!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	mouse
!drug_name	Heroin
!smiles	CC(=O)OC1C=CC2C3CC4=C5C2(C1OC5=C(C=C4)OC(=O)C)CCN3C
!drugbank_id	DB01452
!pubchem_cid	5462328
!cell_type	striatum, day 13 withdrawal
!organism	mouse
!end_metadata
PMCH	-0.261079
SLC17A7	0.234398
TTR	0.138102
WFDC2	0.121968
SLC6A13	-0.118738
TBR1	0.116125
SLC13A4	-0.101164
SLC6A12	-0.099551
C8orf46	0.093523
C1QL2	-0.093408
NRN1	0.092378
NEUROD2	0.092160
MYL4	0.091782
LTF	0.085416
SLC30A3	0.084016
PTGDS	-0.083588
S100A5	-0.083216
STK32C	-0.082457
CORT	0.082316
CRHBP	0.078017
TNNT1	-0.076428
STMN1	0.070692
NPTX1	0.069063
GBX2	-0.068053
BHLHE22	0.067232
ZIC1	-0.066227
PRKCD	-0.064022
CIART	0.063704
CCK	0.060000
KRT14	0.059900
HLA-DQA1	-0.057712
ND5	-0.056992
GAL	-0.056674
S100B	-0.054385
ISL1	-0.053504
PRMT8	0.053356
IGF2	-0.053265
NR4A2	0.053216
IGSF1	-0.052928
FEZF2	0.052676
SERPING1	-0.052512
STAC2	0.051896
C2	-0.051644
ND4L	0.051543
LCN2	0.051027
HRH3	0.050686
RASL11B	0.050459
HBB	0.050244
AEBP1	-0.050074
NTN5	0.049889
TMEM178A	0.048329
CCL21	0.048273
MAS1	0.047739
STX1A	0.047434
ALAS2	0.047107
HSPA5	-0.046870
SLC17A6	-0.046784
THBD	-0.046665
RPS25	-0.046298
TMEM184C	0.045433
CALB2	-0.045288
ARC	0.044812
MAF	0.044622
TSR3	-0.044448
VAPA	0.044368
CRYAB	-0.044277
RGS16	-0.044099
AGT	-0.043206
RASL10A	0.042777
TOMM70A	0.042401
OLFM1	0.042111
FAM180A	-0.041817
PRR7	-0.040524
XDH	0.040266
H1F0	-0.040197
HLA-DRB5	-0.040130
CD74	-0.040111
CHPF	-0.039836
KLK6	-0.039503
BEGAIN	0.039433
PGRMC1	0.039041
JUNB	0.038777
SLC6A3	-0.038763
CYFIP2	0.038292
PRSS12	0.038249
PIK3R4	0.038132
NDUFB9	0.037741
SPINK8	0.037711
DOK3	-0.037208
PRKCG	0.036883
OGN	-0.036388
LGALS3BP	0.036362
PAM16	-0.036126
ATRNL1	0.036084
KLK8	-0.035985
SLC22A6	-0.035881
GSK3A	0.035565
TOP2B	-0.035540
CNIH3	0.035418
MPPED1	0.035327
ARNT2	0.035223
CLDN2	0.034728
KL	0.034469
EMP2	-0.034443
CLDN5	-0.034306
OXT	-0.034201
PHYHIP	0.034200
AVP	-0.034084
FIBCD1	-0.033690
GLUL	-0.033530
LIN7C	-0.033469
LY6E	0.033346
HMGCS2	-0.033269
GPR17	-0.033206
ST13	-0.033199
FAM107A	0.033179
DCTN1	0.033051
UNC5B	-0.032970
MLIP	0.032846
TTC9B	0.032716
DCN	-0.032699
KLHL13	-0.032422
ITIH3	-0.032390
ATP5A1	0.032317
FAM19A1	0.032264
PCSK9	0.032239
DRD2	0.032062
EGR2	-0.031892
PIANP	0.031810
VIP	0.031743
PTGIS	-0.031344
TATDN2	-0.031266
YWHAE	-0.031229
SLC3A2	-0.031104
ECEL1	-0.031009
COX7B	-0.030593
NR1D1	0.030578
VPS4B	-0.030433
S100A8	-0.030220
FOLR1	0.030182
TTYH2	-0.029862
STK32B	-0.029650
GATM	-0.029416
DNM1	0.029357
CSRNP1	0.029333
RESP18	-0.029319
NDN	-0.029236
SERPINI1	0.029111
RPRM	0.028946
SLC12A5	-0.028803
S100A6	-0.028699
NTNG1	-0.028402
TRIM37	0.028345
PER1	0.028258
SP8	-0.028229
CACYBP	-0.028225
VPS26B	0.028175
VAT1L	-0.028161
IDI1	-0.027898
THEM6	0.027831
SLC47A1	-0.027628
DUSP14	0.027527
DGAT2	0.027463
DRD1	0.027279
USMG5	-0.027256
ATP1B1	0.027131
ITIH2	-0.027101
CCT5	-0.027059
ARHGAP15	0.026803
CGA	-0.026687
FOXG1	0.026596
AGPAT3	-0.026494
DBP	0.026354
SPP1	-0.026322
PHYHIPL	-0.026143
SOWAHB	0.025875
RAPGEFL1	0.025773
NGB	-0.025663
KIAA1462	0.025616
DKKL1	0.025582
BTBD10	0.025491
NECAB3	0.025423
PTPN1	-0.025404
MAP2K1	0.025316
S100A10	-0.025286
ZBTB18	0.025277
FOXC2	-0.025115
SLC25A4	-0.025100
ATP6V1A	0.025062
EPN1	0.025041
EMP3	-0.024940
INMT	0.024928
CIRBP	0.024868
FAM131A	0.024825
REM2	0.024692
PET100	-0.024651
RANBP3L	-0.024640
GBP4	0.024640
HSPB3	0.024548
RET	-0.024506
GJB2	-0.024414
EXT1	0.024408
SEPT9	0.024374
FAM196B	-0.024291
BGN	-0.024268
TFRC	0.024211
TMEFF1	-0.024076
TCAP	0.024053
TNNC1	0.024040
HIST1H2BM	-0.024037
LINGO1	0.024018
SSTR2	0.024015
FAM81A	0.024010
NAP1L5	0.023948
SPARCL1	0.023689
OVOL2	0.023675
CHGB	0.023596
CTSS	-0.023579
VGF	0.023322
PFKFB3	-0.023259
SEPP1	-0.023184
CA4	0.023147
RASD2	-0.023142
KLHL40	0.023129
H3F3C	-0.023004
NCALD	0.022979
FSCN1	0.022971
SYN1	0.022968
LMTK3	0.022909
IPCEF1	0.022794
CCT7	-0.022686
SDF2L1	-0.022585
MAPRE3	0.022423
TUBA1A	0.022412
SGK1	0.022392
MYRIP	0.022341
HIST1H2BF	-0.022255
SMARCA5	-0.022239
LRP1	-0.022218
SYNDIG1L	0.022142
PLA2G7	-0.022115
ANO2	0.022040
HIST1H1C	-0.022039
VAPB	-0.022024
OMP	-0.022005
FHL2	0.021992
SUGT1	-0.021907
ITGA10	-0.021862
HEBP1	-0.021861
GPX3	-0.021851
DKK3	0.021763
TEX40	0.021747
HAPLN2	-0.021743
CALML4	0.021684
SLC27A3	-0.021593
COL6A1	0.021544
BHLHE40	0.021532
B9D2	-0.021528
TSHZ3	0.021521
KLC2	0.021447
MTPN	0.021440
HKDC1	0.021317
ANKRD46	0.021227
IDO1	-0.021219
PAM	-0.021160
IGSF21	0.021131
WDR6	0.021029
C15orf59	-0.021028
TTYH3	0.021026
CTGF	0.020978
PCBP3	0.020976
AQP1	0.020943
PGM2L1	0.020922
UBE2QL1	0.020908
ARPC2	0.020900
YWHAQ	-0.020846
KCNE2	0.020840
OTUD6B	-0.020803
EFNB1	-0.020760
CDC123	-0.020738
HIST4H4	-0.020677
ZFP1	-0.020648
RPE65	-0.020645
SLC16A8	0.020567
OPRK1	0.020543
TSPYL4	-0.020505
NONO	-0.020501
MPP2	0.020488
ACTB	-0.020472
C1orf110	-0.020470
PTPRB	0.020451
FMOD	-0.020444
NKX6-2	-0.020181
COX2	0.020144
GAL3ST1	-0.020089
FRMD7	-0.020087
GRIK5	0.020078
HIST2H4B	-0.020053
DOC2A	0.019984
KCNA5	0.019983
ARHGEF39	0.019981
KCNAB3	0.019905
SLC23A2	0.019881
PCNA	-0.019838
HIST1H2BN	-0.019792
NKX2-1	-0.019757
CEBPB	0.019754
C15orf61	0.019727
FAM103A1	-0.019714
HLA-DQB1	-0.019700
C2orf74	0.019697
PKD1	0.019665
RBP4	0.019645
SNAPC1	-0.019629
NOTCH3	0.019611
RSPRY1	-0.019526
TBC1D8	0.019490
ZBTB8OS	-0.019454
EPHB6	0.019448
CDHR1	-0.019438
ASGR1	-0.019424
GABRA3	-0.019419
DUSP7	0.019407
CYP46A1	0.019405
HSPB1	-0.019379
NEU2	-0.019373
PALM	0.019367
MARK4	0.019318
SLC26A4	0.019294
GRIN1	0.019284
SEPT5	0.019276
TEX2	-0.019188
HS3ST2	0.019121
SOX2	-0.019112
HDAC6	0.019086
AP2A1	0.019072
RGMA	0.019027
OLFM2	0.019024
WNT10A	0.018918
LRRC10B	0.018914
KIAA0195	0.018907
PAK1	0.018899
SNCG	-0.018848
ESYT3	-0.018829
ME1	0.018818
RTN4R	0.018781
SOX17	0.018772
CNTFR	0.018717
NOL7	-0.018694
TMCC2	0.018676
DDN	0.018675
GPR68	-0.018670
BRSK1	0.018635
RAPGEF3	-0.018631
EVL	0.018599
GCLC	0.018589
PDIA4	-0.018570
NRARP	0.018494
FIG4	-0.018493
HK1	0.018441
GAL3ST4	-0.018433
TMIE	-0.018395
IRF7	0.018366
CCNG2	0.018345
EIF4EBP1	-0.018312
MTSS1L	0.018304
RSPO2	0.018266
SCARF2	-0.018260
SCRT2	0.018258
WNT2	-0.018256
MCHR1	0.018251
CCL17	0.018239
HOXB8	-0.018235
PLAC8	0.018221
C17orf70	-0.018204
OTX1	0.018193
DLGAP1	0.018168
GHITM	0.018131
GPC3	-0.018128
GATA2	0.018117
RAB26	0.018098
C7orf55	-0.018063
PMPCB	-0.018062
ATP6V1C2	-0.017975
RASAL1	0.017933
AMIGO2	-0.017930
FRS3	-0.017923
PRKCB	0.017922
HIST1H2AM	-0.017887
C7orf60	0.017869
KIAA1239	0.017858
C17orf96	0.017812
PRSS35	0.017797
EVPL	-0.017772
HIST1H2BK	-0.017764
GPR83	0.017718
ITGB4	-0.017711
ADCYAP1	0.017699
AK4	0.017691
HIST1H4K	-0.017690
MMP14	-0.017673
CHMP5	0.017665
C8B	-0.017663
SCRG1	-0.017661
IP6K2	0.017641
TUBB4A	0.017628
MCCC1	-0.017623
ARL4D	-0.017617
RPH3A	0.017612
SLC35D3	-0.017586
PDLIM2	-0.017555
PMEPA1	0.017496
TPPP	0.017458
CCND2	0.017432
NPY2R	-0.017374
SPHK1	-0.017369
R3HDM4	0.017350
NGFR	-0.017340
FHDC1	-0.017332
BDH2	-0.017323
HSD11B1	-0.017299
SMPDL3B	0.017278
OSBPL11	-0.017256
CYP2S1	-0.017239
GJB6	-0.017224
ADRBK1	-0.017193
S100A9	0.017174
FAM127C	0.017170
PLS3	0.017115
FRMD4B	-0.017092
MEDAG	0.017091
PSPC1	-0.016952
ELFN2	0.016925
TSPAN3	-0.016916
SATB1	0.016901
PALD1	0.016886
SUSD4	0.016849
BFSP2	-0.016822
RXFP3	-0.016814
IL18BP	-0.016798
TXNDC12	-0.016791
HIST1H2BL	-0.016772
RGS14	-0.016735
DDAH2	-0.016726
SYTL4	-0.016697
CHCHD3	0.016686
HIST1H2BG	-0.016670
IFIT3	0.016668
PRKAR1B	0.016660
SPRY2	-0.016658
SEL1L3	0.016643
C10orf10	0.016590
BICC1	-0.016562
FRZB	0.016528
SCMH1	0.016515
CADPS2	0.016495
RFNG	0.016454
DGKK	-0.016449
NPTX2	0.016441
UACA	-0.016441
NBEA	0.016427
SPON1	-0.016415
FOXA1	-0.016345
BCAS2	-0.016322
ADCY8	-0.016320
IRS2	-0.016311
FGF5	0.016291
RNF166	-0.016284
DYNLL2	-0.016261
SLC7A8	0.016202
OTOP2	0.016116
CHST12	0.016116
TUBB2B	-0.016071
ATF5	-0.016064
MRPL18	-0.016021
NUPR1	-0.015979
PHOSPHO1	0.015977
R3HDM2	0.015971
C2orf40	0.015969
COQ3	0.015952
BAI1	0.015949
HIST1H3I	-0.015943
ANXA11	0.015897
CH25H	0.015891
P2RY1	-0.015870
DLGAP3	0.015861
CABP7	0.015837
STARD10	0.015837
NCKAP1	0.015817
RPL18A	-0.015798
RLTPR	0.015778
USP2	0.015748
DBNDD1	0.015728
SGSM2	0.015725
ISLR2	0.015709
PCDHB16	-0.015681
EDF1	-0.015675
USP3	0.015669
LAPTM4B	-0.015619
ADAMTS2	-0.015611