!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!ligand_name	17beta-estradiol
!ligand_id	CHEBI:16469
!cell_type	U2OS osteosarcoma cell line
!organism	human
!end_metadata
MAD1L1	0.240431
KRT19	0.235586
ETFB	0.199149
MATN1	0.191070
VIM	-0.175962
ANXA2	-0.168613
CST3	0.167798
LAPTM4B	0.155898
HLA-A	0.141965
MUC1	0.141469
S100A2	-0.138373
MT2A	-0.135921
HSPA8	-0.135440
CYR61	-0.126640
EXT2	0.118984
FKBP4	0.116222
HN1	-0.107962
TMSB10	-0.103890
CLIC3	0.098541
HSPB1	-0.097039
CAPN2	-0.090163
SDC4	0.089830
UBE2S	0.085052
KRT18	-0.083488
LDHA	-0.083334
COX8A	0.081209
HLA-C	0.080809
HSPD1	-0.079693
C3	0.079630
CHPT1	0.079419
HSP90AA1	-0.076514
HMGA1	-0.076173
HLA-B	0.075373
ACTB	-0.074098
RGS10	0.073566
SFN	-0.073554
HSP90AB1	-0.072836
CEBPB	0.072432
CST1	0.067770
SLC9A3R1	0.067757
FKBP1A	-0.063655
GPR56	-0.062209
RPS5	0.060442
ENO1	-0.059495
SLCO4A1	0.059074
SRI	-0.058983
UBA1	0.058571
IRAK1	-0.058149
VWF	0.058139
RPS28	0.056734
MARCKSL1	0.056416
EIF4A1	-0.055773
LDHB	-0.054200
PAPSS1	0.053820
EPHX1	0.053579
NFKBIA	0.052966
PTTG1IP	0.051854
CKB	0.051096
INHBA	-0.050246
ARPC1A	0.050117
ALDH2	0.049584
CORO1C	-0.048204
PKM	-0.046853
INPP5A	0.046440
OAZ1	0.046357
SDCBP	0.046187
RPS17	-0.045887
LSR	0.045736
HOMER2	0.045580
RPL7	-0.045267
MT1X	-0.045198
BLVRB	0.045186
PABPC3	0.044000
IL32	0.043904
TUBA1A	0.043673
ODC1	-0.043611
YWHAZ	-0.042725
LAMB3	-0.042123
LY6E	0.041802
GAA	0.041506
UPF1	0.040938
JAK1	0.040778
ANXA1	-0.040286
TIMP1	-0.039585
EEF1A1	0.039387
TYMS	-0.039046
COL18A1	0.038760
LGALS1	0.038744
RANBP1	-0.038534
CILP	0.038485
ABCA3	0.038346
GPER1	0.037835
TGM2	-0.037791
TPM1	-0.037780
RPL37	0.037612
NME1	-0.037601
CALM2	-0.037419
RPL18	0.037142
NNMT	-0.037140
EIF1	0.037041
CD59	0.037008
PABPC1	0.036285
CA2	-0.036089
IFT27	0.035999
DHCR7	0.035976
IDH2	0.035868
GCH1	0.035846
EEF1A2	0.035676
TPT1	0.034849
CCT3	-0.034782
FLNC	-0.034754
TFF1	0.034391
PTMA	0.034262
UNC13B	0.034073
COX6A1	0.033733
TUBB	-0.033676
DCXR	0.033553
RGS19	0.033490
RHOC	-0.033436
RPL24	-0.033426
UPP1	-0.033330
MXRA7	-0.033222
FHL2	-0.033156
LTBP1	0.032959
RPL22	-0.032952
IMPDH2	-0.032853
PHF11	0.032811
HLA-G	0.032775
UBB	0.032627
ANXA5	-0.032536
ANXA11	0.032372
AXL	-0.032344
FDXR	0.032218
UFD1L	0.032209
AKAP1	0.032156
SLCO2A1	0.032039
GLRX	-0.031676
PCBP1	-0.031610
ATP6V0C	0.031552
NFE2L1	0.031540
FBN2	-0.031430
RPL11	0.031377
TIMP3	0.031275
CALB2	-0.031251
APOBEC3B	0.031175
GALNT1	0.031158
RPL28	0.031141
CD300C	0.030993
GSTO1	0.030841
CST4	0.030734
CTGF	-0.030686
HIF1A	-0.030551
HNRNPA1	-0.030396
HPCAL1	0.030359
CAPNS1	-0.030314
HAX1	0.030219
EXT1	-0.030214
CNN2	0.030183
TPBG	0.030028
CSRP1	-0.029856
NPM1	-0.029776
RPS11	0.029645
SDF2L1	0.029575
HK1	0.029572
RPL41	0.029420
S100A10	0.029258
RPS21	-0.029118
RPL5	-0.029067
SNAPC1	-0.028812
RTN4	-0.028725
H2AFZ	-0.028680
MT1H	-0.028670
IFITM3	0.028491
RPS12	-0.028322
ARF5	0.028319
RTN2	0.028117
C20orf24	0.028051
NCOR2	-0.027936
GADD45A	-0.027564
EIF3E	-0.027428
CLIC1	-0.027355
PRDX1	0.027272
MIF	0.027192
SOD1	-0.027004
PPA1	-0.026941
SERPINE1	-0.026908
RPL23A	0.026853
DUSP1	-0.026814
CAP1	-0.026763
CCT2	-0.026622
DYNLT1	0.026488
ID1	-0.026328
KRT81	-0.026322
PDHB	-0.026212
ZFP36L1	-0.026170
NSG1	0.026042
ASS1	0.026006
TPI1	-0.025633
MDK	0.025625
HSPH1	-0.025610
PEA15	-0.025529
CAPRIN1	-0.025482
DDX21	-0.025458
APEX1	-0.025379
F13A1	0.025077
LAMC1	0.025001
CELSR2	0.024875
EIF4A2	0.024837
KRT17	-0.024784
ID2	0.024719
OVGP1	0.024670
HMGN2	0.024657
HOXC10	0.024597
TJP1	-0.024539
COX6C	0.024497
CTSB	0.024331
COX7A2	0.023975
SLC6A8	0.023974
CCT4	-0.023957
NBN	0.023946
ATP2A2	0.023802
CYP1A1	0.023584
MAPRE1	0.023523
RPS9	0.023455
SFPQ	-0.023421
DDAH1	-0.023400
RPS3	0.023275
SARAF	-0.023210
GNAI3	-0.023189
TNPO3	0.022836
PDGFC	-0.022639
SKP1	0.022512
SOX4	-0.022437
RAN	-0.022365
PSMD2	-0.022343
HMGB1	-0.022341
GABRD	0.022301
KRT8	-0.022297
RPS19	0.022270
ALCAM	-0.022222
ILK	0.022179
ALPP	0.022145
GAS6	0.021972
GDI2	-0.021892
CTBP1	0.021602
AGPAT1	0.021524
RPL13A	-0.021492
HSP90B1	0.021475
PPP4R1	-0.021467
ST3GAL1	0.021402
OXT	0.021087
GPC1	0.021086
SLC38A2	-0.021000
FST	0.020936
RAB31	-0.020917
NFATC1	0.020896
CST2	0.020872
HNRNPAB	-0.020713
GALK1	0.020622
ITM2B	0.020612
PODXL	-0.020610
RPL30	0.020572
IKBKG	0.020545
RND3	-0.020444
CKS2	-0.020414
GNB2L1	-0.020332
FABP5	-0.020304
VDAC3	-0.020277
LAPTM5	0.020262
SERPINE2	0.020133
DSTN	-0.019869
ID3	-0.019862
PSMG2	-0.019647
CCND1	0.019625
LSS	0.019603
RPL19	-0.019576
STUB1	0.019467
FHL1	-0.019334
CYC1	0.019306
MYRF	0.019298
ATIC	-0.019255
S100A11	-0.019244
BCR	0.019206
FLII	0.019197
CEBPD	0.019191
C14orf2	0.019176
GHRHR	0.019162
PTS	0.019052
RALB	-0.019023
RCE1	0.018968
TUBB4B	-0.018938
PTPRF	0.018890
LMNA	0.018872
GSTT1	0.018820
KLK6	-0.018810
NONO	-0.018742
GPRC5A	-0.018595
PAICS	-0.018568
CDK4	-0.018520
CASP7	0.018466
RAB36	0.018441
SRSF2	-0.018430
TNIP1	0.018422
ADSL	-0.018359
TXNRD1	-0.018318
DKC1	-0.018234
LBR	-0.018213
BCL2L1	-0.018185
NHP2L1	-0.018183
MYH9	-0.018056
CCT8	-0.018045
PTPRU	0.017997
MYC	-0.017886
ABCE1	-0.017833
BLMH	0.017799
RALA	0.017784
POLR2F	0.017752
KCNB1	0.017618
CBX1	-0.017612
VDAC1	-0.017528
ZYX	-0.017527
RPLP2	0.017525
CTPS1	-0.017513
SDS	0.017465
NDN	-0.017450
HNRNPA2B1	-0.017413
ARF1	0.017374
RPS27A	0.017336
TMED10	0.017336
ATP5B	-0.017320
GABBR2	0.017312
CCT6A	-0.017307
RPS24	-0.017306
APBB1	0.017301
EIF4G2	-0.017236
CLTC	-0.017197
SHFM1	-0.017195
DFNA5	-0.017042
PAPSS2	0.017019
MGST3	-0.017011
GJA1	-0.016997
TMBIM6	0.016981
SUCLG1	-0.016973
PSMC2	0.016917
RPS14	0.016819
ACO2	0.016809
EDF1	0.016800
KLF10	-0.016789
PGK1	-0.016785
RPS15A	-0.016762
BHLHE40	-0.016723
IL7R	-0.016698
CLCN4	0.016629
NACA	-0.016586
COPE	0.016513
TESK1	0.016501
PHLDA2	0.016487
RPL21	0.016454
RPS15	0.016429
HSD17B4	0.016418
SH2B3	0.016402
LRPAP1	0.016389
USP14	-0.016380
PLOD2	0.016341
DLC1	-0.016331
PCNA	-0.016303
RER1	0.016282
GRHPR	0.016243
COL4A1	-0.016215
CLDND1	0.016186
ATP5J2	0.016139
NPR2	0.016116
SOX9	-0.016108
KTN1	-0.016108
NOP56	-0.016102
ACOX2	0.016082
SMS	-0.016037
PON2	-0.016000
MAFF	0.015935
NCL	-0.015935
ANXA10	-0.015922
GALNT2	-0.015888
SLC6A3	0.015852
MYOF	0.015827
PTGES3	-0.015807
LIMS1	-0.015794
JUND	0.015785
COX17	0.015779
NR2F6	0.015764
SRM	-0.015757
MTHFD1	-0.015751
HNRNPM	-0.015705
PRMT1	-0.015704
BANF1	-0.015704
IPO7	-0.015581
ITGA3	-0.015570
IGHMBP2	0.015570
ITPR1	0.015566
IER2	-0.015494
S100A6	-0.015478
TARDBP	-0.015472
KRT10	0.015390
LLGL2	0.015356
SNAI1	0.015351
SEC61A1	0.015298
RPA3	0.015295
GDI1	0.015284
EZR	0.015241
KARS	-0.015240
RGS3	0.015220
PSMB4	0.015171
SFRP1	-0.015171
RPL37A	-0.015132
CDC20	-0.014955
MAP2K1	0.014910
HSPE1	-0.014893
HOXC11	0.014883
ATP1A1	-0.014881
H2AFY	-0.014876
PSMB1	0.014857
MCM3AP	0.014856
RPL36A	-0.014761
ANP32A	-0.014712
ARL6IP5	-0.014684
YBX3	-0.014671
ERGIC3	0.014658
RAC1	-0.014574
RNPS1	-0.014567
RPS13	-0.014498
PRDX2	0.014495
CNN3	-0.014442
MRPL3	-0.014438
RPS6KA2	0.014427
PHB	-0.014386
PTOV1	-0.014330
PTPRM	0.014324
NDRG4	0.014318
RHOQ	0.014303
TAF6	-0.014284
TNPO1	-0.014284
LTA4H	-0.014275
SEMA3B	-0.014268
PRDX4	-0.014259
KHDRBS1	-0.014247
SLCO2B1	0.014240
PTP4A2	0.014232
ATXN10	-0.014223
EEF1D	-0.014182
CHST8	0.014175
SLC20A1	0.014164
MBOAT7	-0.014161
WNT5A	-0.014153
SEPT7	-0.014110
EIF4B	-0.014075
PPP1R11	0.014003
RPN2	0.013977
CYB5R3	0.013972
SLC6A4	0.013964
GINS2	0.013935
RPL27A	0.013930
NAGA	0.013885
BAG6	0.013880
CTNNAL1	-0.013850
PRNP	-0.013799
MTCH2	-0.013750
PEMT	0.013719
FUT8	-0.013686
RPL38	0.013671
SH3BGRL3	-0.013652
YWHAH	-0.013633
DYNLL1	-0.013615
TSTA3	-0.013562
MCM2	-0.013515
CHCHD2	0.013514
SELT	-0.013508
TNNC1	0.013471
MTCH1	-0.013462
TH	0.013434
COX7A2L	0.013406
WNK1	0.013397
RPL12	-0.013385
SQLE	-0.013380
PPAP2C	0.013362
ATP6V0B	0.013334
FLNA	-0.013312
CA12	0.013293
CD151	-0.013282
EDN1	-0.013247
CTSZ	0.013197
ISG20	0.013162
POLR2B	-0.013148
CYCS	-0.013115
WBSCR22	-0.013100
HIST1H2AC	-0.013091
MPC1	0.013085
XRCC6	-0.013077
GLTSCR2	0.013076
CSTB	-0.013064
RPL7A	0.013057
CCND2	0.013033