!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	rat
!drug_name	Irinotecan
!smiles	CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7
!drugbank_id	DB00762
!pubchem_cid	60838
!cell_type	stomach
!organism	rat
!end_metadata
DDIT4	0.111449
CHAC1	0.104652
RHOB	0.087201
MYL1	0.087169
NR4A1	0.082967
ZFP36	0.082226
GADD45G	0.080366
DUSP1	0.080047
ADAMTS1	0.079614
GEM	0.079524
EGR1	0.077696
ERRFI1	0.072537
GADD45B	0.072357
PIM3	0.071997
UPK1B	-0.069541
PCK1	0.067340
NFKBIA	0.060025
CXCL2	0.059364
RGS2	0.057997
CEBPB	0.056273
JUN	0.053959
ATP8B1	-0.053123
GPM6A	-0.050812
PTF1A	-0.050738
SGK1	0.050041
JUNB	0.048960
CCL11	-0.047955
BTG2	0.047506
KRT15	0.047142
RASD1	0.046421
TSC22D3	0.046162
BHLHE40	0.045420
ARL4A	0.044065
TXNIP	0.044052
FAM43A	0.043589
USP2	0.042719
MCAM	0.041914
RASL11B	0.041749
DUSP6	0.041718
UBN2	-0.041635
TOB2	0.041472
SLC39A8	-0.041333
MB	0.041300
AREG	0.040210
DDX6	-0.040202
MYLPF	0.039974
ASPRV1	-0.039808
PRKACA	0.039774
IER3	0.038902
MKNK2	0.038866
PPP1R15A	0.038646
TMEM252	0.038628
FOXQ1	0.038274
SPRR3	-0.038272
BHLHA15	-0.037985
PER1	0.037935
FAM46C	-0.037687
ZBTB41	-0.037089
CYP19A1	-0.036748
MYC	0.036492
MESDC1	0.036380
SP2	0.035782
GADD45A	0.035540
LMOD1	0.035086
PLCXD3	-0.035065
FURIN	0.035003
KRT5	0.034918
SPINK5	-0.034848
PROC	-0.034753
MIA3	-0.034267
HNRNPL	0.034053
HERPUD1	0.033853
HDC	-0.033642
FOXP4	0.033550
COL4A2	0.033445
PRKAA2	-0.033436
SLC39A1	0.033025
ARC	0.032954
FOS	0.032767
MSLN	-0.032453
ZYX	0.032412
FMOD	0.032300
ABCG4	0.032205
IER2	0.032004
PDK4	0.031952
ACP1	-0.031842
SPARC	0.031832
REG3A	-0.031671
DMPK	0.031325
COTL1	0.031245
RPRML	0.031206
PTPN23	0.031144
HSPA2	0.030961
TMED5	-0.030946
VBP1	0.030866
IFRD1	0.030687
TMED6	-0.030627
CEBPD	0.030551
PFKL	0.030377
RNPEPL1	0.030371
C2CD4B	0.030366
ARHGAP5	-0.030222
DMBT1	0.030202
KCNJ8	0.030187
ATP6V0A1	0.030182
STON2	-0.030140
TNNC2	0.030116
ITGA1	-0.030076
HOXA5	0.030047
KRT78	-0.030027
ATF3	0.029974
KRT1	0.029914
SETD8	0.029867
NFIL3	0.029840
SMIM24	0.029627
KLF4	0.029485
PHLDA1	0.029468
SMTN	0.029395
ENTPD5	-0.029377
SLPI	-0.029296
KRT4	0.029281
FAM83H	0.029241
CDKN1A	0.029014
BNC1	-0.028962
MINK1	0.028904
TPR	-0.028831
WDFY1	-0.028826
HSD17B7	-0.028816
MIS12	-0.028724
KLF2	0.028559
CSRP1	0.028438
SLC38A2	0.028331
UCP2	0.028319
PYCR1	-0.028300
CKM	0.028295
H19	0.028120
NR4A2	0.027902
TRIB3	0.027899
LMCD1	0.027719
SLC4A2	0.027605
MAZ	0.027595
ACTN4	0.027557
FA2H	0.027523
GFM1	-0.027445
MRC1	-0.027346
KRTDAP	0.027333
MAPK14	0.027253
TMEM258	-0.027240
PRRC2A	0.027210
CTXN1	0.027201
GGH	-0.027091
SLC25A25	0.026989
CDC73	-0.026953
HSD17B3	-0.026931
NIPBL	-0.026807
STEAP4	-0.026660
CFB	-0.026561
JPH2	0.026529
MYO1E	0.026447
LDB2	0.026383
CCND2	-0.026372
ATP4A	0.026289
TNFAIP8	-0.026211
ADRM1	0.026200
TMEM140	0.026146
RNF152	-0.026146
EVI5	-0.026094
HGFAC	0.026050
ATF4	0.026032
GAST	0.026019
LPP	-0.025985
CSRNP1	0.025971
FLNA	0.025937
CCKAR	-0.025743
SEC31A	0.025729
CCRN4L	0.025695
ZDHHC20	-0.025637
IRS2	0.025621
FASTKD5	-0.025593
TACC1	0.025510
LPAR6	-0.025495
ENO3	0.025480
ARHGEF25	0.025428
LYZ	-0.025403
VNN1	-0.025382
RBM42	0.025364
EMG1	-0.025363
SERTAD1	0.025345
WASF2	-0.025311
ATF5	0.025254
KLF10	0.025201
SAP30L	0.025193
PPP1R1B	0.025031
RAPGEF2	-0.025000
PLEC	0.024998
LTBR	0.024939
COX16	-0.024924
GRINA	0.024835
BAK1	0.024776
SLC9A3	0.024715
RAB27A	-0.024626
ALDH6A1	-0.024618
VPS37A	-0.024592
POSTN	-0.024542
CD53	-0.024530
ACTA2	0.024488
PLIN5	0.024476
RSAD2	0.024450
ARID4A	-0.024424
INHBB	0.024343
ID3	-0.024309
PON3	-0.024276
HSF1	0.024215
FAM3B	-0.024180
AASS	-0.024150
TRIM16	0.024126
MYH8	0.024066
ALOX5AP	-0.024065
HIST1H2BG	-0.024043
CX3CL1	0.024037
NR0B2	0.024002
HSPB6	0.023976
TMEM109	0.023946
MAFF	0.023919
EGR2	0.023903
CHORDC1	-0.023842
KLF11	0.023836
SERPINI1	-0.023817
IMP3	-0.023790
FOXO4	0.023779
FGFBP1	-0.023745
SCFD1	-0.023722
CPNE3	-0.023697
KPRP	-0.023672
USO1	-0.023644
CFH	-0.023613
ATN1	0.023575
KLF15	0.023566
LPHN1	0.023519
FAR1	-0.023423
EPN1	0.023403
SLC18A2	-0.023346
PCYOX1	0.023314
LOX	-0.023292
UXT	-0.023225
IGFBP4	0.023203
STC1	0.023193
TET2	-0.023171
PRR15L	0.023142
CPED1	-0.023091
SF3B6	-0.023051
VARS2	0.023014
CHD1	-0.022973
RPRM	-0.022945
SLC38A5	-0.022838
COA4	-0.022833
CLDN5	0.022765
CRABP2	-0.022735
MUC13	0.022729
RND3	-0.022710
COL4A3BP	-0.022699
PA2G4	0.022680
KCNE4	0.022573
CALCOCO1	0.022569
BMPR1A	-0.022551
ECE1	0.022541
KIF5B	-0.022531
BARX1	0.022504
CASP3	-0.022473
MTRF1	-0.022472
TRIM28	0.022461
VPS41	-0.022438
DUOX2	-0.022438
ZNF703	0.022382
ST5	0.022343
ACTA1	0.022337
CCDC3	0.022317
KCTD15	0.022316
ZBTB7A	0.022297
KLK8	-0.022238
H2AFJ	-0.022237
GNPTAB	0.022230
GMFG	-0.022183
SERP1	-0.022173
GGA1	0.022167
OSTC	-0.022063
ANKRD37	-0.022056
ELOVL6	-0.022039
SHH	-0.022023
GRP	-0.022011
MAP2K2	0.021950
UBALD1	0.021910
SLC4A4	-0.021895
ADHFE1	-0.021846
TIMM17A	-0.021827
LSMEM2	0.021822
SUMO1	-0.021804
TSN	-0.021776
BCCIP	-0.021756
MSRB1	-0.021683
ABCC4	-0.021679
SF3B5	-0.021667
TRAF4	0.021658
FCHSD2	-0.021629
ADK	-0.021613
UBQLN4	0.021613
ACSF2	0.021575
ADAMTSL4	0.021574
PHIP	-0.021563
LY96	-0.021486
KLK3	-0.021466
RAB3A	0.021417
GPR56	0.021403
IWS1	-0.021401
WDR92	-0.021384
CCR1	-0.021344
WDR61	-0.021322
PHC2	0.021318
GNMT	-0.021312
PSMA2	-0.021308
ARG1	-0.021294
HBEGF	0.021275
SCNN1A	0.021242
MED21	-0.021204
NPAS2	0.021193
PRKAR2B	-0.021165
AKIRIN2	-0.021121
MRPL42	-0.021117
ARFRP1	-0.021044
DNAJB11	-0.021037
PPP6R3	-0.021031
ADM	0.021022
APOA1	-0.021022
COQ10B	0.021011
DTWD2	-0.020922
TMEM27	-0.020916
LRP10	0.020912
DMKN	-0.020908
CISH	0.020895
SMU1	-0.020843
HNRNPUL1	0.020789
PNLIPRP1	-0.020779
ATP6V1H	-0.020748
F13A1	-0.020746
CARM1	0.020724
ROMO1	-0.020698
BRI3	0.020689
IRF2BP2	0.020666
POLR2A	0.020631
PTGS2	0.020616
MRPS28	-0.020603
SYVN1	0.020596
HRSP12	-0.020563
PITX1	0.020541
PGGT1B	-0.020527
CNFN	-0.020505
KCNMB1	0.020499
PPP1R12A	-0.020457
EFCAB14	-0.020375
PPARG	-0.020375
VIM	0.020362
KRT12	-0.020351
SNRPD1	-0.020338
HDHD3	-0.020322
S1PR1	0.020321
UBE3B	0.020270
PENK	0.020261
CDK7	-0.020254
CCNK	0.020233
DENND5B	-0.020233
SERPINB12	-0.020209
DHCR24	0.020193
ARID4B	-0.020188
GLIPR1	-0.020183
SRP19	-0.020170
TMEM45B	-0.020137
DPM3	-0.020132
NOS3	0.020102
RYR3	0.020071
TRIM25	-0.020054
CETN2	-0.020037
EMCN	-0.019995
LRRC32	0.019993
SMIM7	-0.019984
CASKIN2	0.019951
MAGT1	-0.019940
XRN2	-0.019900
ZMIZ2	0.019887
HSPB1	0.019885
ERGIC2	-0.019872
HCFC1R1	0.019817
ARHGEF1	0.019783
FBXO34	0.019774
TAB2	-0.019752
STOML2	-0.019752
COL4A1	0.019749
ARL6IP5	-0.019726
PDGFRA	-0.019720
PAPOLA	-0.019716
SSR2	-0.019695
NUDCD2	-0.019677
PBDC1	-0.019676
MRVI1	0.019661
SEC24D	-0.019661
FGL2	0.019656
LSM10	-0.019631
ATP5L	-0.019610
MTHFD2	0.019604
ACTN1	0.019582
CYR61	0.019577
NET1	0.019572
TRAK1	0.019553
APBB1	0.019538
FOSB	0.019525
LRP6	-0.019504
GDAP2	-0.019484
ABCE1	-0.019452
CHERP	0.019449
PSMD14	-0.019441
SRP9	-0.019438
SPCS2	-0.019424
CKB	0.019354
RPA3	-0.019352
ABCB9	0.019337
RNF208	0.019309
SUN2	0.019300
EML4	-0.019295
DDIT3	0.019282
ATXN2L	0.019264
VASN	0.019223
SDF4	-0.019188
EVA1C	0.019163
CYP1B1	0.019163
SNAPC2	0.019130
ATRX	-0.019116
SERPING1	-0.019063
NEDD1	-0.019054
SSSCA1	-0.019026
ENPP3	-0.019023
TMEM161B	-0.019004
ELP2	-0.018997
CITED2	0.018962
WSB1	0.018961
GNAI2	0.018957
SEC22A	-0.018933
THRSP	-0.018868
GALNT6	0.018866
ZNF451	-0.018862
BDH2	-0.018847
GCLM	0.018831
BCAR1	0.018813
UGDH	-0.018800
ELOVL4	-0.018800
PBXIP1	0.018785
CORO1C	0.018776
DHPS	-0.018737
CADPS2	-0.018731
ANKRD23	0.018729
FLOT2	0.018695
PCP4	0.018694
C1GALT1	-0.018691
GIT1	0.018686
SCG5	-0.018667
ATPIF1	-0.018657
LZTS2	0.018648
LYRM4	-0.018643
PPAT	-0.018636
CA5B	-0.018634
ATXN7	-0.018604
RASA1	-0.018586
MED8	-0.018569
PTDSS1	-0.018557
CDK16	0.018538
TNXB	0.018509
H1F0	0.018494
STBD1	0.018477
NPEPL1	0.018468
RRP8	-0.018452
SOD3	0.018424
HEATR5A	-0.018412
GSTA3	-0.018369
UNC50	-0.018354
VAT1	0.018348
TOB1	0.018347
TAF10	0.018340
NNAT	0.018334
ETV3	0.018317
TGFB3	0.018314
C1QA	-0.018303
TCTEX1D2	-0.018293
AOC3	0.018291
SLC16A7	-0.018284
STRA13	0.018280
MFAP4	0.018254
ERCC6L2	-0.018246
STARD10	0.018240
KANK1	0.018231
ITGB7	-0.018227
PTHLH	-0.018215
EBP	-0.018212