!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!drug_name	MLN4924
!smiles	C1CC2=CC=CC=C2C1NC3=NC=NC4=C3C=CN4C5CC(C(C5)O)COS(=O)(=O)N
!pubchem_cid	73014187
!cell_type	A375 melanoma cell line - 24 Hours
!organism	human
!end_metadata
GADD45A	0.196918
SNAPC1	0.161245
SERPINA3	-0.159970
SLC26A2	-0.143962
ZFAS1	0.134422
UAP1	0.117908
LGALS1	-0.115530
SNHG1	0.103094
IL13RA2	-0.100530
CDK2AP1	-0.097765
NACAP1	-0.095985
TSPAN13	-0.093077
CYR61	0.091335
S100A4	-0.087573
CD63	-0.083280
CTGF	0.082186
CTHRC1	-0.081537
GDF15	0.081119
FTH1	0.080741
TIMP1	-0.078281
C20orf24	0.077859
TXNRD1	0.077382
HSPA8	-0.076179
KRT18	0.074242
FTL	0.074212
TUBA1A	-0.072696
NNMT	0.071627
MARCKSL1	-0.071155
CCNB1IP1	0.070901
DDX21	0.070883
PLK2	0.070363
HLA-DRA	-0.068461
KPNA2	-0.068305
CAV1	0.068283
SNHG12	0.066052
BLOC1S2	0.065156
TRMT112	-0.064764
HIST1H4C	0.064284
MIA	-0.064176
EPB41L4A-AS1	0.062401
ATP5E	-0.062393
PSAT1	0.062142
PFN1	-0.061469
PDLIM1	0.060877
DYNLT3	-0.060638
SNHG17	0.059504
SYTL5	-0.058552
SPRY2	-0.058058
SRPX	-0.057818
WWTR1	-0.057609
LINC01419	-0.057407
DKK1	0.056875
ABHD17C	-0.056741
SDCBP	-0.056457
SLC7A5	0.055943
EBNA1BP2	0.055809
LOXL4	-0.055599
TIMP3	-0.055126
GARS	0.053748
RPS27L	0.053534
GNE	-0.053501
NME1	0.052008
NQO1	0.051813
MTHFD2	0.051619
FHL2	0.050917
BOLA3	0.050483
CKS2	-0.050158
C6orf48	0.050116
SERPINE2	-0.050026
NGFRAP1	-0.049827
MAGEA4	-0.049219
MMADHC	-0.048932
SMNDC1	0.048303
SNHG5	0.047590
IFITM3	-0.047020
MIR21	-0.046999
PPIB	-0.046963
EIF3D	0.046858
MORF4L1	-0.046646
ALDH1A3	-0.046638
IRF2BPL	-0.046417
S100A6	-0.046309
LIMA1	0.045990
SNRPB2	-0.045822
HLA-DRB1	-0.045811
ERRFI1	-0.045761
TRIAP1	0.045198
OAT	-0.044994
CDKN1A	0.044630
HAPLN1	-0.044397
TMSB10	-0.044287
RGS2	0.044015
DDX47	0.043973
PTTG1	-0.043522
DDIT4	0.042915
GABARAP	-0.042786
DBI	-0.042717
EIF6	0.042535
SNHG15	0.042443
GAS5	0.042301
COX7A2	-0.042291
RPF2	0.042140
ANKRD1	0.041732
SPARC	-0.041641
UBE2C	-0.041571
HMGN2	-0.041281
GNAS	-0.041189
ISCU	0.040367
SRXN1	0.040345
PRDX1	0.040315
VIM	-0.040181
MDM2	0.040159
NPTN	-0.039886
TAF1D	0.039864
PRKAR1A	-0.039756
SPCS1	-0.039486
TFRC	0.039437
BIRC2	0.039273
SH3BGRL3	-0.039152
PPME1	0.039107
ARL6IP1	-0.038948
AP3S1	0.038944
FBL	0.038888
RRM2	0.038819
DTL	0.038768
HSP90B1	-0.037853
IL24	0.037739
GGCT	0.037438
FLRT3	-0.037410
ARL6IP5	-0.037352
PPIF	0.037245
TRIB3	0.037239
VDAC2	0.037220
EIF1	0.037083
CCNB1	-0.036990
SH2B3	-0.036812
IER5	0.036680
MRPL15	0.036593
TNC	-0.035472
ISG20	-0.035463
RNF114	0.035421
RRAGA	-0.035417
PRC1	-0.035343
RPL39	-0.035248
RSRC2	0.034838
OVOS2	-0.034802
SRP19	0.034771
ID1	-0.034556
SNRPG	0.034218
SLC3A2	0.034152
RSL24D1	0.034046
RPL41	0.034020
ARPC1B	-0.033962
DYNLL1	-0.033879
SLIRP	0.033688
MAFF	0.033630
PMAIP1	0.033318
LYRM1	0.033235
DCTPP1	0.033221
YWHAZ	-0.033219
TRMT5	-0.032953
PSMA1	0.032894
TUBB	-0.032780
EMG1	0.032738
EPHA2	0.032703
FAU	0.032498
DDB2	0.032323
FTH1P5	0.032298
ADRM1	0.032203
AMOTL2	0.031965
PFDN2	0.031950
AK3	0.031942
PHLDA1	-0.031820
S100A13	-0.031778
NOP58	0.031746
HIF1A	0.031591
TM9SF2	-0.031580
MRPS23	0.031545
RPS5	0.031394
AVPI1	0.031338
PXYLP1	-0.031280
ITGA6	-0.031227
LAPTM4A	-0.031227
HSPA9	0.031219
PDHB	-0.031086
RND3	0.031006
RPL27	0.030887
GLRX2	0.030776
GBE1	0.030734
MANSC1	-0.030706
DUSP6	-0.030672
EIF3I	0.030630
MRPL49	0.030581
RNF145	-0.030568
IFNGR2	-0.030535
C12orf5	0.030476
FABP5	0.030448
KARS	0.030359
EEF2	0.030176
CKS1B	0.030108
NOC3L	0.029988
NOP56	0.029967
MYH10	-0.029858
TOMM20	0.029834
MYL6	-0.029777
AXL	0.029741
HMMR	-0.029571
PEA15	0.029504
ACSL3	-0.029468
MED10	0.029452
TMBIM4	-0.029443
HLA-DPA1	-0.029413
PTTG1IP	0.029368
S100A16	-0.029239
B2M	-0.029177
SLC5A3	-0.028925
RAB13	-0.028771
CD59	-0.028683
GTF3A	0.028537
UBB	-0.028533
HPCAL1	-0.028527
EMP3	-0.028510
PA2G4	0.028407
EIF2S2	0.028360
AKR1B1	0.028241
PKD1P1	0.028104
TUBB4B	-0.028043
CDK1	-0.028014
NARS	0.027956
PDIA6	-0.027860
RPL26L1	0.027802
COX8A	-0.027688
RPS25	-0.027645
TMEM14A	-0.027641
MRPL32	0.027634
ASNS	0.027615
CMSS1	0.027593
CBX3	-0.027552
C16orf52	-0.027532
KRTAP2-3	0.027525
INHBA	-0.027509
GCLM	0.027483
GNL3	0.027458
ITM2B	-0.027293
MICU2	-0.027262
GRPEL1	0.027175
HIGD1A	0.027102
POLE3	0.027093
COA6	0.027033
CNBP	0.026900
YRDC	0.026887
DKC1	0.026754
NIFK	0.026703
RRM2B	0.026665
SRSF7	0.026643
YARS	0.026585
FAM216A	0.026533
TOP2A	-0.026465
TFAP2B	-0.026408
GRPEL2	0.026351
MANF	-0.026302
TMEM230	-0.026221
ERBB3	-0.026190
NUF2	-0.026132
FDXR	0.026037
ATF3	0.026021
SOX11	-0.025973
CYCS	0.025951
TNFRSF12A	0.025942
STK17A	0.025909
DEPDC7	0.025771
ART3	-0.025682
NSA2	0.025626
HMGN1	-0.025625
LINC00326	-0.025625
SEPW1	-0.025517
LMNB1	-0.025503
DUSP14	0.025483
C12orf57	-0.025442
INPP5F	-0.025427
RRP1B	0.025345
CHMP2A	-0.025318
TKT	0.025312
YBX3	0.025274
MAGED1	-0.025245
HMGB1	-0.025226
PRR11	-0.025060
COX7A2L	0.025020
PLIN2	-0.025018
MRPL51	-0.025017
YWHAE	-0.025012
BCAS2	0.025010
SLMO2	-0.024988
STUB1	-0.024967
UBE2S	-0.024914
BTF3	-0.024893
UBE2E3	-0.024803
E2F7	0.024674
CCDC86	0.024639
ATAD1	0.024567
CCT3	0.024526
PLP1	-0.024501
RRN3	0.024497
ATRAID	-0.024454
ATP5L	0.024441
DUT	-0.024403
MICALL1	0.024271
PSMB4	-0.024260
DLEU1	0.024120
TNFRSF21	-0.023998
TMX2	0.023991
ANXA1	-0.023988
TRIM16	0.023921
PFN2	-0.023761
RPL3	-0.023641
BLCAP	0.023615
DUSP11	0.023578
CTSC	-0.023540
PLCXD2	0.023538
IARS	0.023505
TMX4	-0.023503
TIMM17A	0.023462
CHCHD4	0.023423
RPL22L1	-0.023352
WDR3	0.023201
EID1	-0.023198
FGF13	-0.023137
TIMM10	0.023108
HMGB2	-0.023102
CIRH1A	0.022988
SUCLG2	-0.022894
PCNA	0.022867
TGFBI	-0.022843
METTL23	-0.022835
ANLN	-0.022771
BTBD3	-0.022763
NAA20	0.022748
SDC4	0.022727
TUFT1	0.022727
CD96	-0.022703
NPIPA1	0.022656
FAM83D	-0.022652
SNHG6	0.022631
PSMC3	0.022631
DNAJA1	-0.022532
RBM39	0.022529
PTPLAD1	0.022481
TMEM59	-0.022451
LAMB1	-0.022447
SNRPD3	0.022422
ATG12	0.022398
ZCCHC24	-0.022368
PSMA6	0.022359
RRS1	0.022339
MAGEA3	0.022336
MINPP1	-0.022323
TXN	0.022310
ADD3	-0.022303
GHITM	0.022297
HNRNPA2B1	-0.022262
GBAS	-0.022225
CHSY1	-0.022206
CDC37	0.022129
HOXC6	-0.022128
SDE2	0.022062
TUBB3	-0.021999
GTF2H2	0.021964
ANP32A	-0.021947
AGPAT9	-0.021937
DUSP5	0.021852
SSR4	-0.021768
RPS19	0.021727
HSPB1	-0.021668
SF3A3	0.021666
HSP90AB1	-0.021651
CETN3	-0.021574
NDUFB10	-0.021521
ADM	0.021450
WDR54	-0.021433
SNX10	-0.021362
COX7C	-0.021354
SNRPA	0.021329
C1QBP	-0.021310
C14orf2	0.021237
APOA1BP	-0.021218
BNIP3	0.021217
ETS1	0.021177
RBM18	0.021132
PPM1D	0.021032
HSBP1	-0.021003
KIAA0907	0.020962
LINC00493	-0.020957
DAP3	0.020940
CEMIP	-0.020858
ADI1	-0.020769
PRDX6	0.020746
MRPS24	0.020742
PTMA	-0.020654
ESM1	0.020650
BCCIP	0.020594
TRMT11	0.020571
DNAJA2	0.020539
MFAP2	-0.020526
SLC20A1	-0.020430
PAPSS1	-0.020413
TMEM258	-0.020411
ORMDL2	-0.020406
FAS	0.020405
IFITM2	-0.020268
CORO1C	0.020202
JUND	0.020188
SFN	0.020184
SCNM1	0.020088
FXYD3	-0.020086
EIF2S1	0.020078
ANXA5	-0.020063
SERTAD2	0.020035
ODC1	0.019961
ACTG1	0.019960
TRIB2	-0.019928
H2AFZ	-0.019926
SLC7A11	0.019923
CMC2	0.019906
ACADVL	-0.019876
SELK	-0.019870
PCNP	0.019848
GABARAPL1	0.019765
SET	0.019731
C11orf31	-0.019723
CS	0.019720
MLLT11	-0.019681
ATF4	0.019656
C12orf45	0.019639
ORC6	0.019611
APP	-0.019610
WDR74	0.019599
TAF9	0.019599
TMEM2	-0.019588
CCDC59	0.019578
CEBPB	0.019577
PCDHB5	-0.019515
PHB2	0.019469
USMG5	0.019459
TUBA1B	-0.019428
MEOX2	-0.019419
MRI1	0.019384
KIF20A	-0.019354
CCDC58	0.019348
RPA3	-0.019311
TOP2B	-0.019277
SNHG7	0.019259
MAPK6	0.019241
MYL12B	0.019222
CDKN1B	-0.019218
NPM3	0.019207
TOMM5	0.019138
GPN3	0.019095
COX5B	-0.019068
TGFA	-0.019066
LINC00657	-0.019049
AURKA	-0.019025
PNO1	0.019018
TUBA1C	-0.019017
DRG1	0.019017
TCF7L2	-0.019016
ZCCHC8	0.018998
MRPS35	0.018984
EIF4H	0.018948
SGK1	-0.018923
UBE2M	0.018891
MAGOH	0.018861
WBP5	-0.018817
EIF3E	-0.018789
CCNG1	0.018785
PSMA4	0.018773
DNAJA3	0.018735
PRDX4	0.018700
JUN	0.018653
DNTTIP2	0.018640
ETFB	-0.018602
BCAT1	0.018597
SARS	0.018564
SH3KBP1	-0.018557
GNL2	0.018548
VPS72	0.018500
NDUFAB1	-0.018485
ITGAE	0.018456
PRKAR2B	-0.018408
DPYSL2	-0.018349
SLC25A32	0.018346
BUD31	0.018320
HLA-A	-0.018318
SHMT2	0.018301
GABARAPL2	-0.018253
EPS8	-0.018217
CRIM1	0.018211
NGRN	0.018201
RPN2	-0.018194
UCA1	0.018181
TFAP2C	-0.018166