!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!drug_name	Estradiol
!smiles	CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O
!drugbank_id	DB00783
!pubchem_cid	5757
!cell_type	MCF-7 breast cancer cells - 24 Hours
!organism	human
!end_metadata
MME	-0.144071
PLAC1	0.102554
MYBL1	0.090502
COL21A1	0.071504
CYP26B1	0.067332
ACKR3	-0.065854
IL17RB	0.061613
FAM110B	-0.061480
EFEMP1	-0.061300
CXCL12	0.060203
HCAR3	-0.059634
SGK1	0.059596
CERK	-0.057687
TNS3	-0.056581
MMP10	0.056365
CTGF	-0.056004
PDE8B	-0.055326
BLNK	-0.055170
MAMLD1	0.054830
SYBU	0.054725
BFSP2	0.054295
TSPAN12	-0.053286
NELL2	-0.053160
ST6GALNAC5	-0.052547
TNFRSF11B	-0.052268
IL1R1	-0.051999
EXO1	0.051552
MGP	0.051250
HOXC5	0.050997
SASH1	-0.050112
PLK2	-0.049840
ABHD2	0.049805
GRB14	-0.049352
CLSTN2	-0.048938
PMP22	-0.048474
SEMA3E	-0.048393
CTNND2	-0.048323
PGR	0.047519
MATN2	-0.047214
UPK1A	-0.047144
LMCD1	-0.046704
CALCR	0.046560
PALMD	-0.046431
DRAM1	-0.046344
RPRM	-0.046093
KIAA0226L	0.045996
CCNA1	0.044242
RAB31	0.044081
HERC6	-0.044013
KIAA0922	-0.043724
NBEA	-0.043579
TIPARP	0.043120
CAV1	0.043029
CSGALNACT1	-0.042774
SPON2	-0.042556
UGT2B15	0.042153
ELF5	-0.042005
RNASE4	-0.041967
NXPH3	0.041396
ISG20	0.041327
MCM10	0.041135
FKBP5	0.041085
DIO1	0.040786
ARSJ	0.040774
RASGRP1	-0.040666
BIK	-0.040509
NR3C1	-0.040468
WISP2	0.040236
PLCL1	0.040195
LINC00341	0.040019
SHCBP1	0.039730
TMEM194A	0.039609
RAPGEFL1	0.039512
IER3	-0.039469
EFNA1	-0.039399
PCDHA6	0.039295
TIMP3	-0.038865
PCP4	0.038802
HOXC4	0.038795
SLIT2	-0.038760
CITED1	0.038750
SCD	0.038405
OLFML3	0.038377
PPM1E	0.037959
MCOLN3	-0.037842
CENPE	0.037726
ERCC6L	0.037721
EGR3	0.037562
SPC25	0.037351
CALML5	-0.037291
CDC45	0.037284
BLM	0.036853
PSD3	-0.036725
WDR76	0.036644
CELSR2	0.036588
ABCG1	-0.036410
GNA13	0.036406
SLC24A3	-0.036315
SIK1	-0.035768
PBK	0.035609
KCNN2	-0.035405
ATP8A2	-0.035355
RHOBTB1	-0.035313
LAMB1	-0.035043
RNF144A	-0.034995
BAMBI	-0.034972
TPD52L1	0.034940
PARP11	-0.034840
LIMA1	-0.034764
AURKB	0.034719
DHCR7	0.034703
ABLIM3	-0.034447
CEACAM6	-0.034388
NDC80	0.034342
RET	0.034276
BRIP1	0.034227
CD55	-0.034204
SLC22A4	0.034185
NPY5R	0.034181
MYBL2	0.034160
PXDC1	-0.034098
RRM2	0.034050
KYNU	-0.034005
TUBBP5	0.033935
NRGN	0.033924
VCAN	0.033872
AUTS2	-0.033828
SPRY1	-0.033775
NR5A2	0.033752
RLN1	0.033732
SERPINB1	-0.033633
ITPR1	-0.033586
NAV2	0.033563
DEPDC1	0.033538
NUPR1	-0.033289
ELF3	-0.033288
GAREM	-0.033246
LRP8	0.033210
ABCB4	-0.033066
HEY1	-0.032954
NUAK1	-0.032780
CDC6	0.032640
NT5DC3	0.032492
P4HA2	0.032398
CAMK2N1	-0.032393
TMEM120B	0.032326
FOXC1	0.032315
PTPN13	-0.032167
TTK	0.032005
MNS1	0.031950
HCK	0.031693
CDCA8	0.031683
NLK	-0.031616
SPAG5	0.031603
DTL	0.031451
ANXA3	-0.031298
FAM105A	-0.031280
TGFBR3	0.031258
PDZK1	0.031211
SLC19A2	0.031198
UGT2B28	0.031140
ATF3	-0.031126
CHM	0.031093
CXCR4	-0.031080
SLC22A5	0.031073
CLGN	-0.031071
ATP8A1	-0.030833
HEY2	0.030831
SORBS2	0.030704
GPR143	-0.030693
MELK	0.030647
RAD51AP1	0.030594
KIF20A	0.030557
ARID5B	-0.030541
P2RY2	0.030505
RBBP7	0.030493
FKBP4	0.030471
BRCA2	0.030413
TMEM135	-0.030404
GALNT10	-0.030387
EFHD1	-0.030353
GNL3LP1	0.030333
SEPP1	-0.030288
HOXC6	0.030263
TOX3	-0.030236
TFAP2C	0.030175
NCAPG	0.030161
FAM64A	0.030137
TK1	0.030023
CTF1	-0.029960
TNIK	0.029816
SH3BP4	-0.029800
PTGER3	0.029751
ATP2B1	-0.029697
PRSS23	0.029650
ERBB4	-0.029615
ORC1	0.029593
TMEM164	0.029534
SEMA3G	0.029525
ELOVL2	0.029502
HSPA4L	0.029498
METTL4	0.029419
KIF14	0.029385
SDC2	0.029367
CSTA	-0.029354
SLC29A1	0.029340
CORO1A	0.029337
TBX3	-0.029315
HIST1H2AE	-0.029221
CLMN	-0.029040
FABP5	0.029028
ZNF571	-0.029017
SPDL1	0.028900
PDE1A	0.028889
SEMA3B	0.028847
MLLT11	0.028720
SHH	0.028712
AMPD1	-0.028671
ZNF280D	-0.028606
FAM131A	-0.028598
PRC1	0.028549
HIST1H2BG	-0.028515
XRCC3	0.028474
EFNB2	-0.028466
H2AFJ	0.028447
CBFA2T3	-0.028445
CENPU	0.028438
FGF13	-0.028403
GLA	0.028296
HIST1H2AC	-0.028253
NEK11	-0.028182
ACOT7	0.028155
C9orf40	0.028102
CDK1	0.028097
PLK4	0.028089
ZNF711	0.028081
CCNA2	0.028071
C12orf4	0.028018
FBN2	-0.028015
LRIG1	0.027970
SYCP2	-0.027951
ARHGAP5	-0.027889
RAB26	-0.027792
RECQL4	0.027772
C14orf132	0.027769
RNFT1	0.027546
OIP5	0.027537
ANXA2P1	-0.027524
SOX3	0.027418
NBL1	0.027355
ANKRD11	0.027277
ABCC5	-0.027274
CDKN2C	0.027211
INSIG1	0.027210
AGO4	0.027131
FANCI	0.027094
ETNPPL	0.027064
ATAD2	0.027045
PITPNC1	0.027006
HELLS	0.026965
ZDHHC7	-0.026932
SHROOM2	-0.026925
CLDN9	-0.026922
CPEB1	-0.026898
TSPAN1	-0.026878
BCAR3	-0.026841
DNMBP	0.026781
SLC52A1	-0.026692
CHEK1	0.026610
PDLIM3	0.026610
ZWINT	0.026535
RFTN1	-0.026529
CCNE2	0.026525
ARNTL2	0.026516
CDCA3	0.026505
SPRY2	-0.026469
RND3	-0.026435
SFXN3	0.026398
ASPM	0.026344
LDLRAD4	-0.026219
MBOAT2	-0.026218
GSAP	-0.026104
SIDT1	-0.026078
GINS1	0.025979
SERPINA3	0.025961
SERPINA1	0.025933
ESPL1	0.025890
BMP7	-0.025853
ETV4	0.025800
N4BP3	-0.025788
CEP55	0.025731
RLN2	0.025629
MOCS2	0.025622
PRLR	0.025615
SELENBP1	-0.025532
PCDH8	-0.025508
BATF3	0.025443
SLC16A6	0.025408
CCNG2	-0.025405
GSN	0.025388
FOS	0.025382
DLGAP5	0.025377
MKI67	0.025376
MITF	0.025368
ACVR2B-AS1	0.025350
HIST1H2AM	-0.025314
MB	-0.025278
KLHL5	-0.025272
WDHD1	0.025158
GINS3	0.024975
NCAPH	0.024970
GABRR2	-0.024942
TPK1	-0.024930
MIS18BP1	0.024913
TGFB3	-0.024852
GINS2	0.024801
PDZRN3	-0.024776
NCAPG2	0.024740
STON1	-0.024660
KIF15	0.024659
GNG4	0.024630
LRRC75B	0.024620
KIAA0513	-0.024615
GALK1	0.024581
EAF2	0.024577
PYCRL	0.024570
AHNAK2	-0.024554
JUND	0.024524
FAM134B	-0.024492
ARNT2	-0.024467
TUBB6	0.024442
CA12	0.024422
OSBP2	-0.024398
PLIN2	-0.024376
CENPN	0.024372
POLE2	0.024365
KCNJ8	-0.024353
NUSAP1	0.024339
ZNF646	0.024339
BIRC5	0.024203
FEN1	0.024168
G6PD	0.024157
FRS2	0.024117
NPY1R	0.024104
ANG	-0.024018
TIAM1	0.023995
HOMER2	0.023921
FRK	0.023901
TLE2	-0.023891
KIF3B	-0.023883
HDAC5	-0.023742
ASF1B	0.023725
SLC7A5	0.023659
GGH	0.023585
HP1BP3	0.023579
BTBD7	-0.023572
THBS1	-0.023570
GBP2	-0.023534
SKA1	0.023445
POLA2	0.023444
RSRC1	0.023444
KRT23	-0.023442
SLMO1	-0.023405
KAL1	-0.023402
DCLRE1A	0.023365
TOP2A	0.023358
GPSM2	0.023351
NOL10	0.023343
CTRC	-0.023329
CRY2	-0.023326
PLBD1	-0.023288
TACC3	0.023259
LARP6	-0.023256
IL1RAP	0.023231
PIN1P1	-0.023199
CD44	0.023197
LIG1	0.023171
BCL6	-0.023167
MARK1	-0.023157
MAGOHB	0.023141
ACADSB	-0.023134
ERMAP	-0.023070
GAL	0.023041
EYA2	-0.023005
LIN7A	-0.022991
FKBP10	-0.022961
PPAP2C	-0.022958
CLIC5	-0.022913
RMND1	-0.022908
FAM186A	-0.022905
AMN	0.022860
PSRC1	0.022787
KNTC1	0.022784
CENPI	0.022769
EFHD2	0.022741
RNF32	-0.022675
MSMB	-0.022635
KIFC1	0.022602
FAM53B	-0.022582
TPX2	0.022576
C1orf112	0.022561
TRIP13	0.022544
CCNF	0.022539
CA11	-0.022535
STARD5	0.022531
TLR2	0.022530
TAZ	0.022497
GNAI1	-0.022466
E2F8	0.022456
UTRN	-0.022447
HJURP	0.022445
TGFBI	-0.022442
THNSL2	-0.022430
CDKN3	0.022395
FICD	0.022390
SREBF1	0.022359
RPS6KC1	-0.022355
FOXO1	-0.022323
NVL	-0.022323
GTF2H2B	0.022304
TESK2	-0.022220
TFAP4	-0.022160
PNP	0.022132
PPIF	0.022126
KIAA1107	-0.022055
PLAT	0.022038
HPRT1	0.022028
RFC5	0.022007
AMIGO2	-0.021983
MCTP1	-0.021960
DSN1	0.021944
MLLT3	-0.021932
FAM149A	-0.021921
SPTBN2	0.021911
FAM46C	0.021911
NCAM2	-0.021901
TOM1	-0.021884
MCM4	0.021826
SSR3	0.021819
TNFSF10	0.021749
KIF18A	0.021744
ATAD5	0.021713
IPO8	0.021700
LPHN2	-0.021687
PODXL2	0.021687
MSX2	-0.021666
ERBB2	-0.021663
CTSC	0.021647
PRIM1	0.021645
ATP9A	-0.021640
CDH3	-0.021607
CEMIP	-0.021591
MAP4K4	-0.021586
LRRC8E	-0.021551
TGIF1	-0.021527
ENO3	0.021472
TMPO	0.021471
ZXDB	-0.021459
CBX6	-0.021457
SGCG	-0.021426
SUSD4	0.021426
DHRS2	0.021419
KCNV1	0.021389
KIF2C	0.021362
BAG2	0.021354
RAB20	-0.021352
CRIPT	-0.021333
NDC1	0.021327
HIST1H2AG	-0.021298
TFPI	-0.021293
RNF43	-0.021289
CDH18	-0.021288
GPR126	-0.021285
BRCA1	0.021198
PCSK6	-0.021187
LOC81691	0.021164
PTK6	-0.021159
LINC00963	-0.021142
CNTRL	0.021141
HIST1H1C	-0.021110
DEPTOR	0.021046
ZNF222	0.021037
HIST1H3H	-0.021030
MAD2L1	0.021021
LIMCH1	-0.020963
PODXL	-0.020960
SMPDL3B	0.020959
LRRC49	-0.020948
C16orf59	0.020939
CHAF1A	0.020937
ALDOC	0.020919
KIF4A	0.020901
DOCK4	-0.020888
KLK12	0.020886
PDSS1	0.020869
HIST1H2BC	-0.020811
KLHL24	-0.020797
SLC26A2	0.020739
FYCO1	-0.020711
ZMIZ1	-0.020685