!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Mus musculus
!gene	SIRT1
!cell	Liver
!perturbation	SIRT1 activator, SRT2104
!disease	Standard diet - 1.33 g drug per kg of chow
!end_metadata
RGS16	0.113284
LCN2	-0.098197
MOXD1	0.087860
BHMT	-0.087478
CTGF	0.083726
DBP	0.081565
EGR1	0.079231
HHEX	0.075667
BCL6	0.075071
SOCS2	0.068981
SOCS3	-0.068613
CYP1A2	0.066807
CLPX	-0.065956
CHAC1	-0.062914
TXNIP	0.059340
SBK1	0.058128
LRFN3	-0.057401
S100A8	-0.057021
ARNTL	-0.055203
ELOVL6	0.054848
S100A9	-0.054592
GADD45A	-0.053517
THRSP	0.053441
TFF3	0.053300
NREP	0.053283
CXCL2	-0.053180
MYCL	0.053028
HSPB1	-0.052432
RSAD2	-0.049304
GJA4	-0.049013
ESM1	0.048659
NFIL3	-0.048131
FOXQ1	-0.047843
GADD45G	-0.047169
SAA1	-0.046487
BCL3	-0.045533
PLIN4	-0.045467
TJP3	-0.044389
SLC38A3	0.043995
NCEH1	0.043329
ATXN1	0.043248
ELOVL3	-0.043174
ETNPPL	-0.042903
METTL20	0.042812
AQP4	-0.042762
CDKN1A	-0.042339
CHRNA4	0.042313
INSIG2	-0.041494
LNX2	-0.041316
FDPS	0.040722
CRELD2	-0.040376
PLIN5	-0.039850
ABCG8	0.039627
ACACA	0.039419
NMRK1	0.039260
APOA2	0.039189
INSC	-0.038920
MBL2	0.038578
FAM107B	-0.038506
EGFR	0.038392
APOA1	0.038243
TF	0.038135
SQLE	0.037944
MREG	-0.037920
ATF3	-0.037652
RCAN1	-0.037492
FADS2	0.037349
RELL1	-0.037174
SRRM4	-0.036881
ERRFI1	0.036730
TTR	0.036679
AACS	0.036621
DUSP8	-0.036380
CYP2E1	0.036334
ISG15	-0.036304
CFD	-0.036160
GSTA5	-0.036033
CCDC3	0.035925
ASNS	0.035576
PRSS8	0.035422
AVPR1A	-0.035337
HCAR2	-0.035097
LGALSL	-0.035039
NANS	-0.034896
PID1	-0.034650
DCAF11	-0.034650
LENG9	-0.034505
CTSV	-0.034469
ACLY	0.034455
GCLC	-0.034324
CCRN4L	0.034163
ANGPTL4	0.034090
LRTM1	-0.034068
GPX1	0.033992
HSPA5	-0.033982
CIART	0.033816
GLDN	0.033294
SLC2A1	-0.033135
EIF1AX	-0.033105
ZFP36	0.032969
GLDC	-0.032803
GNE	0.032776
SCD	0.032713
APOA4	-0.032588
GMPPB	-0.032559
NRP1	0.032451
DUSP6	0.032399
DDX28	-0.032287
PLXNA2	-0.032272
FAM180A	0.032257
ZNF281	0.032222
ALAS1	0.032057
C10orf10	0.031986
RAPGEF4	0.031868
SLC16A6	-0.031441
JUND	-0.031311
TBC1D8	0.031288
TMEM102	-0.031189
DEXI	-0.030888
NUDT7	0.030880
DDC	-0.030878
DDIT4	-0.030741
CA14	-0.030672
DCLK3	0.030576
SLC30A1	-0.030575
SYVN1	-0.030507
CYP2U1	-0.030465
UPP2	0.030389
RHOB	-0.030339
POR	0.030096
KIAA0907	0.030061
BCKDHB	-0.030059
PRMT6	-0.029972
GADD45B	-0.029922
IGFBP1	-0.029825
ST5	-0.029712
AMBP	0.029696
PGPEP1	-0.029474
PLEKHG3	0.029291
C6	0.029219
CYP17A1	0.029135
THBD	-0.029133
SERPINA1	0.029105
HIST1H2AJ	0.028935
LBP	-0.028853
GDF9	0.028524
PNPLA5	0.028434
LGALS1	-0.028352
SLC30A10	-0.028296
ACSS2	0.028235
PER3	0.028217
SEPT9	-0.028092
FADS1	0.028024
USP18	-0.027988
VPS37B	-0.027874
TREH	-0.027866
C8orf4	-0.027829
FOS	0.027598
SGK1	-0.027563
ARHGEF19	-0.027536
PDK4	-0.027511
PLK3	0.027507
DHX58	-0.027463
LIPA	-0.027287
COQ10B	0.027126
ME1	0.027065
KDM6B	-0.026934
SERPINA6	0.026918
MPP6	-0.026839
SH3BP2	-0.026838
NSDHL	0.026835
MEGF9	-0.026814
UGCG	0.026733
SNX24	-0.026714
ALDH2	0.026605
IMPACT	-0.026599
SLC35G1	0.026592
ID3	-0.026457
INMT	0.026397
FKBP5	0.026377
PPP1R3B	-0.026324
S100A10	-0.026269
ST3GAL5	0.026205
HOXA5	-0.026145
TCF21	0.026088
ZBTB22	-0.025965
CYP51A1	0.025924
ABHD14B	0.025854
TDO2	-0.025711
CMPK2	-0.025619
DMBT1	-0.025612
C19orf12	0.025609
RPS6	0.025599
GRB7	0.025594
FAM102A	0.025510
HDHD3	-0.025497
PLXNA1	-0.025422
HILPDA	-0.025359
ALG12	-0.025318
LUC7L3	0.025274
TJP2	-0.025009
AHCTF1	-0.024991
LASP1	-0.024912
SNTG2	0.024886
PER1	0.024808
G6PC	0.024791
LRG1	-0.024778
HIST1H3B	-0.024725
GSTP1	0.024709
USP2	0.024689
CCNG2	-0.024686
MED24	-0.024661
RBP1	0.024606
UBC	0.024598
FAM160B1	0.024531
COX18	-0.024508
RNASE4	0.024487
PCYT2	0.024382
PPP1R3C	-0.024350
TPRKB	0.024334
KLF2	-0.024330
FAM134B	-0.024310
LPIN2	0.024195
TBC1D2B	0.024192
HIST1H4J	-0.024171
FABP5	0.024164
NDRG1	-0.024124
KRAS	-0.024105
CNST	0.024101
SLC39A4	0.024098
CHKA	-0.024085
DNAJB1	-0.024037
SEC24D	-0.023966
PRKD3	0.023912
WFDC2	-0.023864
ETS2	-0.023856
TGM1	0.023836
TP53INP1	-0.023685
CPS1	0.023677
LRIG3	0.023578
ADH1C	0.023456
FGA	0.023456
TMEM125	-0.023444
SMAP1	-0.023443
TUBB4B	-0.023442
CD93	-0.023415
MTNR1A	-0.023398
ZFHX2	-0.023390
PTEN	-0.023282
FBF1	-0.023219
OVOS2	0.023214
ATXN10	-0.023194
NADK	0.023185
CRYL1	-0.023115
GDF15	0.023059
AASS	-0.023057
WBP2	0.023031
C11orf54	-0.023021
N4BP2L1	0.022955
OSBPL11	-0.022928
RTN4RL1	-0.022905
TMEM167B	-0.022835
STARD4	0.022818
JUN	0.022799
BLOC1S4	-0.022767
COG8	-0.022718
SLC16A10	-0.022703
GNA11	-0.022661
KLHL21	0.022625
SPON2	-0.022595
AZGP1	0.022570
NGFR	-0.022563
ATP5B	0.022447
LSM7	-0.022446
TLCD1	0.022435
GNG5	-0.022381
KLF9	-0.022377
STAB2	-0.022366
SAA2-SAA4	-0.022339
SLC45A3	-0.022336
ABCB11	0.022292
RPS7	0.022222
SLC5A6	0.022219
SRP9	-0.022191
SLC35B1	-0.022186
MRPS15	-0.022182
PALLD	-0.022172
CLDN2	0.022171
NDUFA6	0.022158
SLC40A1	0.022134
RALB	-0.022128
RELN	0.022115
ACTB	0.022060
OSGIN1	-0.021988
EFNB1	-0.021900
TEF	0.021895
PNO1	-0.021882
HDC	-0.021874
CYP27A1	0.021856
MAP3K6	-0.021817
CRTC2	-0.021778
SLC25A47	0.021760
RAPGEF6	0.021718
CRYGN	-0.021707
ULK1	0.021671
ZCCHC14	0.021649
SLC17A2	0.021647
UGT2B7	0.021644
FPGS	-0.021641
FBXO31	-0.021625
PLIN2	-0.021620
PTPRB	-0.021600
BOLA3	-0.021581
NAGS	-0.021545
C19orf80	-0.021528
TUBB6	-0.021523
LHFPL2	-0.021457
RARRES2	0.021403
MIDN	-0.021383
HSPA8	0.021324
ATP6V0B	0.021286
TSR3	-0.021266
SDS	-0.021254
SLC15A3	-0.021225
ELAVL1	-0.021205
INO80B	-0.021201
SLC17A8	-0.021197
BTG1	-0.021196
LTV1	-0.021159
DDX50	-0.021143
ARL4A	-0.021135
NR1D1	0.021120
OSBPL8	-0.021109
C1QBP	-0.021054
FAM171B	0.021029
ACSL5	0.021009
KIAA0319	0.020976
SIAH2	0.020971
SPSB4	-0.020959
ABCD3	0.020946
ASPG	0.020938
AMY2A	-0.020930
NDEL1	0.020910
SPP1	0.020894
IRF2	0.020871
FAIM	-0.020857
MRPS35	-0.020851
PCMTD2	0.020811
SAR1B	0.020781
ABCG5	0.020745
METTL9	-0.020729
ITPR1	0.020669
PRPF18	0.020655
PJA2	-0.020654
ACBD3	-0.020640
HP	0.020614
NAT8	-0.020605
PER2	0.020599
QRSL1	-0.020577
FAM195A	-0.020513
SEMA4B	-0.020489
STBD1	0.020487
OBP2B	-0.020483
STAT3	-0.020479
HELZ2	-0.020471
HPX	0.020452
BTF3	0.020449
ATP1B1	-0.020416
MRAP	-0.020376
DDX52	-0.020375
DPM2	-0.020373
OLFML1	0.020369
TEK	-0.020365
FNDC3B	-0.020354
DLD	-0.020297
HAPLN3	-0.020288
TECR	0.020268
DAPK3	-0.020257
STARD13	-0.020246
RBMS1	0.020227
SLC30A6	-0.020189
HIST1H4F	-0.020182
SLC25A30	0.020167
HR	-0.020162
F2R	0.020151
PIM3	0.020081
CCDC90B	-0.020043
SELK	-0.020040
TPST2	-0.020013
FEN1	-0.020010
NR2C2AP	-0.019995
USP33	-0.019985
AHSG	0.019974
FTH1	0.019960
SLC17A5	0.019939
DCUN1D4	-0.019936
CCDC151	-0.019932
SLC10A3	-0.019921
ITIH1	0.019919
ENPP6	-0.019912
DERL3	-0.019881
MGST1	0.019821
DCTN6	-0.019814
NAT8B	0.019811
LLGL2	-0.019786
FOXA1	0.019780
FMO4	0.019777
HSD17B7	0.019775
SERPINA7	0.019774
KIAA1456	-0.019765
H2AFX	-0.019765
FBXO21	0.019763
ACAT1	-0.019751
C3orf38	-0.019750
PPARGC1A	-0.019729
FKBP11	0.019726
SGPL1	-0.019724
SECISBP2	-0.019723
BGN	0.019718
FOXO1	0.019704
SATB1	-0.019689
RPL10	0.019618
PLS3	-0.019603
TMEM204	0.019570
EPT1	-0.019550
SNX8	-0.019522
SQRDL	-0.019512
ADH4	-0.019506
ADPRH	-0.019485
STX18	-0.019478
WDR53	-0.019474
SERPINA12	0.019449
WNT2	-0.019446
SOWAHB	-0.019443
GFM2	-0.019431
FAIM3	-0.019428
ABCD1	-0.019427
TK2	-0.019420
C9orf142	-0.019399
GAB1	0.019397
DEDD2	0.019380
UBAC2	-0.019365
PSAP	0.019333
RNF145	0.019330
FAM219B	-0.019321
GALM	0.019315
SLC6A9	0.019313
NUPL2	-0.019288
CYP7B1	0.019244
LRP11	-0.019221
GHITM	-0.019217
FHL2	0.019214
DCN	0.019204
ITPK1	-0.019180
ATP5G3	0.019178
STX5	-0.019153
FCHSD2	0.019153
CLDN1	-0.019144
TTPA	-0.019109
ZFPL1	-0.019107
ODF3B	-0.019066
CES3	0.019057
SLC4A10	0.019051
TMIE	-0.019036
LY6E	0.019003
TMED3	-0.018986
TAPT1	0.018962
CYP4F8	-0.018958
ANG	0.018951
TMED2	-0.018937
FAH	0.018936
KRT18	-0.018934
ALDOC	0.018897
PLIN3	-0.018895
CDK2AP2	-0.018865
MKNK2	0.018840
P2RY1	0.018834
GSTZ1	0.018829
RNF186	-0.018809
CRKL	0.018804
ACP2	-0.018733
LMO4	-0.018732
GBF1	-0.018731
AS3MT	0.018725
FGG	0.018724
CCND1	0.018719
RAD54L2	-0.018703
OTOL1	0.018702
SDHAF1	-0.018679
SEC61B	-0.018657
PCK1	0.018646
RAB32	-0.018641
SDSL	-0.018624
RPL9	0.018616
STEAP2	0.018594
UQCC2	-0.018590
MAP1LC3B	-0.018579
HPDL	-0.018573
ST3GAL1	-0.018561
BLOC1S3	-0.018550