!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	rat
!drug_name	Alitretinoin
!smiles	C/C(=C/C=C/C(=C/C(=O)O)/C)/C=C/C1=C(C)CCCC1(C)C
!drugbank_id	DB00523
!cell_type	liver   b
!organism	rat
!end_metadata
ATP6	0.209505
HMGCS1	0.199302
KNG1	0.190042
GSTM5	-0.185752
HP	0.183566
EPHX1	-0.163562
BHMT	0.156098
TAT	-0.151267
THRSP	0.150292
COMT	-0.148163
GNMT	0.147395
HPX	0.145187
TDO2	-0.121114
SLC27A2	-0.118825
APOA2	0.116018
RPS29	-0.113787
SCD	0.113756
FTL	-0.112146
ND5	0.110716
APCS	0.110586
RPS26	-0.109614
CPS1	-0.108488
ITIH4	0.105915
RPL8	-0.103579
SERPINA3	0.103136
CYP2E1	0.103111
ITIH3	-0.098596
RPL26	0.096589
ARG1	-0.094435
MDH1	0.093457
SPP2	-0.092467
COX3	0.091135
FBP1	0.090700
ND2	0.090264
MPC1	0.085841
GSTM1	-0.081513
AMACR	0.078719
COX1	0.076471
SLC28A2	0.076471
SLC41A2	-0.075130
NDUFA4	0.072734
CYP1A2	-0.072673
UBC	-0.071073
HPD	-0.070562
RPL37	-0.069352
PCBD1	0.068615
CP	0.068234
MSMO1	0.068203
TPT1	0.066867
ALDOB	-0.066188
RBP4	-0.065752
RNASE4	0.065484
SULT1B1	0.065324
CRP	0.064996
RPS21	0.063974
PIGR	-0.063895
ACTB	-0.063595
SERPINA6	-0.062930
CYB5A	-0.062286
HSP90AB1	-0.060530
PLG	0.059133
ABCC2	-0.057998
ACTG1	-0.057520
SFTPC	0.057389
B2M	-0.057147
RPLP0	-0.057010
AGT	0.056167
SERPING1	-0.056108
LCAT	0.053391
GSTA5	0.052897
CFB	0.052768
AMBP	0.052494
FGB	0.051802
ATP5O	0.050137
ASS1	0.050015
RPL9	0.049916
C3	0.049550
MAT1A	0.049120
F2	0.048772
RPL19	-0.048447
ASL	-0.048023
HMGCS2	0.048018
SORD	-0.046853
APOA1	-0.046730
ABCD3	0.046260
HSP90B1	-0.046115
GLUL	0.046075
CTSS	-0.045894
HSD3B7	0.045796
KYNU	0.045609
AZGP1	0.045579
TUBA1B	-0.044880
ECHS1	-0.044376
TMBIM6	0.043314
ATP6V0C	-0.043215
TPI1	-0.043175
RPS13	-0.042792
HAL	-0.042390
TTC36	-0.042374
IDI1	0.042097
GHR	-0.041866
COX7B	0.041408
CLU	-0.041407
TTPA	-0.040835
SDS	-0.040817
G6PC	0.040723
PABPC4	0.040547
KCTD13	0.039890
CD81	-0.039298
FASN	0.038916
HSP90AA1	-0.038820
RPS16	-0.038450
F10	0.038070
ID2	-0.037992
APOH	0.037718
HSPA8	-0.037715
COX7A2	-0.037360
PLIN2	0.037013
HAGH	-0.036533
ATP5B	0.036408
SERPIND1	-0.036104
RPL39	-0.035986
METTL7B	0.035758
ATP5H	0.035637
LIPC	-0.035600
POMP	0.035596
ALAS1	0.035393
FGG	0.035232
TUBA1C	-0.035006
ATP5G2	-0.034899
FABP1	-0.034193
ALDH7A1	-0.033277
RPL17	-0.033212
RPL6	-0.033078
GJB1	-0.033070
G0S2	-0.033031
HRSP12	0.032967
RPL21	0.032947
IDH1	-0.032465
IFITM3	-0.032438
PON1	0.032356
NDUFB3	0.032087
KLKB1	-0.032042
BSG	0.031846
CPT1A	0.031829
SEC61B	-0.031748
CYTB	0.031637
ALB	0.031242
ST6GAL1	-0.031132
PHB2	-0.031121
FGA	0.030964
ALDH1L1	0.030880
ACAA2	-0.030675
MGST2	0.030655
NDRG2	0.030449
RPL27	0.030117
RPL4	-0.030012
ATP5A1	-0.029960
OAT	0.029841
CST3	-0.029723
RPL23	0.029678
ALDH2	-0.029628
RPS27L	-0.029321
SLC40A1	-0.029154
FMO1	0.028919
SLC37A4	0.028863
HIBADH	-0.028698
AHSG	-0.028316
UQCRC2	0.028290
RPS4Y1	-0.028100
CAT	-0.028049
CANX	-0.027582
AVPR1A	0.027378
ATP5F1	0.027308
COX5A	0.026995
APOB	-0.026861
PSMB4	0.026751
SLC10A1	0.026461
CD74	-0.026262
MIF	-0.026067
XDH	-0.025978
RPL22	0.025674
ITM2B	-0.025643
RPSA	-0.025318
PAH	-0.025110
GNAS	-0.024886
PTPRF	-0.024861
FAH	0.024606
ACADL	-0.024597
MTCH2	0.024416
CREG1	-0.024387
RPP21	0.024048
OAS1	-0.023967
GAPDH	0.023915
NDUFA3	0.023607
SULT2A1	-0.023451
RPS7	0.023402
C1QB	-0.023340
NDUFS7	0.023276
AFM	-0.023245
SQLE	0.023241
RPL36AL	0.023012
PSAP	0.023006
MBL2	-0.022832
FDPS	0.022761
ASGR1	0.022549
CYP51A1	0.022472
FDX1	0.022374
CLEC4F	-0.022259
ND4	0.022246
SUB1	0.022229
TST	-0.022180
UQCRFS1	0.021956
IGFBP1	0.021901
NDUFB6	0.021809
PGRMC1	-0.021768
ENO1	0.021379
DAK	0.021362
PPIB	-0.021317
IGFBP2	0.021118
ADH1C	-0.021008
PSME1	-0.020935
COX2	0.020664
BAAT	0.020619
MAOB	-0.020606
IL33	-0.020594
RPL18A	-0.020537
SEC61A1	-0.020412
OTC	-0.020264
UGT2B17	-0.020085
RPL13A	-0.019935
CLTC	-0.019925
IGFALS	-0.019858
GNB2L1	-0.019695
RPL12	-0.019434
ACOX2	0.019348
PSMB8	-0.018942
RPLP2	0.018807
MDH2	0.018744
RPS11	-0.018564
AHCY	0.018353
DNAJA1	-0.018294
DYNLRB1	0.018287
GABARAP	-0.018190
RPS27A	0.018130
EEF1A1	0.018038
DYNLL1	-0.017911
DPYS	-0.017907
ACAT2	0.017893
ACSL5	-0.017759
ND6	0.017686
SLCO2A1	-0.017668
F9	0.017657
LIPA	-0.017549
OAZ1	0.017509
CD36	0.017501
TMED2	-0.017408
PRLR	-0.017399
NDUFV2	0.017362
ACY1	-0.017344
QDPR	0.017301
RPS5	-0.017290
EBP	0.017231
ACO1	-0.017197
POR	0.017177
CTPS2	0.017162
UBE2J2	0.017098
HACL1	0.017076
PSMC4	-0.016896
UGDH	-0.016809
DECR2	0.016782
GAMT	-0.016768
RPS9	0.016766
ETNK2	-0.016706
YWHAB	-0.016561
UGT1A1	0.016557
RPL28	-0.016546
VTN	-0.016514
C9	0.016472
PAPSS2	-0.016339
COX8A	0.016236
FN1	-0.016163
SDC4	0.016145
CD63	-0.016120
NUCB1	-0.016094
ZFP36L1	-0.015996
ACSL4	-0.015915
PDIA6	-0.015898
DAO	-0.015893
SLC6A13	-0.015843
UQCR11	0.015796
ACOX1	-0.015719
DDT	-0.015718
CTBS	0.015585
CNN3	-0.015549
AKR1A1	-0.015514
RPL15	-0.015482
PEBP1	-0.015427
MORF4L2	-0.015390
LRRC59	-0.015388
EAF1	0.015290
SREBF1	-0.014978
CES1	-0.014974
MPST	-0.014919
AK4	-0.014832
HSD17B10	0.014816
PTTG1IP	-0.014816
GOT2	-0.014775
SDC1	-0.014711
SLC25A20	0.014674
ALAD	-0.014640
PDK2	0.014628
RPL24	-0.014608
GRINA	-0.014584
EIF4A2	0.014488
SLC22A18	-0.014455
RBBP7	-0.014396
CA5A	-0.014336
STAT1	-0.014313
GSTO1	0.014240
PTPLAD1	-0.014211
NUDT4	-0.014164
NXF1	-0.014142
DDC	-0.014141
CLTA	-0.014118
TMEM205	-0.013989
PSMA6	-0.013920
GRN	-0.013881
GNS	-0.013837
SEPP1	0.013746
GPX4	0.013732
RAB5B	-0.013704
TECR	0.013662
C8B	-0.013659
IGF1	-0.013633
SARDH	0.013626
GNAI3	-0.013588
DLST	-0.013567
FAU	0.013560
ABHD14B	-0.013501
RPS3	-0.013494
ONECUT1	-0.013432
SOD1	0.013378
CYC1	0.013371
COX4I1	0.013314
PROC	-0.013247
LDLR	0.013158
CA2	0.013087
PEMT	-0.013051
RAF1	-0.013033
EEF1G	-0.013027
GC	-0.013025
ACADM	0.013017
HSPD1	-0.012979
TOR1AIP2	-0.012971
PITPNA	-0.012961
C11orf73	-0.012884
YWHAH	-0.012866
PDHB	0.012822
AGXT2	0.012815
MVD	0.012801
RAP1B	-0.012729
TALDO1	0.012720
UPB1	-0.012715
ALDH3A2	-0.012712
PTGR1	0.012643
CROT	0.012615
RABAC1	-0.012600
MAP3K12	0.012590
BTG1	-0.012526
GCLC	-0.012477
NDUFAB1	-0.012441
GPT	0.012418
GNE	-0.012351
RPS6	-0.012335
NR0B2	0.012294
LDHA	0.012195
GCKR	0.012155
PPP1CA	-0.012151
PRKCDBP	-0.012103
RPL3	-0.012091
SCLY	-0.012052
HSD17B4	0.012005
BCKDHB	0.011999
SUCLG1	0.011772
PSME2	-0.011736
RPL5	-0.011713
HSD11B1	0.011674
ACAT1	0.011631
YWHAE	0.011626
AUH	-0.011584
SCGB1A1	0.011579
NDUFV3	-0.011573
NDUFB2	0.011565
UGT1A4	-0.011504
EIF2S1	-0.011475
NAPA	-0.011472
APOA4	0.011390
CUTA	0.011285
PPP2CA	-0.011284
SLC35B1	-0.011253
NDUFB9	-0.011239
SLC22A7	0.011163
FKBP11	-0.011081
RBP1	-0.011070
TXNRD1	-0.011029
RPL18	0.010957
LYZ	0.010948
RPL35	0.010925
ADK	-0.010898
ATP6AP1	-0.010844
HADHB	0.010811
NINJ1	0.010800
ATP5C1	0.010760
ADH5	0.010744
SQSTM1	-0.010716
ATP1B3	-0.010701
COX6A1	0.010652
RPS23	-0.010505
GDE1	-0.010497
AQP8	-0.010416
TNRC6B	-0.010414
BECN1	-0.010374
MAOA	-0.010364
PSMA2	-0.010326
NR1H3	-0.010326
P2RY2	-0.010298
GPX1	-0.010282
CTSD	0.010189
CDIPT	-0.010158
RPL11	-0.010129
HIGD1A	-0.010092
MAP2K2	-0.010042
RBPMS	0.010009
NCKAP1	-0.010007
STAT2	0.009953
YWHAG	-0.009936
SERPINA10	-0.009924
APMAP	-0.009924
TUBA1A	0.009921
NFE2L2	-0.009858
NDUFC1	0.009830
IVD	0.009802
ECH1	-0.009737
PRKAR1B	0.009733
DECR1	-0.009720
PTOV1	-0.009716
SIRT2	0.009666
ANAPC5	-0.009662
CTDSP1	-0.009653
BLVRA	0.009580
RPS25	0.009517
SLC22A5	-0.009506
FKBP2	0.009501
NUDC	-0.009473
PPP2R5A	-0.009409
PFN1	-0.009390
ORMDL2	-0.009380
ITGB1	0.009328
POLR2I	-0.009321
GSTK1	-0.009297
ZFP36	0.009252
CYCS	-0.009247
ORAI1	-0.009233
GRHPR	-0.009230
BNIP3L	0.009204
CAPZA2	-0.009185
BCKDHA	0.009138
CDO1	-0.009052
ATP6V1D	-0.009038
SIGMAR1	0.009032
DNPEP	-0.009018
CYP27A1	0.008985
HMGCR	0.008973
DDAH1	-0.008962
HADHA	0.008946
SGK2	-0.008936
NDUFB4	-0.008936
ETFA	0.008928
ODC1	-0.008926
IMPA2	-0.008918
SCARB1	-0.008818
PPIA	0.008809
HPN	0.008802
CTSH	0.008787
PDK1	0.008742
FDFT1	0.008727
DRD3	0.008595
EIF4E	-0.008592
ARF4	-0.008579
GSTA3	-0.008571
KLF9	0.008563
FABP6	0.008549
SEC62	-0.008544
CYP7A1	0.008539
PTP4A1	-0.008533
PER2	-0.008496
GTF2B	0.008490
LGALS9B	-0.008488
APOE	0.008485