!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!organism	Homo sapiens
!cell_type	MCF7cells
!pert_name	isoleucine
!pert_id	PubChemCID:6306
!organism	human
!pert_type	chemical
!end_metadata
SLC7A11	0.067938
SLC7A11	0.066670
CLGN	0.063356
CHAC1	0.059473
INHBE	0.059273
METTL7A	-0.054865
TNFAIP3	0.054317
ASNS	0.053281
FAM129A	0.053243
PHGDH	0.052266
KLHL24	0.051711
DDIT4	0.049539
VEGFA	0.048857
SLC7A5	0.048095
DHFR	-0.046820
VEGFA	0.045475
KLHL24	0.045291
DHFR	-0.044919
DHFR	-0.044719
GDF15	0.044426
SLC3A2	0.044320
ASCL1	-0.044123
ASS1	0.044067
ATF3	0.043194
HMOX1	0.042477
SKP2	-0.042460
FEN1	-0.042457
DHFR	-0.042280
DDIT3	0.042208
GADD45A	0.042203
MCM6	-0.041401
LRP8	-0.041231
VEGFA	0.041118
MCM10	-0.041000
ASCL1	-0.040601
DCLK1	0.039855
TYMS	-0.039821
FEN1	-0.039773
MICB	-0.039519
TRIB3	0.039389
MAP1B	0.039162
LRP8	-0.039015
LHX2	-0.038635
CEBPG	0.038630
RPS6KA2	0.038605
PCK2	0.038399
TNFAIP3	0.038184
VEGFA	0.037904
TIMP3	0.037874
DTL	-0.037582
TSC22D3	0.037579
FAM129A	0.037501
ASF1B	-0.037202
PMP22	-0.036817
TK1	-0.036719
PIP5K1B	0.036506
STEAP1	0.036145
BTG2	0.035430
KCNJ8	-0.035391
ORC1	-0.034992
PPP1R15A	0.034964
DLX2	0.034473
MCM7	-0.034458
SCD	-0.034353
MCM5	-0.034194
EFNA1	0.034093
TXNIP	0.034047
KCNJ8	-0.034004
CDC45	-0.033942
IRF7	0.033894
TIMP3	0.033853
LAMP3	0.033434
CCL20	0.033430
IFIT1	0.033209
FGF18	0.032918
POLA2	-0.032881
GTPBP2	0.032815
ICAM1	0.032802
CLIC4	0.032557
CDK2	-0.032455
IER5	0.032450
FAS	0.032373
TSC22D3	0.032223
SRSF7	-0.032186
SLC7A11	0.032180
ANXA6	-0.032140
RIBC2	-0.032126
RBM14	-0.032097
MCM7	-0.031989
JUN	0.031942
MCM5	-0.031751
TUBG1	-0.031732
CDC6	-0.031474
CDK1	-0.031443
NFIL3	0.031371
MAFF	0.031349
GEM	0.031156
SOX9	0.031128
S100P	0.031048
TIMP3	0.030960
DUT	-0.030730
CDC6	-0.030590
JUN	0.030557
SCD	-0.030369
CHRNA5	-0.030343
TRIP13	-0.030187
CENPU	-0.030174
TXNIP	0.030142
POLE2	-0.030073
NUPR1	0.030041
EPAS1	0.029669
SLC7A1	0.029622
RRM1	-0.029343
DUT	-0.029270
EIF1	0.029112
MCM3	-0.029085
TUBB	-0.029072
EIF4EBP1	0.029069
CDK1	-0.028964
PPP1R15A	0.028848
KLF4	0.028833
NPY1R	-0.028639
EIF1	0.028591
CD55	0.028570
CDK1	-0.028436
SGCB	-0.028376
HERPUD1	0.028366
PLAC1	0.028229
EIF1	0.028198
SRSF3	-0.028181
HSPA2	-0.028165
ENO2	-0.028134
TUBB6	-0.027950
ATF4	0.027841
CTNNAL1	-0.027808
LMO4	0.027657
DCLK1	0.027650
JUNB	0.027599
ACAT2	-0.027587
SLC7A1	0.027586
SLC1A4	0.027550
YARS	0.027307
PFKP	-0.027278
RFC3	-0.027235
SCD	-0.027228
MARS	0.027203
GALNT12	-0.027195
CCNE2	-0.027138
CDKN1A	0.027065
PPM1E	0.027058
SOX9	0.026996
NFKBIA	0.026996
SLC16A3	-0.026974
FDFT1	-0.026957
SNHG17	0.026954
ENO1	-0.026917
HSPA14	-0.026892
MARS	0.026882
ENO1	-0.026860
RELB	0.026837
CLIC4	0.026808
ETFB	-0.026781
RSRP1	0.026756
TXNIP	0.026712
MCM2	-0.026692
FDFT1	-0.026692
RRM1	-0.026664
HSPA6	0.026664
SRR	-0.026640
SRR	-0.026637
PRLR	0.026599
CARS	0.026563
TMSB15A	-0.026469
DHRS3	0.026418
DUT	-0.026389
CEBPB	0.026376
MCM4	-0.026365
CCNE2	-0.026288
DSCC1	-0.026262
TNFRSF10B	0.026253
DLGAP5	-0.026191
STAU2	-0.026088
BRCA1	-0.026039
CENPI	-0.026021
CARS	0.025972
HELLS	-0.025957
IFRD1	0.025943
STC2	0.025911
ASCL1	-0.025900
GLS	0.025859
MSMO1	-0.025837
RFC3	-0.025824
FABP5	-0.025700
KCNS3	-0.025678
TMEM97	-0.025631
TARS	0.025628
CLIC4	0.025467
XPOT	0.025410
NES	-0.025371
SOX4	0.025350
NUP85	-0.025322
CDC25A	-0.025289
TYRP1	0.025210
AOX1	-0.025205
RDH16	0.025191
MARS	0.025161
AKR1C1	0.025084
MIR22HG	0.025078
ERCC6L	-0.025061
DNAJB9	0.025045
FDPS	-0.025007
RRM2	-0.024979
BBC3	0.024907
H2AFJ	-0.024885
RBM12	-0.024842
ALDOC	-0.024830
PSPH	0.024808
IRF1	0.024799
BRINP2	-0.024760
MAP1LC3B	0.024746
ANKRD11	0.024722
SHMT2	0.024605
RND3	0.024592
SCD	-0.024568
MCM4	-0.024527
GARS	0.024520
GINS1	-0.024520
ADD3	-0.024484
C6orf48	0.024454
PCDH7	-0.024443
CD44	0.024424
BDH1	-0.024423
KRT81	0.024417
FAS	0.024405
SFPQ	0.024383
SNX7	-0.024344
TCP1	-0.024336
PYGL	-0.024300
KIAA0907	0.024204
ABCA1	0.024175
C2orf49	0.024118
N4BP3	0.024114
TMEM97	-0.024013
RSL24D1	0.024002
WDR76	-0.023999
BLM	-0.023961
ELOVL6	-0.023946
GNA13	0.023942
COCH	-0.023931
ULK1	0.023926
HPRT1	-0.023924
SPC25	-0.023905
PTPN2	0.023885
TMEM97	-0.023880
STC2	0.023829
MAP1LC3B	0.023794
RNF187	0.023724
ZFX	0.023659
LINC00341	0.023640
HAUS5	-0.023634
RBCK1	0.023582
KCNE4	0.023493
CBX4	0.023418
TUBB4B	-0.023392
LDHB	-0.023353
FGF18	0.023349
TIPIN	-0.023347
RAD54L	-0.023331
ICAM1	0.023322
TANC2	0.023320
CENPI	-0.023298
POLA1	-0.023277
C9orf114	-0.023211
CD55	0.023195
VRK1	-0.023174
KDM6B	0.023139
TUBB4B	-0.023115
MCM4	-0.023089
NFE2L1	0.023089
BRINP3	-0.023078
MSH6	-0.023025
SLC1A4	0.023013
LSM5	-0.022979
TNFRSF10B	0.022934
BIRC3	0.022872
GINS4	-0.022860
BCL3	0.022860
SKP2	-0.022839
ALDH9A1	-0.022778
WAC	0.022737
MGP	-0.022734
RET	-0.022721
SHMT2	0.022705
RAD51	-0.022700
CCNG2	0.022696
MGLL	0.022665
MCM4	-0.022651
AGA	0.022641
SARS	0.022567
SLC35E2	0.022566
ALDH3B2	0.022565
SQLE	-0.022561
FAS	0.022531
CDT1	-0.022513
ADH5	-0.022477
FANCI	-0.022467
BCL6	0.022418
AURKB	-0.022383
BCL6	0.022377
CD44	0.022360
SUCLG1	-0.022359
PQBP1	0.022346
INSIG1	-0.022330
KCTD15	0.022287
LARP6	0.022255
PRPS2	-0.022254
CBS	0.022246
ECI2	-0.022212
TNF	0.022206
OAS1	0.022191
CUTC	-0.022183
CLK4	0.022179
MLLT11	-0.022179
GPER1	-0.022166
UGT2B17	-0.022152
FANCI	-0.022150
GJA1	-0.022134
ARHGEF2	0.022119
SKIL	0.022115
PQBP1	0.022111
ILF2	-0.022097
MTHFD2	0.022045
MARCKS	0.022041
CDK2	-0.022012
WDR33	0.022006
INSIG1	-0.021995
DOCK10	-0.021881
YAF2	0.021850
RBL1	-0.021790
KLF4	0.021758
GALE	-0.021706
MARCKS	0.021685
STOM	0.021682
CLIP1	0.021593
MSH2	-0.021576
ELOVL6	-0.021568
RET	-0.021555
IFRD1	0.021548
BCAT2	-0.021532
AARS	0.021512
TUBA4A	-0.021501
RECQL4	-0.021497
MLH1	-0.021488
HPSE	-0.021442
IVNS1ABP	-0.021410
MTHFD1	-0.021367
SRSF2	-0.021358
CD44	0.021327
DSN1	-0.021314
TUBB	-0.021293
MSH6	-0.021288
RRM2	-0.021273
NFE2L1	0.021269
FH	-0.021259
TES	0.021247
TOB2	0.021244
FH	-0.021232
TUBB3	-0.021226
SQLE	-0.021208
WARS	0.021196
ADD3	-0.021186
INSIG1	-0.021140
SUB1	-0.021117
H2AFX	-0.021114
KDELR3	-0.021110
IMPA2	-0.021095
HMGCS1	-0.021093
AEN	0.021080
BCKDK	-0.021057
XRCC6	-0.021055
KPNA4	0.021043
TES	0.021042
HNRNPDL	-0.021024
PODXL	-0.020981
C9orf91	0.020926
PHTF2	-0.020910
GINS2	-0.020904
TCP1	-0.020870
TUBB3	-0.020806
KLF9	0.020762
TCP1	-0.020736
SLC1A4	0.020733
FYN	0.020711
KDELR3	-0.020703
CENPQ	-0.020700
U2SURP	-0.020673
ADD3	-0.020649
CA12	-0.020645
MUC5B	0.020617
RAD54B	-0.020612
GABPB1	0.020598
TCEA2	-0.020577
PVRL3	-0.020565
PCYT2	-0.020564
UPF2	0.020536
CENPN	-0.020531
NDUFS1	-0.020505
UBE2N	-0.020501
CALR	-0.020501
RFC4	-0.020500
RIMS3	-0.020478
FANCA	-0.020455
IARS	0.020421
CSPG5	-0.020398
CAV1	-0.020375
TUBB	-0.020373
KLF5	0.020350
CYP1A1	0.020331
KLF10	0.020328
EIF2B3	-0.020304
ESRP1	0.020273
ATAD2	-0.020216
RAD51AP1	-0.020182
QPRT	-0.020177
ZMAT3	0.020173
SRSF6	-0.020152
NFE2L1	0.020147
GRB10	0.020145
RAD54B	-0.020120
KLF9	0.020120
LOC81691	-0.020114
HPGD	0.020106
H2AFX	-0.020098
CAV1	-0.020083
SLC38A6	-0.020077
ASMTL	-0.020039
TACC3	-0.020025
AHR	0.020009
FIP1L1	0.019943
ACKR3	-0.019911
SNRNP25	-0.019904
NCAPD3	-0.019883
OGT	0.019868
CAV2	-0.019865
TIMELESS	-0.019842
EFEMP1	-0.019810
C8orf33	0.019796
TNFRSF10B	0.019791
ANXA3	0.019790
MSMB	-0.019789
NUBP1	-0.019783
CSRP2	-0.019749
VEZF1	0.019719
PNRC1	0.019717
PTPN2	0.019717
CD44	0.019697
SALL2	-0.019691
PCDH9	-0.019651
KLF3	0.019622
EXOSC9	-0.019613
PCYOX1L	-0.019598
KLF5	0.019578
SLC1A5	0.019564
LDLR	-0.019563
CARD10	-0.019555
STOM	0.019548
C9orf3	0.019526
IVNS1ABP	-0.019506
PSPH	0.019463
HIST1H3B	0.019434
LDLR	-0.019433
CCDC170	0.019427
HIST1H4H	0.019423
SHMT2	0.019422
SMYD3	-0.019404
MLF1	-0.019398
N4BP2L2	0.019362
KDELR3	-0.019362
CPM	-0.019362
ASMTL	-0.019356
MEX3C	0.019352
ADM	0.019352
PBK	-0.019338
NCAPG2	-0.019328
CSE1L	-0.019319
SAT1	0.019316
PRPS1	-0.019276
LSM5	-0.019276
PNP	-0.019272
FADS1	-0.019249
SGPL1	0.019247
VWA8	-0.019241
HRK	0.019228
PCNA	-0.019225
PARP6	0.019224
TEAD4	-0.019198
PDK3	-0.019183
LCN2	0.019160
CA12	-0.019152
MKNK2	0.019132