!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Rattus norvegicus
!drug_name	orotic acid
!smiles	C1=C(NC(=O)NC1=O)C(=O)O
!pubchem_cid	967
!cell_type	Livers ( from outbred Wistars - fed a diet with 1% orotic acid) - 1 Day
!organism	rat
!end_metadata
RPL23	-0.261652
VTN	-0.225112
APOA1	0.210705
RPS13	-0.160594
HP	-0.156812
SLC27A2	-0.154091
UPB1	-0.152093
ATP5G1	0.142934
ND5	0.140515
PON1	-0.138352
TMEM205	-0.130872
ARG1	-0.125495
CTH	-0.124827
ACTB	0.122500
RPS29	-0.115549
APOA2	-0.115532
ASS1	-0.115086
COX1	-0.109013
GSTM5	-0.107933
THRSP	-0.104110
FTH1	-0.097060
ATP5B	-0.094323
ATP6	0.093289
PCK1	0.092204
HMGCS1	-0.091268
HSP90B1	0.085044
PAH	-0.083787
METTL7B	-0.083438
ALDH1L1	-0.082470
DDT	-0.080628
KHK	-0.079270
CYB5A	-0.078997
GPX1	-0.077164
MIF	-0.076565
ACTG1	0.076415
PDIA4	0.076253
BAAT	-0.075027
SCD	-0.074442
HSD11B1	-0.073852
PIGR	-0.073337
AFM	0.072146
PCBD1	-0.071907
HSPA5	0.069949
ITIH4	0.069252
RPL19	-0.069022
TTC36	-0.068872
ATP5O	-0.066896
CDO1	-0.066319
RPS12	-0.065187
CLU	-0.064951
TDO2	-0.064773
RPS26	-0.064729
RPS16	-0.064607
HPX	-0.063597
CPS1	-0.062171
G6PC	0.061829
SERPING1	-0.061570
EEF2	0.060764
COX8A	-0.060419
AHSG	-0.059845
ALDOB	-0.059492
EPHX1	-0.058903
GLUD1	-0.057862
SOD1	-0.057797
HRSP12	-0.057749
B2M	-0.057624
RPL5	-0.056564
ND1	0.056499
MST1	-0.055389
SDC4	-0.055245
ADH1C	-0.054173
HAAO	-0.054048
ITM2B	0.053578
PTTG1IP	-0.053547
FBP1	0.053006
CALR	0.052614
ARF1	0.052388
GNAS	0.051479
RPS27A	-0.051167
RPL9	-0.050153
GM2A	0.050061
RBP1	-0.049891
RPL31	-0.049742
RPL30	-0.049552
TTR	-0.049426
PLIN2	-0.049042
ND2	0.048144
FGG	0.048133
PDIA6	0.047698
POMP	-0.047657
GSTM1	-0.047484
RPS23	-0.047233
FAH	-0.046578
CYP2E1	-0.046405
CYP1A2	-0.046358
LCAT	0.046281
ACLY	-0.046256
MGST1	-0.045502
PAPSS2	-0.045475
HPD	-0.045267
NDUFA8	-0.045211
FABP6	-0.044616
CPQ	-0.044514
ACADM	-0.044342
KYNU	-0.043895
ND4	-0.043705
NUP88	-0.043486
APOE	0.042914
ATP5C1	-0.042773
HDLBP	0.042226
UBC	0.041944
C9	-0.041616
SLC10A1	-0.041242
TSC22D1	-0.041054
LAMP2	-0.041027
PROS1	-0.040949
UGT2B28	-0.040928
GLUL	0.040733
GPX4	-0.040694
PRDX1	-0.040215
SPP2	-0.040174
GSTK1	-0.039949
ETNK2	-0.039795
SORD	-0.039734
PLG	0.039692
CSAD	-0.038962
ALDH2	-0.038957
MSMO1	-0.038730
GPT	-0.038420
COX7A2	-0.038379
GAMT	-0.038041
APOH	-0.037885
RPS11	-0.037516
FTL	-0.036907
AKR1D1	-0.036709
SQLE	-0.036630
NDUFC1	-0.036069
RPL35	-0.035865
CFB	-0.035752
GNMT	-0.035718
RPL27A	-0.034982
RPLP2	-0.034969
CTDSP1	-0.034858
HYOU1	0.034709
YWHAB	-0.034593
RPL24	-0.034584
COX4I1	-0.034521
ACAA2	-0.034477
AGXT2	-0.034423
RPSA	-0.034119
APOB	-0.033450
SNRNP70	-0.033439
ATP5G2	-0.033303
PAICS	-0.033277
KRT18	0.033076
DBI	-0.032826
TMBIM6	-0.032786
COX5A	-0.032701
KLKB1	-0.032419
GSTA5	-0.032414
DHCR7	-0.032233
CA3	-0.032186
HSD3B7	-0.032050
ACADL	-0.031884
PROC	-0.031774
ABCD3	0.031615
CYP7A1	-0.031295
DDC	-0.031219
DPYS	-0.031005
OAZ1	-0.030994
AK4	-0.030802
HSD17B6	-0.030608
ADK	-0.030498
ABCB11	-0.030456
PABPC4	-0.030307
UQCR11	-0.030090
NDUFB3	-0.029968
C8B	-0.029914
CAT	-0.029797
AUH	-0.029711
ERRFI1	-0.029081
SEC61A1	0.028763
RPS4Y1	-0.028748
APOC4	-0.028702
SRD5A1	0.028631
SERP1	0.028629
SLC22A18	-0.028606
APOA4	0.028408
ABCC6	-0.028281
ITIH3	-0.028085
SERPIND1	-0.028066
MARC2	-0.028028
OAT	-0.027569
CES1	-0.027471
RBP4	-0.027273
CST3	-0.027203
ACSL5	-0.027169
GSTM2	-0.027120
FN1	0.026771
PSAP	-0.026700
COX6A1	-0.026634
NDUFB9	-0.026631
LIPC	-0.026378
HIBADH	-0.026334
LAMP1	-0.026067
ALAD	-0.025986
SIGMAR1	-0.025839
FDPS	0.025816
G0S2	-0.025587
PGRMC1	-0.025480
NDUFB8	-0.025458
BSG	-0.025308
RPL11	-0.025219
ETFA	-0.025006
PSMA6	-0.024994
SULT2A1	0.024841
MMP14	0.024789
GJB1	0.024672
MAN2B1	-0.024577
EBP	-0.024330
SPINT2	-0.024252
NDUFS7	-0.023911
ATP2A2	0.023706
RPS5	-0.023484
CYP27A1	-0.023483
MGST3	-0.023280
ITGB1	0.022865
KRT8	0.022853
HSPE1	-0.022748
RPS6	-0.022468
FABP1	0.021927
COPS7A	0.021909
LIPA	0.021877
CD14	0.021700
EIF5	-0.021660
ACY1	-0.021596
ATRN	-0.021469
CD74	-0.021247
FGA	0.021027
TMED10	0.020930
HPN	-0.020908
CREG1	-0.020797
LRRC59	0.020725
GCKR	-0.020721
CISH	-0.020406
SEC61B	-0.020298
EHHADH	-0.020259
VCP	0.020250
DIO1	-0.020054
OTC	-0.020044
RPS21	-0.019966
RPL7A	0.019890
DARS	-0.019834
HSPD1	-0.019833
TALDO1	-0.019562
NDUFV2	-0.019514
PGK1	-0.019460
HSPA9	-0.019360
IGFALS	0.019315
AMBP	-0.019216
RPL6	0.019095
ATP5A1	-0.019003
RPL8	-0.018910
CTSB	-0.018865
IDH2	0.018847
PEMT	-0.018783
NDUFB4	-0.018692
IFITM3	0.018680
ST6GAL1	-0.018673
RPL28	-0.018672
MAP3K1	-0.018649
DDRGK1	-0.018634
HNRNPAB	0.018633
GAPDH	0.018451
KNG1	0.018367
NDRG2	-0.018316
SUB1	-0.018277
NPHP1	-0.018218
HSPA8	0.018141
SLC25A5	0.018140
ARF4	0.018137
RPS7	-0.018129
GRHPR	0.018014
NDUFV3	-0.018002
RPL27	-0.017825
CYC1	-0.017726
PPIA	-0.017678
RGN	-0.017673
MBL2	0.017609
NDUFA4	-0.017431
PFN1	0.017411
PCYT2	-0.017339
CD63	-0.017233
ACAT2	-0.017166
SLC3A2	0.017102
GLS2	-0.017059
ID2	-0.017046
TUBA1C	-0.016929
SSR3	0.016723
PPP2R5A	0.016667
SLC22A1	-0.016635
GRN	0.016622
RPN1	0.016459
NME2	-0.016418
RPS8	-0.016395
NR1H4	-0.016144
CTSS	-0.015960
PYGL	-0.015846
ALDH3A2	0.015838
RPLP0	0.015693
NDUFB6	-0.015665
ZFP36L1	-0.015635
COL3A1	0.015621
SDCBP	-0.015584
HACL1	-0.015537
ALAS1	-0.015379
COMT	0.015349
DUSP1	-0.015348
PPIB	0.015301
AES	-0.015289
UGT1A1	-0.015264
HSD17B13	-0.015255
RPL17	-0.015198
ASGR2	-0.015170
NDUFA9	-0.015137
SLC35B1	0.015123
ATP1A1	0.015108
CA5A	-0.015039
RPS14	0.015027
PXMP2	-0.015018
CYTB	-0.014889
TECR	-0.014846
NR0B2	0.014834
DMBT1	-0.014827
PTPLAD1	-0.014682
SLC25A3	-0.014647
AMY2B	-0.014613
FAU	-0.014600
ACAT1	-0.014484
DLST	-0.014378
ABCC2	0.014293
DAK	-0.014287
DAD1	-0.014200
P4HB	0.014100
MAOB	-0.014036
FIS1	-0.014025
PSMD2	0.014003
PNRC1	0.013966
GRB14	-0.013764
IVD	-0.013702
TUBB	0.013615
IDH1	-0.013610
ATP6V0C	0.013576
COX3	0.013572
DDR1	0.013532
GDA	-0.013532
SLCO2A1	-0.013388
MAOA	-0.013387
CEBPA	0.013371
DCAF11	0.013269
MRFAP1	-0.013253
SLC26A1	-0.013227
PDIA3	0.013147
TPI1	0.013146
RPS9	0.013093
FABP7	-0.013060
BAX	0.012884
MTCH2	-0.012848
NINJ1	-0.012718
AP2S1	0.012700
PTP4A1	-0.012653
CP	-0.012623
TST	-0.012548
NQO1	-0.012537
GRINA	-0.012442
PPP1R10	0.012399
RPL10A	-0.012387
RPL13A	-0.012322
IDI1	-0.012313
GPD1	0.012302
BHLHE40	-0.012299
ECHS1	-0.012233
ADIPOR2	-0.012228
AQP9	-0.012204
CSNK2B	0.012179
LITAF	-0.012142
RPL22	-0.011985
GNPTG	-0.011908
BCKDHB	-0.011893
TUBA1A	0.011870
LDHA	0.011831
ASGR1	0.011824
ALDH1A1	-0.011781
FUCA1	-0.011758
AADAT	-0.011754
SERPINA6	-0.011720
F2	-0.011692
EIF4E2	0.011647
FAAH	-0.011628
BHMT	0.011626
SERPINA10	-0.011607
CLTA	-0.011565
MPC1	-0.011410
FDFT1	-0.011358
EIF4A2	-0.011356
TAF10	0.011194
GC	0.011190
DECR2	-0.011166
GNB2L1	0.011148
MYRF	-0.011139
ALPL	-0.011116
NME1	-0.011088
CAPNS1	-0.011071
NDUFB2	-0.011063
TXN2	-0.011040
AIFM1	-0.010969
SDC2	0.010967
INHBE	-0.010963
HSD17B12	-0.010961
PCCA	-0.010929
RPL18	-0.010866
MGST2	-0.010862
PSMC1	-0.010845
DAO	-0.010835
CHKA	-0.010798
APH1A	-0.010774
TAT	0.010759
NR1H3	-0.010746
CNN3	-0.010717
CLEC4F	-0.010710
ADD1	-0.010706
MPST	-0.010678
SCLY	-0.010670
FKBP1A	0.010658
SLC41A2	-0.010639
RPS15A	-0.010616
FGB	-0.010608
ALAS2	0.010572
CXXC5	-0.010547
YBX3	0.010476
RPS15	-0.010417
ADH5	-0.010403
ZFAND6	-0.010348
CNPY2	-0.010295
PRKAR1A	0.010236
ADRA1B	-0.010195
PEBP1	0.010193
GCHFR	-0.010188
C3	0.010160
SDHA	-0.010118
RBCK1	0.010054
DDX3X	-0.010032
PHB	-0.010020
DNAJB9	0.010006
FGGY	-0.009972
FURIN	0.009871
RPL18A	-0.009862
PDLIM1	-0.009810
HADHA	-0.009794
UGT2B17	-0.009792
COX7B	-0.009752
LGALS9B	0.009750
IGFBP3	0.009740
HES1	0.009677
RPS10	-0.009638
CSRP1	0.009634
SYNGR2	-0.009626
PTOV1	0.009603
MED25	0.009553
BTG1	0.009520
SLC16A1	0.009505
RDH16	-0.009500
YWHAE	0.009472
SDS	-0.009390
ACSL4	0.009382
CLTC	0.009370
NDUFA3	-0.009364
GSTO1	-0.009310
HSP90AB1	0.009269
DNAJA1	-0.009234
RPL36AL	-0.009230
RPS27L	0.009191
PPAP2B	-0.009186
CFD	-0.009155
MYH9	0.009152
MRPL3	0.009082
GRK6	-0.009069
SLC28A2	0.008938
PDK2	-0.008925
PGAM1	-0.008911
PRKCZ	0.008900
CDK5RAP3	0.008900
CYP51A1	-0.008888
F9	-0.008879
SARDH	0.008867
UBQLN1	0.008841
FASN	0.008835
ACP2	-0.008808
GGCX	0.008807
FOXA2	-0.008807