21	-0.028800
PTP4A1	-0.028793
VBP1	-0.028793
NOP56	-0.028790
PTP4A2	-0.028775
RPS12	-0.028682
APEX1	0.028596
RPL21	-0.028577
TUBB3	-0.028566
DUT	-0.028300
EIF4G2	-0.028295
NOP58	-0.028273
KRT19	-0.028227
RPS3	-0.028155
ARPC3	-0.028105
H2BFS	0.028079
CDK4	-0.028047
PPIA	-0.027879
NOA1	0.027817
RPS21	-0.027650
NDUFA13	-0.027543
GARS	0.027450
FBL	-0.027420
MAD2L1	-0.027344
TUBG1	-0.027249
RPL41	-0.027213
WDR34	-0.027140
NCOA3	0.027134
CCT7	-0.027031
RPS27	-0.027028
CHCHD2	-0.026900
PFN1	-0.026875
HAT1	-0.026681
ATP5B	-0.026558
GNB2L1	0.026557
ETFA	-0.026548
COX7A2	-0.026430
NPTN	-0.026353
HNRNPAB	-0.026314
NMD3	0.026244
CANX	0.026190
RPS9	0.026186
CD24	0.026146
RPL13A	0.026146
HTATSF1	-0.026111
C1orf43	0.026078
GNG5	0.026065
ATP5F1	-0.026048
TYMS	-0.026019
CALM2	-0.025954
RPL35A	0.025931
HENMT1	-0.025830
SSBP1	-0.025787
POLE3	-0.025776
COX7A2L	0.025729
SKP1	-0.025648
HMGN4	0.025644
TMEM258	0.025543
TMEM14B	-0.025520
SSR4	0.025454
UBA2	-0.025440
VAT1	0.025408
EEF1A1	-0.025386
CCT3	-0.025362
ATP5J2	-0.025320
MEST	-0.025307
HINT1	-0.025289
PSMA1	-0.025233
RPL26L1	-0.025188
PSME2	-0.025021
PPP1CC	0.025011
FTH1P5	-0.024919
RPL17	0.024906
SEH1L	-0.024898
TSPAN13	-0.024619
FAM96A	-0.024576
YWHAB	-0.024565
CCNI	0.024488
GMNN	-0.024473
SNRPB	-0.024463
AKR1C2	0.024451
OXA1L	0.024373
MRPL27	-0.024339
UFD1L	-0.024267
NQO1	-0.024155
CCND1	-0.024130
HMGB2	-0.024108
CAMLG	0.024070
HNRNPA2B1	-0.024049
RAB1B	-0.023981
FDFT1	0.023961
BRIP1	-0.023886
RPL4	-0.023733
MYBL2	-0.023691
MTCH2	-0.023569
NDUFA1	0.023546
MDH2	-0.023529
GLTSCR2	0.023496
S100A14	0.023419
TPI1	-0.023415
POLR2G	-0.023395
GPR160	0.023377
TOMM5	-0.023300
CD81	-0.023204
CDC20	-0.023139
BNIP3	0.023139
ID2	0.023121
INSIG1	0.023058
SRSF1	-0.023054
SARS	0.022997
NPM1	-0.022979
LAMTOR1	-0.022976
TBC1D9	0.022974
ATP6V1F	0.022923
RSL24D1	0.022908
RRM1	-0.022905
GINS1	-0.022833
SRP19	-0.022802
P4HB	0.022796
RPS16	-0.022657
WARS	0.022647
RPS17	-0.022534
EIF6	-0.022475
ERP29	0.022415
SEC11A	0.022408
GPI	0.022308
ANP32B	-0.022288
NONO	0.022247
NOLC1	-0.022202
PSMC1	-0.022084
TOMM20	0.021959
BZW1	-0.021951
RPLP0	-0.021939
NDUFAF4	-0.021935
FABP5	-0.021914
RPL12	0.021894
RPS29	-0.021871
RPL8	0.021848
LINC00493	0.021829
RPL23	0.021821
HSPA5	-0.021797
CHCHD3	-0.021796
NOC3L	-0.021790
POLR2L	-0.021769
MEPCE	-0.021749
STARD7	-0.021671
PIM3	0.021667
C19orf43	-0.021664
PCK2	0.021619
UBL5	-0.021592
COX5A	-0.021453
EID1	-0.021361
C4orf48	-0.021320
MRPL36	-0.021280
NDUFC2	-0.021035
OSTC	0.021012
PSMD2	-0.020988
GLRX2	-0.020984
HSD17B10	-0.020923
MRPL51	-0.020916
UBA1	-0.020893
RPL6	-0.020853
NCL	-0.020852
DCXR	-0.020797
HERPUD1	-0.020795
DYNC1I2	0.020750
NDUFS3	-0.020734
RAB25	0.020699
EBNA1BP2	-0.020645
UQCRC1	-0.020631
NDUFB2	-0.020605
PSMD6	-0.020541
PSMB6	-0.020511
PRELID1	-0.020497
PTTG1IP	0.020353
HIST1H2BD	0.020334
RNASEK	0.020333
MARCKSL1	0.020302
NEU1	0.020209
CAPNS1	0.020170
COX2	0.020145
ADD3	-0.020129
RPL15	0.020011
TAX1BP3	-0.019998
IER5	0.019995
ROMO1	-0.019945
PSMA3	-0.019849
MYL6	-0.019819
MYEOV2	-0.019773
RACGAP1	-0.019695
DGKZ	-0.019647
PSMD14	-0.019625
RPS27A	-0.019624
DHX9	-0.019579
IFI30	0.019565
RPS23	-0.019482
MALAT1	0.019472
EIF1AX	-0.019451
NOL7	-0.019404
RANBP1	-0.019348
RUVBL2	-0.019326
TKT	0.019314
IPO4	-0.019291
ATIC	-0.019264
CBX1	0.019241
GSTO1	-0.019185
UQCRFS1	-0.019167
PRDX5	0.019133
TRIM37	0.019116
TXNIP	0.019101
DDOST	0.019100
MRPL1	-0.019072
RPL32	-0.019058
DNAJB1	0.018985
ABCE1	-0.018978
DCTPP1	-0.018954
MEA1	-0.018926
KPNB1	-0.018912
DHFR	-0.018874
FZD6	0.018870
CLDN3	0.018839
NDUFA4	-0.018813
SHMT2	0.018805
MRPL15	-0.018780
TMED10	0.018728
CISD1	-0.018593
PRDX4	-0.018506
RPS18	-0.018473
KLF10	0.018431
ASNSD1	-0.018375
PRDX6	-0.018346
TAF7	0.018340
CCT8	-0.018331
CDH1	0.018295
AP2S1	-0.018270
SNRPC	-0.018266
PSMC2	-0.018170
BNIP3L	0.018107
TIMM10	-0.018095
CCNB1IP1	0.018082
CD55	0.018062
H2AFX	-0.018056
SLC38A2	-0.018047
TCEAL1	0.017996
ITM2B	0.017991
VEGFA	0.017976
NUP37	-0.017956
HILPDA	0.017910
EMG1	-0.017902
PLP2	0.017877
CD63	0.017858
RPL37A	-0.017841
PRMT5	-0.017832
PCBP1	0.017828
MCM3	-0.017828
IMP4	-0.017809
ERRFI1	-0.017805
MB	0.017725
MRPL10	0.017652
BEX2	0.017625
ISOC1	0.017618
CMC1	-0.017603
ATP5A1	-0.017563
PRMT6	-0.017557
HIST2H2BE	0.017534
MRPL11	-0.017517
YWHAG	-0.017491
SAPCD2	-0.017474
DBF4	-0.017454
S100A10	0.017396
CHAC2	-0.017394
RPL9	-0.017392
RABAC1	0.017287
DYNLT1	-0.017275
AKT1	-0.017247
TUBB2B	0.017150
HMGCS1	0.017135
DDX1	-0.017104
FAM122B	-0.017057
HMCN1	0.017012
CSDE1	-0.016931
TFRC	-0.016929
SH3BGRL	0.016905
CCT5	-0.016890
SDF2L1	-0.016847
FKBP4	-0.016835
PKD1P1	0.016813
GLRX5	-0.016783
MMADHC	-0.016778
APPBP2	0.016678
CLDN7	0.016663
PAN3	0.016652
SMARCD2	-0.016652
PHB	-0.016609
CAPZA1	-0.016557
IFRD2	-0.016543
EIF5B	-0.016513
CTSD	-0.016425
PTTG1	-0.016411
PSMD4	-0.016393
CKS1B	-0.016386
RPP40	-0.016345
METRNL	0.016334
RPL18	0.016307