!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	human
!drug_name	Tretinoin
!smiles	CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C
!drugbank_id	DB00755
!pubchem_cid	444795
!cell_type	ME180 squamous cell carcinoma cell line - 3 hours 10μM
!organism	human
!end_metadata
CCL20	0.155707
CYP26B1	0.109546
TRIM31	0.096604
IL1B	0.089018
GCNT3	0.085119
CXCL8	0.084182
CYP26A1	0.081133
FOSL1	0.079770
F3	0.079749
LIPG	0.067522
IL36G	0.066834
CDH5	0.065566
DUSP1	0.065336
DLX5	-0.065057
KIAA0226L	0.064167
MAFB	-0.059416
RELB	0.058537
GPRC5A	0.057757
ID2	-0.055633
SOX2	-0.052825
BCL11A	-0.051831
MIR614	0.051722
DLX3	-0.051604
HBEGF	0.049973
FOSB	0.049912
TXNRD1	0.049844
SPOCD1	0.049512
TINAGL1	0.049202
ARID5B	-0.048175
ARHGAP20	0.047535
GLIPR1	0.047279
AGPAT9	0.047076
PTPRH	0.046692
CYSRT1	0.046541
LOC646626	0.046456
SLC20A1	0.046269
IGFL1	0.045996
SDC4	0.045558
ENTPD7	0.045440
TSPAN1	0.044678
FAM83A	0.044443
CRCT1	0.044013
DUSP6	0.043397
CPA4	0.043204
TP53INP2	0.043027
HES5	-0.042989
LPIN1	0.042288
TNFAIP3	0.041923
CASP9	0.041515
DRAM1	0.041129
MYPN	0.041069
VAV3	-0.040994
FAM84B	0.040824
EPHA2	0.040570
IL1F10	0.040489
CLDN23	0.040300
DUSP5	0.039714
PLIN2	0.039448
RGCC	0.039286
NRIP1	0.039192
BCL6	-0.039066
ITPKC	0.038723
LURAP1L	-0.038515
ELF3	0.038317
SAMD4A	0.038303
CYR61	0.038099
GADD45B	0.037695
CEMIP	0.037562
CEACAM1	0.037376
TGFB3	0.037050
LIF	0.036920
HPGD	-0.036875
TMEM40	0.036735
ST3GAL1	0.036074
KRT23	0.035758
TNFRSF12A	0.035727
WWTR1	0.035629
PISD	0.035526
ARL14	0.035349
MARK1	-0.035247
AUTS2	-0.034796
SCEL	0.034699
THBS1	0.034366
PPARGC1A	-0.034260
LPAR5	-0.034255
EGR2	0.034213
SEC14L2	0.034207
BARX2	0.033858
LIPH	0.033822
TBC1D2	0.033764
BIRC3	0.033433
GPR115	0.033358
CTGF	0.033325
ARSI	0.033271
HAS3	0.033255
WNT5A	-0.033103
SGMS2	0.033086
C3orf58	-0.033034
ALOX5AP	0.032858
FHDC1	-0.032856
OVOL2	-0.032836
ACOX2	0.032778
SLC20A2	0.032732
EHD4	0.032694
C3orf52	0.032609
SCNN1G	0.032571
MIR205	-0.032410
STAT4	0.032001
VANGL2	-0.031918
RAB6B	-0.031915
FAM117B	-0.031756
MYO1E	0.031732
MIS18BP1	-0.031640
OSBP2	0.031566
GJB4	0.031315
IFIT2	0.031279
PABPC4L	-0.031186
FAM212A	-0.031143
TRIB1	0.031068
IER3	0.031041
EDN1	0.031038
SLC19A3	0.031008
TRIM16	0.030816
JPH1	0.030798
ZMYND15	0.030572
MYLIP	-0.030525
CENPF	-0.030386
TMEM217	0.030336
LHX2	-0.030031
FERMT2	0.030019
GADD45A	0.030009
IL1A	0.030003
PLAT	0.029890
KCTD6	0.029796
RNF39	0.029792
LMO4	-0.029703
TMEM2	0.029694
STAMBPL1	0.029614
SUFU	-0.029592
RAB7B	-0.029472
EPN3	-0.029430
SOX21	-0.029380
FAM102B	-0.029322
KCNH4	-0.029210
PFKFB3	0.029015
KRT34	0.028998
ITPRIP	0.028985
MYEOV	0.028928
MAFF	0.028923
SALL2	-0.028817
LGR4	-0.028748
NFKB2	0.028737
FAM46B	-0.028552
TAGLN	0.028344
TNFRSF10A	0.028160
SOX9	0.028101
TIAM1	0.027957
SERPINB2	0.027875
NYNRIN	-0.027794
MOB3B	-0.027783
STON1	-0.027777
LCE3D	0.027704
ZSWIM4	0.027697
SKIDA1	-0.027625
NCEH1	0.027618
OAS1	0.027581
ALDH1A3	0.027568
CRISPLD2	0.027532
TP53INP1	-0.027482
CHMP1B	0.027432
DOPEY2	0.027427
C22orf29	-0.027227
XPO6	0.027218
KRT80	0.027033
CD55	0.026985
ZFP36	0.026966
PPFIBP2	-0.026890
SNCAIP	-0.026839
EFNA1	-0.026767
ABTB2	0.026677
EPHA4	0.026643
CDR2	0.026617
SDPR	0.026561
MXD4	-0.026524
AMOT	-0.026500
EN1	0.026484
TGFBR3	-0.026480
ZSCAN31	-0.026447
CSRNP1	0.026439
LCP1	0.026416
PRSS22	0.026368
CCNDBP1	0.026244
KIF20B	-0.026229
CNTRL	-0.026205
HMMR	-0.026088
ZYX	0.026027
SOSTDC1	-0.026010
SLCO5A1	0.025999
FHL1	0.025965
SNORA12	-0.025947
HCAR2	0.025919
C15orf39	0.025893
ISL2	-0.025881
EVA1A	0.025821
USH1G	-0.025769
PHLPP1	0.025758
ASPM	-0.025689
ARHGAP10	0.025668
IL1RL1	0.025589
ABCC3	0.025515
HOXA13	-0.025506
PLEKHH3	-0.025406
TMEM158	0.025404
NEK6	0.025402
AOX1	0.025385
CDA	0.025369
KLF9	-0.025362
BCL3	0.025322
IRF1	0.025311
ZNF385A	-0.025263
DAW1	0.025251
PAQR9	0.025231
C10orf2	0.025166
CH25H	0.025156
SUZ12	-0.025062
KRT75	0.025023
SLC35F2	0.024965
KRTAP3-1	0.024948
TIPARP	0.024942
SHISA2	0.024898
CEBPA	-0.024895
SCHIP1	0.024888
PCMTD1	-0.024862
FAM110C	0.024861
ZFP36L2	-0.024845
EFHD2	0.024842
SH2D3A	0.024817
CFLAR	0.024780
MFSD12	0.024769
DLX1	-0.024761
PDLIM5	0.024749
CXXC5	-0.024734
TIMP3	0.024730
INPP1	0.024662
NTRK2	0.024657
NAB1	-0.024619
ADAM19	0.024594
SMOX	0.024582
LAMC2	0.024578
STC2	0.024570
AEN	0.024518
CCDC120	0.024504
FST	0.024499
CCL2	0.024471
ETV4	0.024402
PRR15L	-0.024366
FAM107B	0.024362
MAP3K9	0.024295
C15orf52	-0.024218
SLFN5	0.024123
RAB26	-0.024035
PTK2B	0.024022
PHLDA1	0.023995
RP9P	0.023985
ARID3B	0.023979
PHLDA2	0.023968
CSRP1	0.023859
EMP1	0.023825
CPA2	0.023816
CEP44	-0.023783
PHLDB2	0.023774
KRTAP3-2	0.023599
SPINK6	0.023578
BCL10	0.023546
MAP3K14	0.023536
GRB7	0.023526
APOBEC3B	0.023499
CITED4	0.023487
CLDN4	0.023410
TRIM15	0.023399
DENND3	0.023375
HLTF	-0.023353
DUSP16	0.023335
KIAA0226	0.023264
FZD2	-0.023245
SERTAD4-AS1	0.023226
MXD3	-0.023213
ERO1L	0.023173
TICAM1	0.023034
RASD1	0.022960
MYADM	0.022956
SNAI2	-0.022927
BTG2	-0.022903
RAP2A	-0.022884
UBL3	-0.022827
MESDC1	0.022813
MTHFD1L	0.022790
RDH13	0.022790
BCAR3	0.022785
CLCF1	0.022756
RNF19B	0.022698
KTN1	-0.022695
IGF2BP3	-0.022691
IFFO1	0.022628
PPTC7	0.022538
C5orf24	-0.022537
SMIM3	0.022509
CAMK2A	0.022500
ADORA2B	0.022470
AIFM2	0.022439
PROSER2	0.022381
GABARAPL1	0.022356
FAM65B	0.022350
TIMM13	-0.022344
MKLN1	-0.022342
HOXB5	-0.022299
ASCL2	-0.022286
ATP10B	-0.022100
IRF2BP2	0.022095
CDC42EP1	0.022079
CENPE	-0.022079
NAB2	-0.022055
ZNF750	-0.022055
FLNB	0.022026
HEG1	-0.022003
TNFAIP2	0.021998
TGFA	0.021982
BCL11B	-0.021956
STK10	0.021939
PSD4	0.021931
TMEM123	-0.021901
BBX	-0.021896
BPNT1	-0.021857
ITGA2	0.021792
EPB41L3	-0.021727
DLGAP1-AS1	0.021721
PI3	0.021666
STX11	0.021655
MUM1	-0.021652
MSX2	-0.021606
GPR1	-0.021604
SPRED2	0.021575
JAZF1	-0.021558
DOPEY1	-0.021522
SMAD6	-0.021479
PRR7	0.021411
NET1	0.021402
BIK	0.021398
NUP43	-0.021362
CDK7	0.021276
AQP3	0.021267
PTAFR	0.021234
SLC2A10	-0.021180
PLAUR	0.021165
SPRED1	0.021132
TCHHL1	-0.021126
LDLR	0.021032
TRIO	0.021009
TTC37	-0.021005
PANX1	0.020992
ETS1	0.020983
TBL1XR1	-0.020950
CABLES1	0.020901
SOX7	0.020896
ENDOD1	0.020822
C10orf54	0.020798
FOXN2	-0.020732
E2F7	-0.020730
GUCY1A2	0.020724
MEGF9	-0.020716
STX19	-0.020650
UGCG	0.020637
C10orf67	0.020594
DBP	-0.020578
TRIM51	-0.020577
CCRN4L	0.020577
ERF	-0.020551
MKL2	-0.020548
PKIA	-0.020454
TBX1	-0.020387
USP31	0.020379
TMEM41A	0.020376
SHB	0.020335
LIMA1	0.020327
NPC1	0.020312
CLDN7	0.020308
LOC100129550	-0.020237
MAP3K8	0.020234
NCOA7	0.020227
SIPA1L3	-0.020215
MCL1	0.020194
DOCK5	0.020177
EGLN1	0.020174
TTLL1	0.020167
C11orf24	0.020144
CXorf28	-0.020108
RGS2	-0.020101
ENC1	0.020100
SLC35C1	0.020099
PDCD4	-0.020073
DCUN1D3	0.020066
ZMIZ1	-0.020057
C4orf19	-0.020030
SLC16A3	0.020021
GBP1	0.019973
ABCB1	0.019963
MLLT11	-0.019951
ZNF841	0.019933
NIPA1	-0.019929
KAL1	-0.019924
LOX	-0.019915
SPHK1	0.019882
ACAP2	-0.019877
ID3	-0.019871
C2orf54	0.019848
ZNF680	-0.019835
SAMD8	0.019832
TMEM37	-0.019822
INO80C	0.019806
HS3ST1	0.019792
KRT85	-0.019763
IL4R	0.019753
NEURL1B	-0.019751
CCDC184	-0.019743
LCE3E	0.019741
IVNS1ABP	-0.019728
PVRL2	0.019719
KLK5	0.019712
GDF15	0.019707
PTGS2	0.019670
RTP4	0.019669
DHRS4-AS1	-0.019620
TNS4	0.019603
C1orf52	0.019576
CHPF	0.019568
XDH	0.019560
CAMK2N1	0.019560
PIK3C2B	-0.019532
FAM83B	-0.019459
GPR37L1	0.019419
NKTR	-0.019415
ZFX	-0.019392
TNFSF18	0.019300
KIF21A	-0.019295
JMJD4	0.019279
JDP2	-0.019277
MYCBP2	-0.019266
MARCH7	-0.019262
SEMA3F	-0.019256
RAET1L	0.019235
BMPR2	-0.019232
SLC22A23	-0.019230
HES2	-0.019210
PREPL	-0.019176
SNX30	0.019160
DAPK2	0.019144
HOXB8	-0.019134
CITED2	0.019092
GFOD1	0.019085
RXRA	-0.019080
DCUN1D4	-0.019074
ACACB	-0.019073
CD83	0.019023
ZNF317	0.019002
EIF2AK3	0.018986
PIK3IP1	-0.018961
CD70	0.018953
PAFAH1B1	-0.018945
WNK1	-0.018902
IFT74	-0.018864
PELI2	-0.018849
PJA2	-0.018824
FAM46A	0.018822
ULBP2	0.018818
PLA2G4F	-0.018796
SPTBN5	0.018788
FJX1	0.018763
SAMD11	-0.018752
LRFN4	0.018720
CKAP2	-0.018720
BRD8	-0.018719
PHIP	-0.018686
PPP1R13L	0.018671
IGFBP5	-0.018634
CYB5R2	0.018617
IGIP	-0.018614
C1orf106	-0.018573
JOSD1	0.018568
GPR3	0.018550
PLSCR4	-0.018549
SCARNA9	-0.018532
ISG20L2	0.018526
KPNA3	-0.018519
RRP12	0.018519
SCOC	-0.018514
TXK	0.018509
ZC2HC1A	-0.018508
C1RL	-0.018506
IL13RA2	0.018502
C7orf43	0.018470