!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	mouse
!drug_name	Estradiol
!smiles	CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O
!drugbank_id	DB00783
!pubchem_cid	5757
!cell_type	Uterus - single injection of 400 ug/kg - 2 Hours after treatment
!organism	mouse
!end_metadata
CKB	0.231125
GADD45G	0.221045
ERRFI1	0.179538
IER3	0.160990
RPS19	-0.156835
CEBPB	0.155839
PNP	0.132098
ENG	0.121679
SOCS1	0.112510
ANGPTL2	0.103731
GAS1	-0.100982
SLC7A5	0.100853
ATF4	0.099990
ISYNA1	0.094948
ATP1A1	0.094456
IER2	0.090206
RPL7	-0.089980
GAS6	0.089135
HSD17B11	0.088966
ID2	-0.086787
PRRX2	0.086657
TWIST2	0.085172
HK1	-0.085062
RHOU	0.084381
SOCS3	0.081421
TIPARP	0.077385
APCDD1	-0.076815
RPS26	-0.076305
PLK2	0.076009
TOP1	0.075346
RASD1	0.074627
LAPTM4A	-0.074616
LSP1	-0.073633
RPS10	-0.073597
MIDN	0.073121
ALAS1	0.071763
FOS	0.071509
MAPKAPK2	0.071459
DCN	-0.070316
MAD2L1	0.069742
CSTB	0.065155
BCAT1	0.064182
WNT4	0.064057
PLET1	0.062351
SRSF2	0.061821
RPS5	-0.060317
NCOR2	0.060249
STAT5A	0.060133
PTPN1	0.059400
YWHAZ	0.058835
APP	-0.058529
CEBPA	0.057719
TLE3	0.057102
CNN1	0.057092
GADD45A	0.055637
SNRK	0.054771
DUSP1	0.053797
PLAT	-0.053587
RPS15A	-0.053462
RPL21	-0.052224
IFITM3	-0.051976
PLP2	-0.051714
KCTD12	-0.050451
CTDSP2	-0.050263
PDXK	0.049532
WDR92	-0.049487
HOXA11	-0.049107
PTGES	0.049086
BTG2	0.048533
LUM	-0.048206
RAN	0.047746
S100A6	-0.047623
TSR1	0.047404
HSPH1	0.046743
MYH9	0.046672
RPL10	-0.046459
SPARCL1	-0.046220
RBPMS	0.046167
RELA	0.045783
PLAC8	-0.045762
TUBB	-0.045301
CEBPD	0.045178
NHP2	0.044929
HERPUD1	0.044580
PQLC3	0.044450
INHBB	0.044435
FZD2	-0.044125
COL6A3	0.043680
MYADM	-0.043646
PABPC1	-0.043421
F3	0.043393
LITAF	0.043297
MMP14	-0.043164
TSC22D1	-0.043111
PPIA	-0.043014
PIM3	0.042761
BAG2	0.042687
NRIP1	0.042580
TUBA1A	-0.042349
GNB2L1	-0.041877
SURF4	0.041118
UBC	0.040771
TOB1	0.040298
CTPS1	0.040102
RGS3	0.040045
RPL28	-0.039804
SRSF6	0.039740
HIF1A	0.039700
RGS2	-0.039692
RPL7A	-0.039426
MYLK	-0.039370
RAC1	-0.039172
ITPK1	0.038939
AKT1	0.038886
NR4A1	0.038729
YPEL3	-0.038708
CSNK1A1	0.038604
GTPBP4	0.038491
ZFP36	0.037583
AGPAT5	0.037542
RPL3	-0.037433
MARCKSL1	0.037222
RIN2	-0.037131
RPLP0	-0.037037
ISLR	-0.036976
PNPLA2	0.036747
FKBP4	0.036667
SESN1	-0.036489
MYL12A	-0.036362
EIF4A3	0.036356
WSB1	0.036352
SYNPO	0.036346
TFCP2L1	0.036297
SOX17	-0.036233
ACAA2	-0.036092
SMOC1	0.035931
HSPA5	0.035840
TPT1	-0.035590
RAMP3	0.035549
GPX3	0.035531
COL5A2	-0.035452
DAB2IP	0.035420
MXD4	-0.035291
HOPX	0.034948
RPS23	0.034916
LTBP4	-0.034908
NPM1	-0.034785
NREP	-0.034728
ELF3	0.034612
ETF1	0.034479
COL3A1	-0.034479
KRT83	0.034474
NAB2	0.034454
U2AF2	0.034142
SLC12A4	0.034071
TXNIP	-0.033605
PADI1	0.033545
RPS12	-0.033464
MSX1	-0.033300
RPS11	-0.033300
MARVELD1	-0.033011
PCBP1	0.032955
TRAF4	0.032917
FAM101B	-0.032909
PGRMC1	-0.032892
IGFBP6	-0.032757
SPSB1	0.032748
SLC6A13	0.032737
SLC25A39	0.032668
RPS3	-0.032592
SERPING1	-0.032501
RPL10A	-0.032140
ZFPM1	0.032135
SOX18	0.032088
SIPA1L2	0.031929
FMO1	-0.031852
EID1	-0.031547
CDKN1A	0.031472
IL17RA	0.031462
ACTR3	0.031344
PNRC2	-0.031295
PRKCDBP	-0.031147
NDP	-0.031101
STK40	0.030787
SOCS2	0.030690
RNF167	-0.030683
B2M	-0.030676
LY6E	-0.030577
PTP4A1	0.030573
GDF15	0.030526
SLC39A7	0.030355
GABARAPL1	-0.030291
ARL6IP1	-0.030278
PPP1R15B	0.030242
YBX1	-0.030216
COL1A1	-0.030140
CTSD	-0.030105
GNAI2	0.030071
VEGFA	0.030064
EGR1	0.029996
ANXA6	0.029945
CNN3	-0.029802
EIF3J	0.029633
RAP1GAP	0.029265
LRRC59	0.029260
CXXC5	0.029068
MYH11	-0.029020
PPTC7	0.028988
CTSB	0.028903
PENK	-0.028862
EEF2	-0.028736
DSTN	-0.028488
CST3	-0.028332
IGFBP3	-0.028288
ARHGEF25	-0.028218
HNRNPH1	0.028124
MAT2A	0.028108
MKNK2	0.028099
NRTN	0.027997
S100A10	-0.027831
RPS24	-0.027650
GLCE	0.027528
SOX4	-0.027474
RHOC	0.027431
UNC45A	0.027392
PRKCD	0.027387
ALAD	0.027378
RRS1	0.027298
RABAC1	-0.027255
MAF1	-0.026910
CNBP	0.026866
ITM2B	-0.026865
RARRES2	-0.026838
GORASP2	0.026811
PPIB	-0.026765
PTCH1	-0.026745
MDFIC	0.026697
TINAGL1	0.026593
GNAI3	-0.026580
RAD21	-0.026532
JUN	0.026496
LBP	-0.026440
HIP1R	0.026416
PGF	0.026408
JMJD6	0.026262
ARF1	0.026185
SFRP2	-0.026022
GSPT1	0.025935
SGK1	0.025688
RPL5	-0.025649
TXN	-0.025541
TIMM23	0.025528
ISOC1	-0.025474
ADRM1	0.025454
WFDC2	-0.025382
COL4A2	-0.025363
THY1	-0.025335
H1F0	-0.025328
POSTN	-0.025294
ATP6V0C	0.025212
TRIM27	0.025114
REV3L	-0.025103
LMO4	-0.024858
CORO1C	0.024853
GNG12	0.024844
EZR	0.024833
SDPR	-0.024623
ETS2	0.024609
DBP	-0.024589
ARHGDIA	0.024556
ATPIF1	-0.024455
ANXA5	-0.024379
HPCAL1	0.024347
PSMA6	0.024220
TCF4	-0.024160
MGP	-0.024131
ST5	-0.023963
ATP5A1	-0.023923
RASSF5	0.023919
CCNB2	-0.023901
PSMD7	0.023893
FKBP11	0.023665
EIF3G	0.023516
ANAPC11	-0.023452
MARK2	0.023394
COL1A2	-0.023332
TPI1	-0.023064
UBTF	0.023031
AKR1A1	-0.022995
LTA4H	-0.022969
COL6A1	-0.022930
DDX5	0.022769
H2AFZ	-0.022701
MDK	-0.022657
MSRB1	0.022498
PDHA1	-0.022485
PLK3	0.022277
SLC25A4	-0.022248
GSK3A	0.022161
MORF4L2	0.022075
ECH1	-0.022010
SERINC3	-0.021970
SLC25A25	0.021964
SLC41A1	0.021829
DDX21	0.021686
EFNB2	-0.021633
BDKRB1	0.021497
ELAVL1	0.021480
ELL	0.021453
JUP	0.021402
MAP7D1	0.021392
HSPB8	0.021384
LARP1	0.021220
RRP1B	0.021201
PDK4	0.021193
SLC3A2	0.021178
SERP1	0.021165
SH3BGRL	-0.021085
TAGLN	-0.021062
ANXA1	-0.021026
SERPINB6	-0.020926
BTG1	-0.020924
AZIN1	0.020842
CDC42SE1	0.020750
RAMP1	-0.020709
NDUFB5	-0.020660
GSTP1	-0.020620
TGFBI	-0.020612
VAPA	0.020582
CYR61	0.020545
LGALS1	-0.020311
ERGIC3	-0.020198
GAPDH	0.020147
ARHGAP39	0.020139
RPL27A	-0.020057
NOP2	0.019985
CALB1	-0.019978
TLE1	-0.019975
RNASEK	0.019935
GDF10	-0.019926
PTPRS	0.019917
SAR1A	0.019906
TNFAIP8	-0.019862
DPT	-0.019861
ZNF598	0.019845
GNL3	0.019830
CPE	-0.019798
PLTP	-0.019790
ATL2	0.019655
WFS1	0.019618
APOE	-0.019609
RNASE4	-0.019600
CDR2	0.019568
PLS3	-0.019514
TMEM176B	-0.019500
HDC	-0.019470
TUBA1B	-0.019311
PERP	0.019292
ST6GALNAC6	0.019225
COX7A2L	-0.019178
ITGB1	-0.019173
H1FX	0.019154
IL10RB	-0.019132
SRM	0.019107
VKORC1	-0.019060
CDK2AP1	0.019050
GSTO1	-0.019036
GOLPH3	0.018996
P4HA2	0.018994
PAPSS1	-0.018980
PIM1	0.018977
ZFP36L1	-0.018890
ARGLU1	0.018879
RERE	-0.018857
RECK	-0.018852
EIF3D	0.018834
ATF1	0.018821
NPNT	-0.018716
UBL3	0.018546
HIST1H1C	-0.018529
ANXA2	0.018501
PCP4	-0.018459
ACTA1	-0.018425
EIF1B	0.018408
COL4A1	-0.018396
PTGER4	-0.018338
TSPO	-0.018267
ATP5C1	-0.018261
JUNB	0.018160
PPP4C	0.018155
WDR1	0.018151
TXNL4A	0.018135
WLS	-0.018118
HDLBP	0.018031
SLMAP	-0.017986
TMPRSS2	0.017983
CTSV	-0.017979
PSMC6	-0.017978
FSTL1	-0.017957
DAP	-0.017896
ID1	0.017877
PABPN1	0.017869
DBNDD2	-0.017784
VPS28	-0.017771
EIF4A2	-0.017725
MCAM	-0.017701
PCYOX1	-0.017675
SLC25A36	0.017659
GPC3	-0.017658
EFNB3	0.017647
PTTG1IP	0.017646
PPAP2B	-0.017646
CIRH1A	0.017573
DYNC1I1	-0.017519
GPAM	-0.017493
CBX6	-0.017493
ATF5	0.017431
CHD1	0.017418
SPARC	-0.017375
TGIF1	-0.017370
PADI2	0.017354
NUMA1	-0.017351
WDR6	-0.017350
SELT	0.017235
NCL	0.017228
MRFAP1	0.017216
GTF2I	-0.017212
CAPNS1	-0.017187
CD63	-0.017183
GAA	-0.017133
CYP2S1	0.017076
HCFC1R1	-0.016995
RPL6	-0.016982
CDR2L	0.016980
SEC13	0.016960
RPL18	-0.016951
NT5DC3	0.016948
ZFAND6	-0.016871
C12orf57	-0.016860
KLF4	0.016781
ZBTB16	-0.016730
SS18	0.016722
PSD	-0.016717
DNAJC10	-0.016662
RNF4	0.016656
WSB2	0.016647
MAPK6	0.016634
FPGS	0.016602
CNPY2	-0.016600
FAM171A1	-0.016578
BHLHE40	0.016538
C20orf24	0.016514
LAMP2	-0.016509
PSME3	0.016442
TRIM25	-0.016434
KRT19	-0.016375
SLC2A3	0.016367
ILK	-0.016361
HDAC5	-0.016317
RPS17	-0.016305
CLDN5	-0.016266
BCAR1	0.016201
TBL1XR1	-0.016150
FLNB	0.016146
KITLG	-0.016127
DENND5A	0.016126
PTPRU	0.016122
ETNK1	0.016107
PPIC	-0.016085
WWC2	0.016045
CPNE3	-0.016026
THRSP	-0.015991
STMN1	-0.015991
GPI	-0.015979
RPS27A	-0.015973
WNT5A	-0.015968
NFIX	-0.015966
PPP1R15A	0.015925
HDAC6	0.015909
ACTA2	-0.015898
MED10	0.015845
EYA2	0.015836
ATF3	0.015785
SENP3	0.015678
FAM8A1	-0.015670
PHPT1	-0.015669
CITED2	-0.015640
SEPT9	0.015637
CSRP2	-0.015625
TCF21	-0.015613
KCNJ8	-0.015611
STAT3	0.015602
AIMP1	-0.015600
VPS26B	-0.015562
WDR43	0.015544
CTNNB1	-0.015539
IRF6	-0.015475
TGFB2	0.015408
NFE2L1	0.015399
UBE2R2	0.015396