!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!ligand_name	17beta-estradiol
!ligand_id	CHEBI:16469
!cell_type	U2OS osteosarcoma cell line
!organism	human
!end_metadata
S100A10	-0.204791
VIM	-0.191389
TPM1	-0.171614
MT2A	-0.157785
LAPTM4B	-0.149912
SRI	-0.148339
TMSB10	-0.147118
HK1	0.141363
GJA1	-0.128624
LY6E	0.123138
EEF1A2	-0.120864
ACTB	0.117766
CD9	0.115284
FKBP4	0.111191
C3	0.110290
HPCAL1	0.106552
HSPB8	0.106164
DBI	-0.105345
NNMT	-0.103197
CTGF	0.101305
GPRC5A	-0.099536
HLA-C	0.098367
KRT18	-0.096608
KRT81	-0.093104
CA12	0.090623
NCF2	0.089906
JUND	0.084764
UBE2S	0.084454
MT1H	-0.081891
LOX	0.081843
RPL41	0.077908
CHPT1	0.077085
HSPB1	0.070845
MMP12	0.069318
PABPC1	0.067764
KRT19	0.067284
RHOC	0.067206
EEF1A1	0.066669
HLA-B	0.066556
ABCD3	0.065844
MT1X	-0.065331
MARCKSL1	0.064700
SOD1	-0.063812
ANXA2	-0.063191
RPL23A	0.062876
MAGED1	-0.062506
ACTG1	0.062096
S100A2	-0.061207
RPL23	-0.061087
PAPSS2	0.060947
RPS3	0.059910
CAPN2	0.058819
PTTG1	0.058550
SFN	-0.058406
ID1	-0.058099
CLU	-0.058005
F13A1	0.056992
PPA1	0.056799
RPS28	0.056684
CLEC4M	0.056294
MFAP2	-0.056085
MYL6	0.055429
RRM2	0.055383
SLC38A2	-0.055295
CST3	0.054038
C14orf2	0.053999
FDXR	0.052606
CYR61	-0.052323
C20orf24	0.052217
RPS27A	0.052033
ETFB	0.051763
ANXA11	0.050863
CDC42EP1	0.050457
CAPNS1	-0.050342
CLIC1	0.049525
RPL12	-0.049521
WISP2	0.049478
GAPDH	0.049255
AXL	0.048526
RPS21	0.048479
MAP1LC3B	0.048098
FHL2	0.047642
PRMT1	-0.047392
PSMA3	0.047173
ANXA10	-0.046924
IMPDH2	-0.046885
KRT17	-0.046856
SERPINB6	0.046692
RPL18	-0.046480
LDHB	-0.045662
RPL19	-0.045482
RPS25	-0.045192
ARL4C	-0.044865
CST5	0.044595
GCH1	0.044439
TACC1	0.044303
TNIP1	0.044299
LDHA	-0.044291
SEPT9	0.044179
BMP4	-0.043920
TUBA1A	0.043312
ATP5B	-0.043143
MRPL33	0.042225
TPI1	-0.042202
GPX4	-0.042195
EEF1D	-0.042073
NPM1	-0.042022
ENC1	-0.041833
NCOR2	0.041377
RPL13A	-0.041317
MYRF	0.041223
TPT1	-0.041205
YBX3	-0.041185
ARPC1B	0.041148
CST1	0.041078
RPS14	-0.040865
RPS12	-0.040615
TMBIM6	0.040564
FHL1	-0.040115
GNB2	0.039645
NFKBIA	0.039505
LOXL1	-0.039366
SHC1	-0.039194
AGPAT1	0.038983
TUBB	-0.038967
BLVRB	0.038906
PTP4A2	0.038889
GSTO1	0.038656
SNRPD2	-0.038581
RPL17	-0.038548
AKAP1	0.038457
RPS11	-0.038056
CLDND1	-0.038028
RPS26	-0.037834
APEX1	-0.037811
PTTG1IP	0.037769
RPL35	-0.037684
HSP90AA1	0.037315
FKBP1A	-0.037279
PGK1	-0.036930
MAP2K1	0.036654
SOX4	-0.036591
ACTN1	0.036111
RPL10A	-0.036070
ALPP	-0.035896
TUBB3	-0.035574
BMP5	-0.035529
FBN2	-0.035506
RPS10	0.035501
EIF2AK1	-0.035457
HLA-A	0.035446
ACTN4	0.034982
RPL28	-0.034612
ARL3	0.034522
TNFRSF12A	0.034388
SERF2	-0.034351
VAPA	-0.034152
MTCH1	0.033987
UCP2	-0.033824
GAS6	0.033797
MAPKAPK2	0.033631
EIF4A1	-0.033542
ISG20	0.033426
RPL34	-0.033341
PODXL	-0.033269
RPL36A	-0.032900
CALM2	0.032435
RPLP1	0.032392
RPS13	0.032336
SDC4	0.032309
PDLIM3	0.032309
RPS7	-0.032146
SEMA3B	0.031750
IL32	0.031735
PDLIM2	0.031713
MYL12B	-0.031597
TRIM28	-0.031584
PSMD2	0.031545
HUWE1	0.031445
NPR2	0.031412
CXCL14	0.031265
PPP1R12B	0.031126
DYSF	-0.031030
IL24	0.031008
LAMP1	-0.030833
MN1	-0.030766
BANF1	-0.030478
TJP1	0.030411
UBE2I	0.030352
COL4A1	-0.029983
RPL32	-0.029819
FSCN1	-0.029746
TPBG	0.029675
SERPINE1	-0.029603
SNRPG	0.029258
RASGRF1	0.029063
NFIL3	0.029047
RPS15A	-0.028815
SLC9A3R1	0.028713
HMGN2	-0.028369
CD63	-0.028350
EIF4B	-0.028334
MDH1	0.028158
JAK1	0.028098
EIF1	0.028047
RPS18	-0.027771
XRCC6	0.027707
SH3BP4	-0.027602
FTH1	-0.027501
WDR1	0.027405
SARAF	-0.027073
RPS27	-0.026929
RANBP1	-0.026874
PTMA	0.026821
MAD1L1	0.026787
TMEM258	-0.026775
PHB2	-0.026659
ALDOA	0.026496
NGFRAP1	-0.026434
HLA-G	0.026391
THY1	-0.026299
PBK	0.026219
SELT	0.026172
ABLIM1	-0.026123
YWHAZ	-0.025851
SLC25A5	-0.025635
ANXA5	-0.025627
RAB13	-0.025607
NIPSNAP1	-0.025576
RPS27L	-0.025462
COX8A	0.025347
RPS6	-0.025329
JARID2	0.025300
PPM1D	-0.025300
ATP6V1D	0.025105
CNN3	-0.024976
IER3	-0.024948
ATP6V0C	0.024901
SUB1	0.024841
RAB11A	0.024757
HSPD1	-0.024718
HIST1H2BK	-0.024698
HN1	0.024458
ABCA3	0.024452
EMP3	-0.024286
AFF1	0.024280
LASP1	-0.024218
RAB31	-0.024082
COL1A1	-0.023997
RPL7A	-0.023972
TGM2	-0.023639
EPB41L2	0.023610
NCAM1	0.023590
TNFRSF1A	-0.023549
KLK6	-0.023527
SNAI2	-0.023522
S100A6	-0.023384
LOXL2	-0.023307
MYBL2	0.023291
UBE2C	0.023246
RPS8	-0.023212
RPS16	0.023170
RPS6KA2	0.023093
TGIF1	-0.023085
PLK2	0.023030
TRAM1	-0.023007
CCT4	-0.022978
P4HA2	0.022911
OAZ1	0.022855
GNB2L1	-0.022829
ATP1B1	0.022734
MFSD10	0.022638
RPL6	-0.022420
NDUFB4	-0.022229
COX17	0.022151
PRAME	-0.022135
PHC2	0.022118
SLC12A7	-0.022118
TGFA	0.022036
SDCBP	0.022036
VAT1	-0.022014
CHD4	-0.021985
CDK1	0.021958
HOMER2	0.021902
TFF1	0.021757
KLRC3	0.021748
CHCHD2	0.021645
MXRA7	-0.021582
RCN1	-0.021538
RPL9	-0.021358
CSDE1	-0.021306
CTSB	0.021230
CSRP1	0.021161
KRT8	-0.021075
CAP2	0.021034
TPP1	0.020986
SSR2	-0.020931
RPL22	0.020884
HIF1A	-0.020870
GAA	0.020698
H3F3B	-0.020670
PDLIM4	0.020526
ZNF185	0.020519
TALDO1	0.020470
GM2A	0.020463
RPL13	0.020376
IFNGR2	-0.020355
CEBPB	0.020305
NCL	-0.020172
ATP6V0B	0.020164
RAC2	0.020135
PRC1	0.020092
TPM2	-0.020070
CYCS	0.019877
DBN1	-0.019854
MMP2	0.019841
PACSIN2	0.019721
CCNG1	-0.019708
RAI14	0.019625
NME4	-0.019617
PABPC4	-0.019594
PPIF	0.019489
H1FX	-0.019401
SERPINH1	-0.019325
AHCYL1	0.019320
CTDSP2	-0.019272
HNRNPC	-0.019271
RPS23	-0.019261
TUBB4B	-0.019247
CST2	0.019245
CNBP	-0.019171
SLC6A8	-0.019108
LGALS3	-0.019101
CDKN3	0.019098
UQCR10	-0.019088
GLTSCR2	0.019030
RPS29	-0.018796
ATP5J2	-0.018747
PCM1	0.018683
PAK4	0.018666
STAT3	-0.018622
ACP6	0.018621
RPL38	0.018617
NDRG4	0.018615
LPL	0.018505
MSN	-0.018503
PSME1	-0.018493
ANP32A	-0.018480
GHITM	0.018450
TSPO	-0.018360
HIST1H2AC	-0.018334
GSTP1	0.018321
DHX15	0.018185
MAFF	0.017978
SLC18A3	-0.017933
UPF1	0.017920
CTSA	-0.017892
ZNF395	0.017847
GNAI1	-0.017844
SFRP1	-0.017792
ATP5O	-0.017761
KHDRBS1	-0.017737
MXI1	-0.017700
TAX1BP1	0.017628
SNRPD3	-0.017582
PDGFC	-0.017567
UQCRQ	-0.017512
LPAR1	0.017489
PEBP1	-0.017470
GPX1	-0.017459
GLRX	-0.017458
SOX9	0.017445
RAP2B	-0.017406
ACTR2	0.017372
RPL15	-0.017342
DFNA5	-0.017340
PCBP1	0.017298
TRAM2	-0.017213
GRHPR	0.017163
TNNT1	-0.017161
COTL1	-0.017147
CTSV	0.017134
TWF2	0.017073
LPXN	0.017060
GTF3A	0.016995
USP22	-0.016979
RAPGEF2	0.016979
CARHSP1	-0.016967
TNS3	-0.016933
RPL37A	0.016890
TPST2	-0.016885
H2BFS	-0.016878
DYNLT1	0.016876
LAPTM4A	-0.016729
RPS9	-0.016690
MAGED2	-0.016681
PARP1	0.016619
SUMO3	-0.016562
STAT6	0.016557
COL5A1	-0.016529
CNIH1	-0.016460
USP1	0.016430
CAP1	0.016428
CA2	0.016382
TARS	0.016367
MKNK2	-0.016359
PPIA	0.016310
HADHB	-0.016290
WNT5A	-0.016284
LTBP2	-0.016227
YBX1	-0.016179
TIMM8B	-0.016071
GNG5	-0.016029
NME1	-0.016016
CALM3	-0.015986
COX5B	-0.015973
ZWINT	0.015948
CALB2	0.015948
IRAK1	0.015930
EPS8	0.015927
PTPRM	0.015874
SNRPB	0.015828
RPL24	-0.015791
PDZK1	0.015741
KIF13B	0.015715
PAFAH1B3	-0.015689
CDK2AP1	-0.015686
CCNI	-0.015655
ATP5I	-0.015645
PSMG2	-0.015643
PTP4A1	-0.015607
HMGN1	-0.015560
PSMA1	0.015459
RANGAP1	0.015442
PPP1R15A	0.015414
AKAP12	-0.015402
STAU1	-0.015369
LGALS1	-0.015360
TUFT1	-0.015348
POLR2E	-0.015346
NONO	-0.015322
CTBP1	-0.015313
CERS2	-0.015312
SFPQ	0.015273
RPL8	-0.015225
PAICS	-0.015200
HIST1H2BD	-0.015191
EDIL3	-0.015143
MPST	0.015142
TMSB15A	-0.015121
RNF14	0.015116
INHBA	-0.015078
ADAM9	0.014995
BSG	-0.014967
ALDH3B1	0.014962
DRAP1	-0.014927
PPT1	-0.014914
SPARC	-0.014889
PSMC3	0.014840
GPR176	0.014820
SLC7A5	0.014739
H1F0	-0.014639
KIF2C	0.014617
HBP1	-0.014615
ZMYND11	0.014579
TBL1X	-0.014566
PTPRH	0.014552
TLR4	-0.014545
RPLP2	-0.014528
EPHB4	-0.014474
TAGLN2	0.014419
CRYAB	-0.014367
DPM1	0.014321
SRP14	-0.014311
PCNA	0.014298
SEC61G	0.014272
TXNIP	-0.014257
UBA1	0.014256
RRM1	0.014245
S100A11	-0.014223
PDXK	-0.014164
BTF3	-0.014091
TIMP1	-0.014047
NDN	-0.014039
BIRC3	0.013973
ETHE1	-0.013956
EIF4A2	-0.013951
PRDX6	0.013945
RAC1	-0.013923
ARPC5	0.013897
UBB	0.013892
GCLM	0.013886
ECHS1	-0.013831
SULT1A1	0.013743
TOM1	0.013726
MTHFD1	-0.013725
CPSF1	-0.013674
HMGB3	-0.013636
ATP5E	0.013614
FOXN3	-0.013603