!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!drug_name	Metoprolol
!smiles	CC(C)NCC(COC1=CC=C(C=C1)CCOC)O
!drugbank_id	DB00264
!pubchem_cid	4171
!cell_type	colon
!organism	human
!end_metadata
FOS	-0.130187
XIST	-0.119049
EGR1	-0.116334
NR4A1	-0.088770
GCG	-0.080059
RPS4Y1	0.079659
LOC284454	-0.070125
OLFM4	-0.069276
ERAP1	-0.055352
KRBOX1	-0.054647
MARS2	-0.051783
ADAMDEC1	-0.051466
NR4A2	-0.051280
IGJ	-0.050837
CXCL3	-0.049487
RGS1	-0.047457
SST	-0.047125
C8orf4	-0.044388
CXCL1	-0.044255
CD69	-0.044087
LINC00261	-0.043937
CTAG1A	0.041895
AQP8	0.040917
EGR2	-0.040707
TPM2	0.040297
ZFP36	-0.040080
SLC16A9	0.039208
LINC01405	-0.039033
CCL8	-0.038829
ACTG2	0.038710
MCOLN2	0.038452
HRCT1	0.038365
IER2	-0.037439
DUSP1	-0.037361
KCTD12	-0.037185
DES	0.037105
TUSC3	-0.037002
HBB	-0.036856
MAB21L2	-0.036783
ERAP2	-0.036716
EGLN3	0.036435
ODC1	-0.035834
SAMD10	-0.035833
PSMG1	-0.035537
CCDC58	-0.035494
GREM1	0.034853
LEPREL1	-0.034816
HKDC1	0.034711
ATP6AP1L	0.034639
NUPR1L	-0.034575
RBM48	-0.034569
GREM2	0.034421
C1D	-0.034275
MAD2L1	-0.034051
FHDC1	-0.033825
C3orf14	-0.033731
KCNMB4	-0.033002
ASPN	0.032167
CNN1	0.032118
CCNO	0.032102
CLIP4	0.031712
GBP3	-0.031657
TYRP1	0.031555
WBP5	-0.031362
RRS1	-0.031338
PNP	-0.031226
FMOD	-0.031077
CBWD3	-0.030924
MYLK	0.030839
SQLE	-0.030661
RNF150	0.030558
HAPLN1	-0.030542
LOC642236	-0.030257
PITX2	0.029881
CXCL2	-0.029855
GGH	-0.029205
DCUN1D5	-0.029126
DPP10-AS1	-0.028956
CYR61	-0.028887
SPINK1	-0.028848
GDPD2	0.028826
C11orf96	-0.028586
SELK	-0.028549
SNHG5	-0.028237
C9orf43	-0.028231
CDO1	0.028172
CEACAM6	0.028121
ADAMTS1	-0.028078
IER3	-0.028036
CFD	-0.028029
ARHGAP15	-0.028022
TAGLN	0.028006
SCUBE2	-0.027960
CDR1	-0.027898
GDF15	-0.027841
LXN	-0.027805
GATM	-0.027791
BAALC	0.027773
C22orf23	0.027771
VMP1	-0.027613
KCNE3	-0.027442
KAL1	0.027308
CCL20	0.027291
FAM21EP	-0.027220
MRPS21	-0.027053
TPSG1	0.027015
PTGS2	-0.026996
EEF1E1	-0.026873
RLN2	-0.026682
AGR2	-0.026679
ABHD10	-0.026636
PHF5A	-0.026527
CA4	0.026479
TEX10	-0.026391
SPINK2	-0.026368
NOS2	-0.026339
ZNF367	-0.026322
ARHGEF40	-0.026320
SI	-0.026276
KCNB1	0.026224
TIMM21	-0.026096
ECHDC1	-0.026030
DICER1	-0.025962
MFAP4	-0.025936
PIM3	-0.025927
LINC01120	0.025915
C11orf86	0.025831
ZNF165	-0.025817
AIFM3	0.025770
PITHD1	-0.025736
SGK2	0.025567
SGK1	-0.025542
HLA-C	0.025487
TRIB1	-0.025452
PBK	-0.025394
DAO	0.025249
PLCE1-AS2	0.025208
CABYR	0.025205
DUSP5	-0.025186
CNIH3	-0.025183
S100B	-0.025174
C8G	0.025148
TOP2A	-0.025129
DLL1	-0.025006
C8orf12	0.024998
NEXN	0.024962
KIF18A	-0.024958
TTTY15	0.024883
LOXL1-AS1	-0.024769
MYB	-0.024757
HCN2	0.024682
TSPAN11	-0.024664
HIST1H4B	0.024627
EYA1	-0.024614
LYAR	-0.024546
KIAA1324L	-0.024515
MMACHC	-0.024458
IL20RA	0.024438
C1orf229	0.024386
SLC3A1	0.024386
INPP1	-0.024095
CBWD6	-0.024092
ENC1	-0.024037
POLR1B	-0.024027
GJB2	-0.024008
RGMB	-0.023958
HIST1H4C	0.023956
TTF2	-0.023925
ANKK1	0.023822
HLA-DRB5	0.023693
PARPBP	-0.023649
TPSB2	-0.023468
TMEM67	-0.023415
HEYL	-0.023414
PITX1	0.023397
BHMT2	0.023378
FOXJ2	-0.023344
ANG	-0.023290
GPR110	-0.023262
ID1	-0.023248
COL8A2	0.023242
DDX3Y	0.023195
RPF2	-0.023158
ZNF671	-0.023146
RPS5	-0.023109
NHLH2	0.023094
E2F8	-0.023090
WASH1	0.023052
TUBAL3	0.023035
AXDND1	0.023030
IGKC	-0.022950
PHGDH	0.022925
MESDC1	-0.022919
IFITM5	0.022906
C11orf73	-0.022896
HSPA5	-0.022873
TOMM70A	-0.022873
HLA-A	0.022827
GFAP	-0.022799
SH3D21	0.022797
HMGN5	-0.022792
CSRP2	0.022791
TBC1D31	0.022761
DNA2	-0.022744
NRTN	0.022737
TCF21	-0.022710
CCNJ	-0.022703
PLP1	-0.022690
CRCT1	-0.022674
OIP5	-0.022639
LINC00115	-0.022622
MEIS2	0.022621
MLLT4-AS1	-0.022550
PPAT	-0.022518
SPC25	-0.022463
PTPRR	0.022422
TEX30	-0.022402
BHLHE41	0.022372
PTBP1	-0.022337
GLRX2	-0.022290
FRZB	-0.022286
EIF1AY	0.022283
KRT10	-0.022274
FHIT	0.022139
TMEM200A	-0.022136
MSH2	-0.022097
TMBIM4	-0.022064
NTRK2	0.022036
FGFRL1	-0.022014
LOC100509814	0.022000
ETS2	-0.021993
CREB5	-0.021985
WDR3	-0.021978
KLF2	-0.021928
PLK3	-0.021927
EXOSC3	-0.021903
COX6A2	0.021896
C3orf33	-0.021875
HLA-J	0.021842
OSTC	-0.021830
LINC01351	-0.021791
GNL3	-0.021784
HLA-B	0.021774
SRSF8	-0.021733
ALG5	-0.021729
PRNP	-0.021708
TNFAIP6	-0.021689
PDS5A	-0.021676
H2AFZ	-0.021675
CDC73	-0.021622
TRMT10C	-0.021594
ARMCX3	-0.021526
SERP1	-0.021509
PDGFRB	-0.021461
RLIM	-0.021459
FAM118A	0.021453
PROCR	-0.021398
CYP2A7P1	0.021379
TYMP	0.021361
MSH6	-0.021271
MRPL1	-0.021268
TCEAL8	-0.021257
HIF1A	-0.021233
KRTAP5-8	-0.021199
SYNPO2	0.021188
SEPP1	0.021136
UGT2B11	-0.021135
FGF14-AS2	-0.021110
RAB1A	-0.021095
FNDC4	0.021082
LRRC2	0.021058
CDH13	-0.021056
MS4A12	0.021024
IRX3	0.021022
FGFBP2	-0.021000
RHOBTB3	-0.020981
LGALS2	-0.020946
MFSD6L	-0.020941
PCDH20	-0.020939
CBWD2	-0.020901
CPAMD8	-0.020809
OSR2	0.020788
CTSV	0.020768
MIPEP	-0.020752
MNX1-AS1	-0.020747
MTERF3	-0.020739
RHAG	-0.020736
TCP1	-0.020669
SAP30	-0.020668
FAM169A	0.020614
HSPB3	0.020611
VHL	-0.020560
HCN4	0.020558
SYCE1L	0.020551
FTH1	0.020545
SMC4	-0.020496
SPOCK1	-0.020489
SLC22A18AS	0.020449
RAB27A	-0.020442
RAD51AP1	-0.020435
ZBTB37	0.020429
PDZD7	0.020406
NCAM2	-0.020403
ESCO2	-0.020397
DIMT1	-0.020394
LOC399491	0.020390
NR2F2-AS1	0.020387
LBX1	0.020382
GCNT2	-0.020378
POU2AF1	-0.020338
PHLDA2	-0.020324
HSD17B2	0.020321
CCL23	0.020270
MRPL17	-0.020261
KIAA0895	-0.020235
WIPI1	-0.020228
LINC01116	-0.020220
SET	-0.020203
HSPH1	-0.020180
MGAT2	-0.020130
CDC42EP5	0.020109
BRCA2	-0.020106
TFB2M	-0.020081
LCE1D	0.020081
TSPAN1	0.020071
JSRP1	0.020066
OXCT1	-0.020062
GEMIN4	-0.020020
ABCG2	0.020015
ZBTB1	-0.020001
CCT2	-0.019986
CDCA7	-0.019951
TFAM	-0.019915
ZNF579	0.019902
HBEGF	-0.019886
LINC00621	-0.019867
CHRDL2	0.019867
ZFP36L2	-0.019846
VPS18	0.019834
MRPL50	-0.019818
SEMA3A	0.019812
NEIL3	-0.019801
HMGCS1	-0.019792
CCDC144B	-0.019781
ATP10B	0.019748
FABP6	0.019705
PCSK9	-0.019700
MTFR2	-0.019697
DCAF13	-0.019692
DKC1	-0.019691
SLC26A3	0.019682
TXNDC9	-0.019680
PRAP1	0.019672
SCGB2A1	-0.019638
EIF1AX	-0.019629
PDE8B	0.019614
MAGOH	-0.019608
PHTF1	-0.019605
GRIN2D	0.019596
SDHD	-0.019571
CTAGE10P	0.019563
DDX21	-0.019551
JUNB	-0.019532
PP7080	0.019521
MMP7	0.019504
OCEL1	0.019487
GLRB	-0.019440
GPATCH4	-0.019437
JUN	-0.019436
LCE5A	0.019420
LCE1C	0.019413
PLEKHG4	-0.019412
TPO	-0.019402
HLA-E	0.019393
RARRES1	-0.019377
SAMHD1	-0.019362
ZNHIT6	-0.019345
DNAJA1	-0.019340
NFKBIZ	-0.019304
IRF4	-0.019296
NUP35	-0.019281
DRG1	-0.019279
HEPACAM2	-0.019271
NIFK	-0.019254
IMPACT	-0.019250
OGDHL	0.019241
ADARB1	0.019235
CCNH	-0.019194
RACGAP1	-0.019193
ZNF649	-0.019186
ACAT2	-0.019177
CHSY1	-0.019170
SHOX	0.019163
IRF2BPL	0.019160
TGFB2-OT1	-0.019159
SLC12A2	-0.019125
NCKAP1	-0.019105
PLAT	-0.019099
CARD16	-0.019072
CASP1	-0.019052
ZNF623	-0.019035
POU3F3	0.018961
TMEM155	0.018955
CEACAM7	0.018949
AHSA2	0.018944
CREBRF	0.018925
CAMK2G	0.018914
MRPS17	-0.018912
ZNF432	-0.018866
CAB39L	-0.018853
PARK7	-0.018845
BYSL	-0.018843
LPIN3	0.018835
UBE2J2	-0.018834
PPP6R1	0.018824
SARAF	-0.018809
SUMO1P3	-0.018804
PHOX2A	0.018789
CEACAM1	0.018789
DNALI1	-0.018783
HRASLS2	0.018763
GHR	0.018757
WDR43	-0.018756
KIF13A	-0.018738
LCMT2	-0.018699
PASD1	-0.018672
LINC00957	0.018662
PRMT6	-0.018652
FAM201A	0.018632
BRIX1	-0.018623
ONECUT2	0.018606
HNRNPDL	-0.018606
DNAJB11	-0.018580
PDCD2	-0.018569
ERLEC1	-0.018560
SLC22A18	0.018554
CDC26	-0.018548
C11orf74	-0.018513
FNBP1	0.018490
CD48	-0.018488
C1orf216	0.018483
CGREF1	-0.018410
SPAG16	-0.018393
TSPAN15	-0.018392
UBE3D	-0.018379
DNM1P35	0.018364
SLC9A3R1	0.018357
CAPRIN1	-0.018356
SLC45A4	0.018354
FMN2	-0.018332
INSL5	-0.018321
TYMSOS	-0.018319
GNE	-0.018319
PBRM1	-0.018311
CTGF	-0.018302
REG4	-0.018289
BTC	0.018260
TIMM23	-0.018253
PDIA6	-0.018248
SNORA78	0.018238
GPR150	0.018230
TMEM37	0.018221
C7orf62	-0.018212
GUCA2A	0.018210
OCA2	-0.018203
HPS6	-0.018202
MTFMT	-0.018193
HLA-F	0.018167
PLAG1	-0.018155
POLR3K	-0.018149
PLA2G2A	-0.018136
TM9SF3	-0.018122
ZG16B	0.018121
IGHG4	0.018118
SRP9	-0.018112
LTK	0.018097
H2AFX	-0.018093
PRSS36	-0.018075
ZNF556	0.018075
LOC79160	0.018049
HLA-H	0.018034
COX18	-0.018023
GTPBP4	-0.018019
MND1	-0.017998
IDO1	-0.017992
MPLKIP	-0.017990
SRSF2	-0.017969
ZNF684	-0.017962
AFMID	-0.017961
ANO5	-0.017956
TFRC	-0.017943
ZIC2	0.017942
POLB	-0.017941
HES7	0.017932
TRBV5-4	0.017926
PTGDS	0.017919
FLJ22184	0.017913
LTV1	-0.017908
SPRY1	-0.017908
CKAP4	-0.017887