!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Rattus norvegicus
!drug_name	1-(4-Methoxyphenyl)piperazine
!smiles	COC1=CC=C(C=C1)N2CCNCC2
!pubchem_cid	269722
!cell_type	Hepatocytes
!organism	rat
!end_metadata
HMGCS2	-0.103254
FADS1	0.100806
GPNMB	0.086111
SLC10A1	-0.082272
G6PC	-0.076750
ACAT2	0.073312
TM4SF4	-0.072539
BHMT2	-0.068516
AASS	-0.067063
MSMO1	0.064695
CYP1A1	0.063950
ACOX2	-0.063223
IDI1	0.062995
CYP8B1	-0.062936
FBP1	-0.062845
FGF21	-0.062194
CSRP3	0.061830
MTTP	-0.061763
FABP7	-0.060426
ACSM5	-0.059449
RRAGD	0.059418
CYP2E1	-0.058339
FTCD	-0.058103
IL1R2	0.056819
SQLE	0.056765
SLC37A4	-0.055305
SLC13A5	-0.055004
FAM111A	0.054237
BHMT	-0.053637
RPRM	-0.053522
FDFT1	0.053042
DHCR24	0.053017
CYP51A1	0.052661
TMEM30B	-0.052394
LOX	-0.052048
ANGPTL4	-0.051951
DPYD	-0.051828
PCSK9	0.051603
CXCL3	-0.051378
GLYAT	-0.050980
VNN1	-0.050930
BBOX1	-0.050907
DDAH1	-0.050661
FDPS	0.049695
GYS2	-0.049613
HMGCS1	0.048869
MGP	0.046594
SULT2A1	-0.046537
MAFB	-0.046180
FASN	0.046149
GPM6A	-0.046100
HSPB1	-0.045720
LGALS3	0.045101
CLDN1	-0.044658
MLLT11	-0.044417
GPD1	-0.044146
CRELD2	-0.043138
ACSM1	-0.042910
DPYSL2	0.042904
AOX1	-0.042870
ABCB11	-0.042517
PDIA4	-0.041899
TTC36	-0.041781
SLC4A4	-0.041704
CPS1	-0.041327
GSTA3	-0.041166
ARRDC4	-0.041162
CD36	-0.040784
ALDOB	-0.040133
GADD45G	-0.040041
ZFAND2A	-0.039862
MIOX	-0.039742
ENPP3	-0.039634
HSP90B1	-0.039045
ARG1	-0.039033
SCD	0.038939
UGT2B17	0.038840
ITPR1	-0.038796
HSPH1	-0.038573
SLC25A25	-0.038370
PECR	-0.038243
LY96	0.038213
MCM6	0.038074
HMGCR	0.037798
TRHDE	-0.037641
GPX2	0.037635
GSTK1	0.037607
CYP26A1	-0.037391
DNAJB1	-0.037192
ELOVL2	-0.037064
SLC27A2	-0.036991
CYP26B1	0.036963
DMGDH	-0.036824
HAL	-0.036758
MLC1	-0.036732
HSD17B2	-0.036630
LPCAT1	0.036478
NQO1	0.036335
ADORA2B	-0.036256
HSPA4L	-0.036140
ELOVL3	-0.035978
GUCY2C	0.035740
SLC7A11	-0.035604
HYKK	-0.035590
YPEL2	0.035457
ABCB1	-0.035421
LSS	0.035265
SDR42E1	-0.035242
MGST3	-0.035035
SKAP2	0.034729
SEC16B	-0.034646
SCARA5	-0.034636
ADH1C	0.034557
SERPINF2	-0.034452
GGCT	-0.034140
BHLHA15	-0.034131
STX3	0.033751
GJB1	-0.033727
CEP290	0.033718
BDH2	0.033586
PHYH	-0.033410
MMP15	-0.033179
AGXT	-0.033096
DECR2	-0.033093
ECHDC1	0.033057
SAT2	0.033039
ACSL3	0.032910
APOC2	-0.032854
BCMO1	0.032696
FAM102B	0.032667
PEX11A	-0.032582
NPC2	0.032292
RAPGEF4	-0.031871
TMEM176B	-0.031770
HAO2	-0.031766
PPP1R3C	-0.031762
GNMT	-0.031634
KYNU	-0.031631
DNASE1L3	-0.031626
CEMIP	-0.031589
HAAO	-0.031372
AGMAT	-0.031320
FBXO9	-0.031319
CTH	-0.031298
SULT1B1	-0.031253
GADD45A	-0.031232
TSPO	-0.031209
SEL1L	-0.031199
GJB2	-0.030985
IDH2	-0.030954
SDS	-0.030755
MDH1	-0.030703
AMPD3	0.030687
MORC4	-0.030662
CKAP2	0.030658
GCAT	0.030536
PLSCR1	0.030492
RAB30	0.030442
MAOB	-0.030429
AQP9	-0.030371
DECR1	-0.030193
CA14	-0.030109
HGD	-0.030028
ACAA2	-0.029931
ZNF354A	-0.029924
TMEM170B	0.029891
BMP2	-0.029842
DUSP5	-0.029811
PPAP2B	-0.029612
PNPLA3	0.029431
TM7SF2	0.029340
DCN	0.029318
FMO5	0.029292
EPHA2	-0.029180
SLC45A3	-0.029140
LRP1	-0.029137
DPP7	0.029031
MASP2	-0.028959
TMEM50B	0.028932
ABCB4	-0.028904
ID2	-0.028846
HSPA5	-0.028834
NIPSNAP1	-0.028783
ENPP2	-0.028757
GPR64	-0.028743
INSIG1	0.028720
FADS2	0.028674
REEP6	-0.028636
PLIN5	-0.028632
COPRS	0.028490
SLC50A1	-0.028409
ASPA	-0.028336
CNPPD1	0.028252
METRNL	0.028145
PQLC3	0.027943
HMOX1	-0.027880
PLIN3	0.027701
RUFY1	0.027683
DAO	-0.027678
IRAK3	0.027407
FXYD1	-0.027339
MOSPD3	-0.027335
AGMO	-0.027333
FBXO30	-0.027249
TLCD1	0.027169
DHRS3	-0.027165
ARHGAP22	0.027111
PXMP2	-0.027104
LGALS9B	-0.026960
KLF10	-0.026954
CFH	-0.026914
TXNRD3	0.026874
EMR1	-0.026850
NNMT	-0.026849
PLCB1	-0.026845
IGFBP3	0.026827
SFN	0.026804
NSDHL	0.026777
FAM213A	0.026726
AADAT	-0.026678
APOB	-0.026630
CLDN3	-0.026599
HES6	0.026588
TMEM39A	-0.026453
UPB1	-0.026408
ACAD11	-0.026318
CLEC4F	-0.026291
ALDH1A1	-0.026248
CTGF	-0.026227
CNDP1	-0.026116
SHC4	-0.026097
HNRNPLL	-0.026069
PPCS	-0.025985
SLC6A12	-0.025977
TMEM256	0.025957
GLTP	0.025929
SLC22A7	-0.025846
CACNB4	0.025845
PFKFB1	-0.025838
SMOC1	-0.025785
CALR	-0.025778
IRAK1BP1	0.025765
PROCR	-0.025764
MAP3K1	0.025626
KIAA1217	-0.025461
SULT1C2	0.025422
NDRG2	-0.025379
CITED2	-0.025347
NAGS	-0.025294
BPHL	-0.025259
CES1	-0.025247
PRDM1	-0.025202
FN1	-0.025193
TM6SF2	-0.025173
ROPN1L	0.025133
MBL2	-0.025128
ADCK3	-0.025032
CLN5	0.024993
FOSL1	-0.024950
SELENBP1	-0.024900
SIRT3	-0.024888
BUB1	0.024880
CXCR4	0.024785
OPN3	0.024783
SH3BP5L	0.024689
UAP1L1	0.024608
RAB32	0.024598
NR1I3	-0.024581
PALMD	-0.024569
SLC25A15	-0.024556
C5	-0.024553
STEAP3	0.024552
PAQR9	-0.024546
GNPDA1	0.024522
GRN	0.024496
RBP7	-0.024486
SH2D4A	0.024468
SNN	0.024455
PMVK	0.024441
NMRK1	0.024354
PTPN21	-0.024338
PDP2	0.024303
ALDH6A1	-0.024269
SLC30A1	-0.024214
SDF2L1	-0.024213
PIGR	-0.024181
JUN	-0.024128
STARD4	0.024055
CLDN2	-0.024025
MVD	0.023960
EBP	0.023956
THRSP	0.023911
MKNK2	0.023874
PHKB	-0.023852
LIPA	0.023821
HSD17B6	-0.023803
ACOT2	-0.023802
OPLAH	-0.023796
ONECUT2	-0.023786
GSTA5	-0.023779
SLC6A6	0.023754
REEP3	-0.023645
PAQR8	0.023642
TRIP13	0.023639
RNF145	0.023630
AZGP1	-0.023626
COL4A5	-0.023594
PXMP4	-0.023554
TECPR1	0.023549
SEC24D	-0.023508
SERPINA6	0.023433
AMDHD2	0.023427
MYLIP	0.023395
TEX264	0.023366
SLC26A1	-0.023281
NUCB2	-0.023211
DAPK1	-0.023195
ATF3	-0.023115
RARRES1	0.023083
NHEJ1	0.023082
TMEM176A	-0.023079
PCK1	-0.023072
EPHX2	-0.023056
ABHD5	0.023054
SERPINE1	-0.023026
CABLES1	0.022994
DAPK2	0.022963
FAM46C	-0.022936
SREBF1	0.022929
PRSS23	0.022928
FILIP1L	-0.022870
DYRK3	0.022816
GANAB	-0.022813
UAP1	-0.022798
CA5A	-0.022765
SLC33A1	-0.022759
SGMS2	0.022693
PMS2	0.022634
TCF19	0.022631
DUOXA1	0.022627
GLS2	-0.022568
CLEC14A	-0.022552
AQP8	-0.022482
SERPIND1	-0.022469
INMT	0.022460
AKR1D1	-0.022443
VEGFB	0.022397
ACOT4	-0.022347
SEC11C	-0.022346
MGAT2	-0.022300
CEACAM1	-0.022273
HEXB	0.022268
RSAD2	0.022197
PMM1	0.022173
HSD17B7	0.022170
PROS1	-0.022107
ACADVL	-0.022088
ABCC6	-0.022076
MANF	-0.022046
CA8	-0.021980
BCKDHB	-0.021935
CCND1	0.021896
ANXA5	0.021892
DAK	-0.021878
DIXDC1	-0.021859
CSTB	0.021819
LIN37	-0.021815
CSF1R	-0.021807
TBC1D24	-0.021780
IGFBP2	0.021776
AFMID	-0.021774
ILKAP	0.021772
BHLHE40	0.021752
RRAGC	0.021730
SLC17A2	0.021684
NXT2	-0.021670
MUM1	0.021658
SPTLC2	0.021644
TXNIP	-0.021638
CPEB4	-0.021636
VCAM1	-0.021599
SLC25A20	-0.021566
AGXT2	-0.021552
FUCA2	0.021549
GSTM1	-0.021544
CHAC1	0.021510
CCND2	0.021453
MITF	-0.021439
IFIT3	0.021427
DHRS1	0.021422
OCIAD2	-0.021416
KCTD6	-0.021412
SMYD4	0.021399
CDKN3	0.021399
SH3GLB1	0.021385
IREB2	-0.021373
EHHADH	-0.021369
DDX58	-0.021340
FIBIN	-0.021319
SMPDL3A	-0.021298
ALDH4A1	-0.021277
TIMELESS	-0.021275
RND3	-0.021262
SLC22A18	-0.021236
SEC24A	-0.021209
ADTRP	-0.021193
NFIA	-0.021127
CEP83	0.021124
EMCN	0.021111
SEMA4A	0.021078
SNX24	0.021053
PON3	-0.021052
IL1R1	0.021032
SERGEF	0.021015
PPM1H	0.021012
MED8	0.020937
ABCA4	-0.020888
PLEKHH1	0.020879
RPP25	0.020876
SEMA3C	-0.020851
PANK3	0.020835
GYPC	-0.020815
CREM	-0.020812
HYOU1	-0.020809
DUSP1	-0.020785
ASGR1	-0.020775
EEPD1	0.020747
ERBB3	-0.020730
CD63	0.020698
GAMT	-0.020690
GALK2	0.020687
PPFIBP2	0.020591
AP5S1	0.020574
MGLL	-0.020572
HIBCH	-0.020563
DHTKD1	-0.020547
ACAT1	-0.020547
ST5	-0.020541
PTGFRN	0.020537
RHEBL1	0.020527
WFDC2	0.020463
CD74	-0.020459
SC5D	0.020416
ACY3	-0.020412
CDH17	-0.020405
AACS	0.020401
SVIP	0.020392
GREM2	-0.020373
ME3	0.020368
PDIA5	0.020349
LCAT	-0.020343
FGGY	-0.020331
CCNB1	0.020318
HNRNPH3	-0.020317
MAOA	-0.020314
KLHL24	0.020277
ABCC2	0.020258
TMEM120A	0.020232
ATXN7	-0.020202
NR1H4	-0.020192
TTC39B	0.020190
TROVE2	0.020183
FAH	-0.020182
ZNF467	-0.020170
PLG	-0.020151
MMP12	-0.020118
SEC22B	-0.020111
CDT1	0.020097
MTHFD2	0.020096
IFT57	0.020082
GCKR	-0.020069
EHF	0.020021
XRCC2	-0.019986
CISH	-0.019952
BRI3	0.019897
ALCAM	-0.019897
LHFP	0.019895
OSGEPL1	0.019886
HSD17B12	-0.019866
OS9	-0.019858
NXT1	0.019854
ACAD10	-0.019823
TSPAN7	-0.019820
FAM167B	0.019726
TRIM59	0.019718
PCYOX1	-0.019665
CLSPN	0.019658
GSTZ1	-0.019637
GEM	-0.019629
CCRN4L	-0.019617
SULF2	-0.019615
NKTR	-0.019589
TEAD1	-0.019576
MMP19	-0.019573
CTSF	0.019557
CKS1B	-0.019538
RBL2	-0.019518
AMT	-0.019436
SARDH	-0.019432
MID1IP1	0.019423