!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!ligand_name	estradiol
!ligand_id	CHEBI:23965
!cell_type	breast epithelial cells
!organism	human
!end_metadata
RPS10	-0.181608
SLC7A5	-0.176852
KRT17	-0.164523
NPC2	-0.161256
THBS1	-0.154729
RPS25	-0.139417
MYL6	-0.130303
MYH9	-0.127937
EIF4A1	-0.119318
RPS12	-0.118418
ACTG1	-0.116897
GABRP	-0.116568
ACTA2	-0.115264
EEF1A1	-0.114768
OAZ1	-0.108864
RPS3	-0.108337
MT2A	-0.104445
TGFBI	-0.103850
RPS20	0.101354
RPL21	0.099576
RPL35A	-0.099190
TIMP1	-0.096529
ACTG2	-0.095077
RPS16	-0.093691
GNB2L1	-0.092846
ACTB	-0.092124
IFITM3	0.091455
AMY1C	0.090907
RPL18A	-0.087353
TUBA1C	-0.087128
MT1X	-0.086059
ATP5EP2	-0.084546
LDHA	0.083819
RPL18	-0.082043
ENO1	-0.081574
CCND1	-0.078214
RPS27	-0.074821
RPL37A	0.074680
ACTN1	-0.074483
CDH1	-0.072585
RPL41	-0.071954
RPL8	-0.070750
RN7SL1	-0.070116
UBC	-0.069587
PAM	-0.065915
RPL36	0.065626
IFITM2	0.065603
RPL4	0.065414
RPS27A	-0.065281
TMSB10	-0.065096
COX4I1	0.063572
CD81	-0.061867
YWHAH	0.060801
RPL6	-0.059898
SEPT9	-0.059374
RPS18	0.058802
CTNNA1	-0.058293
CCNI	-0.057974
LAIR1	-0.057253
MDH2	0.055931
CAP1	-0.055842
COX7C	-0.055466
MIF	0.055421
TOMM7	0.055300
CTSB	-0.055233
RPS4X	0.055156
SOD1	0.054413
FAU	0.053888
KRT7	-0.053428
RPSA	-0.053182
MYL12A	0.052988
MT1A	-0.052660
RAB32	0.052019
FOXC1	-0.051983
RPL19	-0.051905
CPA4	-0.051879
TMSB4X	-0.051148
CHCHD2	0.050997
UBA52	-0.050579
EZR	-0.050329
TPT1	-0.049971
SLC7A5P2	-0.049460
RPS6	-0.049345
YWHAZ	-0.049147
MFGE8	-0.048925
SERPINE2	-0.048566
PFDN5	0.048556
CYR61	-0.047946
UQCRHL	0.047614
RPL35	0.046806
HIST1H4C	0.045954
RCC2	-0.045209
RPS3A	0.044582
RPS9	0.044464
SERPINA3	-0.044373
POLR2F	0.043511
FSCN1	0.043280
KRT81	0.043237
RPS2	-0.043188
MMP7	-0.043169
RPS29	-0.043091
RPL27	-0.042593
COX6B1	0.042455
FLNB	-0.041620
ACTA1	-0.041609
CCND2	-0.041482
LASP1	-0.040688
IGFBP5	-0.040651
SPINT2	0.040412
S100A6	0.040217
TMBIM6	-0.040021
LGALS1	0.040017
LITAF	-0.039855
TAGLN	-0.039829
KRT19	0.039815
SUN2	-0.039811
PLIN3	0.038266
NDUFS8	0.038211
VAMP8	0.037733
PSMB3	0.037560
GSTO1	0.037350
TMEM183A	0.037312
TRAM1	-0.037277
EEF1B2	0.037128
HSPB1	-0.036916
MAT2A	-0.036891
RPS5	0.036889
MRPS6	0.036835
COL1A1	-0.036685
RPL3	0.036642
PARK7	0.036364
CTGF	-0.036214
RPL38	-0.036087
SSR4	0.035848
NDUFB5	0.035290
H3F3A	-0.035081
CCDC6	-0.034969
RPLP0	-0.034791
SEC61A1	-0.034554
PHPT1	0.034356
RPS17	-0.034347
B2M	0.034212
IL11	-0.034212
MRPL37	0.033553
PSMB4	0.033393
RPN1	-0.033159
FARSB	-0.033126
TMEM258	0.032976
CALM2	0.032632
PSMB1	0.032577
LSM1	0.032545
PSMB6	0.032513
BGN	-0.032472
SEC61B	0.032467
AIMP2	0.032379
DYNC1LI2	-0.032259
RPL26	0.032192
EIF4G2	-0.032095
CSRP1	-0.031949
ROMO1	0.031831
TUBB4B	0.031770
RPS24	0.031762
ANXA2	-0.031635
DARS	-0.031605
EFEMP1	-0.031597
TPM2	-0.031468
RPS14	0.031349
SRF	-0.031315
TPM1	-0.030992
TKT	0.030829
CEBPB	-0.030755
EEF2	-0.030615
PSMB7	0.030586
GPR56	-0.030581
TMED3	0.030459
TPI1	0.030406
TNFRSF21	-0.030344
DNAJA1	-0.030331
ALDH1A3	-0.030250
HSPA8	0.030130
TUG1	-0.029655
COX6A1	0.029464
MTCH1	-0.029295
NNMT	0.029291
MAPRE1	0.029198
NUCB1	-0.028938
KRT14	0.028931
EIF3K	0.028790
PMEPA1	-0.028754
PSMA6	0.028752
HSP90B1	0.028715
CFL1	0.028703
SLC20A1	-0.028489
KRTCAP2	0.028250
RPS13	0.028238
CNN3	0.028192
ZFAND5	-0.028147
IGFBP7	0.028115
UQCRQ	0.028066
RHEB	0.028046
PSMA5	0.027620
PPIAL4B	0.027300
PLOD2	-0.027116
MSN	-0.027044
VDAC1	0.027040
RPL11	-0.027033
S100A2	0.026815
TALDO1	0.026691
RARRES1	0.026620
ATP5H	0.026455
MGP	0.026407
COMMD3	0.026390
CALM1	-0.026381
C20orf24	0.026359
C1orf106	-0.026330
F2R	-0.026315
PRDX4	0.026301
AKR1C3	0.026285
SLC16A3	-0.025995
RPLP2	-0.025841
GHITM	0.025726
TIMM23	0.025720
ANXA2P1	0.025553
MANF	0.025463
NENF	0.025266
RPS15	0.025258
CD24	0.025225
RPL39	-0.025207
UBE2F	0.025188
TMCO1	0.025107
TCN1	0.025092
UBE2M	0.025041
MRPL21	0.024852
NDUFA8	0.024824
ARPC3	0.024816
FHL2	0.024731
S100A9	0.024718
CSNK1G2	0.024368
PPA1	0.024321
CLDN1	-0.024248
CMC2	0.024042
TNC	-0.023945
DUSP23	0.023929
JTB	0.023586
RPL5	0.023494
CYB5B	0.023457
TMA7	0.023436
MORF4L2	0.023353
PFN1	-0.023234
AP2S1	0.023217
YBX1	0.023150
IMP4	0.023089
DAD1	0.023083
NOL7	-0.023030
CST3	-0.022930
PABPC4	-0.022812
MRPS15	0.022791
SPCS1	0.022714
SNRPD2	0.022688
STOML2	0.022678
EIF3I	0.022504
MMP10	-0.022391
BHLHE40	-0.022316
JAG1	-0.022283
SRPRB	0.022278
SDHB	0.022273
CALD1	-0.022187
RPS28	0.022152
HDAC2	0.022152
SHROOM3	-0.022099
CREB3L2	-0.022095
SGSM2	-0.022090
HOXA5	-0.022063
TFRC	-0.022062
PTPRK	-0.022061
ANP32B	0.021987
PSMC2	0.021900
JUND	-0.021845
RPL10A	0.021812
NDUFA4	0.021790
VDAC3	0.021662
AHCYL1	-0.021620
S100A16	0.021609
PRDX5	0.021567
EIF3B	-0.021556
FASN	-0.021501
NME1	0.021485
DYNLL1	0.021440
ATP6V1G1	0.021405
TXNDC17	0.021260
AP3B1	-0.021162
ATP6V1F	0.021112
MMP12	-0.021043
LSM2	0.020942
RPL17	0.020941
KRT6B	-0.020931
ATP5C1	0.020828
SLIRP	-0.020820
ATP6V1E1	0.020764
TMEM14C	0.020712
MYL12B	-0.020600
LUZP1	-0.020591
MRPL17	0.020574
ATRAID	0.020514
LAMTOR5	0.020513
MAD2L2	0.020507
NOP10	0.020497
PGRMC1	0.020433
LGALS7	0.020406
EIF4H	-0.020341
FAM96B	0.020327
LEPREL1	-0.020303
PNP	0.020263
NDUFAB1	0.020238
ANXA1	-0.020202
LCP1	0.020098
GAPDH	-0.020091
SLCO2A1	-0.020019
PROM1	-0.020004
ROCK2	-0.019984
PUM1	-0.019957
SAT1	-0.019904
COL17A1	-0.019847
PSMB5	0.019749
VIM	0.019723
PHGDH	0.019718
ADIRF	0.019716
NDUFS5	0.019687
PLAU	-0.019656
RRP36	0.019609
DDX47	0.019573
ATP6V0E1	0.019545
ARL6IP5	0.019522
PTHLH	-0.019517
PABPC1	-0.019439
IGFBP3	0.019428
PFKFB3	-0.019297
COX8A	0.019215
EIF4A3	0.019154
NDUFS3	0.019131
ZDHHC8	-0.019097
ITPR3	-0.019089
DDX39A	0.019023
PPP2R1A	0.018999
CXCL8	-0.018981
C19orf70	0.018969
PSMD8	0.018938
NIP7	0.018880
GNS	-0.018816
RPS26P11	0.018815
DCBLD2	-0.018813
RNF181	0.018811
MAP7D1	-0.018736
GSTP1	-0.018662
ARF4	0.018640
LAMC1	-0.018634
SLC9A1	-0.018510
ECHS1	0.018497
GTF3A	0.018480
TMEM179B	0.018460
EMC7	0.018454
SNRPB	0.018422
PTBP1	-0.018413
SRRM2	-0.018372
NARS	0.018357
RPL13AP6	0.018330
MRPL18	0.018280
ARL6IP1	0.018266
CARM1	-0.018260
H2AFY	-0.018218
SF3B5	0.018203
CAV1	0.018201
ORC6	-0.018128
DCTN2	0.018120
HADH	0.018032
SUMF2	0.017969
PSMC3	0.017968
LGALS7B	0.017924
PDXK	-0.017842
DUSP3	-0.017732
DDX5	-0.017651
TAX1BP3	0.017636
LPXN	0.017635
NDUFA3	0.017631
MRPL36	0.017628
GNAS	-0.017621
ATP2A2	-0.017597
RARRES3	0.017577
SRRT	-0.017557
TMEM256	0.017553
GLTSCR2	0.017511
COX5B	0.017481
RAB11FIP1	-0.017471
YBX3	-0.017412
HIGD2A	0.017351
ATXN2	-0.017268
STK24	-0.017252
SLC39A1	-0.017210
EPAS1	-0.017201
C19orf53	0.017154
ZNF207	0.017148
CNN2	0.017147
CYBA	0.017142
RPS21	0.017142
HDDC2	0.017115
POLR1D	0.017063
DECR1	0.017035
IGFBP4	-0.017020
TMEM59	0.017002
APEX1	0.016971
COL4A1	-0.016953
IER3	-0.016844
MOK	0.016821
NDUFB10	0.016750
POLE3	0.016720
EMP1	0.016695
TIMM10	0.016633
CDC37	0.016578
EDF1	0.016564
JUP	-0.016543
NFKBIA	-0.016539
ABCC3	-0.016484
GPX1	0.016454
LAMA5	-0.016441
RPLP1	0.016427
MALL	0.016370
TXLNA	-0.016294
CDC20	0.016273
MRPL14	0.016256
GLRX3	0.016223
CA2	0.016217
ARCN1	-0.016194
TRIM44	-0.016128
HNRNPM	-0.016109
GTPBP4	0.016053
RUSC1	-0.016008
GPN1	0.015924
LAPTM4B	0.015871
RHBDF1	-0.015854
CCL2	0.015829
TMEM87A	-0.015743
TOMM20	-0.015742
CLIC1	0.015722
CLEC2D	0.015646
HGS	-0.015614
MRPL54	0.015612
RPL13A	0.015610
RING1	0.015588
S100A11	0.015582
KRT5	-0.015557
LTA4H	0.015537
DEGS1	0.015518
GLTP	0.015454
HMGN2	0.015435
CKAP4	-0.015426
PTTG1	0.015394
CETN2	0.015388
RPL27A	-0.015387
TST	0.015354
GLRX5	0.015250
KHDRBS1	0.015150
EIF1	-0.015107
CAB39	-0.015104
RAB11A	-0.015074
EMP3	0.015072
VEZF1	-0.015068
HNRNPAB	-0.015021
RBX1	0.015018
POLR3C	0.015004
MYOF	-0.015003
SLC3A2	-0.014977
IRX2	-0.014915
ALKBH5	-0.014905
MRPS17	0.014898
NCOA4	0.014850
RABEPK	0.014849
THOC7	0.014848
FBL	0.014790
PACSIN2	-0.014760
TMEM14B	0.014656
KPNA6	-0.014647
DUSP14	0.014574
ATP5A1	-0.014483
EIF2S3	0.014473
GJC1	-0.014456
RPS7	0.014422
COL6A1	-0.014318
FIS1	0.014288
RPL24	0.014263
KLK7	0.014259
ATP6V0B	0.014228
PLSCR3	0.014195
GOT2	-0.014182
LLGL1	-0.014131
PRPSAP1	0.014096
CX3CL1	-0.014091
TSPAN31	0.014071
GLIPR1	-0.014066
RPL23	0.014064
CERS6	-0.014060