!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	human
!drug_name	Doxycycline
!smiles	CC1C2C(C3C(C(=O)C(=C(N)O)C(=O)C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)N(C)C)O
!drugbank_id	DB00254
!pubchem_cid	5281011
!cell_type	C33KD2 cells
!organism	human
!end_metadata
BIRC8	-0.093563
SAGE1	-0.063423
CHCHD10	-0.061318
ZNF483	-0.059218
CRISP3	-0.057229
TRMT112	-0.051628
CLCA1	-0.051143
KIN	-0.050620
PCDHB15	0.050375
ACADS	-0.046432
TYMS	-0.045870
GLI1	-0.045523
ARG1	-0.044817
HIST1H4B	-0.043780
SPTSSB	-0.043121
SUSD5	-0.042081
CLIC3	-0.041936
C10orf25	-0.041320
FGF23	-0.041199
C11orf85	-0.040933
SLC22A14	-0.040709
NOD2	-0.040654
VWA5B1	0.039691
KRT8P41	-0.039591
CD72	-0.038287
TMEM132D	0.038283
CRADD	0.038267
TCN2	0.038237
LOC100996579	-0.038029
KCNS3	-0.037796
CCDC148	0.037618
CCNE2	-0.037213
UPK1B	0.037107
YOD1	0.037105
HIST1H4C	-0.036704
TMEM123	-0.036684
SLC38A4	-0.036444
LMNTD1	-0.036350
ANKRD46	0.036200
IL12B	-0.035938
TMEM129	-0.035789
LINC01192	-0.035746
RAET1E	-0.035521
GNPDA1	-0.034998
USP27X	-0.034965
PLD6	-0.034901
USP11	-0.034772
LOC100507468	-0.034626
MMAA	0.034508
BEX1	-0.034499
DHX29	-0.034480
CASC11	0.034141
SP8	-0.033585
TDG	0.033050
EXOC6B	0.032989
C3orf20	-0.032953
CSGALNACT1	0.032709
VASP	-0.032639
ZNF772	-0.032593
BAI1	-0.032157
LINC00317	0.032071
IGKV1D-8	-0.032044
CDK2AP1	-0.031989
LPAR1	-0.031811
LOC100996425	-0.031651
CBR3-AS1	-0.031508
PITPNM3	0.031445
PPP2R3C	0.031245
FBXO38	-0.031211
CPED1	-0.030944
CAMKV	-0.030761
CHIT1	-0.030628
BEX2	-0.030611
NCAM2	-0.030568
CACNG6	-0.030522
SUMO3	-0.030470
HAND2	-0.030466
RTN2	-0.030364
CCL18	-0.030268
SLC3A1	0.030160
GLB1L2	0.030123
AP4S1	-0.030111
OTUD3	0.029994
PDIK1L	0.029930
RAB38	-0.029814
DMKN	-0.029803
ZNF22	-0.029780
PADI1	-0.029743
DDX6	-0.029735
SMARCD1	-0.029677
CDIPT-AS1	-0.029670
TNFRSF10D	0.029590
EDIL3	-0.029589
GPR85	-0.029553
HOXA1	0.029536
MDK	-0.029441
LOC100130256	-0.029358
LMOD3	0.029357
ZYG11A	0.029304
CHD8	-0.029240
PPDPF	-0.029201
ARMC3	0.029181
MAGEA10	-0.029150
SLC2A14	0.029135
ZBTB38	-0.029050
TMC3	-0.028884
KCTD4	0.028852
TREML4	0.028797
HIST1H1E	-0.028659
MYO3A	-0.028623
UBE2M	-0.028578
SNORA76C	-0.028526
ADORA2B	-0.028519
IGKV1D-13	-0.028426
CCM2L	0.028399
SLC6A12	-0.028390
GIMAP5	0.028208
KCNF1	-0.028102
SAMSN1	-0.028067
TECRL	0.028032
EOGT	0.027905
PCBP3	-0.027884
TRIML1	0.027876
NDUFAF7	-0.027793
TMEM17	0.027741
IGDCC3	-0.027571
ENPP4	0.027525
LPGAT1	-0.027520
SYS1	0.027458
WBSCR28	-0.027317
FLJ37201	-0.027218
C1QTNF9	0.027208
MGC24103	0.027169
MUC1	-0.027164
RFTN1	0.027119
GNAI2	-0.027110
ASB5	0.027097
TMEM64	0.027063
SRGN	-0.026966
OGDHL	-0.026833
SHCBP1L	-0.026833
FADS1	-0.026685
LIPT1	0.026634
LOC100130156	-0.026493
PTPLAD2	-0.026483
DCT	-0.026475
APOB	-0.026367
KEL	-0.026360
LINC00116	-0.026278
RNF8	0.026099
FBXO27	0.026081
COLCA2	0.026055
ANKRD34A	-0.025997
LUZP2	-0.025872
TFF2	0.025804
FAH	0.025750
EOMES	-0.025555
NR4A3	-0.025487
H1F0	-0.025461
ZFHX4-AS1	0.025390
FBXL12	-0.025293
PSG1	0.025285
FAM213A	-0.025260
CRABP2	-0.025213
DVL2	-0.025192
PNRC1	-0.025178
KLRB1	0.025156
SAMD15	0.025139
ASB11	-0.025035
ZNF362	-0.025023
IL1A	0.024952
PPAP2A	-0.024939
SMLR1	0.024789
SCG2	0.024745
CDYL2	0.024717
EFCAB2	-0.024664
ZNF580	-0.024654
DMRT2	-0.024622
MEIS2	-0.024593
LINC00844	-0.024545
LILRB2	0.024544
FADS6	-0.024495
HEATR9	0.024483
LOC100507311	-0.024408
GPR1-AS	0.024404
PABPC4	-0.024397
EMC6	-0.024309
PCSK6	0.024299
MYL10	-0.024264
SLC4A8	0.024194
FRAT1	-0.024183
MPI	-0.024157
C12orf42	-0.024154
TMEM213	0.024100
PCDHGB2	0.024042
KRT5	-0.024009
DNM2	-0.024009
MTMR9	0.023965
PACERR	0.023949
CD300LD	-0.023906
HORMAD1	-0.023896
EIF2B5	-0.023864
INHBB	-0.023834
NR1I2	0.023831
KCNJ2	0.023702
MEGF11	0.023702
UNC13C	0.023673
SLC22A11	0.023658
SPATA16	0.023595
POU4F2	0.023579
SSBP1	0.023572
CELF2	0.023572
TTLL11	0.023502
ITIH3	0.023493
TMEM63B	-0.023492
LMO3	0.023475
CBX3	-0.023447
HS3ST1	0.023438
SHE	0.023436
HIST1H1C	-0.023423
RABGGTA	0.023382
DIRAS2	0.023369
PLXDC2	0.023360
C7orf31	-0.023344
PRR14	-0.023315
GINS1	-0.023280
NUCKS1	-0.023180
TM4SF19	-0.023134
LOC441052	-0.023111
C6orf136	0.023076
LOC727916	-0.023058
C11orf42	0.023057
PVRL2	-0.023055
ZMAT3	0.023040
VBP1	-0.022996
LOC100506242	-0.022952
REPIN1	-0.022945
PLEK2	-0.022929
CLEC4C	-0.022924
CST9L	-0.022916
FAM206A	0.022845
NTF4	0.022822
PP12708	-0.022815
PTPN21	0.022790
ECSCR	-0.022749
GAS6	-0.022720
FAM150B	0.022700
SH3YL1	0.022691
PCDH9	0.022648
GNG11	-0.022634
OR1A1	-0.022595
AKR1E2	-0.022567
EGF	0.022535
ZKSCAN7	-0.022532
C1orf105	0.022485
CYBA	-0.022462
DHRS7C	0.022462
LGR5	-0.022448
ACTR3	-0.022429
DCUN1D3	0.022416
PIGP	-0.022336
HAUS4	-0.022321
PALLD	-0.022287
AGPAT9	0.022263
SERPINA13P	0.022259
TAF13	-0.022257
AAED1	-0.022257
KIAA1652	-0.022233
EBAG9	-0.022163
ELAC1	-0.022148
SLC25A22	0.022135
TIGD4	0.022126
LOC101927811	-0.022118
LRRC37A11P	0.022035
KRT6C	-0.022009
HIST1H4D	-0.021960
GPR35	-0.021956
PDE8B	-0.021909
FABP7	0.021902
EFCAB13	0.021871
HBP1	-0.021861
SQRDL	-0.021854
DUSP3	-0.021853
GABPB1	0.021843
EFCAB6	-0.021837
AMZ1	-0.021802
USP26	0.021785
PRO2852	-0.021781
DCP2	0.021769
SMNDC1	-0.021762
CTGF	-0.021760
ENDOU	-0.021754
LOC100131131	0.021719
STK32B	0.021713
RNF220	-0.021683
MARCKS	-0.021674
LOC283454	-0.021668
SCUBE3	0.021646
LRRTM3	-0.021642
CHIC1	0.021640
TAC1	-0.021625
PNPLA4	-0.021525
SRPK1	-0.021496
VGF	0.021490
SUGT1P3	-0.021469
PHC1	-0.021437
B4GALT6	0.021401
MFSD3	-0.021387
PHF12	0.021383
SCGB1D1	-0.021380
PNRC2	-0.021368
DACT2	-0.021349
DSC2	0.021331
ZNF701	-0.021330
S100A4	0.021297
LHX6	-0.021295
SLC26A8	-0.021272
MTIF3	0.021249
LOC90834	-0.021216
COMT	-0.021215
QTRT1	-0.021213
ADAM29	0.021205
THBS2	-0.021187
SALL1	-0.021123
CADM2	-0.021109
FAM167A	0.021096
ADCK1	-0.021094
CNTFR	-0.021084
FAM222B	-0.021080
ADRA1B	0.021040
TMC5	-0.021037
CAPN3	-0.021036
GAFA2	-0.021015
NSA2	-0.020997
FAHD2CP	0.020945
EHHADH	-0.020917
SPATA32	0.020873
KLRG1	-0.020871
DUSP27	0.020851
CPA2	-0.020847
DCTN6	-0.020753
CCDC167	0.020710
GABPA	0.020688
L1TD1	-0.020675
C20orf141	-0.020675
NUDT10	-0.020626
TTPA	0.020615
CCL2	-0.020609
SETD6	-0.020607
ZNF503-AS1	-0.020556
HPCA	-0.020515
EML1	-0.020462
NNT	-0.020454
CEP41	-0.020432
LOC100130264	-0.020427
FBN1	-0.020412
GDPD3	0.020402
NGFRAP1	-0.020400
KCNJ16	-0.020397
TYMSOS	0.020396
ZNF736	0.020394
TCN1	-0.020393
CRYGB	0.020375
PLEKHG4	-0.020374
POLR2I	-0.020361
HDDC3	-0.020361
RAET1K	-0.020357
LTBR	-0.020355
C10orf67	-0.020322
LTBP1	-0.020316
PKIB	-0.020307
SMIM13	0.020294
FAM160B1	0.020290
SLC41A3	0.020284
EIF1B-AS1	-0.020280
LAIR1	-0.020254
LOC101927592	0.020244
KPNA5	0.020209
SEC31B	-0.020208
INSL4	-0.020199
SLC34A3	-0.020155
DLAT	-0.020148
ALB	-0.020131
SYNPR	-0.020096
CLPTM1	0.020076
SIDT1	-0.020062
LOH12CR2	0.020029
LRRCC1	-0.020003
GABARAP	-0.019959
XDH	-0.019943
DIRAS3	-0.019898
SPANXD	-0.019875
FAM134B	-0.019867
CYTL1	-0.019865
ACTR3C	0.019859
TBC1D21	0.019849
DCP1B	-0.019843
LOC100131541	0.019838
ARHGEF16	-0.019814
LAD1	0.019805
PLEKHA7	-0.019803
FAM19A1	0.019793
LOC100129406	0.019768
ECEL1P2	0.019751
CLDND2	-0.019740
SMIM10	0.019740
LCLAT1	-0.019739
PCDHA11	-0.019715
ARNTL2	-0.019703
ATXN2L	-0.019691
CENPA	-0.019647
TTTY4C	-0.019647
NEFH	-0.019647
TIMM21	-0.019644
CNGA1	-0.019636
CYP27A1	-0.019634
HOXC11	-0.019633
SPTY2D1-AS1	-0.019618
PRKAB2	0.019598
HIST1H4H	-0.019598
PDE4A	-0.019590
FKBP11	-0.019584
C7orf60	-0.019577
SLCO1A2	-0.019566
SDPR	-0.019545
A2M	-0.019542
LYRM1	0.019519
F2	0.019504
DAZL	0.019492
KIAA0319L	-0.019482
CBLC	-0.019449
CPXM2	-0.019438
AMER3	0.019437
CHST12	-0.019428
BPIFC	0.019426
RAB40B	-0.019421
PDE6H	-0.019414
CALM3	-0.019413
ANKRD34B	0.019377
ISL1	0.019375
TMEM45B	-0.019368
KDM4D	-0.019360
GDF5	-0.019316
HSD3B1	0.019311
RTN3	-0.019274
TMC7	0.019259
CNRIP1	-0.019235
LARS2	-0.019227
CRLF2	-0.019224
AMDHD1	-0.019183
PROSER2-AS1	-0.019154
SLC6A17	0.019148
PGAM2	0.019136
HS3ST3A1	-0.019135
RARB	-0.019126
METTL20	0.019122
C3orf18	-0.019115
SFTA3	0.019115
ID4	0.019098
KLHL24	-0.019078
SLC36A2	0.019072
DPP8	-0.019070
THEG	0.019068
NSG1	-0.019055
KLHL15	0.019054
DET1	0.019024
GRP	-0.019005
RWDD2B	-0.019003
PRAMEF17	-0.018976
ZNF594	-0.018959
SFXN4	0.018889
PARD6B	0.018823
RPL23AP82	0.018811
SCUBE1	0.018807
RAB42	-0.018796
DEFB127	0.018787
C2orf82	0.018773
ZSWIM2	-0.018770
LOC100507419	0.018766
GNA13	-0.018754
NPAS4	0.018704
BRWD1-IT2	0.018671
PBX1	-0.018665
LOC100128816	-0.018651
DDX25	0.018631
GPR19	-0.018599
AQP12A	0.018590
AGPAT3	-0.018565
COIL	0.018562
DUSP6	-0.018551
C11orf87	-0.018534
FST	-0.018531
GMPR	-0.018530
ZNF333	0.018512
PSD	-0.018492
TYRP1	-0.018470
CHST15	-0.018454
COL11A1	0.018444
TMED7	-0.018424
WT1	-0.018422