!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	human
!drug_name	Argyrin A
!smiles	CCC1C2=NC(=CS2)C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(=C)C(=O)N(CC(=O)N1)C)C)CC3=CNC4=C3C(=CC=C4)OC)CC5=CNC6=CC=CC=C65
!pubchem_cid	24978550
!cell_type	MCF7 breast adenocarcinoma cells - 12 Hours
!organism	human
!end_metadata
COX1	0.262024
ND2	0.190707
LDHA	0.190138
COX6C	0.166081
FTH1P5	-0.137435
RPL36A	0.122450
FTH1	-0.120123
IER3	0.116252
GPI	0.112782
BASP1	0.104685
FTL	-0.099598
HIST1H4C	-0.093831
GGCT	-0.090901
TXNIP	0.090706
CEBPB	-0.088259
ATF4	-0.087900
MIF	0.085137
HSP90AA1	-0.082794
SLIRP	-0.082336
ASS1	-0.081523
BNIP3	0.078701
SLC7A5	-0.077754
RPL3	0.076399
NME1	-0.074619
TMA7	-0.074612
RPS26	-0.074260
TFF1	-0.074201
PGK1	0.073919
RPL13A	0.069938
BCAS2	-0.069873
NQO1	-0.067713
C20orf24	-0.067707
HSPA5	-0.067161
HERPUD1	-0.066916
CCNG1	0.066181
TUBB4B	-0.065614
H2AFZ	-0.065237
DDIT4	-0.064545
EEF2	0.064440
RPL34	0.063161
RAN	-0.062969
ALDOA	0.062297
RPL17	0.061876
USMG5	-0.061590
ACTB	-0.061584
NDUFAB1	-0.060409
CDK4	-0.060369
RRM2	-0.060293
COX2	0.060205
NDUFB9	-0.059992
JTB	-0.059624
NHP2	-0.059419
UBE2S	-0.058399
DSP	0.057156
SCD	0.056305
C4orf3	0.056182
PSMB4	-0.055063
RPL7A	0.054552
TALDO1	-0.053901
RPL11	0.053828
FAM162A	0.053548
TPD52L1	-0.053302
DPM1	-0.053228
PSMA6	-0.052944
ERH	-0.052925
G6PD	-0.052502
RPS9	0.052458
EIF4B	0.051999
HSPA1A	0.051818
TUBA1B	-0.051607
CRELD2	-0.051347
HSPE1	-0.051253
ODC1	-0.050917
NAP1L1	0.050131
ACTG1	-0.049985
GARS	-0.049970
GAPDH	0.049585
RPL29	0.048575
HSPA8	-0.047605
TSPAN13	-0.047588
FAM102B	0.047258
SLC3A2	-0.047175
SLC19A2	-0.046956
RPL9	0.046796
KPNA2	-0.045863
ATP5I	-0.045806
NPY1R	0.044929
MSMO1	0.044892
PRDX1	-0.044780
DDR1	0.044672
ENO1	0.044588
GTF3C6	-0.044487
NACA	0.043906
ZWINT	-0.043846
PKIB	-0.043825
RPS3	0.043809
RPL12	0.043582
KARS	-0.043414
PNRC1	0.043400
TUBA1C	-0.043297
LTA4H	0.043228
RPS29	0.043011
EIF3E	0.042966
ATP5E	-0.042911
BNIP3L	0.042895
TOMM20	0.042351
EEF1G	0.042203
MRPL3	-0.042062
UBC	0.041911
SNRPG	-0.041834
PSMC5	-0.041808
KRT18	-0.041632
PSMA4	-0.041466
ZFAS1	0.041187
EPB41L4A-AS1	0.040680
PSMC6	-0.040514
NDUFA1	0.040491
PRSS23	-0.040339
SLC38A2	0.040169
IARS	-0.039750
RPL23A	0.039656
RPL15	0.039368
MORF4L1	0.039368
RPS14P3	0.039199
GNB2L1	0.039076
XPOT	-0.039021
ERRFI1	-0.038875
NEAT1	0.038659
USP32P2	0.038286
RPL31	0.038202
TXNRD1	-0.038171
RPL18	0.038038
OAZ1	-0.038017
SLC25A6	0.037914
HMGN1	-0.037586
RPS4X	0.037481
ATP5B	-0.037235
MTCH1	0.036860
AMIGO2	-0.036759
PSMA7	-0.036740
NDRG1	0.036649
BOLA3	-0.036603
PKM	0.036410
MOAP1	0.036357
TPI1	0.036115
S100A11	-0.035869
SDF2L1	-0.035853
GSTM3	0.035388
DARS	0.035387
GTF3A	-0.035340
UQCRQ	-0.035333
NARS	-0.035159
PPA1	0.034923
MYL12B	-0.034786
TPBG	0.034615
IRX3	0.034487
CBWD1	-0.034417
SRP9	-0.034404
EIF5	-0.034045
POLR2G	-0.034006
YBX1	-0.033978
DDX21	-0.033870
LAMTOR1	-0.033848
HILPDA	0.033653
IFI30	-0.033611
C1QBP	-0.033596
RPS18	0.033435
SOD1	-0.033348
ATIC	-0.033237
CHCHD2	-0.033122
PSMB1	-0.033093
SNHG8	0.033019
PSMC3	-0.032992
CFL1	-0.032990
SAT1	0.032784
SSR4	-0.032626
RPL23	0.032613
TMSB10	0.032595
CYCS	-0.032477
CHCHD1	-0.032331
SNRPF	-0.032081
EEF1A2	0.032080
ENO2	0.032064
EIF3K	-0.032060
GLTSCR2	0.032043
NDUFS6	-0.031945
COX8A	-0.031920
RPS5	0.031780
HYOU1	-0.031622
DYNLL1	-0.031358
CYC1	-0.030985
RPS6	0.030797
AREG	-0.030669
XBP1	0.030654
MXI1	0.030590
ADI1	-0.030544
HMGB1	-0.030418
GAS5	0.030235
KLF10	0.030107
GBE1	0.030087
ANXA2P2	-0.030026
YWHAQ	-0.029918
ALDOC	0.029867
CD164	0.029835
NAA20	-0.029717
PSMD14	-0.029552
PSMA1	-0.029508
NDUFA12	-0.029410
GPR160	0.029075
PABPC3	0.029067
C6orf48	0.028937
FAU	-0.028790
CBX3	0.028693
TUBB	-0.028655
CCT2	-0.028634
MT2A	-0.028327
RPS3A	0.028243
PCK2	-0.028232
RPL4	0.028210
HSPH1	-0.028047
PPIB	-0.027856
RPS2	0.027807
ASNS	-0.027710
TUBB3	-0.027658
THOC7	-0.027656
EIF4A1	-0.027562
BLVRB	-0.027281
LGALS3	-0.027192
S100A16	-0.027107
VBP1	-0.027059
RPL35A	0.026970
CKS2	-0.026935
MTHFD2	-0.026916
MRFAP1L1	0.026885
RPL28	0.026879
PSMB3	-0.026796
DDIT3	-0.026574
RPL41	0.026534
UBB	-0.026524
RPS15	0.026449
EIF3L	0.026426
TCEAL1	0.026201
RPL32	0.025871
PRELID1	-0.025814
UQCRFS1	-0.025640
SRP19	-0.025474
DDX5	0.025382
EPCAM	0.025365
BANF1	-0.024721
PARK7	-0.024720
PSMB6	-0.024706
CACYBP	-0.024666
RPL22L1	-0.024524
CCNI	0.024490
GABARAP	0.024484
KRT8	-0.024446
YWHAB	-0.024282
ARRDC4	0.024192
PTMA	-0.024126
TOB1	0.023950
SNRNP25	-0.023911
ZNF217	0.023828
RPL10A	0.023802
KRT19	0.023796
EDF1	-0.023770
FDFT1	0.023636
PSMD2	-0.023582
BOD1	-0.023502
SRM	-0.023306
POMP	-0.023271
AGR2	-0.023254
HENMT1	-0.023254
NOC3L	-0.023250
GHITM	-0.023225
MAL2	-0.023215
EIF4G2	-0.023034
DEK	0.022972
ATP6	0.022874
EMG1	-0.022798
LGALS1	0.022766
STUB1	-0.022759
P4HA1	0.022655
YWHAZ	0.022647
MANF	-0.022597
SLC25A5	-0.022492
PRMT6	-0.022462
RPL24	0.022430
HIF1A	-0.022415
ST13	0.022394
SH3YL1	0.022361
ZMPSTE24	-0.022286
PSAT1	-0.022254
POP5	-0.022230
TOP1	-0.022193
ADRM1	-0.022169
DCXR	-0.022154
PRDX6	-0.022077
SNRPE	-0.021943
SLC25A3	0.021933
WDR54	0.021931
BZW2	-0.021916
PRDX4	0.021896
LXN	0.021843
RPS25	0.021840
RPL22	0.021802
LSM5	-0.021783
CDK2AP1	-0.021778
CCT3	-0.021772
RPL5	0.021768
DBI	-0.021754
EEF1B2	-0.021744
GATA3	0.021674
CHCHD3	-0.021655
PLP2	0.021592
MRPL15	-0.021507
ATP5L	-0.021457
SLC39A6	0.021431
MGST1	-0.021223
SSBP1	-0.021197
SLC25A39	-0.021121
HSPB1	0.021060
AHSA1	-0.021023
LINC00657	0.021016
PAN3	0.020884
UGDH	-0.020813
HMGN4	0.020793
MALAT1	0.020779
DAP3	-0.020777
CYP1B1	-0.020737
CCNB1	-0.020633
ACLY	0.020626
RPS27L	0.020626
HSPD1	-0.020618
ATP5G3	-0.020616
AIMP2	-0.020596
RPS7	0.020572
TIMM10	-0.020560
RPS11	0.020555
RPL14	0.020538
SEPHS2	-0.020532
DHX40	0.020516
KLHDC2	0.020353
ECHS1	-0.020351
PSMA3	-0.020342
RPL8	0.020310
RPL26	0.020298
PKD1P1	0.020294
ATP1B1	-0.020283
WDR34	-0.020269
CCT7	-0.020200
DDX39A	-0.020195
DBF4	-0.020141
RPS8	0.020129
EIF6	-0.020042
C6orf211	0.019998
MDH2	-0.019967
TRIP13	-0.019962
ID2	0.019924
HNRNPA1	0.019881
GLRX5	-0.019873
RBBP8	-0.019807
TRIM28	-0.019800
TAF7	0.019732
GLRX2	-0.019680
PSMC1	-0.019670
IFRD1	-0.019661
IL20	0.019653
TAX1BP3	-0.019626
RPL13	0.019591
CBX4	-0.019582
PPP1CA	-0.019555
CELSR2	-0.019513
RPA3	-0.019496
PPIL1	-0.019488
IRAK1	-0.019483
NOP56	-0.019475
PSMB7	-0.019466
TMBIM4	-0.019446
TRAK2	-0.019444
CXXC5	-0.019258
NDUFS3	-0.019234
NDUFAF4	-0.019226
MRPL32	-0.019205
MRPS23	-0.019179
PCMT1	0.019134
CALM2	-0.019124
HIST1H2BK	0.018842
SQLE	0.018766
CDC20	-0.018757
UFD1L	-0.018693
FABP5	-0.018688
SNHG19	0.018584
PTDSS1	-0.018539
CAPNS1	0.018530
AP2S1	-0.018502
IMP4	-0.018501
SF3B5	-0.018479
MOCS2	-0.018462
DKK1	-0.018449
ITM2B	0.018412
PSMB5	-0.018397
SUMO2	0.018369
TXN	-0.018209
NDUFA13	-0.018060
AKR1C2	-0.018053
NAA50	-0.018003
PSMD4	-0.017971
RHOD	-0.017945
RPLP0	0.017901
CDKN3	-0.017836
CAMLG	0.017832
UBL3	0.017807
BTF3	0.017772
PRR13	-0.017770
CRNDE	0.017752
TMEM45A	0.017693
RARS	-0.017690
CTSD	-0.017665
SEH1L	-0.017648
PTPLAD1	0.017625
CEP55	-0.017610
MRPL11	-0.017601
AK3	0.017581
UBA2	-0.017555
SNHG6	0.017524
ILF2	-0.017523
EIF3D	0.017485
ICT1	-0.017478
FLNA	-0.017474
IFRD2	-0.017454
TMEM123	0.017423
RPS16	0.017399
RUVBL2	-0.017397
C3orf14	-0.017361
NOL11	-0.017358
GLA	-0.017322
INSIG1	0.017180
GTF2H2	-0.017137
TRMT5	-0.017126
TAGLN2	-0.017110
RPL36	0.017048
ATP5G1	-0.017033
ARPC1B	-0.017013
PDLIM1	0.017006
PTGES3	-0.016998
IDI1	0.016982
PSME1	0.016951
RPL6	0.016948
SAC3D1	-0.016946
NOL7	-0.016919
TMED2	-0.016877
MRPL27	-0.016862
GOT1	-0.016860
SLC35B1	-0.016847
DNAJB9	-0.016836
CHCHD10	-0.016793
TUBB2B	-0.016791
SLC1A5	-0.016779
HINT1	-0.016777
SERINC1	0.016770
DYNLT1	-0.016760
ABHD17C	0.016724
CHMP4A	-0.016617
CCDC59	-0.016577
PHB	-0.016556
RPN2	-0.016552
PCBP1	0.016539
DLD	-0.016515
DNAJB11	-0.016501
PSMA5	-0.016494
MRPS30	-0.016487
COX4I1	-0.016456
ASNSD1	-0.016446
CKS1B	-0.016436
ATP5J	-0.016421
SGK3	0.016418
C11orf48	-0.016414
ENOPH1	-0.016360
TRIM16	-0.016354
PGAM1	0.016335
XRCC5	-0.016313
DDB2	0.016270
NDUFA4	-0.016246
JUND	0.016244
LAPTM4B	-0.016242
IER5	0.016210
ZNF593	-0.016203
CHAC2	-0.016194
PSMD12	-0.016161
AARS	-0.016119
SLC7A11	-0.016075
SKP1	-0.016053
ARL6IP1	-0.016039
PRMT1	-0.016005
FZD6	0.015998
EID1	0.015996
CHAC1	-0.015972
NDUFC2	-0.015960
PNPT1	-0.015903
PABPC1	0.015898