!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!drug_name	Doxycycline
!smiles	CC1C2C(C3C(C(=O)C(=C(N)O)C(=O)C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)N(C)C)O
!drugbank_id	DB00254
!pubchem_cid	5281011
!cell_type	RT112 cancer cell line (FGFR3 knocked down with shRNA 2-4)
!organism	human
!end_metadata
AOC1	0.078723
NDN	0.067842
PLAGL1	-0.052827
MDK	-0.051813
NAP1L5	-0.049504
SLC6A14	0.046224
PYCARD	-0.044328
PCK1	0.042277
H19	0.038933
PLEKHS1	0.037829
TRIM22	0.037648
HDX	-0.037589
MED18	-0.036486
DAPL1	0.036129
ANKS1A	0.034101
SERPINH1	-0.032489
CDH5	0.032345
APCDD1	0.032031
TMEM139	-0.031411
ROBO1	-0.030792
LGR5	-0.030606
MAP10	0.030603
ABCA12	0.030595
AGPAT9	0.030396
GALM	0.029545
LINC00470	-0.029226
FUT11	-0.029155
AASS	0.028539
RARRES3	0.028301
PLAU	-0.028195
SLC1A6	0.027915
F9	-0.027722
DMBT1	0.027163
GIMAP2	0.026702
TMEM132D	-0.026296
AIM2	0.026010
FABP5	-0.025868
LOC286083	-0.025717
TMSB15A	0.025275
PPT2	0.025046
HIST1H1C	0.025038
EFEMP1	0.025027
ZNF432	0.024888
NUAK1	0.024828
CLDN8	0.024821
MGAM	0.024796
HMX2	-0.024523
GBP4	0.024296
LYSMD2	0.024215
RAPGEF4	0.024074
DUSP10	0.023943
DPP10-AS1	-0.023925
EPHX4	0.023884
PRAMEF12	-0.023762
GABRE	0.023445
GPT2	0.023410
BDH2	-0.023349
GJA1	0.023247
F13B	-0.023166
ZNF204P	0.023109
C5AR1	0.023058
HIST1H2BG	-0.023045
CYP51A1-AS1	-0.022873
NAP1L2	0.022837
SEMA3A	0.022644
DEPDC1-AS1	-0.022566
LOC284788	-0.022482
LOC646903	0.022444
PDZK1	0.022429
CYP2F1	-0.022396
PPBPP2	-0.022221
FBXL2	0.022195
CLDN20	-0.022030
CLCA4	-0.021985
CCDC113	0.021871
NKX6-2	-0.021869
PP14571	0.021824
CCK	-0.021824
PILRB	0.021817
DNAJC28	0.021733
HBQ1	-0.021714
FIRRE	-0.021708
LOC100506718	0.021460
LDOC1	0.021417
ALLC	-0.021295
ZBTB20-AS1	-0.021222
SLC6A3	-0.021191
SCRN1	0.021175
BTAF1	0.021143
C9orf91	0.021079
MRGPRX2	-0.021003
C11orf44	-0.020971
LOC643072	0.020944
OCM2	-0.020886
OR2H4P	-0.020855
SLC18B1	0.020788
PFKFB3	0.020755
C17orf78	-0.020727
XAGE-4	-0.020693
LOC729324	-0.020615
PLSCR4	-0.020596
CD302	-0.020587
MAMDC2	0.020583
LOC102723927	-0.020546
MGC2889	-0.020485
CXorf58	-0.020435
NHSL2	-0.020422
SLC35G3	-0.020391
MIR181A2HG	0.020352
PRR34-AS1	0.020323
LOC100128288	0.020288
POMT1	0.020262
COX3	-0.020243
SGK1	0.020139
ST6GALNAC1	0.020096
MACROD2-AS1	-0.020019
SUCNR1	-0.020008
LINC00520	0.019981
BBOX1	0.019907
RTP4	0.019883
ABCG5	-0.019850
F5	0.019845
P2RX7	-0.019824
PLCZ1	-0.019787
LOC100272216	0.019774
C11orf80	0.019743
LOC375196	-0.019718
IGFBP3	0.019712
FLJ32255	0.019708
LOC101928626	-0.019705
YBX2	-0.019672
TMCC3	0.019599
SLC39A12	-0.019564
HPN	-0.019534
LINC00847	-0.019511
RASSF6	0.019451
LOC101929505	-0.019435
FBXW11	0.019424
LOC644852	-0.019421
LOC100129406	0.019300
LOC149401	0.019124
FRAS1	-0.019121
ARID3B	0.019109
LRRN1	-0.019066
PTX3	-0.019063
NCF4	0.019020
NPIPB3	0.019014
ANKRD6	-0.019010
BOLL	-0.019000
KDELC2	-0.018973
KCNE1L	-0.018960
TEX38	-0.018956
ADM	0.018946
NAA11	-0.018929
HIST1H4PS1	-0.018929
RNFT1	0.018918
NTSR2	-0.018861
NPHS2	-0.018824
TAS2R1	-0.018801
SECTM1	-0.018783
DDI1	-0.018755
FGF14-IT1	-0.018744
CNPY1	-0.018738
C8orf48	-0.018737
SLC47A2	-0.018707
FBLL1	-0.018637
TEX14	-0.018637
ZP2	-0.018635
PM20D1	-0.018626
ZFP3	-0.018623
ACOXL	0.018622
PRO2852	0.018553
ACOT6	-0.018546
RFPL3S	-0.018532
PLEKHA7	0.018526
IL25	-0.018505
AFAP1L2	0.018488
ZNF404	0.018456
TAF1L	0.018377
LOC100505716	-0.018355
TMEM133	0.018352
LOC158402	0.018312
FOXO6	0.018288
LOC728613	-0.018268
C15orf52	0.018253
PEAR1	0.018233
C5orf55	0.018173
CPEB4	0.018160
GPR84	-0.018156
ANKRD19P	-0.018138
LOC100131541	0.018124
FRK	0.018111
STK33	-0.018105
TRIM16	0.018093
DCST1	-0.018076
SEL1L2	-0.018060
LRRK2	-0.018051
RAB36	0.018028
GPCPD1	0.017991
DNAJC15	0.017983
FNDC1	-0.017983
SMIM2	-0.017951
TRAV12-2	-0.017924
FLJ44896	0.017921
UNC5CL	-0.017920
HYPM	-0.017913
PPY	-0.017912
OFD1	0.017909
C6orf164	-0.017906
ITLN1	0.017898
HCK	-0.017897
MMP13	0.017890
KRTAP17-1	-0.017889
LOC101928135	-0.017885
OTOGL	-0.017846
FAM110C	0.017836
LINC00641	-0.017826
LINC00948	-0.017813
KIAA0247	0.017793
LOC100129620	-0.017776
PCAT4	-0.017757
LINC01468	-0.017753
LRRC4B	-0.017742
LINC01165	-0.017731
LINC00529	-0.017730
OXGR1	-0.017725
MMP12	-0.017711
SAMD9	0.017704
MLNR	-0.017697
ZNF883	-0.017682
C12orf5	0.017662
MUC16	0.017645
IGDCC4	0.017631
LEPREL4	0.017625
PLXNB3	-0.017623
LINC00857	0.017595
ZNF132	0.017585
SAA4	-0.017581
LOC101928909	-0.017574
KLK11	-0.017560
KCTD21	0.017548
SPATA16	-0.017522
ZNF302	0.017476
PROP1	-0.017472
TUSC7	-0.017454
LINC01428	-0.017453
PDYN	-0.017430
ZNF418	-0.017423
ALKBH6	0.017422
CNNM1	-0.017399
BST2	0.017376
LINC01019	-0.017354
CD109	-0.017319
DCST2	-0.017312
TBC1D27	-0.017302
LOC100131262	0.017302
RNASE7	0.017301
KCNJ14	-0.017280
DKK1	0.017261
UROC1	-0.017251
LOC51145	-0.017245
C5orf28	0.017239
MIR101-1	0.017227
YEATS4	0.017190
TTTY11	-0.017177
SLC22A2	-0.017176
MBL2	-0.017140
TLR9	-0.017126
SLC22A17	-0.017111
LOC101929229	-0.017108
ZNF37BP	0.017106
SH2D4B	-0.017105
C3orf18	-0.017095
PRND	-0.017088
CNTFR	-0.017078
SMYD1	-0.017069
ZNF645	-0.017067
FAM73B	0.017062
GPR133	-0.017054
LOC283737	-0.017048
TRPC4AP	0.017047
FAM181A	-0.017018
OR5P2	-0.017018
DUSP26	-0.017012
IFI44	0.017011
PTPRK	0.017000
RNF208	-0.016997
MAGI1-IT1	-0.016988
FOXL2	0.016980
TTTY15	-0.016975
GRPR	-0.016966
ST8SIA5	-0.016947
TTLL7-IT1	-0.016945
SLC30A10	-0.016938
CPB1	-0.016905
LINC01482	-0.016899
TMEM88	-0.016892
OR8B8	-0.016878
DENND5A	0.016873
ETNPPL	-0.016873
CDS1	0.016861
NLRP7	-0.016842
LINC01018	-0.016833
ZNF491	-0.016811
DNALI1	-0.016798
HOXB1	-0.016794
LINC01103	-0.016793
HOXA13	0.016783
WDSUB1	0.016776
KHDC1	-0.016763
KLHL21	0.016758
PLVAP	-0.016757
SDR16C5	0.016754
LPPR4	-0.016753
MSLN	-0.016746
SLC35B3	0.016737
C8G	-0.016735
LOC100130268	-0.016733
FHOD3	0.016726
LINC01095	-0.016723
LINC00661	-0.016705
PCDHB14	0.016704
MGC15885	-0.016701
PLA1A	-0.016697
LINC01214	-0.016685
TSPO2	-0.016684
LOC100131662	-0.016663
C12orf75	-0.016656
TCL1B	-0.016630
LDHC	-0.016607
ANXA1	0.016602
PTPRM	0.016584
LOC653160	-0.016579
ZBED6	-0.016574
KRT35	-0.016573
PROKR2	-0.016554
MEG9	-0.016553
TMCO2	-0.016533
EFHD1	-0.016512
LOC101928651	-0.016500
TAS2R4	-0.016494
CTSW	-0.016481
SFTA2	-0.016478
CBFA2T3	0.016462
KBTBD3	0.016448
SV2B	-0.016443
MIR31HG	-0.016423
KCNK4	-0.016403
LOC100507513	-0.016397
CCDC68	-0.016383
GZMA	-0.016380
PRSS58	-0.016376
CST7	-0.016360
NAT10	0.016356
TIMP2	0.016348
LINC00112	-0.016339
MYO9A	0.016335
RAB38	-0.016333
OPN4	-0.016330
LCA5	0.016330
TRBV27	-0.016305
LAMC2	0.016287
GABRA6	-0.016269
LOC101060019	-0.016253
ENDOU	-0.016251
HIST1H2AM	-0.016237
C12orf80	-0.016225
GPA33	-0.016225
BPIFB1	0.016210
LCT	-0.016200
IFI16	0.016195
ANKRD36	0.016195
AATK	-0.016189
DPH3P1	-0.016189
LEFTY2	-0.016186
MPPED2	0.016181
WBSCR17	-0.016173
LOC101929154	-0.016168
GABRB1	-0.016168
SULT1E1	0.016168
C2orf40	-0.016165
CCDC142	0.016164
NEUROG2	-0.016158
RNASE6	-0.016135
NOBOX	-0.016131
NR2E1	-0.016113
C5orf30	0.016101
TMEM57	0.016095
RASL10A	-0.016092
CLDN23	0.016076
LOC340357	-0.016065
LINC00605	-0.016063
MAGEH1	0.016061
SLC35F4	-0.016046
LOC100507397	-0.016041
RPGR	0.016016
KRTAP4-6	-0.016015
S1PR1	-0.016013
HAND1	-0.015992
SORD	0.015990
MBIP	0.015979
HHIP-AS1	-0.015973
DUSP27	-0.015967
KRTAP10-12	-0.015964
TAPT1-AS1	0.015948
CLIP2	0.015944
RWDD3	0.015943
UGT1A	-0.015937
KRTAP5-2	-0.015932
SH3BGRL2	0.015926
SEMA5B	-0.015909
RSPO1	-0.015905
CYBRD1	0.015879
ZNF616	0.015875
CBR1	0.015865
DEF6	0.015864
TXNDC8	-0.015859
PTPRR	0.015858
PHF11	0.015850
OXT	-0.015826
ZNF667	-0.015821
LMAN1L	-0.015801
LOC728196	-0.015797
LOC101927123	-0.015792
APOA1	-0.015791
DPEP2	-0.015787
NAG18	-0.015779
ZUFSP	0.015777
SMKR1	-0.015775
RAP1GAP2	-0.015758
MTL5	-0.015757
GADD45A	0.015754
SH3BGRL	0.015752
S100G	-0.015745
PCP4L1	-0.015739
PLAC1	-0.015737
DIRC1	-0.015732
FOXR1	-0.015726
AKAP3	-0.015726
PANX1	0.015720
CLPS	-0.015714
CCDC84	0.015713
FLJ41170	-0.015713
SLC5A5	-0.015695
PRKCD	0.015692
TTTY12	-0.015692
LOC101928940	-0.015685
RTP3	-0.015679
LINC01088	-0.015670
CHUK	0.015668
RACGAP1P	-0.015657
PELP1	0.015646
LINC00892	-0.015637
GIMAP8	-0.015633
LOC100129449	-0.015629
DEPDC7	0.015625
NPAS4	-0.015610
QRICH2	-0.015608
KRT1	-0.015608
ACAD8	0.015605
RAPSN	-0.015605
ACVR1C	-0.015604
CLSTN2	-0.015586
PCSK1	-0.015583
PLAC8	0.015580
SERPINA7	-0.015579
POPDC3	-0.015579
DUSP9	0.015577
LOC100132661	-0.015561
WRN	0.015559
IFITM2	0.015511
GRM4	-0.015501
SLC35G2	-0.015497
CXCR1	-0.015485
IRAK1BP1	0.015481
LOC101927914	-0.015473
ZNF536	-0.015463
LOC389765	0.015461
AA06	-0.015460
MTCP1	0.015460
FRY	0.015457
PANX3	-0.015447
PARP15	-0.015444
PRO2214	-0.015441
THAP9-AS1	0.015441
SRM	0.015439
F3	0.015438
LOC100130219	-0.015431
TMEM104	0.015431
LINC00565	-0.015416
LCN2	0.015410
SEMA3C	0.015406
KRTAP5-8	-0.015390
POU5F1P3	-0.015381
TCTE1	-0.015379
FGR	-0.015377
MYO18B	-0.015369
SCGB1D1	-0.015364
APOBEC3G	0.015360
SHOX	-0.015348