!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	human
!drug_name	Methotrexate
!smiles	CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
!drugbank_id	DB00563
!pubchem_cid	126941
!cell_type	PBMC
!organism	human
!end_metadata
MALAT1	0.109207
ANKRD36B	0.091136
HIST1H4C	0.087325
PLEKHA2	0.066124
ANKRD36	0.064428
AGAP4	0.064232
SMC3	0.063176
SMCHD1	0.061740
SLX4IP	0.060803
IQGAP1	0.058208
CCL8	0.055537
ABLIM1	0.053271
OSBPL8	0.050848
LOC100129917	0.050505
KIAA1551	0.050003
NFAT5	0.049395
HELB	0.048976
ATRX	0.048914
SYNC	0.048141
KLF13	0.047093
ANXA1	-0.046007
OTUD4	0.045899
EIF4G1	0.045419
LTN1	0.045354
CXCL10	0.044981
LOC285178	0.043747
CXCL5	0.042791
SLC16A7	0.039953
SLC16A10	0.039639
SOCS3	-0.039411
PTPRC	0.039302
A2M-AS1	0.038487
DLGAP5	-0.038006
BRE-AS1	-0.037998
IL24	-0.037574
CHD9	0.037438
SERPING1	0.037392
MTPN	-0.036967
CDC20	-0.036823
TTC3	0.036614
RRM2	-0.036543
SYNJ2BP	0.036521
DUSP4	-0.036180
BOD1L1	0.036173
THRAP3	0.036116
CNTRL	0.036062
SDPR	0.036042
LOC727820	-0.035871
PTENP1	-0.035728
ZNF567	0.035700
PBK	-0.035563
CEP55	-0.035468
CDC42-IT1	0.035379
CCL20	-0.035295
CDKN3	-0.035055
CXorf38	0.034983
THBD	-0.034893
KANSL1-AS1	-0.034885
RNF19A	0.034617
KCNJ2	0.034597
KIAA1033	0.034519
CXCL3	-0.034289
LOC145474	-0.034034
ZBED6	0.033896
GJB6	-0.033608
B2M	0.033313
CXorf21	0.033231
CDK1	-0.033202
IGKV1D-8	-0.033184
HIST1H3H	0.033014
PRKAR2B	0.032990
CHD4	0.032865
EIF3C	-0.032649
MELK	-0.032315
C19orf43	0.032050
IKZF3	0.032046
ATXN7L3B	0.032024
CAV1	-0.031845
OIP5	-0.031814
PLCG1-AS1	-0.031797
ARHGAP18	0.031776
LOC101927027	0.031750
SLC25A36	0.031568
TMEM200B	-0.031309
TRBV27	0.031282
IFIT2	0.031257
HPS5	0.031197
GPAM	0.031068
RSPH10B2	-0.030993
NRGN	0.030887
EMC7	-0.030828
RPAP2	0.030767
TSPAN18	0.030726
LY6E	0.030676
NEXN	0.030266
THOC7	-0.030258
GUK1	-0.030231
DDX24	0.030143
IFI16	0.030023
CCDC186	0.030013
TUBB1	0.029845
RSAD2	0.029835
CCNA2	-0.029755
ADTRP	-0.029722
ZBED1	0.029630
SPAG9	0.029534
HP	-0.029505
EGR2	0.029475
USP3-AS1	-0.029310
BEND2	0.029159
FLJ10038	0.029044
HMMR	-0.029017
ALDH1A1	0.028947
NDC80	-0.028844
IFIT3	0.028738
CXCL8	-0.028731
PLBD1	-0.028722
NUF2	-0.028674
PWAR5	0.028637
PCNP	0.028601
SSSCA1-AS1	0.028565
C15orf48	-0.028565
ZNF785	0.028493
SF3B4	0.028440
ZNF641	0.028420
GPATCH8	0.028368
LINC00528	0.028349
GPR84	-0.028315
ZNF566	0.028309
CCNB1	-0.028177
DACT1	-0.028079
XAF1	0.027966
RNF182	-0.027887
SARS	0.027763
SLFN5	0.027567
C2orf88	0.027550
KIF11	-0.027491
GTF2H3	0.027484
CEP350	0.027448
IDI2-AS1	-0.027438
SNORA21	0.027381
APCDD1	-0.027313
DAPP1	0.027190
P2RY12	0.027177
SOCS2	-0.027171
CHN1	-0.027165
MYL9	0.027115
PDZK1IP1	0.027017
CCL4	-0.026982
TEP1	0.026963
CD40LG	0.026944
GNG11	0.026860
RFWD3	0.026817
ICOS	-0.026816
LOC100134822	0.026758
THAP6	0.026732
AP3D1	0.026713
ZNF136	0.026658
CCR10	-0.026657
LOC100996286	0.026613
CAPN2	0.026608
C6orf25	0.026538
RASEF	0.026491
EEA1	0.026464
GZMK	-0.026404
NFATC2IP	0.026387
IFI44L	0.026287
EEF1E1	-0.026252
NR4A2	-0.026208
XK	0.026181
EHBP1	0.026167
NGLY1	0.026166
GGH	-0.026087
C15orf54	0.026087
CENPU	-0.025977
OLR1	-0.025941
EREG	-0.025778
MIS18BP1	0.025754
IFI27	0.025501
RPL13P5	0.025458
IFI44	0.025399
HOOK1	0.025329
ZNF655	0.025319
MMP8	-0.025277
ANKRD13D	0.025228
KCTD12	0.025213
IRF7	0.025185
ST6GALNAC1	-0.025043
IGJ	-0.024987
KIF28P	-0.024949
TXN	-0.024948
LNX1	0.024946
TNFRSF17	-0.024891
ZNF37A	0.024881
IGSF6	0.024851
MND1	-0.024848
SNORD8	0.024678
ASAP2	0.024585
ELOVL7	0.024560
ST8SIA1	-0.024527
PF4	0.024498
OXTR	0.024495
ARID4B	0.024465
P2RY13	0.024465
PMCH	-0.024452
BBS4	0.024406
FTX	0.024398
CLK4	0.024258
P2RX7	0.024224
LOC100129447	0.024203
LPGAT1	0.024139
MZB1	-0.024108
MGEA5	0.024061
SAMSN1	0.024043
CDO1	-0.024010
LYRM5	-0.023965
SON	0.023903
FAM46C	-0.023888
PPP1R10	0.023752
SECISBP2L	0.023752
FLJ13773	0.023684
NFKBIZ	-0.023683
ANKRD12	0.023653
ZNF331	-0.023647
FABP5	-0.023637
RGS18	0.023547
TYMS	-0.023544
ZNF83	0.023522
NKTR	0.023515
ARL2BP	-0.023494
CMPK2	0.023458
RNF19B	0.023428
MX1	0.023369
BCL7A	0.023351
WBP2	-0.023338
TPX2	-0.023322
NR1D2	0.023320
TTC37	0.023316
APOBEC3B	-0.023270
SART3	0.023269
HSP90B1	-0.023260
TAF15	0.023256
REL	-0.023239
MAP3K7CL	0.023235
MAD2L1	-0.023224
MIF-AS1	-0.023177
ADM	-0.023139
BRK1	-0.023096
CCL2	0.023050
CTDSPL2	0.023018
CRISP3	-0.022992
TNRC6B	0.022969
SEC14L5	0.022904
ESF1	0.022903
RPLP2	-0.022865
LIMS1	0.022840
NCAPG	-0.022830
RGS1	-0.022825
ACPP	-0.022822
IGLV1-36	-0.022809
PF4V1	0.022748
BDP1	0.022746
INO80D	0.022700
MS4A7	0.022667
ENO1-AS1	-0.022644
SOS1-IT1	0.022634
MRPL47	-0.022543
FAM161B	0.022527
HECTD1	0.022504
EZH1	0.022495
NUDT9P1	-0.022482
ZNF674-AS1	-0.022478
PRC1	-0.022461
ALG5	-0.022461
SEC11C	-0.022402
BBS12	-0.022386
LIMA1	0.022348
IGLV1-44	-0.022300
SLC16A6	-0.022282
LOC202181	0.022269
KISS1R	-0.022222
LOC100506083	-0.022128
RAD23A	0.022109
PAPD5	0.022078
VGLL4	0.022042
CD3G	0.021995
TNNT1	-0.021990
CREM	-0.021981
MOGAT1	0.021981
SIGLEC1	0.021959
TOP1	0.021901
PPIL1	-0.021780
NFKBID	0.021709
PLEKHH1	-0.021696
PP12708	0.021680
ELANE	-0.021654
CXCL9	0.021627
PARL	-0.021600
DDX11L2	0.021551
ZBTB7A	0.021538
MS4A4A	-0.021536
RGPD1	-0.021530
LY6G6F	0.021526
HSH2D	0.021510
CABP5	0.021486
PTTG1	-0.021460
ZNF165	-0.021443
GPS2	0.021431
PRRC2C	0.021332
G0S2	-0.021329
LINC00996	-0.021241
ZNF254	0.021235
ZFP91	0.021226
PKHD1L1	-0.021092
IGKV1OR2-108	-0.021087
SMA4	0.021082
GBP1	0.020954
C19orf33	0.020951
C12orf45	-0.020892
CENPK	0.020890
IFIT1	0.020808
LOC148413	-0.020755
LOC100507281	0.020753
TRIM11	0.020753
SF1	0.020649
KDM5D	0.020600
SLC7A5	-0.020569
IGKV4-1	-0.020547
LTBP1	0.020530
CCNT1	0.020485
IER3IP1	-0.020432
F3	-0.020397
CCRL2	-0.020392
ANKRD19P	-0.020361
RIF1	0.020344
CHAC2	-0.020321
LAP3	0.020303
MRPS15	-0.020276
GFI1B	0.020199
CYCS	0.020193
FLVCR1-AS1	0.020186
SSBP3-AS1	0.020181
TTK	-0.020151
KIF20A	-0.020147
DDX50	-0.020095
KIAA1731	0.020092
LOC101929162	-0.020060
MEIS1	0.020055
ELAC1	-0.020009
TMEM200A	-0.019991
TRIM38	0.019932
MMD	0.019918
DNAJB14	0.019917
PDGFRL	0.019890
GNPNAT1	-0.019886
THBS1	-0.019877
ERMN	-0.019848
FFAR2	0.019811
RANBP1	-0.019799
FAM169A	0.019775
TSIX	-0.019760
PIM2	-0.019738
IGLV1-40	-0.019705
USP16	0.019678
GPR34	-0.019676
NEFL	-0.019671
NFIL3	-0.019657
NBPF10	0.019628
BAG2	-0.019615
DTL	-0.019609
SUZ12P1	0.019603
GLG1	0.019555
STK24	0.019551
OR7E14P	-0.019510
BMP8B	-0.019504
RP9	-0.019489
MAT2B	-0.019455
IFI6	0.019440
CD79A	0.019360
RBPMS2	0.019298
JAK1	0.019289
KIAA0101	-0.019229
AREG	-0.019228
TLR7	0.019216
S100A12	-0.019210
APOBEC3A	0.019198
LGALS9	0.019185
BPI	-0.019152
DSC1	-0.019132
ATP6V0E1	-0.019103
TGS1	0.019089
EHMT1	0.019024
PRKD3	0.019017
C17orf75	-0.019001
HIST2H2BE	0.018994
ANKRD22	0.018957
LYRM4	-0.018945
RPS4Y1	0.018920
IL1B	-0.018913
BATF2	0.018900
TPSB2	0.018893
GLDC	-0.018891
PDE4B	-0.018887
OCIAD2	-0.018880
IGLV2-23	-0.018864
HYPK	-0.018863
OAZ3	-0.018862
EGR1	0.018858
ING2	-0.018858
KIAA1147	0.018844
EIF3F	-0.018828
EEF1D	-0.018827
SRGAP2C	0.018809
BTBD18	-0.018779
ADSS	-0.018762
PLK2	-0.018735
TYMP	0.018717
CXorf56	0.018717
DDIT4	-0.018694
CCDC88A	0.018662
MORF4L2	0.018657
ID3	0.018651
RAI2	-0.018643
TRMT2B	0.018638
KLHL24	0.018621
JUND	0.018617
ITGA3	-0.018608
RAB32	-0.018577
FANK1	-0.018569
IGKC	-0.018569
OSTC	-0.018550
PAN3-AS1	-0.018543
DEPDC1B	-0.018502
CTSW	0.018500
LOC100129104	-0.018448
CYB5D1	-0.018411
DNAJC7	-0.018408
NME9	-0.018398
NAMPT	-0.018364
TMEM158	0.018350
AQP9	-0.018338
CISD1	-0.018262
LAIR2	-0.018259
WARS	0.018240
TSPAN4	0.018239
UHRF1	-0.018238
C16orf54	0.018225
GUSBP5	-0.018221
MTR	0.018219
MME	-0.018206
UBE2H	0.018182
FAM226B	0.018177
ATP8B1	0.018163
ZEB1	0.018159
LOC100130278	0.018156
RBM5	0.018156
NPHP3	0.018149
MCEMP1	-0.018143
RBM27	0.018129
SCFD1	0.018124
GZMA	-0.018118
RUSC1-AS1	0.018102
MZT1	-0.018093
CLIP1	0.018066
PANK2	-0.018045
NAPSB	0.018044
TRIM58	0.018044
FAM118A	0.018042
LILRA3	-0.017994
BIK	-0.017992
UCP2	0.017989
TRIM14	0.017984
PLA2G7	-0.017972
GTSF1	-0.017966
CLEC4F	0.017964
LOC100507557	-0.017947
TCTEX1D2	-0.017938
SLC22A4	-0.017928
GADD45A	-0.017899
TPPP3	0.017845
DOCK8	0.017806
XRCC2	0.017787
FAM177A1	-0.017745
DSC2	-0.017732
WDR36	0.017721
IRF5	0.017650
PABPC3	0.017640
KIF21A	0.017628
XIST	-0.017621
ALOX12	0.017612
CDC45	-0.017590
S100A8	-0.017576
KMT2A	0.017569
GNLY	0.017566
KIF18B	-0.017551
METTL9	-0.017534
MLH3	0.017531
SNRPE	-0.017524
ADD1	0.017520
PRIMPOL	-0.017511