!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Rattus norvegicus
!drug_name	orotic acid
!smiles	C1=C(NC(=O)NC1=O)C(=O)O
!pubchem_cid	967
!cell_type	Livers ( from inbred Kyotos - fed a diet with 1% orotic acid) - 3 Day
!organism	rat
!end_metadata
PABPC4	-0.265529
ND5	0.198422
CLU	-0.187755
KNG1	-0.178577
APOE	-0.173784
HSP90B1	0.161933
COMT	-0.155384
MPC1	-0.144635
GC	-0.141585
MGST1	-0.126494
ITIH3	-0.123596
PIGR	-0.120638
UBC	-0.112815
FABP1	-0.112611
PCBD1	-0.110482
APOH	-0.106660
ACAA2	-0.101974
AGT	-0.100935
CALR	0.098821
RPS29	-0.098480
INSIG1	-0.097969
PON1	-0.097515
CYP1A2	-0.097171
ADH1C	-0.097132
SOD1	-0.095485
THRSP	-0.094273
MGST3	-0.093552
GPX1	-0.093122
BHMT	-0.092679
LIPC	0.091745
COX3	-0.091442
ATP6	-0.091290
AMBP	-0.089547
C9	-0.084398
F2	-0.082524
HPX	-0.080472
HPD	-0.080017
HSD11B1	-0.079811
GAMT	-0.079106
GSTM5	-0.078591
ARG1	-0.078369
F10	-0.075670
RPS12	-0.075187
ITIH4	-0.075163
PPIA	-0.073050
HRSP12	-0.072755
FBP1	-0.071678
ZFP36L1	-0.071148
SULT2A1	-0.070018
METTL7B	0.069865
RPS21	-0.069507
PEMT	-0.067894
PDIA4	0.067383
UPB1	0.066926
UGDH	0.065998
PAH	-0.065167
PCK1	-0.064421
PDIA6	0.063697
AHCY	-0.063242
TAT	-0.062845
GSTA5	-0.062578
POMP	-0.062485
RPS16	-0.061258
SDC4	-0.061014
SULT1E1	-0.060138
CA3	-0.058747
EPHX1	-0.058426
APOM	-0.058112
ALDH2	-0.058018
HMGCS1	-0.057639
CTH	-0.057341
PCYT2	-0.057067
KHK	-0.056941
COX4I1	-0.055730
APOA1	-0.055255
BSG	-0.055038
HMGCS2	-0.054548
NDUFB2	-0.054269
ACADM	-0.054186
B2M	-0.053461
SORD	-0.053138
G6PC	0.052120
HSPA5	0.052089
RPS13	-0.051735
CFB	-0.051706
TECR	-0.051621
AFM	-0.051611
ALDH1L1	-0.051250
TTR	-0.050904
COX8A	-0.050857
TPI1	-0.049375
ERRFI1	-0.049076
FTH1	-0.048531
CPS1	-0.048524
ATP5G1	0.047321
GABARAP	0.047207
HAO2	-0.046357
SLC27A2	0.046162
RPS25	-0.045713
GNMT	-0.045562
RPL27	-0.045411
CYP2E1	-0.045348
FDPS	0.044543
RPL22	-0.044539
TMBIM6	0.044326
GSTM1	-0.043894
ATP5H	-0.043618
APOC4	-0.043279
ECHS1	-0.042514
SEC61B	0.042386
NDUFB9	-0.041951
HDLBP	0.041901
GHR	-0.041788
ABCD3	0.041493
PAICS	-0.041157
COX2	-0.040862
SEPP1	-0.040553
HAAO	-0.039872
LDHA	-0.039539
P4HB	0.039266
SLC37A4	-0.039038
CRP	0.038887
ACTG1	0.037864
ALDH6A1	0.037638
CDO1	-0.037620
RPL10	0.037266
FGG	-0.036722
TMED10	0.036654
DAO	-0.035906
SULT1B1	-0.035789
GJB1	-0.035674
GSTO1	-0.035392
CTSS	-0.035301
FAU	-0.034818
AKR1D1	-0.034806
CAT	-0.034615
COX1	0.034607
ACTB	-0.033640
NDUFC1	-0.033559
APCS	-0.033487
SLC35B1	0.033270
TMED2	0.032516
OAZ1	-0.032482
SCD	-0.031934
KYNU	-0.031828
PGRMC1	-0.031792
HSPD1	-0.031744
MIF	-0.031689
PPIB	0.031596
PSAP	-0.031546
RBP4	-0.031515
UGT2B28	-0.031393
VTN	-0.031390
FMO1	-0.031386
HIBADH	-0.031303
SLC25A5	-0.031113
APOB	-0.030870
DBI	-0.030687
FAH	-0.030572
SERP1	0.030469
ASGR1	-0.030390
MORF4L2	0.030215
FTL	-0.029579
PHB2	-0.029535
DDT	-0.029527
GPX4	-0.029399
CSAD	-0.029312
PXMP2	-0.029300
TPT1	-0.029202
SPP2	-0.029096
COX6A1	-0.028802
CD81	-0.028488
COX7B	-0.028336
RPL7A	0.028282
RPL27A	-0.027937
CPT2	0.027897
KRT18	0.027851
PTTG1IP	0.027489
TDO2	-0.027007
LCAT	-0.026995
SLC22A1	-0.026768
PPP2R5A	-0.026473
UGT2B17	-0.026253
ATP2A2	0.026247
SEC61A1	0.026058
RPS27L	-0.026055
ND1	-0.025934
HSPE1	-0.025816
LAMP2	-0.025709
PPDPF	-0.025202
ARF4	0.024860
NDUFB4	-0.024623
MAOB	-0.024608
ACOX2	-0.024399
SLCO2A1	-0.024283
RPN2	0.024228
BAAT	-0.024191
PSMB2	-0.024136
NDUFA3	-0.024078
CTSH	-0.024056
NDUFA6	-0.024040
GLUL	-0.023927
HSPA8	0.023893
SLC22A7	-0.023880
PGK1	-0.023796
TTC36	-0.023750
TMEM47	-0.023613
RPL37	-0.023558
PDIA3	0.023508
MARC2	-0.023227
FABP6	-0.023194
TST	-0.023186
GOT2	-0.023157
ABCB11	-0.023093
ARF1	0.023062
ST6GAL1	-0.023058
CLEC4F	-0.022998
ACLY	-0.022756
HSP90AA1	-0.022719
CES1	0.022662
MDH2	-0.022601
YBX1	-0.022484
CST3	-0.022480
GAPDH	-0.022409
CTDSP1	-0.022364
HSD17B13	-0.022312
LAMP1	-0.022132
CD14	0.022076
MGST2	-0.021983
NEDD8	-0.021933
RPS8	-0.021604
ACSL1	-0.021549
ABCC6	-0.021515
ECI1	0.021485
AQP9	-0.021476
RPL28	-0.021310
CYB5A	-0.021215
ABAT	-0.021115
RPL17	0.021110
DIO1	-0.021084
UGT1A1	0.021026
G0S2	0.020980
SLC3A2	0.020883
SERPINA3	-0.020823
IDH1	-0.020769
CISH	-0.020620
CTSC	0.020517
IGFBP1	-0.020384
YWHAB	0.020381
GLUD1	-0.020286
GRN	-0.020233
BDH1	-0.020141
QDPR	-0.019965
GAA	-0.019939
ALDH7A1	-0.019901
FKBP11	0.019775
ACADL	-0.019528
PPIF	-0.019468
APOA4	-0.019162
GDI2	0.019155
ALDOB	-0.019079
LGALS9B	0.019034
CPQ	-0.018932
ORMDL2	0.018903
AVPR1A	-0.018714
OPLAH	-0.018563
FUCA1	-0.018422
RPL39	-0.018279
PTGR1	-0.018260
DUSP1	-0.018118
CD63	-0.018065
IGF1	0.018038
DHCR7	-0.017896
ALDH3A2	0.017885
TMEM205	0.017877
HSD17B10	-0.017769
RPS17	0.017709
ATP6V0C	-0.017694
SNRNP70	-0.017666
PROC	-0.017610
KMO	-0.017580
FN1	0.017578
ECH1	0.017555
AK3	-0.017535
ADH5	-0.017520
PDK2	-0.017368
COPS7A	0.017367
JUN	-0.017366
NDUFA4	-0.017364
ALAD	-0.017175
ACSL5	-0.017136
PSMB5	-0.017045
DCAF11	-0.016663
HYOU1	0.016599
SERPING1	-0.016472
CTSB	-0.016445
PDYN	-0.016439
TUBA1B	0.016167
DECR1	-0.016162
RPS3	-0.016138
HSD17B4	-0.016118
IFITM3	-0.016082
RPN1	0.015954
RPS27A	0.015913
ALAS1	0.015879
TMEM59	0.015845
SIGMAR1	-0.015822
GSTK1	-0.015701
RNASE4	0.015635
PRDX1	-0.015589
EIF3D	0.015442
COX7A2	-0.015393
RGN	-0.015363
CP	-0.015192
KLF9	-0.015184
CYC1	-0.015159
RPL30	-0.015144
SLC25A3	0.015135
RPS5	0.014970
SERPIND1	0.014895
RPL13A	-0.014893
NDUFV3	-0.014849
EBP	0.014723
SLC6A13	-0.014688
MBL2	-0.014614
PSMB4	-0.014611
TUBB	0.014555
NDUFV2	-0.014552
AQP8	-0.014546
ZFAND6	0.014535
RAF1	-0.014501
PSME1	-0.014428
SDHA	0.014386
PEBP1	-0.014294
RPL18A	-0.014283
DNAJA1	-0.014263
MSMO1	-0.014230
GOT1	0.014180
MAGT1	0.014140
GABARAPL2	-0.014120
CALU	0.014012
PRODH2	-0.013987
NDUFB10	-0.013908
NUCB1	0.013906
CREG1	0.013779
RPSA	0.013726
HSD3B7	-0.013713
CTSD	-0.013701
RPL18	0.013576
PRKCG	-0.013566
DAD1	0.013503
PFN1	0.013477
HAGH	-0.013454
CYP51A1	-0.013387
RPS14	-0.013380
CDC37	-0.013299
SERPINA10	-0.013272
HIGD2A	-0.013251
ACADS	-0.013204
ATRN	-0.013179
ABHD14B	-0.013171
ENPP3	-0.013170
GDI1	0.013119
EHHADH	-0.013102
GNE	-0.013030
TTPA	-0.013029
HACL1	0.012998
PARK7	-0.012979
RPL35	0.012970
NCKAP1	0.012967
SERPINA6	-0.012892
RPS7	-0.012862
RPL5	-0.012845
CYP27A1	-0.012797
TSC22D1	-0.012786
APMAP	-0.012723
RPL9	-0.012691
COPZ1	-0.012655
CITED2	-0.012524
TARS	0.012407
ODC1	0.012405
GCKR	-0.012373
SDS	-0.012356
DHFR	-0.012321
GRB2	-0.012268
EGR1	-0.012245
UBR5	0.012135
APOA2	0.012080
ATP5F1	-0.012034
GNAS	-0.011999
HNRNPAB	-0.011961
COPS8	0.011940
NQO1	-0.011919
TUBA1C	0.011876
MAOA	-0.011795
ALB	-0.011726
CNBP	-0.011668
RPL23	-0.011646
ATP1A1	0.011555
F9	0.011514
UQCR11	0.011433
CHP1	0.011430
PLIN2	-0.011404
RPS23	-0.011292
GSTM2	-0.011228
PSMD2	-0.011212
RPL12	-0.011211
EEF2	0.011183
BCKDHA	-0.011065
YWHAE	0.011046
SLC25A10	-0.010996
NDUFB3	-0.010988
HSD17B12	-0.010904
FCGRT	-0.010889
OAT	-0.010749
CA5A	-0.010731
MAP1LC3B	0.010684
PYGL	-0.010524
SLC25A30	-0.010480
LEP	-0.010461
PPP1CA	-0.010440
TMEM53	-0.010409
PSMD11	0.010380
SLC28A2	-0.010361
MAT1A	0.010346
CYTB	0.010342
ACAT2	-0.010336
PLG	-0.010335
GCHFR	-0.010290
DPYS	-0.010251
SEC11A	0.010188
CD82	-0.010173
SLC22A18	0.010124
HADHB	-0.010057
RABAC1	-0.009929
RPS6	-0.009873
C8B	0.009808
RBP1	-0.009803
RXRG	-0.009791
NR1H3	-0.009772
DDC	-0.009721
PRDX6	-0.009704
SLC41A2	-0.009684
ENPP2	-0.009681
RPL19	-0.009641
PSMB8	0.009616
FGB	-0.009533
RPL31	-0.009495
KRT8	0.009483
C1QB	-0.009439
PRKCZ	0.009424
NDRG2	0.009401
GPT	-0.009292
LMAN1	0.009289
HMGA1	-0.009167
PROS1	-0.009156
RPL26	-0.009146
PTP4A1	-0.009136
PTOV1	0.009121
ARFGAP2	-0.009110
AES	-0.009098
ARL1	0.009058
FOXA2	-0.009053
AMACR	-0.009004
RPS9	-0.008968
ZNF706	0.008961
MFGE8	-0.008941
HNRNPU	-0.008939
CD151	-0.008932
UBQLN1	0.008900
EIF2S1	0.008885
CFP	-0.008856
CNN3	-0.008822
ASS1	0.008765
ITGB1	-0.008749
FDFT1	0.008741
PHGDH	0.008689
SRD5A1	0.008684
ATP5A1	-0.008681
CSNK2B	-0.008651
ACAT1	-0.008612
ATG13	0.008565
SUOX	-0.008535
RBCK1	-0.008527
KCNH3	-0.008464
DNAJA3	0.008441
MDH1	0.008404
TRAP1	-0.008398
ASGR2	-0.008367
UNC50	0.008360
GRB14	-0.008263
SPINT2	0.008252
NDUFAB1	-0.008163
AHSG	0.008114
HNRNPF	-0.008070
CHKA	-0.008068
PDLIM1	0.008064
PTP4A2	-0.008061
RPL10A	-0.008047
SPR	-0.008015