!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	rat
!drug_name	Irinotecan
!smiles	CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7
!drugbank_id	DB00762
!pubchem_cid	60838
!cell_type	NA
!organism	rat
!end_metadata
INS	0.121985
GBP2	-0.082126
HSD3B1	0.067371
TIFA	-0.066304
GDF15	0.063032
ADAMTS1	0.061895
GEM	0.059326
DDIT4	0.056917
DUSP1	0.056542
ADM	0.054726
LBP	-0.053783
SLC37A2	-0.052008
TGM3	-0.049096
IER3	0.045523
TLR4	-0.043623
RHOB	0.042896
CCRN4L	0.042006
UBD	-0.041692
GADD45A	0.041162
BTG2	0.039804
AMY2B	0.039460
GKN2	-0.038589
CHAC1	0.038372
GADD45G	0.038370
IFI44L	-0.038142
EGR1	0.038059
GP2	-0.038010
AQP8	0.037577
PPP1R15A	0.036914
IER2	0.036789
MTTP	-0.036702
SGK1	0.036603
DUSP6	0.036469
SCGB1A1	-0.036326
NR4A1	0.035335
THBS4	-0.035110
RNF180	-0.035087
FXYD4	-0.033674
NOX1	0.033293
IL7	-0.033117
GADD45B	0.032990
UBE2C	-0.032977
RAPGEF2	-0.032794
DTX3L	-0.032553
SCG2	-0.032202
GZMA	-0.032124
EGF	-0.032051
ANPEP	-0.031739
PGC	-0.031627
ETS1	-0.030756
KIF20B	-0.030718
HBEGF	0.030369
FAM76B	-0.030195
RASL11B	0.030141
ABCC4	-0.030113
SLC15A1	-0.030032
FAM43A	0.029920
KCNE4	0.029691
TDRD3	-0.029670
EDN1	-0.029635
SPINK4	0.029608
SLC30A1	0.029448
TMIGD1	0.029432
PSMB10	-0.029417
CCNB2	-0.029171
ID2	0.029129
CLDN4	0.029122
JUNB	0.029043
CPNE8	-0.028998
TPPP	-0.028963
SLC2A13	-0.028938
SLC6A14	-0.028873
GPX2	-0.028858
CENPF	-0.028851
GNA14	-0.028721
SALL1	-0.028613
MSH3	-0.028585
STAB1	-0.028505
TRMT1L	-0.028373
FBXO32	-0.028356
ST3GAL4	-0.028151
DTWD2	-0.028061
ACSL4	-0.028020
IL15	-0.027823
RGS1	-0.027794
TM4SF4	-0.027768
SEMA4A	-0.027666
BFSP1	-0.027515
DBP	-0.027437
ATP12A	-0.027375
PTRHD1	-0.027297
ASB11	0.027200
ENO3	-0.027147
NMU	-0.027138
EPC2	-0.027103
PDGFRA	-0.027019
IWS1	-0.026949
XDH	-0.026945
GKN1	-0.026796
NR1H3	-0.026746
ZNHIT6	-0.026703
TUBA4A	0.026677
ZFP36	0.026633
SCFD1	-0.026588
ANO1	-0.026574
GRP	-0.026461
ZNF521	-0.026439
MCM4	-0.026404
CTGF	-0.026356
FOSB	-0.026263
JUN	0.026240
MAT2A	0.026213
MYSM1	-0.026213
CKS2	-0.026194
TUSC3	-0.026165
PHTF2	-0.026161
AREG	0.026063
ZFAND2A	0.026011
KIF15	-0.026008
DNAJB1	0.025915
MSL2	-0.025909
FBXO11	-0.025759
STARD13	-0.025730
B3GNT7	-0.025579
TMEM140	-0.025574
SBSPON	-0.025572
ATF3	-0.025552
ARL4A	0.025446
MCM6	-0.025436
FA2H	0.025395
VCAM1	-0.025243
COL4A5	-0.025242
ASPM	-0.025204
LPO	-0.025191
TBC1D2	0.025157
VHL	0.025156
DEPDC7	0.025137
AURKA	-0.025131
EFCAB7	-0.025080
CCNB1	-0.025050
CALB2	-0.024969
PAPSS2	-0.024967
BUB1	-0.024931
RUVBL1	-0.024838
DSCC1	-0.024781
NUP133	-0.024770
NRIP1	-0.024749
HGFAC	-0.024731
SHQ1	-0.024712
SKA1	-0.024658
REM2	0.024540
MRC1	-0.024525
ZDHHC14	-0.024509
ITGB6	-0.024380
IAPP	0.024370
BET1	-0.024304
LRIF1	-0.024304
IRF1	-0.024282
IL18R1	-0.024273
B3GALNT1	-0.024253
CEBPD	0.024165
RDH14	-0.024158
CDCA8	-0.024126
DGKI	0.024112
PCSK9	-0.024080
MCOLN2	-0.023972
MED30	-0.023932
CSRNP1	0.023923
DPH5	-0.023896
H1F0	0.023872
BHLHE40	0.023806
NIPAL2	-0.023805
GJC1	-0.023794
BUB1B	-0.023685
KNTC1	-0.023625
SSBP3	-0.023616
ARHGAP24	-0.023599
CSE1L	-0.023581
PANK1	-0.023576
RBM14	-0.023553
BNC2	-0.023520
UBAC1	-0.023431
FABP1	-0.023343
RGS2	0.023334
TOB1	0.023332
CHRM5	0.023289
TIMM10	-0.023285
TMEM117	-0.023251
HERPUD1	0.023204
FAM208A	-0.023200
CENPK	-0.023182
SDF2L1	-0.023181
DYRK1A	-0.023115
TMCO4	-0.023113
KLF10	0.023094
FAM98B	-0.022991
NUP205	-0.022823
BOC	-0.022679
FANCB	-0.022679
MME	-0.022661
ZNF407	-0.022643
TIMP1	-0.022584
GOLM1	-0.022488
GPRC5A	0.022484
STMN2	-0.022439
PYY	-0.022429
TSC22D3	0.022424
IFRD1	0.022377
CCDC125	-0.022327
HIST1H2BG	-0.022304
HIRIP3	-0.022212
FAM83D	-0.022181
HIVEP2	-0.022180
TIMM21	-0.022167
CADPS2	-0.022164
CEBPB	0.022124
CEP44	-0.022103
CCNA2	-0.022100
SPON1	-0.022080
PSTPIP2	-0.022078
ANKRD44	-0.022048
SLC2A2	-0.022003
VEGFC	-0.021983
CPT1A	0.021957
CLK1	-0.021934
NRP1	-0.021931
TFDP2	-0.021904
ARHGEF3	-0.021894
DUOX2	-0.021854
PSMB8	-0.021841
ZNF778	-0.021833
TUSC5	0.021822
RNASE1	0.021822
IL1A	-0.021774
TASP1	-0.021747
CXCL3	0.021746
LNX1	-0.021732
TULP1	0.021716
TNC	-0.021711
SPATS2L	-0.021703
IL34	-0.021648
GALNT5	-0.021645
PHIP	-0.021640
RTP4	-0.021616
SPATA5	-0.021579
SLC35F1	0.021566
BBC3	0.021513
CYP1A1	0.021512
HOXD10	-0.021497
NME1	-0.021471
EFNA2	0.021423
PRMT3	-0.021416
TIFAB	-0.021373
GABRG1	0.021259
IGSF9	-0.021235
PEX2	-0.021217
TLE4	-0.021216
DCPS	-0.021164
SLC25A45	0.021158
TTC27	-0.021155
PDZK1IP1	-0.021133
TGFBI	-0.021112
ACER1	-0.021109
CENPJ	-0.021095
PIM3	0.021079
PIK3R3	-0.021062
PHYHIP	0.021044
ACLY	-0.021032
TAC1	-0.020988
RNF213	-0.020946
PAFAH1B3	-0.020929
PCGF5	-0.020926
MRPL1	-0.020924
SLC37A1	-0.020913
WSB1	0.020905
SND1	-0.020896
PFKL	-0.020856
MRPL54	-0.020832
ECHDC1	-0.020830
NPTX1	0.020828
TAF2	-0.020827
ZNF280D	-0.020816
IGJ	0.020812
S100A9	-0.020807
POLA1	-0.020793
PPIL1	-0.020772
CDK1	-0.020770
FMO1	0.020723
PIK3C3	-0.020712
FASTKD5	-0.020697
NDEL1	-0.020689
ARAP2	-0.020676
MTAP	-0.020668
KLF4	0.020667
MTHFD1	-0.020640
KAZN	-0.020620
PTS	-0.020614
HSD17B6	0.020588
MRPS5	-0.020581
PARP9	-0.020581
TET2	-0.020561
NFIL3	0.020536
HS6ST2	0.020514
SCARA5	-0.020504
TRPM8	0.020461
CHSY3	-0.020452
DNAJC3	-0.020431
SEMA6D	-0.020399
CCR3	0.020383
PBDC1	-0.020369
GSK3B	-0.020358
YARS2	-0.020358
TSSK2	0.020337
BID	0.020327
DARS	-0.020292
MND1	-0.020280
CHST6	-0.020253
CHEK1	-0.020251
DNMBP	-0.020216
IRF9	-0.020148
GLCCI1	-0.020131
NMI	-0.020115
LTBP1	-0.020102
MED14	-0.020093
EBNA1BP2	-0.020075
FASN	-0.020056
ENOX2	-0.020054
TRIM24	-0.020053
PLA2G1B	-0.020053
CRISP2	0.020035
TMEM106A	-0.020012
MORC4	-0.020001
IBTK	-0.019999
QDPR	-0.019949
EXO5	-0.019933
TTYH2	0.019913
MDM1	-0.019904
DAPL1	0.019864
MORC3	-0.019849
CENPN	-0.019840
SEMA3C	-0.019816
VPREB3	0.019790
DENND2D	-0.019748
FGF16	0.019748
CLEC14A	-0.019699
MOSPD2	-0.019677
ERRFI1	0.019669
NCK1	-0.019666
HIAT1	-0.019649
ACSM1	0.019632
ZDHHC23	-0.019631
MDFIC	-0.019626
CENPL	-0.019615
MYOZ1	0.019607
VPS13B	-0.019568
SLC38A2	0.019563
TRPC6	-0.019557
INO80C	-0.019551
MRPS28	-0.019545
CWH43	-0.019530
LTA	0.019526
HTRA1	-0.019514
CAPN13	-0.019513
GPNMB	-0.019503
GPD2	-0.019455
ZNF518A	-0.019449
VGLL4	-0.019426
EXOSC8	-0.019425
CTCF	-0.019423
PDGFA	-0.019406
TMEM55A	-0.019404
USP2	0.019367
DHX15	-0.019358
CBLB	-0.019357
PDPK1	-0.019348
ADRA1A	0.019330
PANK3	0.019296
ING3	-0.019286
GTDC1	-0.019272
HMMR	-0.019262
TMPRSS2	-0.019253
SLC25A33	0.019245
AHCTF1	-0.019231
RABL3	-0.019226
EED	-0.019219
MTIF2	-0.019199
ATIC	-0.019195
MED6	-0.019194
AATF	-0.019177
TNFRSF14	-0.019162
DPP4	-0.019145
NEDD9	0.019145
HIC2	0.019140
PER1	0.019129
NEFL	-0.019122
APOA4	-0.019117
FAM3B	-0.019086
UBE2L6	-0.019071
ERAP1	-0.019070
LACE1	-0.019066
HERC6	-0.019060
GTPBP10	-0.019046
MCCC2	-0.019036
VMP1	0.019009
ACE2	-0.018998
FHL2	-0.018997
TMEM165	-0.018995
TERF1	-0.018994
CNOT2	-0.018989
CPB1	0.018977
SLC41A2	-0.018970
GFM1	-0.018970
SLC16A6	-0.018961
RSAD2	-0.018958
P4HA1	-0.018954
CTRC	0.018941
TGM1	0.018894
RASSF6	-0.018864
KIF22	-0.018863
CIDEC	0.018861
RAPGEF5	-0.018855
RIPK3	-0.018855
CCPG1	-0.018817
ID3	-0.018812
JAKMIP1	-0.018775
PDIA4	-0.018771
NECAB1	0.018730
ATG14	-0.018717
ZFP36L2	0.018713
IFIT2	-0.018705
LPAR1	-0.018703
TCTEX1D1	0.018701
ARHGAP32	-0.018701
RWDD2B	-0.018696
SLC26A6	-0.018695
ZFYVE21	-0.018685
OVOL1	0.018676
FAM13B	-0.018675
PRLHR	0.018672
CHRNA2	0.018667
OPN1SW	0.018629
RFC3	-0.018628
NAT2	-0.018614
ILF2	-0.018614
SPAST	-0.018610
TBC1D10C	-0.018610
MYH9	-0.018597
RUNX1	-0.018582
RBL1	-0.018576
TIPARP	0.018562
FBXO33	-0.018545
CD200R1	0.018529
LHFPL3	-0.018513
FBL	-0.018495
ENDOD1	0.018476
HSD17B2	-0.018474
NFKBIA	0.018470
AXIN2	0.018465
ENPEP	-0.018453
SEMA4B	-0.018452
TRAIP	-0.018444
MYOF	-0.018437
CNTN3	0.018428
ODF1	0.018417
KMT2D	0.018394
FAF1	-0.018386
MAP6D1	0.018359
RNF19A	-0.018358
SCLT1	-0.018358
MYZAP	-0.018352
SLC22A7	0.018328
NHSL1	0.018313
PLCE1	-0.018310
NBN	-0.018291
CTSE	-0.018290
CC2D2A	-0.018286
PGF	0.018285
MKI67	-0.018282
B3GNT5	-0.018265
ECT2	-0.018265
PRR5L	0.018264
EIF2AK3	-0.018258
PSPC1	-0.018233
KPNA3	-0.018230
NCBP1	-0.018227
NDUFS3	-0.018205
KATNA1	-0.018201
STAT3	-0.018200
UBR1	-0.018197
GINM1	-0.018189
ZSCAN12	-0.018157
ITGAE	-0.018152
CCDC96	0.018146
FRG1	-0.018123
ITGB3BP	-0.018093
ZNF519	-0.018088
PLEKHD1	-0.018079
SERPINE2	-0.018072
PEX7	-0.018053
MRPL39	-0.018040