!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	human
!drug_name	curcumin
!smiles	COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O
!pubchem_cid	969516
!cell_type	U937 monoctyes exposed to oxidative stress - 18 Hours
!organism	human
!end_metadata
CCL2	0.173516
FTH1	0.159821
FTL	0.159566
RPS18	0.131356
UBC	0.127449
CXCL8	0.126316
HSPA1A	0.124536
HLA-B	0.123212
COX1	0.121937
IL1B	0.116158
RPS10	0.115945
CCL4	0.114406
GAPDH	0.113372
IFI30	0.108881
FTH1P5	0.105758
MMP1	0.105223
CCL1	0.101837
RPL30	0.100301
TPT1	0.099705
RPLP0	0.096310
MMP9	0.095767
TIMP1	0.091492
MMP7	0.090005
SPP1	0.088073
TMEM158	0.085775
TALDO1	0.085126
CHCHD2	0.083962
ACTB	0.081845
TREM1	0.081269
RPL41	0.080811
RPS3	0.078468
RPL9	0.078319
RPS17	0.077940
GLO1	0.076975
SRXN1	0.076018
PPIB	0.075979
COX2	0.075424
CAPG	-0.075188
TUBA1C	0.074913
MYL12A	-0.074120
HLA-C	0.071680
HMOX1	0.071280
C20orf24	0.070406
RPS20	0.069411
B2M	0.068776
RPL8	0.068132
BCAP31	0.067563
HLA-A	0.067200
EEF1A1	0.067123
TMSB10	0.066523
GARS	0.066260
SOD1	0.066248
LYZ	-0.065647
RPL39	0.065322
RPL13A	0.064765
SEC61G	0.062221
PPBP	0.062138
CEBPB	0.061290
DUSP5	0.061108
RPL23A	0.060151
CCL8	0.059916
ISCU	-0.059690
VIM	0.058113
S100A4	-0.057819
ATF4	0.057277
MMP10	0.057245
VIMP	0.057090
OLIG1	-0.057078
ATP6V0B	0.057024
PSMA6	0.056510
RPL34	0.055438
RPL21	0.055404
S100P	0.055174
S100A9	0.055057
RPLP1	0.054791
TMEM123	-0.054643
RPL32	0.054471
PSMD8	0.053807
GSTO1	0.053081
OAZ1	0.052743
LGALS1	0.052139
RPL12	0.052096
S100A11	-0.051944
LCP1	0.051665
SEC13	0.051612
TUBA1B	0.051601
RPS15	0.051068
ITGB2	-0.051053
TXNRD1	0.050308
CFL1	0.048586
RPS5	0.048342
GPX1	-0.048331
IER3	0.048260
P4HB	0.048157
LAPTM5	0.047841
PTDSS1	0.047788
TDP2	0.047513
TXNIP	0.047059
PLAUR	0.046741
PRDX1	0.046555
ANXA2	0.046461
MMP12	0.045979
ALDOA	0.045272
UBA52	0.045052
RPL27	0.044437
CD52	-0.044425
ARF4	0.043590
SQRDL	0.043552
PAPSS1	-0.043468
HSPB1	0.042965
ARL6IP5	-0.042184
SRGN	0.041988
RPL36A	0.041964
CSTB	0.041713
RPL17	0.041682
RPS12	0.041672
ZFAS1	0.041222
MAFB	0.041210
THBD	0.041021
UBB	0.040990
HSPA6	0.040524
ISG15	0.040422
JTB	0.040178
INHBA	0.039996
HSP90B1	0.039980
EEF1G	0.039716
MRFAP1	0.039522
ITGA6	-0.039349
PSMA7	0.039257
CDIPT	-0.039223
METRNL	0.039195
GPR34	-0.038988
DYNLL1	0.038941
RPS28	0.038534
RPS3A	0.038506
CHI3L1	-0.038466
H3F3B	0.038273
CD93	0.038269
DDIT4	0.037966
SHFM1	0.037943
SELK	0.037457
HSP90AB1	0.037307
RPS13	0.037163
HSP90AA1	0.037103
PSMD14	0.036864
SAT1	0.036739
CD63	0.036659
COX3	-0.036390
RPS7	0.036303
PABPC3	0.036158
RPL10A	0.036124
SRP9	-0.035869
TNFSF15	0.035830
CTSH	-0.035791
CXCL10	-0.035657
ARPC1B	0.035597
RPS23	0.035348
RPS21	0.035341
RPS4X	0.035241
RPL23	0.034866
FABP5	0.034831
NCF2	0.034627
TYROBP	0.034613
PPIA	0.034501
SERF2	0.034396
ZFAND2A	0.034393
EIF3E	0.034057
RPS11	0.033967
NACA	0.033877
DCSTAMP	0.033780
MKNK2	0.033389
OSTC	0.033373
PSMB4	0.033176
HIST1H2BK	0.033148
MGST1	0.033116
HMGN1	0.033058
TXN	0.033025
AHCYL1	0.033023
HLA-G	0.032968
PRG2	0.032941
GNG5	0.032872
FAM129A	0.032852
ANXA1	0.032844
SEC11A	0.032787
NDUFA1	0.032724
FXYD5	0.032706
H2BFS	0.032693
NOP10	0.032634
TRAM1	0.032462
RPN2	0.031975
IFIT1	-0.031819
HDAC1	-0.031769
FAU	0.031501
GLRX	0.031478
RPL27A	0.031475
SLC3A2	0.030842
GPI	0.030824
MMP3	0.030732
FGR	0.030612
EIF1	0.030596
IFI6	0.030582
TMEM258	0.030580
HUWE1	0.030555
PLAU	0.030528
IFITM2	-0.030403
RPS29	0.030366
TBCA	0.030241
RPL3	0.030204
TLR2	0.030153
KDELR2	0.029963
RPS16	0.029898
PSAP	0.029760
TM4SF1	0.029733
ARHGDIB	-0.029600
NPTN	-0.029566
MANF	0.029467
CD36	-0.029436
GRN	-0.029257
CLIC1	0.029184
RGS1	-0.029101
TRIB3	0.028952
DAD1	0.028834
ABRACL	-0.028581
RABAC1	0.028564
PDCD10	-0.028474
CCL20	0.028408
HIST1H2AC	0.028250
SGK1	-0.028228
PGRMC1	0.028221
H2AFZ	-0.028081
YBX1	0.028074
PLEK	0.028068
RPL11	0.028004
ATP6AP1	-0.027982
FCGR2C	0.027798
RPSA	0.027617
GPNMB	-0.027599
OST4	0.027442
ATP6V0D2	-0.027287
METTL9	-0.027214
CLEC2B	0.027075
MIF	0.026894
UPP1	0.026602
TMBIM6	0.026585
RPL37A	0.026548
SLC25A6	0.026425
PSMA4	0.026300
SLC7A11	0.026261
VASP	-0.026204
C5AR1	0.026199
DAP3	0.026091
PABPC1	0.026087
CYFIP1	-0.026020
CLEC5A	0.025677
GLA	0.025621
DNAJB1	0.025621
AHRR	-0.025439
GYG1	-0.025427
HNRNPK	-0.025339
COL22A1	0.025252
SNHG6	0.025249
CTSA	-0.025248
MRPL33	-0.025191
ATF3	0.025176
PTMA	-0.025156
NAMPT	0.025057
PSMB1	0.025015
RAC2	0.024997
RPS19	0.024912
UXT	0.024890
CD163	-0.024856
DDOST	0.024843
ND2	0.024831
CTSD	-0.024779
RPL28	0.024570
RPS27	0.024563
TMA7	-0.024545
IER2	0.024513
C19orf10	0.024508
CHSY1	-0.024348
DNAJB9	0.024310
CUTA	-0.024139
SNHG5	0.024121
IFITM1	-0.024036
RPL31	0.023680
FCGR2A	0.023177
PSMB5	0.023074
TDO2	0.023025
TGFBR1	-0.022914
UBL5	-0.022907
PSAT1	0.022861
NQO1	0.022803
PGD	0.022757
RPS15A	0.022754
MEA1	0.022743
HEXB	-0.022732
SLC1A4	-0.022720
HERPUD1	0.022703
RPL22	0.022683
RPL10	0.022639
HIST1H2BD	0.022628
CCT4	0.022610
HYOU1	0.022567
CRELD2	0.022302
GPX4	0.022285
C3AR1	-0.022272
SSR3	0.022158
KPNA2	-0.022090
NDUFB9	0.021841
SCP2	-0.021714
S100A8	0.021702
HMGN2	0.021551
CDK5RAP2	0.021515
PSME2	0.021409
SNRPD2	0.021373
RALA	-0.021338
RNF13	0.021117
SMAD7	0.021092
NDRG1	0.020903
RPS24	0.020838
SLA	0.020789
C1orf43	0.020726
NDUFB4	0.020696
PPIF	0.020657
EIF5	0.020628
RPS2	0.020611
SEC31A	0.020512
AGPAT9	0.020448
HLA-E	0.020376
DUSP6	0.020349
GAS5	0.020331
PSMB2	0.020320
MAPRE1	0.020262
MSN	-0.020217
AP1S2	-0.020210
MAP2K1	0.020136
B3GNT2	-0.019874
ENO1	0.019834
ACOT9	0.019685
PSMB3	0.019627
SEC61A1	0.019619
EVI2B	-0.019609
PHC2	0.019593
BST2	-0.019541
RPS6	0.019538
APEX1	-0.019533
MMADHC	0.019521
LAP3	-0.019487
HPCAL1	0.019478
ACSL5	0.019409
SSR2	0.019398
RPL4	0.019392
IFNGR2	-0.019350
IFIT3	-0.019273
PDIA4	0.019178
TNFRSF12A	0.019144
RNF11	-0.019123
GFPT1	0.019114
PSMD11	0.019079
FCER1G	0.019061
AKR1C2	0.019001
SMS	-0.018968
ABHD17C	-0.018896
RAP1B	0.018895
IARS	0.018791
SF3B5	0.018723
CSNK2B	0.018678
CORO1A	-0.018654
SRPR	0.018614
TUBA4A	0.018474
OLFML2B	-0.018422
SH3BGRL	-0.018416
BRI3	-0.018380
NCF1C	-0.018336
EIF3I	0.018332
RNASEK	0.018312
SEC11C	0.018250
MYD88	-0.018195
MNDA	-0.018142
YWHAQ	0.018044
TPM4	0.017955
NFE4	0.017938
FLNA	-0.017880
HSD17B11	-0.017868
PSMC1	0.017782
RPL24	0.017771
GTF3C6	-0.017683
LPXN	0.017567
C14orf166	0.017473
PSMC4	0.017433
S100A10	0.017390
BNIP3L	0.017291
HSPA5	0.017261
RNF181	0.017218
PABPC4	-0.017206
DYNC1I2	0.017202
IER5	0.017186
LMAN1	0.017179
EPDR1	0.017157
C16orf54	-0.017138
NPC2	0.017060
SUMO2	-0.016984
HIF1A	-0.016980
CD14	0.016962
ADRM1	0.016955
LEPROT	0.016927
TPSAB1	-0.016879
NDUFA4	0.016877
GPR82	-0.016866
AHSA1	0.016772
FABP4	-0.016750
IL4I1	-0.016723
MORF4L2	0.016716
CST7	-0.016710
SLC25A5	-0.016682
MCEMP1	-0.016660
CXCL3	0.016641
TIPARP	0.016625
COPS2	0.016530
SURF4	0.016470
CYTIP	-0.016454
PSMB6	0.016438
ANXA4	-0.016436
RGCC	0.016323
RPL38	0.016223
TARP	0.016181
PSMD4	0.016178
ADI1	0.016157
COX7A2	-0.016151
SRP19	0.016092
TPSB2	-0.016012
ODC1	0.015947
GNS	-0.015938
PMAIP1	0.015841
RHOA	0.015804
SMOX	0.015801
ANP32B	0.015790
SERP1	0.015790
ARL6IP1	0.015788
MMP19	0.015785
UBA2	-0.015763
GCLM	0.015751
C3	0.015727
RGS16	0.015702
LYPLA1	-0.015683
PEA15	0.015650
CANX	0.015649
MORF4L1	0.015631
ZBTB8OS	0.015582
SCAMP2	0.015569
VEGFA	0.015455
ITM2B	-0.015362
CITED2	-0.015312
BEX1	0.015270
CAPN2	0.015216
GOLGA7	0.015058
EEF2	-0.015048
CD82	-0.015044
STAT1	-0.015033
RPL13	0.014997
C6orf48	0.014937
AKR1C1	0.014897
COX7A2L	0.014882
PEPD	-0.014863
BTBD1	-0.014789
RHOC	0.014788
MMGT1	-0.014787
PSMD6	0.014718
EIF2S2	0.014649
ATP6AP2	-0.014578
ACADM	-0.014563
LAMP2	-0.014549
COA6	0.014528
IGF2R	-0.014446
TMEM251	-0.014446
RPS8	0.014426
MRPL18	0.014385
IFI16	-0.014347
RPL37	0.014285
CXCL2	0.014277
OSBPL8	-0.014274
RPS14	0.014271
UBE2E1	-0.014258
RGS19	-0.014186
ARPC5	-0.014154
PFDN2	0.014089
PFN1	-0.014068
EPB41L4A-AS1	0.014050
MS4A4A	-0.013978
COMMD8	-0.013925
MYO1F	-0.013901
ANXA2P2	-0.013894
RAB7B	-0.013869
PTGES3	0.013866
VAMP3	0.013842
TMEM230	0.013810
TAGLN2	-0.013804
CAPZA2	-0.013754
RPL18	0.013703
PSMC5	0.013686