!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Mus musculus
!ligand_name	estrogen
!ligand_id	CHEBI:50114
!cell_type	aorta
!organism	mouse
!end_metadata
GREM2	0.174399
ANO4	0.160727
MMD2	0.097996
GALNT15	0.088762
WIF1	-0.084680
TRIM10	0.080430
ALB	0.079830
VWF	0.079232
RSAD2	0.076267
DLL1	0.075616
CYP2E1	-0.075318
HEPH	0.074985
CAMK2B	0.071640
TIPARP	0.069976
GHR	0.067945
ID1	-0.066912
GCLC	0.065901
CA2	0.064908
VLDLR	0.064237
SOX18	0.060940
LMO2	0.058601
LRG1	0.058483
SFRP4	0.057964
SLC4A1	0.057314
THBS1	0.057096
MYRIP	0.056504
GPX3	0.056077
ISG20	0.055673
GDA	0.054647
CILP	0.054641
SOST	-0.054596
MFAP4	-0.051976
INMT	0.051821
CPN2	-0.051132
FZD8	0.051098
SLC27A2	-0.050879
ADH1C	0.050767
UBE2O	0.050436
ISYNA1	0.049540
CCRN4L	-0.049302
EMB	-0.048703
CISH	-0.048632
HP	0.048305
SFRP2	-0.046239
SPTA1	0.045678
IGFBP6	0.045198
OMD	0.044912
G6PD	0.044368
GJA4	0.044280
HTRA4	0.044272
AR	0.043846
PKDCC	-0.043795
ID3	-0.043764
EREG	-0.043725
EPYC	-0.043690
SEMA3G	0.043553
KCNAB1	0.043466
ALAS2	0.043353
ADH7	0.043278
EVA1A	0.043151
UCHL1	-0.043106
GMPR	-0.042628
PLOD2	0.042311
S100A8	0.041695
ANGPTL7	-0.041598
LAT	-0.040711
FAM220A	0.040297
CFD	0.039952
UBE2C	0.039675
TTR	0.039560
UPK3B	-0.039510
STAT5A	0.039508
AKAP12	-0.039483
STC1	0.039171
CMBL	-0.039146
RAG1	-0.039063
PAQR6	-0.038971
RETN	-0.038915
PPP1R15A	0.038795
BPGM	0.038681
MKI67	-0.038627
TRABD2B	0.038622
NR1D1	0.038260
TMEM45B	0.038174
LYVE1	0.037857
C3	0.037811
BMX	0.037541
CRY1	-0.037497
OGN	0.037433
FAM46C	0.037254
PECAM1	0.037067
IGFBP3	-0.036949
CASQ1	-0.036938
PLA1A	0.036670
FOS	-0.036629
DGAT2	-0.036575
TRIOBP	0.036570
CCDC3	0.036384
MYL7	0.036348
FAM20A	-0.036084
MKRN1	0.036011
GRIA1	0.035623
CLEC10A	0.035537
SERPINH1	-0.035165
COL1A1	-0.034982
SDC4	-0.034902
METTL24	0.034870
DAPK2	0.034645
LGALS3BP	0.034551
PPARGC1A	-0.034480
SLC6A7	-0.034335
BCAN	0.034333
NNAT	0.034312
KANK4	-0.034072
RGS5	-0.034030
CA4	-0.033996
LRRN4	-0.033970
TNMD	0.033815
SCIN	0.033799
MMP3	0.033729
WISP1	-0.033559
FRZB	0.033441
SPP1	0.033371
MYB	-0.032951
MMRN2	0.032849
SEMA3D	0.032767
LBP	0.032645
C1QTNF3	-0.032461
COL14A1	-0.032399
LGALS3	0.032350
DZANK1	-0.032307
RGS4	-0.032209
MAFF	0.032082
GBE1	-0.031974
CYR61	-0.031959
FAM214A	0.031902
HYPK	-0.031839
LY96	0.031579
CDH2	-0.031550
FAM107A	0.031535
SERTAD4	-0.031492
P2RX5	-0.031453
SOCS2	0.031227
ERRFI1	0.031189
MFAP5	-0.031186
PFKFB1	-0.031184
CTSH	0.031050
FAT4	-0.030946
RASA3	0.030697
CNTN6	-0.030593
LAMC3	-0.030579
MYO1H	0.030558
TMEM132A	-0.030514
UBE2L6	0.030481
MATN2	-0.030308
GADD45A	0.030222
COL18A1	-0.030217
ATF3	-0.030128
NRIP1	0.030012
FECH	0.029917
MLXIPL	0.029755
AFF3	0.029754
P2RY10	-0.029741
KLK10	0.029531
APLNR	-0.029516
FIBIN	0.029515
PLBD1	-0.029303
FXYD3	-0.029277
DHX35	0.029271
DCAF12	0.029245
RRAD	-0.029243
LRCH1	0.029233
FXYD6	0.029107
CD274	-0.028940
SNCA	0.028917
SSR3	0.028895
SPNS2	0.028827
LGI2	0.028782
COX7A1	-0.028699
KCTD15	-0.028667
ALDH1A2	0.028659
IRS1	0.028598
PIK3R3	0.028581
TFDP2	0.028523
PFN1	-0.028509
PM20D2	-0.028492
CYP2B6	0.028466
ACSL5	0.028388
SLC36A2	-0.028364
SPARCL1	0.028311
IGF1	-0.028266
HLA-DRB5	-0.028261
CD34	0.028224
QPCT	-0.028222
NTN4	0.028209
HSD11B1	0.028177
VSTM2B	0.028133
C2orf40	-0.028100
FMOD	-0.028004
LTBP2	-0.027889
SLC25A37	0.027831
IRF7	0.027806
COLEC11	-0.027765
IL4R	0.027761
CCNDBP1	0.027690
ANPEP	0.027609
ATP2A3	0.027526
S1PR1	0.027471
CDK5RAP1	0.027471
NDNF	0.027380
SLC40A1	-0.027374
NDRG1	0.027262
ZDHHC23	-0.027196
RBP7	-0.027168
NEGR1	-0.027168
CALML4	0.027120
KLHL42	-0.027065
PDGFRL	-0.027051
FLRT2	0.027027
SLCO2A1	0.027018
BNIP3L	0.026990
APOD	0.026916
IRF4	0.026848
ASPN	0.026753
STARD13	0.026608
ICAM1	0.026536
CLDN5	0.026523
NXNL2	0.026372
SYT11	-0.026363
CYGB	0.026359
RAMP2	0.026240
CYP1B1	0.026046
SHE	0.026025
AQP1	-0.025995
BICC1	-0.025901
CEBPB	-0.025894
PAK3	0.025863
GXYLT2	-0.025819
TMEM120A	-0.025749
SPON1	0.025729
MEOX2	-0.025665
G0S2	-0.025606
C1GALT1	0.025564
KRT7	-0.025549
NOX4	0.025503
SORCS2	-0.025501
PANK3	0.025480
TSKS	-0.025472
NFIL3	-0.025445
TES	0.025438
ADAMTS9	-0.025427
FAM84A	-0.025426
PPP1R14C	-0.025362
APBA3	-0.025153
PPA1	-0.025149
APOBEC1	0.025126
FBXL4	0.025093
ID4	-0.025089
VSTM4	-0.025026
MMP2	-0.024998
CASP1	0.024969
HSPA8	-0.024905
CAP1	0.024854
MYC	0.024852
KCNS3	0.024774
HSD17B4	-0.024755
BHLHE40	0.024723
ASB5	-0.024677
CACNB2	0.024637
TAF1B	0.024606
ECI1	-0.024543
KCNJ15	-0.024480
FGF7	0.024412
HOPX	-0.024390
KAZALD1	-0.024351
EZH2	-0.024340
FGA	0.024290
RAD1	-0.024265
HSPH1	-0.024203
PLVAP	0.024178
CD3G	-0.024172
GBP6	-0.024169
CDR2	0.024118
FAM81A	0.024101
CA5B	0.024045
LIN52	0.024034
EPHB3	-0.024010
FMO3	-0.023960
NPR2	0.023947
ANKRD46	0.023934
CHST1	-0.023919
ID2	-0.023873
DHCR7	0.023823
RMND5B	0.023821
EEFSEC	0.023786
THUMPD1	-0.023708
APLN	-0.023672
PGM3	-0.023669
BCKDHB	-0.023652
IGFBP2	-0.023650
ICAM2	0.023645
SERPINE1	-0.023625
IL17RA	0.023593
B3GALT2	0.023580
PTGS1	0.023549
IGSF21	-0.023526
DNTT	-0.023522
FFAR4	-0.023506
HOXB6	0.023486
HSPA4	0.023441
GPR124	-0.023380
ZNF25	-0.023369
SMOC1	0.023369
NDUFA4	-0.023313
ACACA	0.023250
HNRNPH2	-0.023230
GOT1	-0.023195
ZMIZ1	0.023120
TXNIP	0.023094
ADAMTSL2	-0.023051
UCP2	0.023049
LSM5	-0.023017
HTRA3	0.022913
RRM2	-0.022880
NDE1	0.022843
MYBPC3	-0.022835
METTL7A	0.022794
ACTG2	0.022758
COL4A6	-0.022579
EMILIN2	0.022557
TEK	0.022548
MIB2	-0.022535
PIK3IP1	0.022534
TMEM88	0.022516
GDF10	-0.022510
CCL19	-0.022494
LEPREL1	0.022485
SEPT4	-0.022439
HLF	-0.022400
TUBB2B	-0.022398
HPSE	0.022356
UPB1	0.022331
CNTLN	0.022323
ALDH1A1	0.022294
YPEL5	0.022265
RRS1	0.022252
KIAA0355	0.022251
NAGA	-0.022229
TWIST2	-0.022181
SLC2A13	-0.022158
FBLN1	-0.022137
IVNS1ABP	-0.022070
AFF4	0.022066
POLG2	0.021994
IGFBP5	-0.021970
C1QTNF9B	-0.021930
MICAL2	0.021905
EHD4	0.021893
AGTR1	-0.021886
ADAMTSL4	-0.021883
FOXC1	0.021844
MTFP1	-0.021826
STMN1	-0.021780
IL33	0.021763
ACTC1	0.021714
COL3A1	-0.021689
TMEM35	-0.021646
ANGPTL1	0.021645
FKBP10	-0.021600
COL1A2	-0.021573
ITM2A	-0.021551
FAM195A	-0.021496
DYNC1LI1	-0.021480
CLEC14A	0.021440
MTUS2	-0.021381
ISCA1	0.021354
PNPO	0.021353
DHRS11	0.021328
RMDN3	-0.021313
VEZF1	0.021306
AMACR	-0.021304
CLDN22	-0.021286
TNFSF13B	0.021155
ADPRHL2	-0.021146
IFNGR1	-0.021072
ATP6V0E2	-0.021067
EFCAB7	0.021063
DENND3	0.021038
CLEC11A	-0.021025
CRISPLD2	0.021005
PAMR1	-0.020999
CRADD	0.020952
KCNK1	0.020949
KLF11	0.020908
TUSC5	-0.020863
SPHKAP	-0.020849
METTL20	0.020835
EHHADH	-0.020824
HEMK1	-0.020812
WWP2	-0.020802
TGFBI	-0.020768
HSPA2	-0.020764
KCNC4	-0.020762
TSPAN11	-0.020759
ABCC9	0.020723
PHEX	-0.020679
ITIH4	0.020570
ELK3	0.020557
DDT	-0.020536
FBXO31	0.020535
ATOH8	-0.020514
TMEM26	-0.020451
MIA	-0.020451
ADCY7	-0.020381
BASP1	-0.020367
FBF1	-0.020319
CERK	-0.020317
ACADS	-0.020305
CIRBP	0.020292
HOXC8	0.020279
UQCR11	-0.020209
GCLM	0.020209
FBLN7	0.020178
TMEM80	-0.020150
ISLR	-0.020101
FGD5	0.020050
BNC2	0.020023
C8orf4	-0.020009
BAMBI	-0.019999
C18orf21	0.019974
SERPINA3	0.019972
TTC23	0.019949
OAS1	0.019949
PCDHGC4	-0.019947
ZNF746	-0.019901
MAP2K1	0.019887
MACROD1	-0.019881
TCP11L2	0.019792
SEMA3B	0.019791
MOSPD2	0.019781
CTSK	0.019776
SERPING1	0.019748
COL15A1	-0.019745
GNG12	0.019707
DESI2	0.019688
AP3B1	0.019665
CIDEA	-0.019658
CES1	-0.019607
KIAA1211L	-0.019605
KLC3	-0.019601
WISP2	0.019568
TRAF7	0.019547
INTS3	-0.019544
ZNF551	0.019534
CCL11	0.019514
BCAP29	0.019512
MYO18A	0.019500
SIRT7	0.019490
WSCD2	-0.019488
C1S	0.019482
GPR137	-0.019462
NPAS4	-0.019457
SEPT9	-0.019441
KDR	-0.019387
RGS3	0.019348
ADCY3	-0.019259
GRAMD1A	-0.019248
PPP1R1A	-0.019231
PAQR9	0.019224
EML2	0.019220
LAMB1	-0.019198
INSIG1	-0.019192
CYP4V2	0.019170
FGFR2	-0.019145
CACNB3	-0.019137
ASB11	-0.019136
VWA5A	0.019124
ROBO4	-0.019117
DCUN1D3	-0.019002
FOXC2	0.018977
CNOT3	-0.018975
ATP1B2	0.018968
ARAP1	-0.018967
SKA2	-0.018951
SLC7A5	0.018946
FAM26E	0.018910
AIMP1	0.018895
KRT79	-0.018890
CARD10	0.018870
PABPC1	0.018869
OXTR	0.018868
ABLIM3	-0.018863
PET100	-0.018854
LRCH2	-0.018854
P4HA2	-0.018838
COL27A1	-0.018828
GM2A	-0.018805
CRYZ	0.018797
SCARB2	0.018795
GLI1	-0.018785