!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!ligand_name	17beta-estradiol
!ligand_id	CHEBI:16469
!cell_type	U2OS osteosarcoma cell line
!organism	human
!end_metadata
HLA-A	0.169877
TPM1	-0.151612
ETFB	0.151552
MMP12	0.146693
VIM	-0.139842
MARCKSL1	0.135513
RPS27A	-0.133789
MAD1L1	0.133577
S100A10	-0.121582
SRI	-0.104946
GJA1	-0.102040
RPL8	-0.101370
TMSB10	-0.101255
CYR61	-0.099926
ANXA2	-0.098256
GPRC5A	-0.097011
NNMT	-0.094847
HLA-C	0.094107
RPL34	-0.091521
KRT18	-0.086649
ACTN1	0.086511
HPCAL1	0.085475
EPHX1	0.083155
CHPT1	0.083103
HSPB1	-0.081624
HK1	0.080782
EXT2	0.080135
LDHB	-0.079874
RRM2	0.077632
PABPC3	0.077456
RPL36A	-0.077321
LDHA	-0.077032
C3	0.074890
C20orf24	0.074362
LGALS1	0.073980
GSTO1	0.073274
LY6E	0.072277
RPS28	0.071928
SDCBP	0.070706
HSPB8	0.070318
CYCS	0.069622
TYMS	0.069474
CST3	0.068196
SLC38A2	-0.067497
FKBP4	0.067481
GCH1	0.066684
RPS3	-0.066531
ID1	-0.065483
CFL1	0.065270
TP53I3	0.064924
DBI	-0.064748
SOD1	-0.064369
BAG1	0.064351
HLA-B	0.064310
NCF2	0.064132
PTP4A2	0.062941
PTTG1	0.062590
GPR56	-0.061217
HNRNPA1	-0.060472
PABPC1	0.060171
CEBPB	0.060052
IL32	0.058636
TUBA1A	0.058463
PDLIM3	0.057630
LSR	0.057502
FKBP1A	-0.057480
UBE2S	0.056656
SDC4	0.056398
RPL5	-0.055427
ACTB	-0.055208
RPS11	0.054152
RPS18	0.054083
CA12	0.053990
UBB	0.053817
PAPSS2	0.053406
KRT19	0.052562
HIF1A	-0.051862
ANXA10	-0.051783
SFN	-0.050722
ISG20	0.050581
KRT81	-0.050033
PTTG1IP	0.049732
RPS16	0.049616
CLU	-0.049339
MAFF	0.049119
ARL4C	-0.048738
S100A2	-0.048513
RPS12	-0.048453
CYC1	0.047982
HSP90AA1	-0.047750
BLVRB	0.047656
CAPNS1	-0.047499
PKM	-0.047400
RAB11A	0.047184
FTH1	-0.047013
VWF	0.046898
HSPD1	-0.046809
SLC9A3R1	0.046626
BMP5	-0.046377
COX8A	0.046239
LOX	0.045935
GALNT1	0.044862
RAB31	-0.044820
EEF1D	-0.044434
IDH2	0.044093
FHL1	-0.043982
HSP90AB1	-0.043804
NDN	-0.043718
PTMA	0.043294
RPL12	-0.043252
PTOV1	-0.043044
MDK	0.043009
LAMP1	0.042882
ANXA1	-0.042593
HSPA8	-0.042547
AKAP1	0.042436
DHCR7	0.042403
MPC1	0.042085
INPP5A	0.041937
NGFRAP1	-0.041812
IMPDH2	-0.041653
CALM3	-0.041616
INHBA	-0.041429
SERPINA1	0.041364
GAS6	0.041318
SHFM1	0.040971
RPL23A	0.040713
RTN2	0.040710
ANXA11	0.040379
RAB1A	0.039472
SOX4	-0.039468
PSMA3	0.039382
NFKBIA	0.039358
DUSP1	-0.038890
RPS10	-0.038534
RPS15A	-0.038529
RPS21	-0.038464
HOMER2	0.038438
RPL36AL	0.038352
SLCO4A1	0.038235
LTBP1	0.037895
GAA	0.037827
JUND	0.037472
PSMC2	0.037436
CITED2	-0.037419
MXRA7	-0.037188
EEF1B2	-0.037027
TRIM28	-0.037014
MORF4L2	0.036853
RPL14	-0.036459
FBN2	-0.036243
ATP1B3	0.035937
TPI1	-0.035932
ATP6V1D	0.035906
GSTP1	-0.035815
MAGED1	-0.035671
GABBR2	0.035515
UPF1	0.035453
SNAI2	-0.035140
RPL7	-0.034920
RPL13	-0.034868
TNFRSF12A	0.034822
NPC2	-0.034758
RALA	0.034545
CD63	-0.034229
SH3BP4	-0.033953
RPL37	-0.033763
ABCG2	0.033727
PCM1	0.033681
OAZ1	0.033550
CASP7	0.033497
LAMC1	0.033465
CYP19A1	0.033404
AP2M1	-0.033178
KRT8	-0.033130
TPT1	-0.033053
SGK1	-0.032969
RPLP2	-0.032786
MAP2K1	0.032655
MAP1LC3B	0.032648
ENO1	-0.032346
MFAP2	-0.032248
PPA1	-0.031972
CCT3	-0.031946
DYNLT1	0.031795
MXI1	-0.031760
WDR1	0.031654
MAGEB2	0.031488
GAPDH	0.031430
RPS26	-0.031033
CLIC1	0.030824
ATP5E	0.030807
NIPSNAP1	-0.030706
NCL	-0.030669
EIF2AK1	-0.030643
CDK4	-0.030537
FHL2	-0.030514
RBP4	0.030297
ABCD3	0.030242
PRMT1	-0.030176
VAPA	-0.030139
PTS	0.030111
RHOQ	0.030043
CADM1	-0.030041
SPTAN1	-0.029954
MAPRE1	0.029940
MGST3	-0.029850
ALDH2	0.029734
CORO1C	-0.029590
HSD17B4	0.029568
EEF1A1	0.029517
CALM2	-0.029500
PRC1	0.029471
KLK6	-0.029425
PLOD2	0.029303
ALCAM	-0.029200
EDF1	0.029198
NME4	-0.029050
TMBIM6	0.028989
RPL4	-0.028936
MUC1	0.028785
RPL30	-0.028750
SEMA3F	0.028716
ARPC1A	0.028631
UBE2C	0.028574
SLC7A5	0.028515
IL13RA2	0.028414
ENC1	-0.028124
LAPTM4A	-0.028044
CST1	0.028008
FLNA	-0.027883
TAGLN2	-0.027772
CNN3	-0.027726
TUBB4B	-0.027689
COX5A	0.027442
RPS27	-0.027438
TUBB	-0.027310
PAPSS1	0.027300
CHCHD2	0.027273
PBK	0.027194
APEX1	-0.027146
GNB2L1	-0.026967
ATP6V0B	0.026928
NME1	-0.026899
MT2A	0.026850
LAMB3	-0.026736
RPL13A	-0.026717
RPL22	-0.026675
SERPINB6	0.026615
STK24	0.026513
S100A6	-0.026420
CYP26B1	-0.026304
QARS	-0.026226
CTGF	0.026110
BANF1	-0.025988
CTSZ	0.025899
TIMM8B	0.025892
VTI1B	-0.025885
ARPC1B	0.025865
NONO	-0.025768
SLCO2A1	0.025745
UQCRQ	-0.025718
CLIC3	0.025634
WNT5A	-0.025623
DYNLL1	0.025607
UBE2D3	0.025567
BMP4	-0.025555
IFT27	0.025481
YBX3	-0.025381
TPBG	0.025365
PRDX6	0.025196
JAK1	0.025192
TNIP1	0.025153
RGS10	0.025153
LAPTM5	0.024882
GRHPR	0.024824
IRAK1	-0.024777
H1FX	-0.024684
AFF1	0.024644
ERH	0.024541
MAGED2	-0.024396
RPL28	0.024260
SPARC	-0.024116
PDGFC	-0.024014
SEC61A1	0.023946
F13A1	0.023908
MYH9	-0.023846
FAU	-0.023620
MT1H	-0.023579
AGPAT1	0.023547
WNK1	0.023522
GPX4	-0.023475
CSE1L	-0.023453
RCN1	-0.023452
CD300C	0.023193
PLIN2	0.023095
CLEC2B	0.022975
EIF3E	-0.022917
GPER1	0.022804
PTPRF	0.022748
MDH1	0.022666
RANBP1	-0.022604
PSMB7	0.022529
LPL	0.022525
SFRP1	-0.022471
MIF	0.022468
TPP1	0.022458
POLR2E	-0.022396
COL18A1	0.022387
COX17	0.022385
SELT	0.022354
GTF2A2	0.022337
VAT1	-0.022295
RPL36	-0.022270
DDAH1	-0.022219
RPS13	0.022173
FLNC	-0.022171
RPL27	-0.022124
SEC61G	0.022118
UCP2	-0.022092
RPS7	-0.022090
HAX1	0.022060
PEA15	-0.021782
SERPINE2	0.021759
RPS15	0.021724
CDKN3	0.021694
KPNA2	0.021598
PON2	-0.021536
CSRP1	-0.021502
RAB36	0.021418
HDGF	-0.021345
SMS	-0.021319
PPM1D	-0.021301
CD81	-0.021300
ECHS1	-0.021290
SERPINE1	-0.021215
DNAJA1	0.021082
SEPT9	-0.021044
IGHMBP2	0.021037
RHOC	0.021036
TRAM1	-0.020981
SUB1	0.020968
EPB41L2	0.020953
MTCH2	-0.020917
KRT17	-0.020914
MED27	0.020913
CKB	0.020900
PRNP	-0.020881
RNF14	0.020853
EXT1	-0.020846
CAPN2	0.020841
CNN1	-0.020786
COL4A1	-0.020714
MTHFD1	-0.020682
TAF6	-0.020678
ITPR3	0.020661
GHITM	0.020620
RPL11	-0.020543
RPS27L	-0.020529
CAV1	-0.020528
LGALS3	-0.020519
MYC	-0.020501
GLTSCR2	-0.020480
ULBP2	0.020406
P4HB	-0.020369
RASGRF1	0.020299
GRSF1	-0.020256
AHCY	-0.020243
RPL37A	0.020144
EMP3	-0.020128
BCL2L1	-0.020114
SNRPD2	-0.020099
MYRF	0.020091
ABLIM1	-0.020075
CHD4	-0.020061
SNRPF	-0.020055
RPL19	-0.019949
UFD1L	0.019908
ERP29	-0.019779
DHX15	0.019779
ANXA5	-0.019566
SF1	-0.019475
LDOC1	-0.019446
CCT2	-0.019416
BUD31	0.019370
CPSF1	-0.019335
ABCA3	0.019335
RAP2B	-0.019310
FDXR	0.019286
TPM2	-0.019270
LPAR1	0.019162
RPS25	-0.019130
VDAC3	-0.019103
CELSR2	0.019052
GALNT2	-0.019021
RGS19	0.018968
ATP6V0C	0.018917
CTSV	0.018915
HNRNPA2B1	-0.018797
TUBB3	-0.018796
TBCA	0.018791
FUT8	-0.018743
CCNI	-0.018681
SHC1	-0.018656
ZWINT	0.018554
ZBTB18	0.018543
PPIF	0.018543
ARF4	0.018527
GCLM	0.018393
RPL39	0.018261
TACC1	0.018254
MBOAT7	-0.018193
FIBP	-0.018156
TGIF1	-0.018114
DFNA5	-0.018109
MAPKAPK2	0.018106
RTN4	-0.018095
TNS3	-0.018058
DSTN	-0.018039
NPM1	-0.018026
GALNT7	0.017958
SKP1	0.017943
SLC10A3	0.017894
PSAP	-0.017868
EIF4A1	-0.017848
LTBP2	-0.017842
RNASET2	-0.017827
ATP6V1B2	0.017824
PRAME	-0.017802
PHC1	-0.017650
SRP14	0.017614
GNAI1	-0.017516
ACTN4	-0.017502
CALCOCO2	0.017488
NFIL3	0.017478
PSMD2	0.017428
TMED9	-0.017404
CBFB	0.017378
MTCH1	-0.017331
MEF2A	0.017302
COX6C	0.017276
PRDX2	0.017254
GRB10	-0.017242
PFN1	-0.017237
GSTM2	-0.017199
S100A11	-0.017154
SEPW1	0.017063
RPS9	-0.017051
IL18	-0.017033
PAK4	0.017014
PDLIM2	0.016975
LPXN	0.016969
LASP1	-0.016897
MRPL33	0.016868
PGK1	-0.016812
MLF2	0.016794
PABPC4	-0.016774
YWHAH	-0.016720
HMOX2	0.016717
GTF3C1	0.016715
ZNF395	-0.016709
PHB2	-0.016704
BIRC3	0.016670
CCNG1	-0.016646
TMEM258	-0.016614
PFKM	-0.016602
ZYX	-0.016592
RCE1	0.016554
ROCK1	0.016553
TSPO	-0.016552
TXN	-0.016494
RPL29	-0.016493
ATP5B	-0.016482
B2M	0.016430
CKS2	0.016368
ACTG1	0.016265
COTL1	-0.016248
DDX17	0.016225
UBA1	0.016149
IGF2R	0.016144
DCXR	0.016131
SCAF11	0.016105
RAB13	-0.016015
ARF3	-0.016010
CYP1A1	0.015988
HLA-G	0.015959
ZFP36L1	-0.015881
CHST8	0.015855
RCN2	-0.015846
TCEB1	0.015806
MYL6	0.015764
ZMYND11	0.015754
PPP3CA	-0.015746
SNRPA	-0.015743
CCT4	0.015720
ATIC	-0.015719
BAI2	-0.015707
PAM	-0.015682
ERBB2IP	-0.015598
ME2	-0.015585