!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!drug_name	MLN4924
!smiles	C1CC2=CC=CC=C2C1NC3=NC=NC4=C3C=CN4C5CC(C(C5)O)COS(=O)(=O)N
!pubchem_cid	73014187
!cell_type	A375 melanoma cell line - 4 Hours
!organism	human
!end_metadata
HMOX1	0.310209
TXNRD1	0.200333
FTL	0.194073
SRXN1	0.150334
CTGF	0.138470
GCLM	0.130456
SLC26A2	-0.122116
HSP90AB1	0.120084
SLC7A11	0.119981
NQO1	0.118360
SPRY2	-0.117561
HSPA1A	0.112419
UBB	-0.106762
PSAT1	0.093844
FTH1P5	0.087857
OVOS2	0.084701
HSPA8	0.083651
ERH	0.079474
IER3	-0.076126
HOXB2	0.075919
AMOTL2	0.074669
ERRFI1	-0.072876
TRIM16	0.072651
PFN1	0.071981
WNT5A	0.070294
MIR21	0.069630
SLC20A1	-0.069172
DKK1	-0.068484
FTH1	0.066430
PPIF	0.064763
PMAIP1	0.064156
H1F0	-0.064067
ID1	-0.062807
MTHFD2	0.061598
STK17A	0.060799
TSPAN13	-0.060186
PRNP	0.059891
RPL27	0.059493
BNIP3	0.059457
UBC	-0.058479
CCT2	0.057814
FST	-0.057716
SNHG5	0.057526
ENO1	0.056911
CTSL	0.056802
MAD2L1	0.056665
ID3	-0.056567
HLA-DRA	0.056453
NNMT	0.056439
NARS	0.056125
PTTG1IP	0.055029
RSL24D1	0.054692
MT2A	-0.053293
PRDX1	0.053118
PSMA4	0.052305
FLRT3	-0.051306
PCNA	0.050023
SNRPD2	0.049607
ORC6	0.049166
TXN	0.049085
OPHN1	-0.049072
SMURF2	0.048958
CDK2AP1	-0.048406
TMA7	0.048179
PLK2	0.047828
EEF2	-0.047624
CCND1	0.047611
NEAT1	-0.047079
RPL26	0.046420
IGF2BP3	0.045687
FBXO30	0.045651
POLE3	0.045645
COX1	-0.045290
TMSB10	-0.045175
SLBP	0.044803
NONO	0.044781
TUBA1A	-0.044518
FAM84B	-0.044374
CYR61	0.044278
C20orf24	0.044211
HOXC6	-0.044182
MAGEA3	0.043515
ADM	0.043482
MANSC1	-0.043391
ABHD17C	-0.043301
LINC01419	-0.043006
MAT2A	0.042908
DUSP6	0.042501
TM4SF1	0.042357
RPS3A	0.042198
AKR1B1	0.042122
PGAM1	0.041875
EIF4A3	0.041324
DNAJB1	0.041188
EIF6	0.041078
RPS25	0.040545
MT1HL1	0.040270
DNTTIP2	0.040174
AGPAT9	-0.039882
TGFA	-0.039051
INHBA	-0.038865
SMNDC1	0.038522
ZNF217	0.038347
SH2B3	-0.038167
RRM2	0.038162
PHLDA1	-0.038094
XPOT	0.037972
OAZ1	0.037879
SOD1	0.036925
MICU2	-0.036497
MAGEA12	0.036054
HHEX	0.036028
IRF2BPL	-0.035877
SNRPB	0.035855
EIF3I	0.035818
RPL7	0.035769
FOS	-0.035712
KARS	0.035665
DKC1	0.035545
TRIB3	0.035452
NUDT19	0.035372
TAGLN2	0.035352
TOMM20	0.035277
CDC123	0.035267
RPL36	0.035047
RPL19	0.035046
SNRPG	0.035024
GGCT	0.035011
MYL12B	-0.034753
BTG1	-0.034407
GARS	0.034357
TUBB	0.034202
DNAJB4	0.034085
GNG5	0.033929
SLC3A2	0.033700
RPL9	0.033592
MALAT1	-0.033534
PTPLAD1	0.033375
RPS8	0.033375
DCTPP1	0.033204
MT1H	0.033026
ZWINT	0.032921
COX3	-0.032907
ATP5B	0.032648
S100A11	-0.032543
SERPINA3	-0.032434
RPL13A	0.032354
GLA	0.032285
CAV1	0.032199
PGK1	0.031965
BTBD3	-0.031885
MRFAP1	0.031755
NEIL3	0.031585
IER2	-0.031476
TFAP2C	-0.031460
RPL22L1	0.031448
ARPC5	0.031244
PPIA	0.031230
RPL30	0.031086
SRSF2	0.030940
GABARAP	-0.030574
PAICS	0.030446
RPL21	0.030443
HSPE1	0.030379
RRS1	0.030329
SHFM1	0.030298
GHITM	0.030270
PRC1	0.030042
PABPC3	0.029913
TNPO1	0.029792
STIP1	0.029731
LDHB	0.029709
LDHA	0.029650
KPNA2	0.029551
WDR82	0.029474
DDX21	0.029424
SUMO2	0.029369
UBE2E3	-0.029219
RPS13	0.029208
UAP1	0.029166
NSA2	0.028840
ANKRD50	-0.028665
SNHG6	0.028602
OAT	0.028557
RBBP7	0.028446
ZCCHC8	0.028262
GLRX2	0.028257
IL17RD	0.028040
TFRC	0.028026
NOP56	0.027912
MLLT11	0.027486
CD3EAP	0.027443
RPLP0	0.027388
SNRPE	-0.027290
HSP90AA1	0.027249
LASP1	-0.027178
RPS19	0.027158
PKM	0.027131
ACTG1	0.027023
TMEM2	-0.026887
SGK1	0.026768
ALDH1A3	-0.026765
HMGB2	0.026698
PRDX6	0.026682
LINC00657	-0.026578
DTL	0.026402
DEK	0.026371
NOB1	0.026307
CDC37	0.026242
MSH2	0.026182
DHX15	0.026169
SLC25A3	0.026130
LSM7	0.026023
ND2	0.025920
CDC25B	-0.025890
PRDX3	0.025878
ILF2	0.025790
ASF1A	0.025551
ILK	0.025516
RPL3	0.025290
MAGEA6	0.025258
PSMC3	0.025177
DDX1	0.025106
EIF4EBP1	0.025045
TFPI2	0.025002
TKT	0.024985
ENOPH1	0.024956
HINT1	0.024952
NACA	0.024855
HSPA5	0.024821
NDUFAB1	0.024719
PPA1	0.024696
C14orf166	0.024639
S100A4	-0.024620
UFC1	-0.024549
RAN	0.024529
ASNS	0.024528
EIF3L	0.024392
CYCS	0.024300
TIPARP	-0.024264
SMAGP	0.024214
SLIRP	0.024189
FAM76B	-0.024120
GTF2H2	0.024063
UNG	0.024039
ANXA2	0.023971
RPS17	0.023961
LINC00622	0.023943
DLEU1	0.023909
HLA-A	0.023770
CD63	-0.023676
GLO1	0.023642
RPLP1	0.023638
RASSF8	-0.023604
METTL23	-0.023466
FEN1	0.023442
AXL	-0.023294
CPOX	0.023227
EIF1	0.023213
GAPDH	0.023068
MIF	0.022984
MRPL27	0.022979
SKP1	0.022900
CCNE2	0.022834
CKS1B	0.022823
PXYLP1	-0.022782
ERBB3	-0.022778
MAPK6	0.022737
CSE1L	0.022637
GNL3	0.022562
GADD45A	0.022534
RPL11	0.022533
MRPL24	0.022459
AHR	-0.022455
EXO1	0.022415
RPL17	0.022383
TALDO1	0.022360
NHP2	0.022348
KRTAP2-3	0.022302
SNRPD1	0.022287
PPARG	-0.022275
SNHG16	0.022262
DEPDC7	-0.022250
COL9A3	-0.022070
TPRKB	0.022049
PHB	0.022038
ANXA1	0.021894
ARCN1	-0.021861
LMNB1	-0.021729
DUSP4	0.021713
GABARAPL2	-0.021692
FBL	0.021666
MRPL15	0.021632
HIF1A	0.021588
SRPX	-0.021513
TFAP2B	-0.021492
NDUFA13	0.021472
ANXA2P2	0.021375
HSPD1	0.021337
TNFRSF1A	0.021299
DDX5	0.021288
HLA-DRB1	0.021216
FAU	0.021110
TRMT10C	0.021104
MRPL32	0.021086
NAE1	0.021060
WWTR1	-0.021059
SRP14	0.021046
PTRH2	0.021046
WBP11	-0.021014
MGST1	0.020970
NFKBIZ	-0.020960
TMX2	-0.020948
NPTN	0.020817
NPM1	0.020724
RPS26	0.020641
CALM2	0.020506
DDIT4	-0.020473
GRAMD1B	0.020402
SLC25A46	-0.020365
GMNN	0.020318
EPHA2	0.020304
PSMB6	0.020172
SLITRK6	-0.020166
DANCR	-0.020162
NUTF2	-0.020158
EBPL	0.020113
RCAN1	-0.020059
ATP1B1	-0.020040
ELK3	0.020012
HSPH1	0.020009
BCCIP	0.020008
CDKN1B	-0.020006
IER5	0.019947
RRM1	0.019885
USP53	0.019868
RPL28	0.019841
DNAJA1	0.019817
HNRNPUL1	-0.019808
CDC6	0.019786
IMP3	0.019588
NPC2	0.019554
TCERG1	0.019525
TMBIM6	0.019524
IRS2	-0.019521
SLC7A5	0.019490
GNAS	-0.019461
NEDD8	0.019455
ATP5E	-0.019445
UFD1L	0.019415
PSMA3	0.019412
ARHGAP12	0.019369
NDUFA1	0.019288
RPL35	0.019260
GSR	0.019258
TIMM17A	0.019256
SPCS1	-0.019247
LINC00326	0.019235
CEP55	0.019215
EPRS	0.019199
RACGAP1	-0.019198
HMGB1	0.019150
PSMD14	0.019136
RNPS1	0.019101
MEIS2	-0.019084
RPL31	0.019082
PUS7	0.018982
HK2	0.018941
ATP5L	0.018939
PTMA	0.018906
CTNNAL1	0.018851
CDC42EP3	-0.018751
SLC5A3	-0.018731
RPL18	0.018690
USP1	0.018659
NGFRAP1	-0.018611
MYC	0.018584
MALT1	0.018540
GCLC	0.018539
SAE1	0.018538
FAT1	0.018530
ITGAE	0.018494
IRS1	0.018488
PSMB3	0.018478
DDX39A	0.018330
TGFBI	0.018327
MCM7	0.018294
EI24	0.018268
RPS20	0.018237
CSDE1	0.018215
PHC2	-0.018209
LBR	0.018186
TSC22D1	0.018124
GNE	-0.018087
EIF4H	0.018065
NOLC1	0.017993
NAF1	0.017949
RPS7	0.017948
H3F3B	0.017904
GRPEL1	0.017903
SRSF9	-0.017871
SH3BGRL3	-0.017851
ANKRD1	0.017829
RPL12	0.017824
GBE1	0.017819
RARS	0.017815
RAB8A	0.017769
CAPNS1	0.017755
LOC344887	0.017740
SEP15	0.017733
TMEM165	0.017729
TOB1	-0.017692
PITPNB	0.017672
FAM60A	0.017668
PPP1R15B	-0.017618
GTF3C6	0.017581
CNBP	0.017573
TSPO	0.017567
HNRNPA2B1	-0.017563
TPI1	0.017547
NOP58	0.017541
LRP8	0.017502
COPB1	-0.017476
ENC1	-0.017463
EIF3E	0.017460
ZFAS1	0.017417
RPL38	-0.017412
SPDL1	0.017391
YWHAG	0.017377
RPL29	0.017350
ACP6	-0.017337
ARL6IP5	-0.017337
MOK	-0.017327
LAMTOR5	0.017292
E2F6	0.017288
CRLF3	0.017281
MAGEA1	0.017269
PLP2	-0.017257
FABP5	0.017254
LOC100129361	-0.017251
TUBA1B	0.017240
SDCBP	0.017230
CEBPB	0.017199
RPL26L1	0.017169
SLC38A1	0.017149
ADRM1	0.017145
NACAP1	0.017132
MRPL18	0.017131
LYPLA2P1	0.017119
F2RL1	0.017116
CDK4	0.017107
NHP2L1	0.017034
HERPUD1	0.017028
STUB1	-0.017013
ATF4	0.016994
DPM1	0.016992
RPL35A	0.016957
MAP3K1	0.016952
CALR	-0.016929
RPL7L1	-0.016922
HYOU1	-0.016922
COX2	-0.016909
TOMM5	0.016883
GLRX	0.016872
DYNLT3	-0.016836
BLMH	0.016830
SUB1	0.016829
NOP10	0.016817
ZFAND2A	0.016796
EIF2S2	0.016789
ZNF146	0.016701
VDAC1	0.016665
TERF2IP	-0.016633
RPS10	0.016573
GSTO1	0.016558
TUBA1C	0.016544
BAG3	0.016542
EIF5A	0.016519
MRPS6	-0.016513
SOX10	-0.016493
PDLIM1	0.016480
CTSB	0.016474
INPP5F	-0.016455
SRSF5	-0.016438
GPI	0.016422
SET	0.016410
DDOST	0.016398
PHB2	0.016394
IARS	0.016351
MARCKSL1	-0.016323
TUBB4B	0.016320
TES	0.016317
CHCHD1	0.016254
HDAC1	-0.016150
MELK	0.016141
SNAPC1	0.016117
KIAA0101	0.016115
ZFP42	0.016112
EEF1B2	-0.016098
H2AFZ	0.016082