!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!drug_name	Methotrexate
!smiles	CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
!drugbank_id	DB00563
!pubchem_cid	126941
!cell_type	HT29 colon adenocarcinoma cell line
!organism	human
!end_metadata
HAPLN1	-0.269591
S100A4	-0.226563
TMEM167A	-0.216142
DHFR	-0.202119
TM4SF4	0.156708
AKR1B10	-0.151277
IFI27	0.138292
ALDH1A1	0.137439
DKK1	-0.122934
HLA-C	0.114002
B2M	0.113323
AKR1C2	-0.111473
HLA-B	0.102189
ZCCHC9	-0.101051
AKR1C3	-0.098867
VBP1	0.092160
HLA-A	0.090784
TSPAN8	0.090059
SSR4	0.089542
UQCRFS1	-0.086835
MMP7	0.086327
TMSB10	-0.083509
SLC25A6	-0.083390
CD24	0.077845
FDFT1	-0.077253
COX6B1	-0.077242
EDIL3	-0.075325
AKR1C1	-0.072409
GPI	-0.071511
IFITM2	0.070942
BCAP31	0.070407
CCNG1	-0.069397
NDUFS6	-0.067548
RPL30	0.066667
IFITM3	0.065927
ECHS1	-0.064651
PODXL	-0.061728
IRAK1	0.061510
OAT	-0.059777
EIF3H	0.059733
RRM2	0.059484
CAPNS1	-0.058271
DKC1	0.058120
PABPC3	0.056392
MRPL13	0.055806
USMG5	-0.055621
DNAJA1	0.055602
LYZ	0.054505
OCIAD2	-0.053580
YWHAZ	0.053527
RPL8	0.053525
GSTO1	-0.052881
EEF1A2	-0.049745
NOP10	0.049650
RPS14P3	-0.049549
TSPAN13	-0.048796
KRT8	0.048785
KLK6	0.048755
PGAM1	-0.048365
BZW2	-0.047323
UBE2C	0.046812
PTMA	0.046287
KRT18	0.046057
RPN2	0.045916
ZWINT	0.045698
HLA-G	0.045628
HMGN1	0.045493
COX2	0.045447
EIF6	0.044499
ISG15	0.044306
RPS6	0.044120
S100A11	-0.044013
ALDOA	-0.043923
TMED7	-0.043715
NDUFA4	-0.043478
DSTN	-0.043395
UBE2S	0.043258
LGALS4	0.042967
EIF3E	0.042945
TAF7	-0.041365
CDH1	0.041065
CRABP2	0.040928
MT1E	0.040909
GTF3C6	0.040458
XRCC4	-0.039443
PSME2	0.039346
RAN	0.038947
RPL12	-0.038808
CHMP2A	-0.038177
FAM96A	0.037942
ACTN4	0.037668
MSN	-0.037657
HSPE1	0.037613
PTGES3	0.037207
RPL4	0.036996
PROM1	0.036825
SEPW1	0.036677
SNHG6	0.036462
BST2	0.036148
LAPTM4B	0.036101
KRT20	0.036011
LCN2	0.035865
LAP3	0.035835
SPINK1	-0.035429
CLPTM1L	-0.035107
CTSH	0.034992
HSPH1	0.034883
MAPRE1	0.034775
PSMD2	-0.034774
CD55	-0.034492
LGALS3BP	0.034301
HSPA8	0.034038
GINS1	0.034008
PRDX5	-0.033780
NMI	0.033738
RPF2	0.033663
C14orf2	-0.033594
HMGN2	0.033331
FAM60A	0.033262
YBX1	0.033016
FABP5	0.032855
MAL2	0.032813
ID1	-0.032727
SSR2	-0.032725
CD164	0.032594
MRPL36	-0.032511
PTPLAD1	0.032505
TXNIP	0.032464
HEBP2	0.032445
PLSCR1	0.032269
CMBL	-0.032169
CLDN2	-0.031828
AP2S1	-0.031739
SNRPD2	-0.031470
ITM2B	-0.031418
KIAA0101	0.031357
CRIP2	-0.031295
RGS2	-0.031269
RPA3	-0.031263
TOMM20	-0.031029
SMNDC1	-0.030975
MRPS21	0.030926
WDR54	-0.030535
OST4	-0.030524
PLS1	0.030397
MRPS30	-0.030309
HIST1H2BK	-0.029972
TOMM5	0.029927
TATDN1	0.029891
ATF4	-0.029757
EIF3J	0.029684
DYNLL1	0.029611
VAMP7	0.029608
RPL10	0.029601
EPHX1	-0.029555
PPIB	0.029505
NGRN	0.029205
NDUFV2	-0.028844
UFD1L	-0.028777
HDAC1	0.028774
COX5A	0.028752
IARS2	-0.028530
ANXA5	-0.028491
P4HB	-0.028414
RPS4X	-0.028386
LDHB	0.028238
CALB2	-0.028143
ANXA4	0.028132
ANXA13	0.028067
LY6E	0.028027
ALYREF	0.028017
CRIP1	-0.027770
PDIA6	-0.027663
FXYD3	-0.027663
S100A6	0.027659
CSE1L	0.027630
HSP90AB1	0.027509
FMR1	0.027269
SUMO2	0.027264
DHX32	-0.027236
IPO7	0.027203
CD99	-0.027189
NDUFB9	0.027182
STIP1	0.027052
PSMA4	0.027000
CAPN2	-0.026979
PTS	0.026876
RAD21	0.026844
AURKA	0.026760
NDUFB5	-0.026699
PRR13	0.026682
CKMT2-AS1	-0.026514
HMGN3	0.026292
RPL3	-0.026014
CCT3	0.025980
RPS23	-0.025947
CYC1	0.025885
CAV1	-0.025876
PABPC1	0.025659
ETFB	-0.025657
NUSAP1	0.025596
VIMP	0.025584
NOP58	0.025562
NME7	-0.025411
SNRPB	-0.025198
ENOPH1	0.024975
ADAM9	-0.024848
PRC1	0.024830
ANP32B	0.024818
PTDSS1	0.024734
UBA2	-0.024693
DAP	-0.024636
ATP6AP1	0.024595
MRPL17	0.024470
BRCC3	0.024464
FAM84B	0.024424
LASP1	-0.024418
FXYD5	-0.024418
UBB	0.024387
ANKRD27	-0.024382
ATAD2	0.024367
MT1HL1	0.024353
AGPAT5	-0.024297
ASUN	0.024268
MRPL3	-0.024249
CDK1	0.024235
NELFCD	0.024188
ZDHHC6	-0.024178
TYMS	-0.024088
MRPL15	0.024024
PPP1R1B	-0.024024
UHRF1	0.023932
LTA4H	-0.023589
RPS20	0.023522
GNL3	0.023513
ATP1B1	-0.023436
COX6C	0.023355
LAMP1	0.023143
MEST	0.023129
MORC4	-0.023079
IMPA1	0.023023
MAPK6	0.023018
TPX2	0.022992
MT2A	0.022963
PSMA7	0.022943
LAPTM4A	-0.022917
COTL1	-0.022910
GTF3A	0.022807
YWHAB	0.022770
LYPLA1	0.022669
RRM1	0.022586
SNRPA1	0.022559
S100A16	-0.022556
EIF2A	-0.022547
IFITM1	0.022517
HIF1A	-0.022495
COPS5	0.022377
PAM	-0.022350
NSA2	0.022329
HPRT1	0.022326
CKB	-0.022317
KNSTRN	0.022291
OIP5	0.022253
PHB2	-0.022211
OSTC	-0.022031
TRMT5	0.021891
TWSG1	-0.021873
GPX1	0.021855
IER3	0.021811
ATRAID	-0.021782
PTTG1	-0.021688
MRPS35	0.021680
ADRM1	0.021659
CTPS1	0.021639
AQP3	0.021538
ANLN	0.021501
CTNNAL1	0.021461
MORF4L1	0.021431
HLA-F	0.021415
ID2	-0.021411
C12orf57	-0.021326
EPB41L4A-AS1	-0.021319
PSMB8	0.021233
EIF2S2	0.021109
SLC25A32	0.021082
TCEAL4	-0.021066
KPNA2	-0.021033
SLK	-0.020955
HPCAL1	-0.020923
RFK	0.020844
BUB1B	0.020793
C1QBP	0.020694
UBE2T	0.020682
UPF2	-0.020670
BCCIP	-0.020650
FBL	0.020615
RAB25	-0.020550
ZDHHC16	-0.020514
PPIF	0.020463
DDX39A	0.020443
SRP14	0.020391
SLIRP	0.020386
MTHFD1	0.020256
FAM122B	0.020219
AHSA1	0.020140
LYSMD2	0.020075
PAICS	0.020057
FUNDC2	0.019995
CXorf40A	0.019958
CCT2	0.019950
GDI2	0.019949
GLRX3	-0.019939
RPS7	-0.019934
UQCR10	-0.019909
ANP32A	0.019873
IFI6	0.019819
PLOD2	-0.019803
ESRP1	0.019751
IDH3G	0.019749
PGM1	-0.019690
SERPINA1	0.019631
NCAPG2	0.019631
FANCI	0.019578
MRPL33	-0.019570
SORD	0.019564
MRPL27	0.019506
ARL6IP1	-0.019432
PNRC2	0.019420
KLK11	0.019370
PSMD11	-0.019345
CXorf40B	0.019296
CENPW	0.019227
GCNT3	0.019179
EIF1AX	-0.019055
CKS1B	0.019031
AFG3L2	-0.018972
KIAA1191	-0.018922
AP2M1	-0.018918
TRIM28	-0.018865
CAV2	-0.018846
NDUFAB1	0.018836
RPS2	-0.018822
KIAA1598	-0.018804
CBWD1	-0.018803
KIF5B	0.018773
GMDS	0.018758
UCHL3	0.018742
ZNF706	0.018733
SPINT2	-0.018693
PITPNB	0.018651
TCEB1	0.018588
DYNLRB1	0.018565
S100A10	-0.018495
IARS	0.018437
SGK223	-0.018391
RPL9	0.018375
TMEM54	0.018374
ABLIM1	-0.018322
CD59	-0.018243
CETN2	0.018240
VDAC3	-0.018180
CYFIP1	0.018148
SEC61G	-0.018143
MXI1	-0.018139
TUBA4A	0.018131
ALDH3A2	-0.018114
SIGMAR1	0.018048
ANXA10	-0.018039
ZNF511	-0.018036
RAB11A	0.018025
EEF1A1	0.018012
ETFA	0.017993
ZWILCH	0.017989
EEF1D	0.017988
POLR2K	0.017951
EREG	0.017934
PTPRK	0.017913
CYP3A5	-0.017861
TUBA1C	0.017758
KARS	0.017748
NAE1	0.017740
H2AFZ	0.017736
LACTB2	0.017724
SLC1A1	0.017723
PSMA1	0.017720
TUBB2A	-0.017719
SYT13	-0.017692
NDUFB2	0.017627
PRSS2	0.017568
YES1	-0.017530
ALDH3A1	-0.017521
OAZ1	0.017507
PLEK2	-0.017503
CBFB	0.017499
EMC4	0.017479
MSH3	-0.017428
MRPL42	0.017384
IGFBP7	-0.017363
NPTN	0.017328
IFNGR1	0.017325
SNX3	0.017305
UGDH	-0.017219
PSME1	0.017191
LINC00493	-0.017173
TAF1D	0.017155
ATIC	0.017143
TMEM258	-0.017139
TUBA1B	0.017114
DSCC1	0.016947
RPS27L	0.016942
RUVBL2	0.016941
PCBP1	-0.016930
EZH2	0.016902
ATP6V0B	0.016899
EIF3A	-0.016885
TSPAN1	-0.016865
PPP1CB	-0.016862
ACADM	-0.016860
NEK7	-0.016849
CDKN2A	0.016834
REPIN1	0.016819
CYSTM1	0.016805
TSC22D1	-0.016802
PRPS1	0.016764
EIF2S3	-0.016754
BANF1	0.016733
CHORDC1	0.016612
ARPC1B	0.016611
RPL24	0.016609
COPB1	-0.016608
USP14	-0.016573
MRPL16	0.016507
RNF139	0.016489
MDH1	-0.016459
SFXN3	-0.016449
ODC1	-0.016421
C12orf75	0.016403
DCTPP1	0.016383
PSMG1	-0.016340
ARHGAP18	0.016325
ARMCX6	-0.016325
ATP5I	-0.016324
H3F3B	0.016256
GAPDH	-0.016232
RPS12	0.016230
ANXA2R	-0.016230
LBR	0.016188
CIRH1A	0.016176
VMA21	0.016168
PFDN2	0.016162
PTTG1IP	0.016135
NHP2	-0.016121
FAM91A1	0.016107
CHCHD3	0.016095
AMIGO2	-0.016088
RPL23	-0.016070
EIF1	-0.016068
TPD52L2	0.016057
TPT1	-0.016001
TSG101	0.015992
MTIF2	-0.015983
PLP2	0.015918
SH3KBP1	-0.015898
NEAT1	-0.015895
SRSF2	0.015887
RPLP0	-0.015884
QPCT	-0.015867
SOD1	0.015854
CFL1	0.015844
HEXB	0.015833
CCNI	-0.015829
ENC1	0.015816
CKS2	0.015802
MELK	0.015798
TM9SF3	-0.015783
CDCA7	0.015768
TOB1	-0.015758
EIF5	-0.015745
RTN4	-0.015745
HMGB3	0.015739
PIGP	0.015737
PFN2	-0.015704
MCM7	0.015692
MTHFD2	-0.015611
TRMT11	0.015586
YWHAQ	-0.015581
RBBP7	-0.015507
HSP90AA1	0.015490
SEC11A	0.015480
NMB	0.015465
SLC25A1	-0.015422
SERPINB1	0.015400
CEACAM6	0.015379
GGCT	0.015343
MUC13	0.015341
HERPUD1	-0.015257
RBMX	0.015246
ERMP1	0.015190
COX3	-0.015160
CCT6A	0.015131