!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	human
!drug_name	MEK inhibitor (MEKi : AZD6244)
!smiles	CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO
!pubchem_cid	10127622
!cell_type	SW480 cancer cells
!organism	human
!end_metadata
MT1F	0.199815
MT2A	0.196370
MT1E	0.184149
DUSP6	-0.181157
MT1X	0.154033
MT1H	0.142930
TUFT1	0.122743
EGR1	-0.122142
MT1HL1	0.122114
RAP2B	0.082341
KRTAP2-3	0.079902
USP43	0.079622
CYR61	0.075953
APCDD1	-0.074147
F3	0.073651
MYADM	0.071053
SDC4	0.070945
SLC30A1	0.070521
CXCL3	0.066433
WNT5A	-0.063364
TNNC1	0.062321
ASAP2	-0.061909
PIM3	0.061433
GCH1	0.060015
SNAPC1	0.059674
TNS4	-0.058267
MYL9	0.057789
DNAJB6	-0.057729
JUN	0.057261
HEG1	0.057229
IER5	-0.056571
KRT80	0.056258
LINC00341	-0.056200
C16orf54	-0.055765
EDAR	-0.055507
DNMBP	-0.053944
EN2	-0.053911
FGF19	-0.053325
ETV5	-0.052733
PPME1	0.052405
GADD45A	0.052394
NET1	-0.052227
IRF2BPL	-0.051813
ZXDA	0.051395
MT1G	0.050298
RND3	0.050116
CCRN4L	0.050076
DCUN1D3	-0.049482
BAMBI	0.049401
ETV3	-0.049398
HOXB7	-0.048981
TNFRSF1B	-0.048958
TNFAIP2	0.047006
HIST2H2BE	0.046854
ZNF468	0.046447
ADORA2B	-0.046142
TMEM2	0.046054
HIST3H2A	0.045822
IER3	-0.045765
CST4	0.045639
ZNF260	0.045470
ETS1	0.045199
NDP	-0.044933
SMURF2	-0.044346
ALDH1A3	-0.044336
FAM171A1	0.044320
AJUBA	0.044319
ADM	0.043891
CST1	0.043884
TRIM16	0.043021
HOXA1	-0.042685
NFKBIA	0.042381
TP53INP2	0.042310
NABP1	0.042068
CD24	0.042022
CDKN2B	0.041764
SERTAD2	0.041489
UBE2E3	-0.041338
MALAT1	0.040886
RBM12	0.040879
UCP2	0.040703
MIR21	0.040005
TPM1	0.039511
MGAT5	-0.039484
NGFRAP1	-0.039266
CEBPG	0.039243
SLC38A2	-0.039163
ILF2	-0.038930
MYL12A	-0.038822
CD83	0.038625
TIPARP	-0.038470
PHLDA1	-0.038064
SUCO	0.038031
RPL41	0.037971
ID2	-0.037780
TLE3	-0.037697
ZIC2	-0.037231
IRS2	-0.037087
EPHA2	-0.036954
SFN	0.036262
KLF6	0.036043
SLC39A10	-0.035899
ACTG1	0.035694
DKK1	0.035382
PMEPA1	-0.035364
IER2	-0.035198
SPIN4	-0.035006
MAPK6	0.034986
ARHGAP12	-0.034914
THBS1	0.034681
SAT1	-0.034558
PARP4	-0.034453
POC1B	-0.034424
LOC100130468	-0.033923
CDCA7L	-0.033860
HMGA1	-0.033673
MIR503HG	0.033598
IL17RD	-0.033386
TOPBP1	-0.033382
ORAI3	-0.033335
EVA1C	-0.033193
NGFR	-0.033013
FHL2	0.033004
SCAF8	-0.032979
CCND1	-0.032821
RPL9	0.032758
OSBPL3	-0.032204
DHCR24	-0.032053
ICAM1	0.031884
GPRC5A	-0.031839
CTDSP1	-0.031805
MYL6	0.031725
SPRY2	-0.031667
SEPHS2	-0.031651
NR2F1	0.031513
RIN2	0.031390
CPSF3	-0.031304
TBC1D4	-0.031282
RGS9	0.031175
SMARCD2	-0.031148
KLK6	-0.031065
SMNDC1	-0.031016
GADD45B	0.030948
C6orf62	0.030943
UBLCP1	-0.030942
WBP1L	0.030845
LIMS3	-0.030805
MISP	0.030755
SGPL1	0.030606
DYNLL1	-0.030534
MCM4	-0.030528
AFAP1L2	-0.030513
NOTCH2NL	0.030486
ALDH1B1	0.030468
ZDBF2	0.030453
TINAGL1	-0.030175
METTL9	-0.030103
B4GALT5	-0.030045
ALDH9A1	-0.029910
NIF3L1	-0.029781
RNF43	-0.029693
PLAUR	0.029610
KIAA0226L	0.029598
CRIM1	0.029570
FERMT2	0.029387
COX3	-0.029337
ELK3	-0.029176
SLC5A3	0.029068
APOBEC3C	-0.029038
OTUD1	0.028865
AATF	-0.028853
RPL34	0.028809
VMP1	0.028798
KCNJ5	-0.028749
CPOX	-0.028655
IRF2BP2	-0.028513
CDV3	0.028189
ANXA6	-0.028175
SH3BGRL2	0.028110
IGFBP3	-0.027949
BIRC3	0.027790
CALR	-0.027616
HOXB5	-0.027576
HSD17B11	-0.027542
EPPK1	0.027496
SRSF6	0.027480
ARRDC3	0.027358
PALD1	-0.027279
GPR137B	-0.027189
C2orf54	0.027131
DHRS3	-0.027113
EIF5A2	-0.027088
DEPDC7	-0.027049
LENG8	0.026872
ANAPC11	0.026771
MPP5	0.026751
CITED2	0.026674
S100A16	-0.026642
PPP1CC	-0.026592
SNX9	-0.026577
IGFBP4	-0.026521
MID1	0.026504
ATP1B1	0.026417
FOSL2	0.026403
ZWINT	-0.026401
ODC1	0.026373
CLDN11	-0.026332
TMEM123	-0.026280
CTR9	-0.026260
PCBP1	-0.026214
LMNB1	-0.026159
SLC1A5	-0.025969
LASP1	-0.025947
STC2	0.025884
ALMS1-IT1	0.025834
CAV1	0.025823
IRS1	-0.025772
ATF4	0.025664
HOXA3	-0.025584
SELK	0.025542
CHSY1	0.025508
ARL4C	-0.025498
MRPL3	-0.025453
MYEOV	-0.025389
STRADB	0.025325
SLC31A2	0.025315
UNC50	-0.025314
BIRC2	0.025260
TGFBI	-0.025244
PAX6	-0.025232
TMX3	-0.025203
GALNT4	-0.024970
TMEM45A	0.024913
LAMP3	0.024892
EZR	0.024796
MIR22HG	0.024773
EDN2	0.024611
HOXB8	-0.024593
SLC2A3	0.024569
INSIG2	0.024510
SP6	0.024494
UBA52	0.024488
KIAA0907	-0.024477
TIAM1	-0.024424
SYPL1	-0.024378
GLRX	-0.024360
CHCHD3	-0.024239
SLC16A1	-0.024233
OXTR	0.024136
SPRY4	-0.024109
CSRP1	0.024098
SRF	0.024082
LHFPL2	0.024045
LNX2	0.024025
ZNF680	0.023853
PSTPIP2	0.023847
KLF7	0.023787
KCTD11	0.023759
RASSF3	-0.023754
ARHGEF3	-0.023747
MYH9	0.023741
PRF1	-0.023698
ATP13A3	0.023517
RAP2C	-0.023516
RACGAP1	-0.023501
JARID2	0.023479
MALL	-0.023450
HDAC4	-0.023438
CDC25B	-0.023437
ELF3	0.023420
LOC284454	0.023419
LCOR	0.023414
HOXB3	-0.023409
PIM1	-0.023372
CTPS1	0.023354
GSTO1	-0.023346
CHMP5	-0.023318
SHC1	-0.023277
MTHFD2	0.023232
SPRED2	-0.023183
MAP1B	0.023171
CHST11	-0.023084
MB21D2	0.023028
KRT13	0.023026
NDUFB3	-0.023007
ND2	0.022990
RGCC	0.022981
CRY1	-0.022970
CASC3	0.022954
PARP12	0.022898
ITGB5	-0.022824
FANCL	-0.022814
ITGA6	-0.022791
CLPTM1L	0.022752
CIRBP	0.022703
KDM7A	-0.022673
FAT1	-0.022627
SH3KBP1	-0.022602
CKS1B	-0.022544
RPSA	0.022540
ZNF217	0.022462
TOB1	0.022461
HSPB1	0.022393
PTCH1	-0.022364
HOXB6	-0.022356
HIST1H2BK	-0.022353
CLCC1	-0.022343
ZFPM2	0.022290
APP	-0.022266
MRGBP	-0.022177
RCN2	0.022174
SLC7A1	0.022136
SLC7A7	-0.021967
ZNF280C	0.021960
UQCRQ	0.021952
CRISPLD2	0.021897
HOXA10	-0.021889
SOWAHC	-0.021888
ULBP2	0.021882
NRIP3	0.021876
FAM13B	0.021809
SS18L1	0.021741
BMP7	-0.021705
ARHGEF18	-0.021702
JHDM1D-AS1	-0.021668
CXCL1	0.021663
C1orf198	0.021659
DYNLT3	0.021626
CTDSP2	-0.021618
SLC16A6	-0.021579
GPSM2	-0.021544
ZBTB21	0.021543
CASP7	0.021535
TNFRSF21	0.021531
CXCR4	-0.021486
ACN9	-0.021481
PLEKHA1	0.021421
SEC14L1	-0.021404
PLK2	0.021366
FAM102B	-0.021354
PROSER2	0.021348
GJB1	-0.021331
HOXC6	0.021285
SHQ1	-0.021253
CNEP1R1	-0.021246
CIPC	0.021243
SAV1	-0.021194
MAFB	0.021178
RAD21	-0.021162
RPL7L1	0.021161
MSANTD3	0.021146
POLR2I	0.021140
SLC48A1	-0.021114
STEAP2	0.021079
TMEM126A	-0.021048
AMMECR1L	0.021017
NPC2	0.020921
HIF1A	-0.020799
UBAP1	0.020788
SPRY4-IT1	-0.020756
UBA2	-0.020672
IRF2	-0.020666
TNIP1	0.020638
C6orf211	0.020581
NANOS1	-0.020549
RNF220	-0.020508
ZBTB43	0.020505
CXADR	0.020495
PET117	0.020394
SERINC5	-0.020356
EZH2	0.020320
DDX6	0.020318
RHPN2	0.020277
ZNF562	0.020263
GLRX5	-0.020252
YWHAQ	-0.020215
AP1S2	-0.020205
MEST	0.020198
MTM1	0.020182
GTF2E1	0.020176
SNHG1	0.020142
CNN2	0.020142
RAB22A	0.020111
EIF1	0.020097
MAT2A	0.020078
FAM134A	-0.020074
RPL21	0.020019
SERPINE1	-0.019956
MIRLET7DHG	0.019908
ZCCHC24	-0.019885
TMEM243	-0.019871
PHB2	-0.019854
DUSP5	-0.019844
LRRC47	0.019833
MORC4	0.019828
PPIF	0.019814
MMGT1	0.019810
IL32	0.019764
B3GNT2	-0.019754
TRIM68	0.019713
ZNF675	0.019711
HSPE1	-0.019711
FUCA1	-0.019687
LPCAT2	-0.019681
JTB	-0.019675
LATS2	0.019669
CDH1	0.019660
TIMP1	-0.019642
APOBEC3B	-0.019574
DHX15	-0.019563
KRTAP3-1	0.019554
ZNF45	0.019484
PDP1	-0.019451
MRPS24	-0.019436
PODXL	0.019420
SHFM1	0.019409
LOC100288675	-0.019396
METAP1	-0.019384
GOLPH3L	-0.019376
HNRNPUL1	-0.019357
TNFRSF12A	0.019318
RPS18	0.019317
PTPRJ	-0.019303
TXNDC12	-0.019290
KRT23	0.019281
COX2	0.019261
ARL4A	0.019223
BRIP1	0.019215
TNFRSF1A	-0.019208
FAM8A1	-0.019188
VCL	0.019132
EPHA4	-0.019125
YAP1	-0.019120
FAM107B	0.019095
PCSK5	0.019027
CYB5B	-0.019012
RPS7	0.019011
AMD1	0.019006
VDR	-0.019005
OPHN1	0.018999
C17orf96	-0.018908
DBF4	-0.018906
MAP3K1	-0.018876
FAM171B	-0.018869
SWI5	-0.018858
CXCL16	0.018848
FAM60A	-0.018844
SEH1L	-0.018841
NME7	0.018790
EBNA1BP2	-0.018784
PDGFA	-0.018764
POLR3F	0.018755
LOC285074	-0.018675
MPZL2	0.018645
THAP10	-0.018640
GLCE	-0.018632
NDC80	-0.018580
TMEM52B	0.018567
ZNF706	-0.018536
ACTB	0.018535
GTF2A1	0.018493
PSMD2	0.018478
GABPB1	0.018469
COA6	-0.018464
CXCL14	0.018425
OXR1	-0.018397
CHCHD4	-0.018378
PIGW	-0.018378
FUT1	0.018367
TSPAN5	-0.018363
CTNNAL1	-0.018361
COQ10A	0.018354
LOC100507507	0.018305
DDX20	0.018305
LINC01119	0.018304
CDKN1A	0.018302
ACTL6A	-0.018269
CAV2	0.018230
CNN3	0.018221
RBL2	-0.018210
LINC00623	-0.018183
IMPA1	0.018098
APOBEC3G	-0.018093
THAP1	-0.018066
LYRM1	-0.017977
IFRD1	0.017918
TXNIP	-0.017914
FAIM	0.017913
CPEB2	0.017889
PABPC3	-0.017888
SUMO2	-0.017886
PTPN12	-0.017882
MOAP1	-0.017880
OXSR1	0.017858
PNMA1	0.017851
MTMR4	0.017848
RNF38	0.017823
MRPS6	-0.017819
MARVELD2	0.017811
SIMC1	-0.017810