!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Mus musculus
!drug_name	Imiquimod
!smiles	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N
!drugbank_id	DB00724
!pubchem_cid	57469
!cell_type	psoriatic skin from back
!organism	mouse
!end_metadata
PLA2G4D	0.081923
FETUB	0.081134
TMPRSS11A	0.078346
SERPINA9	0.076829
S100A8	0.071544
LPO	0.070302
AKR1D1	0.068866
NMU	0.065032
FHL2	0.064784
GJB6	0.063415
CHI3L1	0.062833
KRT6B	0.061636
LRAT	0.061283
CDHR1	0.059241
TCF23	0.058894
PADI1	0.058026
LCN2	0.057857
SERPINB4	0.057242
FAM3D	0.055333
DEGS2	0.054188
SLPI	0.054142
KCNJ16	-0.053982
SLC7A11	0.053643
KRT77	-0.052923
MOS	0.052197
DAB1	-0.051698
SCGB1A1	-0.051086
CPXM2	-0.050949
PLA2G4E	0.050794
KLK12	0.048840
UPK3B	-0.048697
AQP5	0.048114
ALOX15B	0.047941
PLA2G4B	0.047562
DNMT3L	0.047406
S100A9	0.047006
KCNK1	0.046903
CGREF1	0.046839
KRT25	0.046115
KRT84	0.045487
KLK6	0.045357
SLC24A3	-0.045221
SAA1	0.045033
CA2	0.044949
FCGBP	-0.044696
STAC2	0.044616
SEMA3D	-0.044383
TMPRSS11E	0.043943
GJB2	0.043862
PRSS27	0.043782
KAZALD1	-0.043606
ADA	0.043553
TUBB3	0.043416
HAS3	0.042974
SLC43A1	-0.042542
KRT73	0.041695
UPP1	0.041497
IGFBP2	0.041458
SERPINB11	0.041448
MMP13	0.041370
TMEM229A	-0.041288
SH2D5	0.041186
KRT16	0.041111
PRSS12	0.040813
SLC2A12	-0.040535
IGF2BP2	0.040514
PKIB	-0.040259
TTPA	0.040234
RAB11FIP4	-0.040113
PITX1	0.040040
KCTD12	-0.039361
SOD3	-0.038991
C10orf90	-0.038965
BCMO1	-0.038801
SLC27A2	-0.038780
CYP4V2	-0.038714
TCHHL1	0.038320
ACHE	-0.038164
CCL3L3	0.038000
PENK	0.037816
OTOP2	0.037629
MYL7	0.037321
STAB1	0.037259
TPPP	-0.037167
PAQR7	-0.037151
FPR2	0.037141
GRIP1	0.036915
COL4A6	-0.036872
TRIM2	-0.036701
SGPP2	0.036662
GPHA2	-0.036457
PLS1	-0.036001
LRRC4	0.035973
CD96	-0.035919
LGI2	0.035834
LAMA1	-0.035813
RAB3B	-0.035753
TIE1	0.035598
ANKRD1	0.035591
PRR9	0.035579
DUOX1	0.035577
PRRG3	-0.035560
TESC	-0.035329
HS3ST6	-0.035254
ALDH1A3	0.035234
SLC6A4	-0.035215
ABLIM3	-0.035185
TRAT1	-0.034972
TYRP1	0.034940
FMO2	-0.034913
TMEM35	-0.034801
AFF3	-0.034801
CD7	-0.034385
RPTN	0.034103
PHLDA1	0.033983
TMEM119	0.033811
YPEL4	-0.033714
CRYGN	-0.033709
DUOXA1	0.033642
RND1	0.033636
IL36A	0.033321
BTC	-0.033269
PVRL3	-0.033207
CYP2W1	-0.033111
BBOX1	-0.033059
KRT24	-0.033054
ADH1C	-0.033050
IL1F10	-0.032752
KCNU1	-0.032705
KRT27	0.032689
SEBOX	-0.032590
P2RX2	-0.032541
ASB17	-0.032521
CCDC3	-0.032460
ELF3	0.032438
TSPYL4	-0.032405
SLC7A6	-0.032289
WISP2	-0.032156
PSPN	0.032011
PPARA	-0.031798
ARHGEF26	-0.031749
KCNH1	0.031583
STEAP1	0.031554
GPR37	-0.031425
GNA14	-0.031360
BMP4	-0.031309
TRANK1	-0.031232
CES1	-0.031107
ABCA5	-0.031040
CRLF1	-0.031039
PLA2G16	-0.030885
KCNJ12	0.030872
RAB31	0.030776
HBEGF	0.030746
KRTAP3-3	-0.030620
HSD17B2	0.030556
ACSM1	-0.030527
TNXB	-0.030294
SERPINB12	0.030283
MMP12	0.030277
NFE2	-0.030248
SHISA7	-0.030131
TMEM45B	0.030037
SECTM1	-0.029898
GEM	-0.029769
ASAP3	-0.029724
PIWIL2	0.029722
BCL2L14	-0.029715
GLDC	-0.029668
CYP26B1	-0.029594
IL34	-0.029547
SMPDL3B	0.029398
LTBP2	-0.029377
KRT32	-0.029120
TCEAL7	0.029079
GUCA2A	-0.029024
DAPL1	-0.028983
IL22RA2	-0.028866
NUDT4	0.028740
HEPH	-0.028728
IL17B	0.028721
IGSF3	0.028669
CYP7B1	0.028519
FAR2	-0.028512
IL1B	0.028506
IL15	-0.028458
CES4A	-0.028426
RASL10A	-0.028319
RBP2	0.028227
RBP1	0.028191
SIRPB1	0.027908
KLK9	0.027862
CDH4	-0.027808
CCL4	0.027752
IRX4	0.027657
MYH3	0.027636
MMP8	0.027564
NTF3	-0.027505
FPR1	0.027463
CYP4B1	-0.027452
TMEM177	-0.027411
FADS6	0.027410
KRT71	0.027366
THBD	0.027322
LOC729800	0.027229
TEX40	0.027162
TSPAN8	-0.027156
BFSP1	0.027155
LGR6	-0.027147
C11orf65	-0.027110
GPRIN2	-0.027096
CXCR2	0.027074
SPRR3	0.027039
PYY	-0.026985
IL20RA	-0.026886
PHLDA2	0.026868
FAM117A	-0.026852
PNPLA5	-0.026816
CCND2	-0.026795
ARSI	-0.026794
ANGPTL7	-0.026738
NKG7	-0.026581
TMEM117	0.026547
CD3G	-0.026522
FOS	0.026471
GALNT6	0.026315
ALDH1L2	0.026295
PLSCR4	-0.026248
GABRP	-0.026247
TGM3	0.026230
ENDOU	0.026216
EPGN	0.026180
SPP1	0.026147
TNNT1	0.026100
HSPA2	-0.026014
LPCAT4	0.026008
KCNG4	-0.025949
ATP13A4	0.025942
ARHGAP44	-0.025926
MLANA	0.025912
THBS3	-0.025905
ALOX5	-0.025892
KRT15	-0.025879
SHF	0.025773
GDNF	-0.025760
PAQR9	0.025756
PLA2G2D	0.025718
RSPO3	-0.025691
IRF4	-0.025689
GNG13	-0.025635
COL8A2	-0.025531
ATP2B4	-0.025445
KIF26B	0.025436
TUBB6	0.025386
UROC1	0.025351
SCNN1B	0.025246
BCL3	0.025238
ANO4	0.025200
GPR31	0.025149
ARSA	-0.025133
IFIT3	-0.025125
MYL2	0.025002
FAM221A	-0.024951
ENAH	0.024949
PRSS22	0.024947
SLC5A8	0.024902
FXYD4	0.024818
TMIGD1	0.024798
ESAM	0.024798
GJB1	0.024737
GAL3ST1	-0.024719
PSORS1C2	0.024715
SEMA4D	0.024708
C3AR1	0.024641
GPR84	0.024594
UACA	0.024566
TSLP	0.024553
CRACR2B	-0.024548
MAP6	0.024545
BDKRB2	0.024517
TTLL7	0.024389
DAGLB	-0.024350
PFKFB4	0.024337
TINAGL1	0.024284
SUCNR1	-0.024277
SYDE2	-0.024275
GSDMC	0.024228
GRK5	-0.024222
ABHD3	-0.024126
ALDH3A1	-0.024123
KLK4	0.024078
KCNQ4	0.024055
SOX18	0.024033
IL36B	0.024019
CAMK2N2	0.023956
FMNL2	0.023939
PTPN21	-0.023911
FGF18	-0.023906
NYAP1	-0.023899
IL31RA	-0.023893
MAD2L2	-0.023807
KLK10	0.023793
GPR35	0.023758
GCSAM	-0.023727
PDCD1	0.023725
SCNN1G	0.023669
PTGER4	-0.023632
RNASE6	-0.023601
GPX2	0.023589
FAIM3	0.023550
EBI3	0.023534
SLC37A2	0.023516
GNAT1	-0.023425
CAPSL	-0.023418
IRGM	-0.023406
AREG	0.023402
CLEC4D	0.023394
PELI2	-0.023392
ARG1	0.023387
MCU	-0.023379
ECHDC3	-0.023376
EMCN	0.023366
DHX34	0.023339
ANKRD9	0.023208
CYP8B1	0.023197
CD207	-0.023193
CCDC88B	0.023121
TMEM56	-0.023081
CEMIP	0.023074
IGFBP6	-0.023062
MCF2L	-0.023055
MICU1	-0.023035
NPR3	-0.023001
COL23A1	-0.022992
TNFRSF13C	-0.022958
MAN1C1	-0.022919
HIGD1B	0.022909
CREB3L3	0.022898
SLC10A6	0.022891
GPR110	0.022875
DCT	0.022827
RGS5	0.022824
NT5DC2	0.022823
WEE1	-0.022797
GLRX	0.022796
AQP3	0.022788
SIGLEC9	0.022741
HSD3B7	-0.022728
C6orf15	0.022726
ACKR4	-0.022682
SH3D21	-0.022617
UNC5B	-0.022616
SCIN	-0.022615
PPP1R3B	0.022611
GRAP	0.022587
HK2	0.022549
CGN	-0.022532
TRIM66	-0.022517
ADCY6	-0.022514
TXNDC16	-0.022462
ITGB8	0.022401
RAMP3	-0.022378
SMCO3	-0.022367
CYP1A1	-0.022348
TMIE	-0.022348
SLCO1A2	0.022312
EGFL6	-0.022243
CXCL3	0.022189
APLNR	0.022126
MARVELD2	-0.022051
PPIL6	-0.022033
GBP6	-0.022010
CAMKK1	-0.021980
GDPD2	-0.021978
BDH1	0.021954
RAP1GAP	0.021951
KIAA1045	-0.021879
SEC14L4	-0.021865
COL16A1	-0.021865
SMAD6	0.021854
CTHRC1	0.021749
SYT16	0.021673
SCARB1	0.021672
THY1	-0.021658
SERINC2	0.021648
ARL4C	-0.021624
FABP7	0.021613
PROM1	0.021593
FBP2	-0.021580
KLHL29	-0.021540
SLC34A2	0.021528
FGF3	0.021486
DBP	-0.021451
ALAD	-0.021450
ISX	0.021414
SKIL	0.021408
HLF	-0.021399
PRSS23	-0.021377
SORBS3	-0.021347
LYVE1	-0.021318
SERPINB1	0.021305
MAP3K6	0.021288
ELTD1	0.021224
PCDHB3	0.021194
ZNF395	-0.021188
THBS2	-0.021170
IRF7	-0.021119
SLC5A1	0.021106
TNFRSF11B	-0.021088
KRTAP4-9	-0.021083
LPIN2	0.021051
PIK3IP1	-0.021031
EPHX1	-0.020987
AMY2A	-0.020971
MYOZ2	0.020959
C12orf39	0.020901
CD300C	0.020898
F2R	-0.020894
SORCS2	0.020892
ITGB6	0.020803
CASQ2	0.020722
SPRED3	0.020713
MEIOB	-0.020684
OLIG1	-0.020673
VSIG8	0.020635
PROSER2	0.020612
KRT23	-0.020605
IL1R2	-0.020550
PGLYRP1	0.020541
ZNF704	-0.020519
IKZF2	-0.020518
GRAMD1B	-0.020511
MAOB	-0.020498
MAGI3	0.020494
RHPN2	-0.020486
ARHGDIG	0.020466
SYT4	0.020451
TSC22D3	-0.020411
ARMCX1	-0.020409
GNE	0.020396
PDE9A	0.020382
HIST1H2BJ	-0.020381
KLF7	0.020372
TIRAP	0.020358
CAPN12	0.020353
PROCR	0.020350
PTPRZ1	0.020349
CD3E	-0.020343
BCL2L15	0.020322
WNK4	-0.020276
PAK3	-0.020267
CTSC	0.020243
SNCG	-0.020239
SLC23A3	-0.020232
DPPA2	0.020227
STK10	-0.020221
FAM81A	-0.020216
DUSP18	-0.020214
MMRN2	0.020209
PDE12	0.020201
MYOG	0.020194
FA2H	-0.020163
CCR6	0.020133
MAFB	0.020080
TLE6	0.020077
OOEP	-0.020057
CCL24	-0.020049
KCNC4	0.020046
RHBDL3	-0.020019
MESP2	-0.020018
HSDL1	-0.019992
PI15	0.019989
HSF2	-0.019989
SFRP4	-0.019985
AGR3	-0.019961
IL6R	-0.019944
OGFRL1	-0.019941
WIPF3	-0.019940
VEGFA	0.019939
HPGD	0.019922
EPAS1	0.019904
KCNK16	0.019901
ZNF667	-0.019841
CD3D	-0.019826
FAM46B	0.019811
AGO4	-0.019804
GSTO1	0.019765
THSD1	0.019751
ELK3	0.019727
SAMD12	0.019711
SATB1	-0.019688
LMO4	-0.019686
PILRA	0.019666
PRAMEF12	-0.019645
BAG2	0.019635
CYP2F1	-0.019620
SVEP1	0.019617
TNNI1	0.019592
WNT3	-0.019579
HLA-G	-0.019568