!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	human
!drug_name	Methotrexate
!smiles	CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
!drugbank_id	DB00563
!pubchem_cid	126941
!cell_type	PBMC (peripheral blood mononuclear cells)
!organism	human
!end_metadata
HIST1H2AM	-0.091168
UTS2	-0.063758
MYL9	0.059666
HIST1H2BG	-0.058264
S100B	0.054451
GZMK	-0.052172
CXCL10	-0.051515
SNORA28	0.051134
ST6GALNAC1	0.047443
IGJ	-0.047249
CXCR6	-0.047042
PRKXP1	0.046206
CES1	0.045037
PPP1R14A	0.044479
RC3H1	-0.044231
CCL4	-0.043250
MYOM2	0.042414
SNORA72	0.042199
DSP	-0.041969
HIST1H2AE	-0.041253
PF4V1	0.040901
A2M-AS1	-0.039189
ANKRD20A11P	-0.038346
RHOBTB1	0.038287
IL7	0.038107
IL1B	-0.037836
KCNN4	0.037619
CCR5	-0.037559
LOC285835	0.037149
SPON2	-0.036470
CCL8	-0.036279
MIR181A2HG	-0.035930
WASF3	0.035881
HIST1H4C	-0.035756
EGR1	-0.035263
COL18A1	0.035172
CCL2	-0.035064
MIR21	-0.035007
G0S2	0.034967
HCG27	-0.034745
CXCL8	0.034529
EOMES	-0.034064
FLJ12120	-0.034017
PRDM1	-0.033999
GPR171	-0.033878
CST7	-0.033741
HBQ1	0.033622
LAPTM4B	0.033441
LAIR2	-0.033301
IGLV1-36	-0.033134
KLRC3	-0.032900
C15orf54	-0.032831
MMRN1	0.032600
PSPH	-0.032519
FCGR3B	-0.032516
CLC	0.032508
LOC145474	-0.032362
PROK2	-0.032238
PYHIN1	-0.031961
CDKN1C	-0.031616
VMP1	-0.031498
MS4A3	0.031149
RTP4	-0.031140
TGFBR3	-0.031078
LOC285628	-0.031056
GPR34	0.030939
XIST	-0.030834
ABCC4	0.030763
LOC389834	0.030758
LTBP1	0.030619
TCL1A	-0.030495
XK	0.030428
GZMA	-0.030338
RNF175	0.030298
CLHC1	-0.030148
IGLL3P	-0.029901
SIRPB2	0.029843
HIST1H2BN	-0.029833
GTF2H2B	-0.029829
SERPINB2	0.029828
AMFR	-0.029643
GCOM1	-0.029431
FCRL5	0.029335
DDX11	0.029317
SLC35E2	-0.029281
GZMH	-0.029241
LINC00565	0.029194
LTB4R2	-0.029039
CD160	-0.029037
TEKT4P2	0.028923
OAS3	-0.028871
NEFL	0.028818
TAPT1-AS1	-0.028744
ALOX12	0.028711
GCSAML	0.028583
KRT72	0.028528
LAG3	-0.028447
PDIA5	0.028200
RPS4Y1	0.028140
HIST1H4F	-0.028056
NPIPB15	-0.028021
P2RY14	-0.027998
KCNJ2	-0.027908
CPA3	0.027861
ANXA3	-0.027723
LAMP5	0.027670
PDK4	-0.027634
KDM5D	0.027461
METTL21B	0.027440
TTC7B	0.027400
CHAC2	0.027320
ITGB3	0.027156
SUGCT	-0.027100
HLA-DPA1	-0.027025
IFIT3	-0.027015
CRISP3	0.026996
ABLIM3	0.026941
BIK	0.026922
PADI4	0.026920
LINC00936	-0.026782
PFKFB3	-0.026702
GPRASP2	-0.026626
ARL17A	-0.026626
RPS27A	0.026586
LOC642236	0.026530
GNLY	-0.026525
FAAH	0.026411
GBP2	-0.026205
S1PR3	0.026190
LOC283914	0.026180
NAIP	-0.026086
LINC00865	-0.026074
MEST	0.025982
NUCB1	0.025883
EPB42	0.025829
PLA2G4A	0.025786
LGALSL	0.025704
BZRAP1	-0.025628
FAM110D	-0.025502
CCR9	0.025496
PAX8-AS1	0.025349
ROBO1	0.025293
GBP1	-0.025280
NUF2	0.025272
CLEC12B	0.025219
FFAR2	-0.025154
CCDC68	-0.025125
AHSP	0.025122
PASK	0.025012
ADRA2A	0.024907
MXI1	0.024846
BEGAIN	-0.024808
TRIM58	0.024795
CX3CR1	-0.024785
PRO1082	-0.024745
LRRC37A2	-0.024726
C8orf44	-0.024707
SOD3	-0.024693
PDZK1IP1	0.024686
PTX3	0.024581
SIGLEC5	0.024495
MGC24103	-0.024467
TMEM151A	-0.024446
NAMPT	-0.024441
GBP5	-0.024405
LOC728613	-0.024369
CMPK2	-0.024351
MAP7	0.024334
ZCCHC18	-0.024324
LRRC37A4P	0.024308
TGM5	0.024291
CYP11B2	-0.024241
HPSE	0.024240
CMC1	-0.024171
LOC151174	-0.024147
FBXO6	-0.024058
CEACAM8	0.024055
LYZ	0.024004
CDKAL1	-0.023952
LOC730961	0.023902
LINC00852	0.023854
H1F0	0.023844
LOC153682	-0.023831
FASLG	-0.023740
TARP	-0.023738
TNNT1	0.023731
IGLV2-23	-0.023698
HP	0.023665
ANKRD22	-0.023603
SNCA	0.023593
IL18R1	-0.023506
GTF2H2	-0.023455
MYOF	-0.023432
SERPING1	-0.023411
CXCL9	-0.023358
SCUBE1	-0.023346
TMEM45A	0.023317
ST20	0.023145
SH3BGRL2	0.023098
MAP4K3	-0.023092
LOC285181	0.023069
EMR3	-0.023010
CAPG	0.023007
USP53	-0.022977
AQP9	-0.022969
GP5	0.022943
NPCDR1	0.022943
KLRF1	-0.022932
NUP43	-0.022916
NET1	0.022911
KLRD1	-0.022868
TCN1	0.022768
PSRC1	0.022757
TEC	0.022724
SESN3	0.022723
C14orf79	-0.022699
JUNB	0.022696
FZD6	0.022524
CLEC1B	-0.022437
GNG2	-0.022408
BAP1	0.022379
RPS24	-0.022325
TCF7L2	-0.022321
IGKV1D-8	-0.022287
ZDBF2	0.022214
CYB5D1	0.022211
BRE-AS1	0.022130
TCEA3	0.022120
IFIT2	-0.022116
ITM2A	-0.022094
TNFRSF17	-0.022082
EGF	0.022070
TRGV5	-0.022055
CCDC58	0.022048
LOC100507281	-0.022017
FAM124B	0.021978
IKZF3	-0.021913
CCZ1B	-0.021876
KIAA0101	-0.021848
LOC100288152	0.021830
IDO1	-0.021811
DEPDC7	0.021782
FAM129A	-0.021757
FNBP1	-0.021708
LINC00877	-0.021695
LOC200772	-0.021665
C10orf95	-0.021614
DSC1	0.021555
OVOS2	0.021528
PRF1	-0.021490
CSGALNACT1	0.021483
IL18RAP	-0.021480
HCAR3	-0.021445
CD48	-0.021431
RSAD2	-0.021428
SLFN12	-0.021393
CTF1	-0.021343
MCAT	0.021338
TMEM176B	-0.021306
ARSA	-0.021285
CEP83-AS1	-0.021284
CLIC3	-0.021243
VPS37D	-0.021223
LOC100506476	0.021222
EPHA4	0.021193
LOC643733	-0.021164
RIC3	0.021152
AURKC	0.021147
DYNLT1	-0.021137
THUMPD3-AS1	-0.021133
F2RL1	0.021126
TSPAN4	0.021122
FAM179A	-0.021122
KIF5C	-0.021117
ISG15	-0.021115
SESN1	-0.021068
FLJ21369	-0.021064
ZNF785	-0.021055
CMTM8	-0.021036
HPGD	-0.021023
RGPD1	-0.021020
GPR160	0.020947
TBC1D10B	0.020919
DDX3Y	0.020863
DHRS9	0.020849
GBP3	-0.020787
SERPINB9P1	-0.020773
PLD6	0.020763
CHI3L2	-0.020761
HIST1H3G	-0.020756
HRASLS	0.020730
PRB1	0.020723
JUN	0.020644
PLEC	0.020615
NID1	0.020597
CDC6	0.020574
FOS	0.020571
ODF3B	-0.020548
LRRC75A	-0.020519
ZNF267	-0.020504
CCL5	-0.020484
FAM184B	-0.020470
LOC284454	-0.020469
SPATC1L	0.020421
LINC01355	-0.020328
CHP1	-0.020309
EXTL1	-0.020307
CLIC2	-0.020278
CA2	-0.020266
GSTM2	0.020224
MS4A2	0.020224
HDDC2	-0.020214
HERC5	-0.020213
ORMDL3	0.020197
SNHG17	0.020194
IFI44L	-0.020183
TTC8	0.020181
TRBV25-1	-0.020175
LOC100287497	0.020137
CYP4F22	-0.020104
KLF10	0.020009
PRSS21	0.020005
DACT1	0.019986
SERPINB9	-0.019960
LOC100270804	-0.019958
SUZ12P1	-0.019957
RPPH1	0.019939
HDGFL1	0.019930
NSG1	0.019924
ERAP2	0.019911
HAND2	-0.019900
LOC101927027	-0.019875
IFI6	-0.019864
ZNF480	0.019860
LHB	-0.019860
LOC729732	-0.019856
DFNA5	-0.019802
ZNF702P	-0.019781
CD101	0.019770
MLH3	-0.019758
SNAPC2	-0.019714
LAP3	-0.019701
ASRGL1	0.019700
FBLN2	-0.019694
IFI35	-0.019691
CTTN	0.019601
EIF4G1	0.019583
SCRG1	0.019565
TCAP	-0.019558
PRG4	0.019557
RETN	0.019543
ARHGAP15	-0.019536
USP30-AS1	-0.019536
TCF15	-0.019533
FCRLA	-0.019523
EIF2AK1	0.019503
UAP1L1	0.019502
SLC7A10	-0.019497
NKAPP1	-0.019488
KLRG1	-0.019478
RAMP2-AS1	-0.019453
FAM129C	-0.019445
LY6G5C	0.019438
MYOG	-0.019422
GRAP	0.019414
CCDC71	-0.019376
SYF2	0.019371
DCLRE1B	0.019357
NCAPG	0.019324
MT2A	-0.019297
HEATR3	-0.019264
TRBV27	0.019238
MS4A7	-0.019230
OASL	-0.019215
MCU	0.019186
PMM2	0.019175
LOC157860	-0.019113
FPR1	-0.019111
GSTM1	0.019099
C9orf41	0.019073
BPGM	0.019067
TAF15	-0.019017
LRRN3	-0.018991
GUSBP3	-0.018969
IER3	0.018963
LOC100996579	0.018950
TAP1	-0.018945
USP46	0.018941
ADAT1	-0.018935
ABCA5	-0.018930
KLRK1	-0.018927
GPHN	0.018906
MTMR3	0.018895
PCDH9	-0.018870
IFNG	-0.018869
GRASP	-0.018864
PTGER4	-0.018861
RUNX3	-0.018856
UBASH3A	0.018855
RPGRIP1	0.018853
SMG1P5	-0.018816
TKTL1	-0.018813
IGLJ3	-0.018797
TGFB1I1	0.018783
GIMAP8	0.018769
CD8A	-0.018766
ASAP1-IT1	-0.018745
MS4A4A	-0.018735
BCL10	0.018678
C11orf86	-0.018669
RNASE4	0.018666
LINC00685	-0.018655
BCL2A1	-0.018614
AGO3	-0.018600
HYMAI	-0.018589
VRK2	-0.018527
SH2D1B	-0.018509
ACVR2A	0.018502
KLHL28	-0.018481
TRPM5	-0.018460
DSC2	0.018458
DDX6	-0.018454
LOC100131043	-0.018446
BARX1	-0.018435
CD38	-0.018431
GFOD1	-0.018429
MGC70870	0.018420
CNN1	0.018419
JAM3	0.018406
TRIP13	0.018404
ITPK1-AS1	-0.018404
CTNNAL1	0.018377
PRLH	-0.018373
HIST1H3H	-0.018367
MGLL	0.018362
PPAPDC2	-0.018334
SLC22A18	0.018324
HIST1H4H	-0.018302
LOC100127972	-0.018294
HIST1H2BI	-0.018287
FNBP1L	0.018268
XAF1	-0.018244
JADE3	0.018201
SAMD13	0.018184
CKAP4	0.018182
VIM	0.018168
DUOXA2	-0.018154
LOC728445	0.018153
CD96	-0.018152
RAD54B	0.018070
PYGM	-0.018069
ZNF711	0.018068
CEP192	-0.018052
ADM	-0.018052
LINC00853	0.018049
FAM118A	0.018045
IMPA2	0.018034
NKG7	-0.018016
LINC00920	0.018015
NEIL1	-0.018007
PRPF6	0.018006
LOC100134822	-0.017996
TNFAIP3	-0.017985
ICAM4	-0.017972
HTATSF1P2	0.017959
CD93	0.017946
FRMD7	-0.017945
PROS1	0.017943
NHLH1	-0.017921
PCDHA10	-0.017914
LAMB2P1	0.017896
SPOCK1	0.017892
ITGA2B	0.017885
TYMP	-0.017881
DKFZp779M0652	-0.017875
IL17RE	-0.017824
KLRB1	-0.017812
CCDC91	-0.017808
RGS1	-0.017795
LOC101927274	0.017780
PLOD2	0.017779
LINC00563	0.017774
WDR6	0.017772
LOC100134445	-0.017766
PVALB	-0.017760
SPESP1	0.017741
ABHD12	0.017740
VMO1	-0.017734
MATK	-0.017732
FIP1L1	0.017716
ARL16	-0.017709
NEAT1	-0.017701
IQCC	-0.017688
CFD	0.017678
IL18	0.017677
PARVB	0.017669
DAPK1	0.017661
LINC01208	0.017630
PHGR1	-0.017618
CECR5-AS1	-0.017617