!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	mouse
!drug_name	Estradiol
!smiles	CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O
!drugbank_id	DB00783
!pubchem_cid	5757
!cell_type	Uterus - single injection of 400 ug/kg - 72 Hours after treatment
!organism	mouse
!end_metadata
LTF	0.321791
CLCA1	0.200984
CA2	0.199135
PIGR	0.161088
RPS19	0.155312
CKB	-0.152371
LCN2	0.149501
C3	0.133925
TUBA1B	-0.132022
LTBP4	-0.129733
RPL13	-0.126606
PLET1	0.125206
GSTO1	0.117704
WFDC2	0.109980
LY6E	0.108543
BCAT1	0.105956
TUBB	-0.099260
LAPTM4A	0.099110
JUND	0.096058
FCGBP	0.095240
ACTB	-0.093729
TUBA1C	-0.092747
ACTG2	-0.088982
LDHA	0.085687
PLAC8	0.085427
APP	0.085040
IGFBP6	0.082882
ELF3	0.077885
MYL12A	0.077626
TMOD3	0.077489
CFL1	-0.076440
LGALS1	-0.076370
TMEM176B	0.075355
SPP1	0.073940
TAGLN	0.072893
SAT1	0.071577
CHD4	0.070094
RPS2	-0.067386
CTSV	0.066882
LAMC2	0.066785
RPS3	-0.064743
CD14	0.064607
CTSD	0.063296
SERPINH1	-0.061988
DIO2	0.061948
CFI	0.060341
DSTN	0.059737
GNG5	0.059282
PRNP	0.058560
IFITM3	0.056588
RPS10	0.056215
FSCN1	-0.056082
TACSTD2	0.055915
GJB2	0.054248
ISLR	-0.054130
WDR92	0.053773
MMP14	0.053768
RPL28	-0.052705
APOE	0.052102
MFGE8	0.051518
LAMP1	0.050423
ACTA2	-0.049866
TGFB1I1	-0.048756
TUBA1A	-0.048111
LMNA	-0.047934
RPS15A	0.047067
FAM213A	0.046801
TMEM176A	0.046374
PLEKHB2	0.045930
RPS27A	-0.045859
KRT8	0.045639
CP	0.045269
B2M	0.043965
APCDD1	-0.043755
CCNB2	-0.043437
RPS11	-0.043337
CYC1	-0.043054
CRTAP	-0.042886
KRT19	0.042727
MAGED1	-0.042229
MORF4L1	-0.042139
S100A6	-0.041987
GOLM1	0.041615
FMO1	-0.041522
TNXB	0.040555
FKBP1A	-0.040414
UBE2R2	0.040318
RPL10	0.040059
IER3	0.039265
VKORC1	-0.039230
PADI1	0.039137
RPL18	0.038702
GNB2	-0.038589
GPI	0.038330
HLA-A	0.038231
VMP1	0.037862
PADI2	0.037561
YBX1	0.037228
COL1A1	-0.036958
DCN	0.036921
MAGED2	-0.036754
GSTP1	-0.036615
COL15A1	-0.036347
PTOV1	-0.036334
CNN1	-0.036063
UQCRC2	0.035983
RHOJ	-0.035623
CAPNS1	0.035612
RPS26	0.035502
TXN	-0.035042
TIMM13	-0.035005
CDC20	-0.034879
RPS23	-0.034802
CDH5	-0.034575
RAN	-0.034411
ALDOA	0.034196
IGFBP3	-0.034109
KDELR1	-0.034092
SPARC	-0.034068
CLDN7	0.034012
IMPDH2	-0.033853
TPT1	-0.033772
LAMP2	0.033644
HOXA11	-0.033467
DAZAP2	0.033346
PLAT	0.033287
RPL7	0.033032
CHCHD10	0.033009
ANAPC5	-0.032699
RARRES2	-0.032577
DDX39B	-0.032512
LBP	0.032316
KIF22	-0.032212
ZFAND5	0.032178
MYADM	0.032174
ARL2BP	-0.032158
HMGN1	-0.032122
WDR6	-0.031909
KRT7	0.031874
PNPLA2	0.031390
FTH1	-0.030641
RPL3	-0.030377
CEBPD	0.030332
COL5A2	-0.030312
C11orf31	-0.030182
CTSA	0.030038
SERP1	0.029990
STMN1	-0.029852
ANXA1	0.029782
CAPN5	0.029481
CTDSP2	0.029296
ANXA5	-0.029291
LPP	0.029228
ZFP36L1	0.029122
GNB2L1	0.029074
CD63	-0.028982
PCOLCE	-0.028934
FXYD3	0.028520
COL6A1	0.028519
SOX4	0.027973
SSR3	-0.027902
TUBB6	-0.027775
RIN2	0.027762
NFIX	-0.027736
CTSB	0.027657
UBC	-0.027613
MYH14	0.027245
TRIM28	-0.027127
HGFAC	0.026965
UQCRHL	0.026726
A2M	0.026700
GNAS	-0.026606
NDUFB8	-0.026558
SOX17	-0.026410
FKBP9	-0.026382
VAMP8	0.026364
H1F0	-0.026350
PENK	-0.026340
DYNC1H1	0.026314
RNASE4	0.026183
CDK2AP1	-0.026165
CYBA	0.026052
ALPL	0.026024
CNDP2	0.025945
RPL37A	-0.025930
CPT1A	0.025813
H2AFX	-0.025770
SFRP2	-0.025595
FAM20C	0.025541
COL5A1	-0.025496
ATP6V0C	0.025495
HSPD1	-0.025438
MDK	-0.025257
PLEC	0.025241
GSR	0.025174
PAPSS1	-0.025148
POLD2	-0.025081
CPE	0.025010
RRAGA	-0.024985
GAS1	0.024953
ENG	-0.024948
ACTA1	-0.024879
TIMP3	0.024850
TGFBI	-0.024825
RAC1	0.024776
GSN	-0.024686
ANGPTL2	0.024637
PLK3	-0.024507
TMED9	-0.024477
LLGL2	0.024457
DMPK	-0.024344
PRKCSH	0.024305
CLU	0.024291
AKIRIN2	0.024246
ID2	-0.024186
AES	-0.024170
SAR1A	-0.024055
EFNB2	0.023997
TIMM23	0.023974
CKS1B	-0.023861
RPL21	-0.023780
GABARAPL1	0.023663
RSU1	-0.023585
RPL27A	-0.023415
ARFGAP2	0.023398
H19	-0.023291
MMP7	0.023289
CLEC11A	-0.023214
PDHA1	0.023212
ACO2	-0.023073
MXD4	0.022901
AAMP	-0.022896
GPC3	-0.022870
COX6A1	0.022833
WBP1	-0.022710
PSMA3	0.022670
LRG1	0.022590
DDB1	0.022351
CTSS	0.022342
ATP5C1	-0.022322
SVIL	-0.022270
SMTN	-0.022246
PRKCDBP	-0.022106
H2AFV	-0.021938
H1FX	-0.021937
MGP	-0.021885
CTNNB1	-0.021836
EEF1A1	-0.021755
BPIFB1	-0.021701
COX7A2L	0.021535
SDC4	0.021529
HADH	-0.021494
NRTN	0.021360
RNF167	-0.021297
MEF2D	0.021294
SNRPB	-0.021271
NDUFA7	0.021157
CLDN4	0.021143
SLC39A4	0.021077
IMPAD1	-0.021038
GJA1	0.021011
GTF2I	-0.020982
ACTG1	0.020973
COL6A2	-0.020936
RPS12	0.020935
H2AFZ	-0.020908
HINT1	-0.020902
PRC1	-0.020866
RNF149	0.020861
ARPC2	0.020836
CSDE1	0.020810
ABCC3	0.020772
HOXD11	-0.020758
CDCP1	0.020564
PLTP	-0.020552
CYFIP1	0.020552
SEC61A1	0.020515
SURF4	0.020436
OGN	0.020417
DDAH2	-0.020406
ARG1	0.020377
COL1A2	0.020371
CD34	-0.020339
EMD	-0.020335
FKBP8	-0.020298
SMOC2	-0.020297
POLR2G	-0.020239
CDK1	-0.019997
ARF5	-0.019934
TAGLN2	0.019891
NPNT	-0.019832
PROM1	0.019815
SLMAP	0.019761
PABPC1	0.019749
MORF4L2	-0.019659
UGDH	0.019657
IGFBP4	-0.019647
CLPTM1	0.019629
COL18A1	-0.019607
AGO2	-0.019567
CCT7	-0.019509
FBL	-0.019439
RPL13A	-0.019432
ISOC1	0.019283
SERINC3	0.019280
MBTPS1	-0.019280
C1QTNF3	0.019278
HSD17B11	0.019137
SELT	0.019065
HSPA8	0.019023
ACAA2	0.019001
PABPN1	-0.018995
ALDH2	-0.018985
AOC1	0.018954
FZD2	-0.018912
PGK1	0.018877
CSTB	0.018866
CCNA2	-0.018853
SIDT2	0.018756
NFIC	-0.018655
MSX1	0.018645
GPS1	-0.018597
UQCRC1	-0.018516
LMO4	0.018482
SRM	-0.018456
RHOQ	0.018446
NPC2	0.018446
PPTC7	0.018442
MRFAP1	-0.018381
PNP	0.018349
SOD3	-0.018311
ADH5	-0.018299
TRIM25	0.018298
HIST1H3C	0.018290
CA12	0.018242
PGLYRP1	0.018229
SLC44A4	0.018225
TGIF1	0.018216
F3	0.018162
NDUFC1	-0.018120
JTB	0.018110
MED24	0.018082
SMPDL3A	0.017980
ABCA1	0.017972
KDELR3	-0.017901
CREB3L1	-0.017867
BROX	0.017850
RPL5	0.017815
TCF4	0.017814
PRRX2	-0.017709
C15orf39	0.017657
HNRNPH1	-0.017609
SHISA5	0.017606
ARPC3	0.017572
ARL6IP1	0.017517
WLS	0.017410
PTP4A1	0.017323
PUF60	-0.017280
BRK1	0.017218
PSAP	-0.017171
FTO	-0.017116
GNAI3	-0.016896
FSTL1	-0.016864
GNG12	0.016845
WBP1L	0.016810
C1QC	0.016764
HOXD9	-0.016758
FKBP4	0.016750
DDX5	0.016748
SLC39A1	0.016739
CSNK1G2	-0.016733
SDHB	-0.016725
RPL6	-0.016674
GAS6	-0.016673
CSRP1	-0.016669
CEACAM1	0.016615
C14orf2	-0.016608
YWHAG	0.016583
CD47	0.016571
TPST1	-0.016555
RELA	0.016554
ADD1	-0.016532
MYH9	0.016497
ILK	-0.016489
RNF10	0.016467
TMPO	-0.016461
WDR1	0.016400
GDF10	-0.016336
NREP	-0.016174
ANPEP	0.016124
BTF3	-0.016119
PKNOX1	-0.016098
C5orf15	-0.016071
CDO1	0.016064
CCND3	-0.016002
BHLHE40	0.015992
AP1S1	0.015960
HSPG2	-0.015952
GATA2	-0.015924
NELFA	-0.015889
ANXA6	-0.015807
NUCB1	0.015806
SPRR1A	0.015727
GORASP2	0.015668
LGALS3BP	0.015639
FOXO3	0.015596
CDC42EP4	-0.015581
PKDCC	-0.015565
SMC4	-0.015520
SND1	-0.015517
EPHX1	0.015456
PRKAR1A	-0.015445
NAPSA	0.015420
HSPA5	0.015392
GSK3A	0.015379
CD9	0.015305
RPS24	-0.015282
LEMD2	0.015264
ARHGEF25	-0.015248
DSP	0.015236
SPINT1	0.015222
NUMA1	0.015183
KLF5	0.015170
TWIST2	-0.015170
POSTN	-0.015142
PCBP1	-0.015121
FOXM1	-0.015117
LIMK1	-0.015073
KDM6A	-0.015064
RTN4	0.015035
POMP	-0.015033
LPHN1	-0.015018
SQSTM1	0.015014
SLC25A4	-0.015000
NCKAP1	0.014975
CORO1C	-0.014973
ACTN4	0.014923
GADD45A	0.014845
CDKN2C	-0.014837
CSNK1D	-0.014783
CDC42SE1	0.014752
RNF181	0.014730
EIF3M	0.014726
JAK3	0.014715
TOMM7	0.014708
PKM	-0.014682
S100A10	-0.014674
ALOX15	0.014598
NHP2	0.014577
ACTC1	-0.014576
C19orf43	-0.014572
FLII	0.014570
NPM1	0.014558
XBP1	0.014513
HSPH1	0.014478
WDR5	-0.014462
PUM2	-0.014453
UBA2	-0.014408
LGALS3	0.014364
ANXA11	0.014360
LYZ	0.014324
WDR83OS	-0.014316
C1QA	0.014276
PPP2R1A	-0.014268
CNOT1	0.014254
PSMA6	0.014228
BANF1	-0.014182
ITGAV	0.014161
GDI1	-0.014130
TCF12	-0.014107
ANLN	-0.013992
ID3	-0.013977
PSD	-0.013973
EIF3K	-0.013953
MFAP4	-0.013915
SPOCK2	-0.013902
REV3L	0.013886
APOA1BP	-0.013868
SLC29A1	-0.013863
ZMIZ2	0.013860
COL6A3	-0.013844
NDUFV1	-0.013774
HNRNPL	-0.013766
DDR2	-0.013717
ATP6V0E1	0.013693
TP53INP2	0.013604
LMNB1	-0.013580
ALDH7A1	-0.013546
LSP1	0.013542
H6PD	0.013530
EMP3	-0.013486
B4GALT1	0.013427
GTF2F2	0.013423
CHTF8	-0.013422
NDE1	-0.013420
ATP1B3	0.013414
MAEA	-0.013412
PPP1R14B	0.013248
IDH2	-0.013240
TPI1	0.013230