!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	rat
!drug_name	Isoflurane
!smiles	C(C(F)(F)F)(OC(F)F)Cl
!drugbank_id	DB00753
!pubchem_cid	3763
!cell_type	Whole brain - 5 exposures
!organism	rat
!end_metadata
TTR	0.573226
TUBA1A	-0.200069
MBP	0.156997
DNM1	0.128695
CKB	0.125129
COX8A	-0.112279
SLC12A5	0.107591
ACTG1	-0.099812
MRFAP1	0.095914
MDH1	-0.091996
PPIA	-0.091787
HSPA8	-0.088233
COX4I1	-0.087615
RPS16	-0.086063
ND2	0.083611
RPS29	0.080597
GSTM2	-0.078325
NDUFA8	-0.078185
PABPC4	0.075990
ITM2B	0.075040
TUBA1B	0.073782
COX3	0.071767
GLUL	0.070766
RPL9	-0.070512
PRNP	0.070440
CYTB	-0.070168
TPT1	0.069540
ND5	-0.069434
ATP5B	0.068601
CST3	0.068440
MPC1	-0.065823
COX6A1	-0.065294
GRINA	0.064871
APOE	-0.064298
SPOCK2	-0.064029
RPS8	-0.062389
ENO2	0.061303
UQCR11	-0.061261
ALDOC	0.060702
UCHL1	-0.060002
BASP1	-0.059855
CCK	-0.058943
ND1	0.058083
FKBP1A	-0.056984
PTGDS	-0.055599
YWHAH	0.055425
NCDN	0.054852
SNAP25	0.054746
TECR	0.054420
COX1	0.054244
RPS26	-0.052695
ENPP2	0.052694
PSMB4	-0.052307
NELL2	-0.052044
RPL19	0.051664
NME2	-0.050887
YWHAZ	-0.050854
ATP5G1	-0.050802
PCBP4	0.050686
CX3CL1	-0.050484
RPS14	-0.049744
OAZ1	-0.049659
NDRG2	0.049332
BCAT1	-0.049172
GSTM5	-0.048703
POMP	-0.048631
CRP	0.048520
ATP5O	-0.048508
RPS3	-0.048207
NDUFB9	-0.047987
DDN	-0.047763
PRKAR1B	-0.047553
EIF4A2	-0.047178
RHOB	0.047124
PENK	-0.046999
ATP6V0C	-0.046856
APP	0.046802
OXT	-0.046783
SLC25A3	0.046744
CFL1	0.046558
MAPK8IP1	0.046390
S100B	-0.046190
NDUFV2	-0.045523
RPL31	-0.045287
AVP	-0.045258
CTBP1	-0.045112
RPS27A	-0.045037
PRDX2	-0.043663
NDRG4	-0.042924
ATP6V0A1	0.042565
FAU	-0.042560
MOBP	0.041976
COX7A2	-0.041813
SYP	0.041509
HSP90AB1	-0.041450
YWHAB	-0.041238
DGKZ	0.041156
KCNC1	0.040790
COX2	0.040718
PTN	-0.040459
RPS23	-0.040249
RELN	0.039819
PAICS	0.039447
SCN1B	0.039420
CPE	-0.039109
AKR1A1	-0.038563
PCP4	0.038479
RPS4Y1	-0.038021
CLU	-0.037964
SLC25A5	-0.037799
CHN1	0.037495
SNRNP70	0.037425
NDUFB4	-0.037355
GRM4	0.037288
PVALB	0.037098
RPL7A	-0.036931
HSP90AA1	-0.036740
RPLP0	-0.035123
CAMK2N1	-0.034941
VAMP2	0.034707
GAPDH	-0.034618
MDH2	-0.033793
GDI1	0.033548
NACA	0.033091
CAMK2B	0.033012
RPS9	-0.032616
CLTA	0.032592
PLP1	0.032297
CD63	0.032182
RNF112	0.032035
SPARCL1	0.032032
TRAPPC3	-0.031878
GAA	-0.031849
NCKAP1	-0.031655
EEF1A2	0.031515
SYN1	-0.030871
RAB10	-0.030362
RPL22	-0.030322
SDCBP	-0.029885
LDHB	0.029740
EEF2	-0.029608
SOD1	-0.029586
STX1B	0.029453
GABARAP	0.029352
COX7A2L	-0.029352
RPS5	-0.029117
NEUROD1	0.029110
LDHA	-0.029017
CAPNS1	0.028870
VGF	-0.028431
BSG	0.028379
CACNA2D1	-0.028370
RPL6	-0.028250
PKM	0.027998
SST	-0.027988
TPI1	-0.027906
CXCR1	-0.027659
PAK1	0.027647
GPX4	-0.027529
RPL10	-0.027512
DYNLL1	-0.027500
FEZ1	0.027433
OLFM1	-0.027387
NDUFB8	-0.027349
DAD1	-0.027266
UBC	0.027174
MFGE8	-0.027128
RPL11	-0.027127
RPL23	-0.027021
DYNLRB1	-0.026994
FTL	-0.026730
ST3GAL5	-0.026714
STXBP1	0.026513
PTGIR	-0.026339
ACTB	0.026114
CALB2	0.026067
BIN1	0.026064
SLC6A1	0.026023
GFAP	-0.025986
ATP6	-0.025949
NEFL	0.025912
HSPD1	-0.025720
FAIM2	-0.025708
GDA	-0.025697
SYT4	0.025687
TCF4	0.025614
RPLP2	-0.025586
THY1	0.025445
TAC1	-0.025296
RAB6A	-0.025283
CNTNAP1	0.025276
NEFH	0.025269
MGST3	-0.025045
VAMP1	0.025006
DCTN1	0.024998
RPL39	0.024998
TUBA4A	0.024937
MAPK8IP2	0.024740
AATK	0.024699
TMA7	-0.024144
CTXN1	-0.023810
MYL12A	-0.023550
PSMB1	-0.023535
APLP2	0.023516
CDK17	-0.023513
ZMYM3	0.023360
VSNL1	0.023216
TNK2	0.023184
RPL24	0.023183
IRGQ	-0.023100
MORF4L2	-0.022974
ALDOA	0.022617
CALB1	0.022586
SDHA	0.022538
ENO1	-0.022506
TNRC6B	0.022431
TSPAN3	-0.022424
CHN2	0.022404
APBB1	0.022327
OXR1	0.022315
DNAJA2	-0.022270
RPL4	-0.021902
LPHN1	-0.021844
APOD	0.021775
CHGB	0.021706
SLC25A4	-0.021638
RPS21	-0.021369
RPL15	-0.021344
RPS17	-0.021312
FTH1	0.021205
CXXC5	0.021182
UBQLN1	0.021163
MAG	0.021118
FAT2	0.021107
RGCC	-0.020912
ATP1A3	0.020859
UQCRC2	-0.020639
EHMT2	0.020610
ATP6AP1	0.020589
COX5A	-0.020563
CNP	0.020352
SV2A	0.020336
NDUFB3	-0.020313
SV2B	-0.020188
SDC4	-0.020095
ATP5G2	-0.020074
SEC62	0.020033
UBALD1	0.019875
RPL18A	-0.019857
LEP	-0.019830
SOSTDC1	0.019781
CTRC	-0.019762
TMEM55B	0.019742
FAM96B	0.019580
CSRP1	0.019563
FABP6	-0.019559
HPCAL1	0.019510
SLC27A1	0.019502
CBFB	-0.019430
ITIH3	0.019422
FKBP2	-0.019318
PDIA6	-0.019275
CSPG5	0.019179
ATP1A2	0.019108
SIRT2	0.019014
CLCN3	-0.018971
ATP5F1	0.018970
H1F0	0.018961
SLC25A23	0.018947
SH3GL2	0.018944
VEZF1	0.018865
RPS11	-0.018789
RPS25	-0.018743
GATM	0.018730
RPL36AL	-0.018665
XPNPEP1	0.018646
SLC3A1	-0.018627
ATP5C1	0.018596
CD81	0.018551
CAMKV	-0.018485
RPS6	-0.018482
GAP43	-0.018475
PSMB3	-0.018408
AES	-0.018370
NFYC	0.018240
B2M	-0.018196
HMGA1	0.018127
PSMC1	0.018096
ADRBK1	0.018030
GRIN2C	0.017972
SLC6A8	0.017949
SCHIP1	0.017921
INA	0.017879
CYB5A	-0.017724
PTP4A1	-0.017700
MAP1LC3A	0.017681
CYC1	-0.017596
CYFIP2	0.017589
PTPRS	0.017495
CPQ	-0.017490
GSTO1	-0.017454
DYNC1I1	-0.017152
GNAS	0.017087
RPL27A	-0.017059
PEBP1	0.017014
IGFBP2	0.016944
GIT1	0.016886
ATP5H	-0.016774
CALU	-0.016750
PPP2R5A	0.016727
RPL37	-0.016620
ATP1A1	0.016613
ASIC1	0.016501
SUB1	-0.016484
CAMK2N2	0.016476
NAPA	0.016383
RPL12	-0.016372
SRSF11	0.016231
SYT17	-0.016197
MGST2	-0.016188
TCEA2	-0.016137
RPL8	-0.016078
EIF2B2	-0.016062
EIF3B	0.015981
PSMA7	-0.015980
YWHAQ	-0.015884
KCNJ11	0.015869
COX7B	-0.015682
RPS15A	0.015665
APEX1	-0.015663
PSMB5	-0.015634
SLC25A11	0.015560
MAPK10	-0.015525
NDUFS7	-0.015515
MRPL45	0.015490
APH1A	0.015450
STX1A	-0.015450
RAB11FIP5	0.015414
ECHS1	0.015357
MYRF	0.015232
HPCA	-0.015109
ABI2	-0.015055
NCAM1	0.015001
TNFRSF1A	0.014985
CA4	0.014959
RPS7	-0.014939
CYB5R1	-0.014930
PLAT	0.014920
RESP18	-0.014897
NR1D1	0.014859
P4HB	0.014838
DYNC1H1	0.014834
RBBP7	-0.014820
PPP1R10	0.014777
TMBIM6	0.014729
PYGB	0.014658
ALKBH7	-0.014633
CUTA	-0.014615
FABP5	-0.014417
ID3	-0.014400
GLUD1	-0.014359
GABRB1	-0.014356
EGR1	-0.014340
SSH3	0.014329
NEK7	-0.014280
RPL26	-0.014277
PADI3	-0.014247
SNCB	0.014216
ENPP1	-0.014200
HK1	0.014180
LGALS1	0.014165
TNFRSF11B	-0.014157
PPP1CB	-0.014022
PSMA4	-0.013999
ABCC6	-0.013991
PPP2CB	-0.013958
EIF4H	-0.013879
YWHAG	-0.013832
UBR5	-0.013693
CCNDBP1	0.013671
GABRA6	0.013669
ATP6V1C1	0.013662
ID2	0.013652
STRAP	0.013647
RNF4	-0.013633
PRKAG1	0.013604
SLC4A4	0.013599
PET100	0.013572
UNC5B	0.013565
PRKAR1A	0.013556
PPP2R1A	-0.013544
ATP2A2	0.013523
FAM160B1	-0.013522
INPP4A	-0.013518
PDK2	0.013474
SPARC	0.013442
PFKM	0.013429
SYT1	0.013407
NUCB1	0.013396
HPCAL4	-0.013392
CDC37	-0.013381
HSPA9	0.013360
GRB2	0.013345
CALR	0.013283
GRM3	-0.013283
SIGMAR1	-0.013234
ADCY2	-0.013230
ATP2A3	0.013229
DDX3X	0.013139
PITX3	0.013107
KCNH3	-0.013075
COLQ	0.013055
KLK6	0.013054
AGT	0.013033
TSPAN17	-0.012992
DRD3	0.012985
SNCA	-0.012934
CS	0.012933
IDH3G	0.012920
RPH3AL	0.012908
DNPEP	0.012908
PPP1R21	0.012873
AMH	-0.012834
PIM3	0.012822
GABRB2	0.012806
NEDD8	-0.012796
SOD2	-0.012787
INADL	0.012770
NDUFC1	-0.012762
MTMR7	0.012725
GTF3C1	0.012687
CCND2	-0.012650
ND4	-0.012615
PPP2R2B	-0.012611
HSPB1	-0.012585
ZNF580	0.012565
DBN1	0.012483
GSTP1	-0.012467
ATP1B1	-0.012460
GABRD	0.012454
TOMM6	-0.012444
RAB3A	0.012415
RNASE4	-0.012327
CHST10	-0.012327
HNRNPU	-0.012325
RGS14	-0.012319
CNTN2	0.012304
NDUFB2	0.012283
CACNA1A	0.012277
BLMH	-0.012253
VAMP3	0.012212
LAMTOR1	-0.012210
PJA2	-0.012162
RGS12	-0.012088
TH	0.012086
SPP1	0.012054
LYZ	-0.012049
RPS10	-0.012029
PTK2	-0.012029
JTB	-0.012014
SLC3A2	0.011995
TAOK1	-0.011942
PHB2	0.011937
PRDX3	0.011908
NDUFA4	-0.011846
NDUFB11	0.011840
PTPN5	-0.011794
RRAGA	0.011748
KLC1	0.011705
CNRIP1	-0.011701
POLR2A	0.011627
NDUFB5	-0.011579
PITPNA	0.011557
MAL	-0.011554
CTSD	0.011534
ADAM2	-0.011507
ANAPC5	0.011470
USE1	-0.011465
GAMT	-0.011444
BCLAF1	0.011408
GAD2	0.011330
LEMD2	0.011303
CYTH2	0.011274
ATP5D	0.011269
AP2M1	0.011238
TMEM259	0.011192
MYO5B	-0.011148
GABRR1	0.011146
KCNC3	0.011146
MAOB	-0.011114
PPP1R1A	-0.011097
JUP	0.011081
PTPN23	-0.011074
INSIG1	0.011068
ATPIF1	-0.011067
BCAN	-0.011066
GRIP2	-0.011064
PFKP	-0.011055
THRA	-0.011038
ENSA	-0.011011