!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	human
!drug_name	Morphine
!smiles	CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(C=C4)O
!drugbank_id	DB00295
!pubchem_cid	5288826
!cell_type	Striatum - SWR/J mice - Chronic morphine treatment
!organism	mouse
!end_metadata
PTGDS	0.206485
BSG	-0.083767
RPL27A	0.083352
SGK1	0.081565
PISD	0.081346
SPARCL1	0.078469
FABP7	-0.078104
ZBTB16	0.076608
EEF1A1	0.075908
FAM107A	0.075083
RPS28	0.074099
GNB2	-0.071743
RPS29	0.070717
APOD	0.069606
LY6H	-0.066266
PFDN6	-0.064414
RPS8	0.062489
RPS19	0.061638
RPS14	0.060221
SEPP1	0.059937
RPL3	0.059520
ADORA2A	-0.059093
CRYAB	-0.056062
CST3	-0.055156
TSC22D3	0.055037
RPL38	0.053412
UQCRC1	-0.053356
FAU	0.052823
SLC22A16	0.052703
PLP1	-0.052106
PSD	-0.051740
TF	-0.051704
ITPR1	0.051197
ACOT7	-0.051116
RPL10A	0.050770
C19orf60	-0.050743
LOC728392	-0.050664
ALDOC	0.050377
RPS21	0.050280
RPS11	0.050230
CAMK1G	0.049705
RPS27A	0.049508
RPL35	0.049363
PLD3	-0.048363
GJB6	0.048217
WFS1	0.048107
AATK	-0.047447
CTXN1	-0.047133
RPL4	0.047061
QDPR	-0.046809
RPS23	0.046591
ARL6IP5	-0.046369
RPL26	0.045874
RPL7	0.045415
HSPA5	-0.045333
RABGGTA	-0.045311
SYNDIG1L	-0.045285
DLGAP3	-0.045239
ROBO2	0.045122
OSBPL8	-0.044826
PFKL	-0.044509
CTGF	0.044477
FAM19A2	-0.044476
HSP90AB1	-0.044417
MAG	-0.044174
SKP1	-0.044125
TUBA3E	-0.044109
RPL13A	0.043886
CNP	-0.043419
DRD2	-0.043201
RPL37A	0.043124
NDRG2	0.043105
CHCHD10	-0.042937
ID4	-0.042636
C15orf59	0.042558
MID1IP1	-0.042307
RPL18A	0.042214
RPL11	0.042190
HRAS	-0.042115
HSPH1	-0.042085
LRRC4B	-0.041452
GSTM3	0.041195
HIST1H2BI	-0.041121
TMEM50B	-0.041087
SLC2A1	0.041058
HMGCS1	-0.040882
HIST1H2BO	-0.040611
CALR	-0.040556
HSPD1	-0.040413
HPCA	-0.040234
GPR155	-0.040164
PDP1	-0.040143
RPS5	0.040091
HENMT1	0.040084
HSPA8	-0.040001
LXN	-0.039734
TUBB2B	-0.039685
FBXL16	0.039647
NREP	-0.039493
SYNPR	-0.039301
CCT7	-0.039272
XBP1	-0.038842
RPS7	0.038834
RPS24	0.038330
FAM127A	-0.038102
COX4I1	0.038078
ATP1A1	-0.038073
TUSC2	-0.037587
HDAC5	-0.037431
SCAND1	-0.037368
GPM6A	0.036720
ATP2B1	-0.036717
RPS2	0.036582
KCNJ4	-0.036530
LGMN	-0.036464
DUSP14	-0.036433
S100A16	-0.035829
NDUFC1	-0.035546
DNAJA1	-0.035166
MLC1	-0.035152
GOT1	-0.034956
RPL14	0.034869
GRM3	-0.034860
TUBB3	-0.034714
MANF	-0.034655
PFN1	-0.034566
FEZ1	-0.034467
PRKCB	0.034325
TPPP	-0.034304
VCP	-0.033731
PSMB7	-0.033564
MTCH1	-0.033493
YWHAH	0.033486
ITGB1BP1	-0.033456
FASN	-0.033383
PENK	-0.033370
LOH12CR1	-0.033315
TAGLN3	-0.033292
RPS10	0.033283
TSPAN13	-0.033246
RPL24	0.033192
UGT8	-0.033179
CCDC14	0.033062
ANKRD13A	0.033005
PXDN	0.032970
PIN1	-0.032956
ARHGAP33	-0.032905
HNRNPUL1	0.032769
SLC50A1	0.032484
C10orf10	0.032444
SYT11	-0.032280
CALB2	-0.032270
ARHGEF26	0.032268
SGTA	-0.032171
GPX1	-0.032122
RPL6	0.032024
SST	-0.031961
XKR6	0.031900
NDUFS7	-0.031822
CX3CL1	-0.031738
PLIN4	0.031733
ANKRD63	-0.031670
RPL13	0.031469
SHANK3	-0.031433
RPS13	0.031343
CNIH2	-0.031239
COX5A	-0.031004
GPR17	-0.030858
BRK1	-0.030791
SMIM13	-0.030730
TUBB4A	-0.030619
MAPK8IP1	-0.030560
SEPW1	0.030387
NDUFA6	-0.030366
SHCBP1L	-0.030343
TMCO1	-0.030319
SUB1	0.030250
HES5	0.030114
UBC	0.030105
NPAS4	-0.030000
BCL11B	-0.029981
TTR	0.029917
VAT1L	-0.029895
OLIG1	-0.029875
OAZ1	0.029830
CLU	0.029805
NCKAP1	-0.029753
PRMT2	-0.029606
CDK5R2	-0.029570
FAM69B	-0.029558
TOMM40	-0.029489
MBD3	-0.029450
TPI1	-0.029380
ZNF692	0.029371
TUSC3	-0.029307
SEPT4	-0.029000
RHOU	0.028967
PSAP	-0.028781
RAB3GAP1	0.028678
DALRD3	-0.028478
FKBP5	0.028462
TMA7	0.028447
RPL9	0.028418
C14orf1	0.028335
STMN2	-0.028299
FTH1	0.028282
BAI2	-0.028204
CIRBP	0.028188
MIEN1	-0.028091
GAA	-0.028089
CALY	-0.028075
PDIA3	-0.028058
PHB	-0.028056
TUBA4A	-0.028051
CACYBP	-0.028005
RASGEF1B	-0.027977
MERTK	0.027919
ABHD8	-0.027861
STIP1	-0.027832
PAIP2	-0.027751
GLUL	0.027722
ARL2BP	-0.027523
JOSD2	-0.027403
HSP90B1	-0.027314
UQCR11	-0.027309
MAGED1	-0.027304
DYNLL2	-0.027210
PHACTR3	0.027104
MRPL4	-0.027007
GPS1	-0.026990
GLTP	-0.026705
UCHL1	-0.026705
HSP90AA1	-0.026676
DNAJC15	-0.026670
SHFM1	-0.026623
AP2S1	-0.026595
NT5C	-0.026452
SREBF2	-0.026328
RPL5	0.026260
FABP5	-0.026258
SCG2	-0.026219
SLC34A2	0.026154
HAP1	-0.026112
RGS2	-0.026048
LONRF1	-0.026029
RBM3	0.025974
RGS10	-0.025923
SOST	-0.025893
HMGN1	-0.025833
MLF2	-0.025753
PSMC3	-0.025729
NEFL	0.025719
DNAJB2	-0.025674
DNAJB11	-0.025580
SPAG4	0.025570
HLF	0.025526
ALDH6A1	0.025520
SP7	0.025477
RPN1	-0.025460
FAM169A	0.025440
ID3	0.025356
STARD10	-0.025343
COCH	-0.025315
RPL31	0.025313
ZMPSTE24	-0.025304
TMEM147	-0.025268
ATP5D	-0.025267
GSTM5	0.025250
MAN1A1	-0.025167
PBX3	-0.025166
PRKCH	-0.025130
ARID3A	0.025098
NRSN1	0.025034
PRKCZ	-0.025033
DAD1	-0.025011
TMEM151A	-0.024951
TECR	-0.024905
RGS4	-0.024890
ATP6V1F	-0.024730
COA3	-0.024724
EIF4A2	0.024679
SRM	-0.024661
HCFC1R1	-0.024595
CSPG5	-0.024593
SPNS1	-0.024574
TRIM9	-0.024573
CAP2	-0.024535
CA11	-0.024534
ABHD3	-0.024489
TPST1	-0.024458
CLDN5	-0.024438
RCAN2	0.024410
RPL10	0.024371
MAP1LC3A	-0.024300
RXRG	-0.024294
SEC61G	-0.024278
UNC5D	0.024272
YWHAZ	-0.024157
HRSP12	0.024146
C11orf96	-0.024144
ATP6V0B	-0.024138
B2M	-0.024115
RPL23	0.024052
VWA9	0.024037
PHYHIPL	-0.024013
STT3B	-0.023976
ELMOD1	-0.023966
CACNA2D3	-0.023948
PPP1CA	-0.023929
TMCC2	0.023919
RPS26	0.023908
GPR88	-0.023785
SRSF9	-0.023744
TYRO3	-0.023717
DDX3X	0.023702
AES	-0.023643
COX6A1	0.023619
SLIRP	-0.023607
RHBDL1	-0.023594
ARMCX2	-0.023572
MGLL	0.023514
AHSA1	-0.023484
MZB1	0.023476
ZNF428	-0.023456
KCNA1	0.023375
ANKRD34A	-0.023367
MAT2A	0.023346
CLDN12	-0.023333
UPK2	0.023328
ETNPPL	0.023309
SPCS2	-0.023295
EIF2S3	0.023291
DYNLL1	-0.023235
NPTX1	0.023224
LRP12	-0.023204
DPYSL2	0.023200
FH	-0.023150
OXCT1	-0.023139
C6orf57	-0.023105
RAPGEF4	0.023098
CNR1	-0.023049
TUBB2A	-0.023034
CBX6	-0.022995
RPS20	0.022969
SOX2	-0.022960
SPARC	0.022924
GSTP1	0.022861
FKBP2	-0.022857
RPS15	0.022833
SDHC	-0.022826
MYBPC1	0.022825
CRYM	0.022756
PRMT8	-0.022737
VGF	-0.022696
RELL2	0.022668
TIMM13	-0.022629
SULT4A1	-0.022594
PPP1R1B	-0.022589
RPS4Y1	0.022558
PODXL2	-0.022547
RABAC1	0.022506
NGEF	-0.022424
LPL	-0.022413
HNRNPM	-0.022322
NEXN	-0.022305
NOV	0.022262
ELOVL5	-0.022241
SLCO1C1	-0.022201
TM2D3	-0.022127
NAP1L4	-0.022122
CLPTM1L	-0.022091
RPL28	0.022078
LMO4	-0.022033
SWI5	-0.022033
TRANK1	0.022006
NAA38	-0.021983
CCT5	-0.021962
SFPQ	-0.021949
TNIK	0.021936
CHORDC1	-0.021927
SYT1	0.021901
VBP1	-0.021884
SLC7A10	-0.021855
FOPNL	0.021794
SH2D2A	0.021780
PCSK1N	-0.021775
USP54	0.021741
TMEM179	-0.021734
GPR6	-0.021727
PRELID1	-0.021708
SQLE	-0.021693
IDI1	-0.021680
CADM4	-0.021601
DCTN1	-0.021584
CAP1	-0.021550
AGPAT1	-0.021542
SDF2	-0.021537
MAP2	0.021509
RTN2	-0.021496
EIF3D	-0.021465
PDXP	-0.021442
SNCA	-0.021438
DLG4	-0.021411
PRDX1	-0.021404
FBXO25	-0.021404
RARB	-0.021376
WIPF3	0.021338
NACA	0.021327
CCAR2	-0.021324
SYNE1	0.021279
SEMA3F	-0.021279
CHRM1	-0.021278
DBP	0.021241
AMER2	0.021230
HEXA	-0.021218
PHYHD1	0.021211
BHLHE22	0.021148
PTN	-0.021084
RESP18	-0.021074
SYNGR3	-0.021068
RUNDC3B	-0.021024
TSPAN3	-0.020998
DDN	0.020997
KIAA1211L	0.020969
SQSTM1	-0.020949
PEA15	0.020923
AGT	0.020922
SEMA7A	-0.020912
EMC6	-0.020887
SNX3	-0.020848
STMN4	-0.020839
FNTA	-0.020831
NFYC	0.020827
ATP1B3	-0.020752
NUDT3	-0.020720
C16orf45	-0.020712
RPS18	0.020670
BAG1	-0.020663
CXXC5	-0.020652
LAMTOR5	-0.020648
ASTL	0.020644
CCT6A	-0.020634
FKBP3	-0.020632
EEF1E1	-0.020610
GAL3ST2	-0.020604
LDHA	-0.020601
NUP35	-0.020575
GDE1	-0.020543
TALDO1	-0.020512
EPS8L2	-0.020494
ARF5	-0.020467
IMMP1L	-0.020447
UQCRB	-0.020445
MATK	-0.020393
TCTE1	0.020379
HN1	-0.020305
RPL19	0.020301
VDAC2	-0.020289
HSPA4	-0.020285
ZNF804A	-0.020270
EDAR	0.020243
EMG1	-0.020226
RPL21	0.020194
SNIP1	-0.020193
EIF3F	0.020171
BAALC	-0.020166
NAP1L3	-0.020148
SUCLG1	-0.020099
SH3BGRL3	-0.020098
PSMB4	-0.020095
CEPT1	-0.020082
NAT14	-0.020079
RARS	0.020077
VTN	0.020018
ADAP1	-0.020008
ARPC4	-0.019992
HSBP1	-0.019963
PNPLA2	0.019930
FAM134A	-0.019919
KHDRBS3	-0.019906
WDFY2	-0.019901
PCBP4	-0.019868
MORF4L2	-0.019820
PIK3R2	-0.019796
GAP43	-0.019789
REXO2	-0.019767
PHLPP1	-0.019759
C1QTNF4	-0.019736
PFDN1	-0.019735
NDUFS6	-0.019699
NDRG1	-0.019690
CNST	-0.019679
PTGES3	-0.019672
MBP	-0.019669
RPS12	0.019668
POLR2E	-0.019666
KRT78	0.019659
SLC25A22	-0.019629
GRIA1	0.019622
PDZD2	0.019602