!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	human
!drug_name	Morphine
!smiles	CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(C=C4)O
!drugbank_id	DB00295
!pubchem_cid	5288826
!cell_type	Striatum - DBA/2J mice - Chronic morphine treatment
!organism	mouse
!end_metadata
PTGDS	0.251477
CCDC14	0.098935
SESN3	-0.092320
EGR1	0.089402
TUBA1A	-0.089362
PISD	-0.087650
TTR	0.087021
RABGGTA	0.081496
ZBTB16	0.070986
RNF145	-0.070077
SERPINE2	-0.068985
ARC	0.068204
NAP1L5	-0.063729
PGRMC1	-0.062714
ELMOD1	-0.062129
PENK	-0.060203
UBL3	-0.059699
SGK1	0.058101
TMA7	0.056280
GNG7	-0.056274
CALR	-0.056247
CD81	-0.056232
ACTG1	-0.055890
PDE1B	-0.055587
ZCCHC12	-0.055194
NCKAP1	-0.055176
CCK	0.055161
RPL10A	-0.054412
ANKRD63	-0.052271
APOE	0.051036
FAM71F1	-0.050944
CTXN1	-0.050052
IMP4	-0.049952
YWHAE	-0.048750
RPL10	-0.048648
PPP1R1B	-0.048276
NCDN	-0.047928
TSC22D3	0.047800
FOPNL	-0.047654
TUSC2	-0.047608
ARL3	-0.047542
BSG	-0.047476
TUBA1B	-0.047267
CTRB2	0.046485
RARB	-0.046040
ZIC1	-0.045979
RPL3	-0.045888
ZCCHC18	-0.045679
GNB2	-0.045625
NR4A1	0.045158
SLC2A1	0.045153
GPR155	-0.045035
PFDN6	-0.044440
RPL27A	-0.044391
HSP90AB1	-0.044352
GPR6	-0.044138
PPP2R1A	-0.044075
PLP1	-0.043876
TSPYL4	-0.043781
PCP4	-0.043581
MERTK	0.043506
ID4	-0.043441
OAZ1	-0.043187
TRIM46	-0.042988
LPPR4	-0.042935
OLFM1	0.042659
WASF1	-0.042652
DENND5A	-0.042519
CELF5	-0.042416
NRN1	0.042153
FAM102B	-0.041894
MAN1A1	-0.041666
FABP7	-0.041594
NGEF	-0.041367
TCP1	-0.040759
LSM14B	-0.040665
AKAP11	-0.040123
PCSK1N	0.040040
RPL7A	-0.039845
GABRA4	-0.039525
C8orf46	0.039421
DRD1	-0.039369
BLCAP	-0.039243
APOD	0.039069
ATP2B1	-0.039016
GPRASP1	-0.038942
NPTX1	0.038652
BEX1	-0.038638
HTRA1	0.038557
ASIC4	-0.038176
DZANK1	-0.038142
CYP46A1	-0.037745
PPAP2B	-0.037705
RGS10	-0.037539
RPS15	-0.037436
NDUFA1	-0.037353
TRAM1L1	-0.036914
UQCRB	-0.036855
RHEB	-0.036793
SNX3	-0.036780
SLC17A7	0.036699
VAT1L	-0.036656
MGP	0.036509
GAP43	-0.036479
TTC9B	0.036402
BAI2	0.036278
EIF4A2	-0.036260
BCL11B	-0.036223
NNAT	-0.036131
NGFRAP1	-0.036061
CHST1	-0.035920
TMEM178A	0.035440
OLIG1	-0.035328
QDPR	-0.035320
ARMCX2	-0.035282
MAGEE1	-0.035057
DNAJB14	-0.034912
DBP	-0.034853
ZDBF2	-0.034735
GOLGA7	-0.034679
EIF5A	-0.034623
RSL24D1	-0.034555
DCLK3	-0.034391
LZTS3	-0.034360
MGLL	0.034302
DNAJB9	-0.034285
DRD2	-0.034094
C14orf1	-0.034001
HNRNPU	-0.033914
NKIRAS1	-0.033743
NDN	-0.033723
SYNPR	-0.033610
ST8SIA3	-0.033536
CACNA2D3	-0.033224
TUBB2B	-0.033176
HPCAL4	-0.033067
LMO2	-0.032981
MRFAP1	-0.032803
UGT8	-0.032800
SCN3B	-0.032643
KLHL13	-0.032639
GABRB3	-0.032427
DARS2	-0.032377
PNMAL2	-0.032353
TUBA4A	-0.032288
HMP19	-0.032237
LRRC19	-0.032235
PDE10A	-0.032051
PTCH2	-0.031905
RAB3GAP1	-0.031867
PMM1	0.031726
FKBP1A	-0.031691
SCN1B	0.031613
RPL38	-0.031516
ACTB	-0.031209
ITM2C	-0.031164
TMEM50B	-0.031137
EFNB3	-0.031057
MEIS2	-0.031036
SCG2	-0.030991
RHOB	-0.030950
SH3GL3	-0.030940
COX4I1	-0.030835
KCNAB1	-0.030658
YWHAZ	-0.030570
HTR2C	-0.030563
EFHD2	0.030486
GNB5	-0.030444
CA2	-0.030389
KIFAP3	-0.030335
GSTM3	0.030310
ATP5B	-0.030267
OSBPL8	-0.029970
POLR2K	-0.029943
SNCA	-0.029835
RPL28	-0.029835
CEPT1	-0.029773
VDAC1	-0.029587
G3BP2	-0.029508
PRKAR2B	-0.029450
UBC	-0.029440
RAP1A	-0.029410
NDUFA13	-0.029406
METTL9	-0.029298
ALCAM	-0.029260
RPS17	-0.029228
SLC35D3	-0.029181
CAP1	-0.029172
VBP1	-0.029101
KIAA1024L	-0.029096
CNR1	-0.029020
EEF1E1	-0.028772
TUBB4A	-0.028735
CCAR2	-0.028661
GPR88	-0.028661
CCDC90B	-0.028517
ARHGAP33	-0.028415
CDK17	-0.028324
HSD3B1	-0.028297
NDUFA4	-0.028186
TSPAN3	-0.028138
CA11	-0.028118
ENOPH1	-0.028108
TMCC2	-0.028042
ADCY1	0.028038
R3HDM2	-0.028000
GLRX5	-0.027964
CHGB	0.027946
XBP1	-0.027844
TFB2M	-0.027819
ATP6AP2	-0.027809
PRKCH	-0.027758
FAM107A	0.027756
CALY	-0.027692
CCT6A	-0.027662
RPL4	-0.027647
LAMTOR1	-0.027624
TCTE1	0.027559
MDH2	-0.027553
HSPA5	-0.027519
THY1	0.027499
RUNDC3B	-0.027351
COX5A	-0.027309
KIAA1462	-0.027232
TMEM158	-0.027168
VTI1B	-0.027167
NEXN	-0.027164
WFS1	0.027118
FAM8A1	-0.027082
PFN2	-0.027046
YWHAQ	-0.026999
BHLHB9	-0.026944
TSPAN13	-0.026941
NAP1L3	-0.026849
RPS3	-0.026815
ZNF483	-0.026805
IVNS1ABP	-0.026757
CNBP	-0.026750
FUT9	-0.026746
ADSS	-0.026694
C1orf198	-0.026686
CDH2	-0.026645
HNRNPA0	-0.026629
CHCHD10	-0.026606
ATOH8	-0.026593
NUDC	-0.026548
IMPAD1	-0.026269
PSMC5	0.026257
DDN	-0.026249
ZMYM1	0.026181
AMER2	0.026164
ZNF503	-0.026156
STX16	-0.026081
SMAP2	-0.026040
MORF4L2	-0.026028
CD200	-0.025933
ATP5G3	-0.025917
PDE7B	-0.025907
HNRNPH2	-0.025880
RASL10B	-0.025871
SFR1	-0.025850
PAIP2	-0.025828
FBXO2	0.025805
STRN	-0.025723
SYNE1	0.025694
EEF1G	-0.025668
ZNF575	-0.025591
PPP2R5B	0.025489
PPP1CA	-0.025434
DSEL	-0.025421
SPOCK3	-0.025391
USMG5	-0.025380
NPDC1	0.025322
MORF4L1	-0.025208
SCG5	-0.025114
RGS9	-0.025069
TAC1	-0.025053
CNIH2	-0.025002
RAC1	-0.024919
MID1IP1	-0.024915
MYO18A	-0.024873
PHYHIPL	-0.024870
KCTD13	-0.024869
RPL26	-0.024854
FAM134B	-0.024837
GPM6A	-0.024790
DCTN3	-0.024752
RPL18A	-0.024750
FBXO41	-0.024748
NETO1	-0.024735
RPS26	-0.024730
FAT3	-0.024718
LOH12CR1	-0.024706
CLIC4	-0.024699
LPL	-0.024655
ABHD17A	0.024639
RIC8B	-0.024601
DHX40	-0.024560
IGIP	-0.024528
ARHGAP32	-0.024526
MFSD2A	0.024508
DEK	-0.024366
DUSP26	-0.024366
FBXO11	-0.024363
PPP2CA	-0.024352
GNAL	-0.024328
MCFD2	-0.024258
RESP18	-0.024240
HSPA8	0.024095
EPHB1	-0.024044
OVOS2	0.023999
TIMP2	-0.023978
CTGF	0.023945
TMEM47	-0.023943
HIST1H1C	-0.023923
SPTBN4	-0.023802
WDR7	-0.023797
PGM2L1	0.023763
RFTN1	-0.023714
NDFIP1	-0.023675
CLPTM1L	-0.023641
PAPSS1	-0.023630
TUBB	-0.023583
AIMP1	-0.023555
LRP12	-0.023531
BAIAP3	-0.023509
PHLPP1	-0.023417
SLC25A5	-0.023376
DUSP6	0.023360
DNPEP	-0.023351
CHTF8	-0.023334
RPL6	-0.023300
APLP1	-0.023283
HIGD2A	-0.023269
FAM192A	-0.023231
GGT7	0.023200
TECR	-0.023199
PICALM	-0.023158
DNAJC7	-0.023106
SV2B	0.023019
PLEKHB1	-0.023002
ITGB1BP1	-0.022900
ATP2A2	-0.022896
STX1A	0.022833
SLC4A10	-0.022787
KCNJ11	-0.022781
RABAC1	0.022772
TOMM70A	-0.022737
SCOC	-0.022736
DGKZ	0.022713
TOB1	-0.022704
RPS27A	-0.022703
WBP2	0.022697
RPS2	-0.022648
TMEM9B	-0.022635
TRRAP	-0.022631
LYPD4	-0.022607
LOC728392	-0.022579
C19orf60	0.022557
NAP1L2	-0.022531
SCN4B	-0.022529
TMEM185A	-0.022488
RASGEF1B	-0.022461
C18orf32	-0.022429
HPCA	-0.022423
KCNJ10	-0.022392
AMD1	-0.022386
SLC12A5	-0.022346
CDC34	0.022306
SAR1B	-0.022287
HMGN1	-0.022282
SNAPC2	-0.022242
SMIM13	-0.022158
RPL19	-0.022087
TMEM130	-0.022051
SEC23A	-0.022048
WSCD2	-0.022044
GPX1	-0.022042
APP	-0.022022
ZNF804A	-0.022000
FKBP5	0.021992
SLC30A3	0.021982
PCBP1	-0.021969
MED16	-0.021943
SHROOM2	-0.021932
STIP1	-0.021920
TMEM126A	-0.021908
OMG	-0.021819
C11orf87	-0.021799
HSPD1	-0.021794
RPS14	-0.021792
GJB6	0.021789
SLC38A2	0.021788
NDUFB3	-0.021773
TGFA	-0.021773
VDAC3	-0.021700
TTYH1	0.021677
SPNS2	0.021648
ARHGAP44	0.021645
BAI3	-0.021625
RGS7	-0.021617
CSTF2T	-0.021614
ATP6V0C	-0.021578
PDE2A	-0.021557
SEC11C	-0.021542
NECAB2	-0.021528
ARF1	-0.021485
FAM49B	-0.021480
MRPL16	-0.021420
STRIP2	-0.021409
RELN	-0.021395
AHI1	-0.021390
FOXG1	-0.021367
ECEL1	-0.021358
EGR3	-0.021291
ATP6V1A	0.021287
KLHDC1	-0.021286
JDP2	0.021272
BCAS1	-0.021245
YWHAB	-0.021245
CADM4	0.021204
SPINT2	-0.021176
KBTBD7	-0.021133
GAPDH	0.021075
PPM1B	-0.021073
CST3	-0.021062
ARL6	-0.021036
DSTN	-0.021029
GRM4	-0.020993
MRPS18C	-0.020975
KLHL2	-0.020962
PFKM	0.020948
HSP90B1	-0.020938
VSTM2A	-0.020931
BRK1	-0.020923
SERTAD4	-0.020914
TPPP3	0.020843
CALB1	-0.020836
CCDC136	0.020815
MFGE8	-0.020802
MAP2K1	-0.020798
IGFBP6	0.020790
CRY2	0.020763
KIAA1598	-0.020761
NDUFC1	-0.020742
ADCY5	-0.020735
PUM1	-0.020713
PPP2R2C	-0.020682
STRN4	-0.020672
PIGP	-0.020667
HNRNPK	-0.020666
CLDN12	-0.020644
VAPA	-0.020626
DAZAP2	-0.020617
FBXW5	0.020602
PPP2R5D	-0.020601
PLXNB2	-0.020581
CLU	-0.020577
CCDC13	-0.020556
RXRG	-0.020538
GNG3	-0.020518
RPS25	0.020409
OAT	-0.020304
UBA1	-0.020277
LEMD2	-0.020275
KCND2	-0.020267
SMARCA1	-0.020218
FOXO1	-0.020217
HNRNPH3	-0.020175
CIC	-0.020165
TSPAN7	-0.020150
RHOA	-0.020144
SYBU	-0.020141
C6orf136	-0.020136
SOX2	-0.020134
FAM49A	-0.020079
PRMT2	-0.020063
PLIN4	0.020005
WDR82	-0.020001
DKK3	0.020000
PNCK	-0.019957
CORO2B	-0.019951
ERMN	-0.019894
CARM1	-0.019875
COX7A2	-0.019861
RUFY3	-0.019760
HNRNPH1	-0.019747
CPNE5	-0.019729
GABRA5	-0.019724
UQCRC1	0.019719
SERPINI1	0.019626
LGI1	-0.019605
RNF167	-0.019580
POLR2B	-0.019579
LINGO3	-0.019512
COPB1	-0.019508
NDUFA9	-0.019504
ZMPSTE24	-0.019471
NTS	-0.019469
PCDH8	-0.019458