!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	human
!drug_name	MEK inhibitor (MEKi : AZD6244)
!smiles	CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO
!pubchem_cid	10127622
!cell_type	SW480 cancer cells
!organism	human
!end_metadata
DUSP6	-0.169696
MT1F	0.116306
IER3	-0.113608
MYL9	0.111616
TNNC1	0.105568
MT1E	0.105303
EGR1	-0.093667
LAMP3	0.084249
SOX9	-0.079823
PCNA	-0.079336
MT2A	0.077535
CDCA7L	-0.069996
LPCAT2	-0.066449
ANXA2P2	0.065725
HIST3H2A	0.065673
MALL	-0.065324
TUFT1	0.064644
UCP2	0.063970
ZNF367	-0.063680
CD24	0.063590
DPYSL2	-0.063330
KRT81	0.063101
BMP4	0.063081
FLNA	0.062738
PPME1	0.061930
RGS9	0.060632
KRT13	0.059376
KRT80	0.059319
TUBA1A	0.059305
RRM2B	-0.057147
SLC16A1	-0.054499
TPM1	0.054289
FGF19	-0.053630
NGFR	-0.053144
EN2	-0.052581
DCLK1	-0.052574
MYH9	0.052073
CTNNAL1	-0.051740
UNG	-0.050939
KLF10	-0.050849
DUT	-0.050237
TCEAL4	0.050153
METTL9	-0.050090
IL32	0.050046
FAM171A1	0.049781
NUDT15	-0.049430
AKAP12	-0.048509
SMURF2	-0.048383
NET1	-0.048264
CXCL14	0.048108
EPHA2	-0.047951
LINC00341	-0.047413
ANKRD1	-0.047236
RMI1	-0.047196
GLRX	-0.046782
MAP1B	0.046768
POC1B	-0.046716
UHRF1	-0.045842
RBBP8	-0.045120
MT1X	0.044753
PDLIM1	0.044680
BAMBI	0.044210
H2AFZ	-0.044094
WNT5A	-0.043878
C1QBP	-0.043700
KIF11	-0.043309
RIN2	0.043297
DNMBP	-0.042935
LYRM1	-0.042574
WBP1L	0.042441
PODXL	0.042067
KRTAP2-3	0.041896
RFC4	-0.041719
SAT1	-0.041386
HMGA1	-0.041386
ETV3	-0.041379
OSBPL3	-0.041335
SLC39A10	-0.041303
AP1S2	-0.041261
RGCC	0.040915
CCDC3	0.040503
ITGB5	-0.040468
MCM7	-0.040369
NABP1	0.040151
PRIM1	-0.040072
TMEM14C	0.040045
SLC20A1	-0.039908
ZNF45	0.039889
CLDN7	0.039769
CHST11	-0.039385
SEH1L	-0.039358
ZWINT	-0.039175
RAD51AP1	-0.038896
ANXA3	0.038794
DUSP5	-0.038682
LIMS3	-0.038493
APOBEC3C	-0.038456
STARD4	-0.038245
CPOX	-0.037876
PALD1	-0.037865
FLG-AS1	0.037710
TNS4	-0.037695
ETV5	-0.037437
F3	0.037171
DCUN1D3	-0.037133
TRIM16	0.037058
MSMO1	0.037051
YAP1	-0.036860
CDC7	-0.036772
CXCR4	-0.036734
TRIM29	0.036654
GMNN	-0.036605
RAB31	0.036135
TBC1D4	-0.035932
TMEM45A	0.035712
FAM101B	-0.035703
SH3KBP1	-0.035657
CAPNS1	0.035566
RMI2	-0.035528
PIM1	-0.035341
NEIL3	-0.035140
RAB8A	-0.035134
IGFBP3	-0.035063
CAV1	0.034994
RAB13	0.034971
IER2	-0.034919
ABAT	0.034792
TCTA	0.034728
UBE2C	-0.034448
CCND1	-0.034356
FEN1	-0.034353
HMGB3P1	0.034195
TINAGL1	-0.033786
VSTM1	0.033783
CKS1B	-0.033766
QPCT	0.033713
STARD7	-0.033591
UBE2T	-0.033555
NRARP	-0.033547
RAP2B	0.033539
IL17RD	-0.033446
MYL12A	0.033332
CRIP1	0.033189
SYNGR2	0.033152
DCK	-0.033066
LMAN2L	0.033063
TMEM163	-0.033055
RPL11	0.033052
ANLN	-0.032985
ZNF260	0.032936
ERRFI1	-0.032903
C2orf54	0.032789
C1orf106	0.032753
KDM3B	-0.032707
ASF1B	-0.032694
CORO1C	-0.032675
MCM6	-0.032662
HEG1	0.032654
MSL2	-0.032448
MMD	-0.032201
NCAPD2	-0.032105
ZNRF3	0.032103
ALDH1A3	-0.032049
KRT23	0.031878
LOC284023	-0.031871
SLC16A6	-0.031862
CSRP1	0.031840
GINS1	-0.031780
POLA1	-0.031766
PPL	0.031741
PPIC	0.031676
PRDX6	0.031666
FTH1P5	0.031663
FABP5	-0.031564
NELL2	-0.031533
MIR21	0.031484
ACYP1	-0.031384
CYR61	0.031302
ZXDA	0.031181
PLS3	0.031103
SMC2	-0.031061
EPAS1	-0.030999
UBE2E2	0.030957
SMIM14	0.030916
SERPINE1	-0.030837
MYL6	0.030721
SORBS1	-0.030700
DHFR	-0.030553
ANXA6	-0.030336
PTPRN2	-0.030199
DBF4	-0.030093
CDK1	-0.029796
NR2F1	0.029792
ZNF284	0.029750
UXS1	-0.029708
SPIN1	-0.029659
PDGFA	-0.029631
AFAP1L2	-0.029534
TYMS	-0.029385
SMAP1	0.029294
ANKRD20A5P	0.029283
GOLPH3	-0.029240
AURKA	-0.029139
CYB5B	-0.029103
OPHN1	0.029063
TMEM2	0.029030
EBNA1BP2	-0.029025
H1F0	-0.028989
FAM171B	-0.028950
LPCAT1	0.028892
MCM2	-0.028819
CDH1	0.028793
CLU	0.028766
CDCA4	-0.028676
GALNT4	-0.028652
CHCHD3	0.028635
INTS2	-0.028618
GLUD1	-0.028515
DNAJB1	-0.028480
FGF13	-0.028462
MELK	-0.028164
LSM5	-0.028108
SLC2A3	0.028081
KCNJ5	-0.028046
IGFBP4	-0.028042
GALNT7	0.027998
USP1	-0.027997
ITGA6	-0.027983
TAX1BP3	0.027966
GXYLT2	0.027864
SPC25	-0.027816
KIAA0101	-0.027795
GJB1	-0.027750
ALDH2	0.027712
MGAT5	-0.027641
TMA7	-0.027534
KRT19	0.027502
HAT1	-0.027453
LTA4H	-0.027415
GLRX5	-0.027311
PLAUR	0.027310
PHYH	0.027301
CXADR	0.027295
FAM102B	-0.027288
EMP1	-0.027250
TIAM1	-0.027210
IPO5	-0.027186
HSPB1	0.027148
MRGBP	-0.027124
SNX18	0.027091
RALA	0.027061
RND3	0.027061
TMEM194A	-0.027050
CXCL16	0.027045
NCAPG2	-0.027022
PTGES3	-0.026954
ZNF185	0.026925
STEAP1	0.026852
VAMP8	0.026791
ACN9	-0.026751
COTL1	0.026687
EDAR	-0.026682
RBKS	0.026679
GLOD4	-0.026673
TGFBI	-0.026656
SRSF2	-0.026653
CHP1	0.026624
MAP4	0.026579
IPO7	-0.026497
ATP6AP1	0.026450
RPA3	-0.026393
SPIN4	-0.026330
PPP1R2	-0.026302
ZIC2	-0.026281
TNFRSF1B	-0.026261
YBX1	-0.026237
DHRS3	-0.026229
MRPL18	-0.026171
GNG10	0.026137
PSMC4	0.026073
CLPTM1L	0.026036
RRM2	-0.026029
ABLIM1	-0.026027
HMGB1	-0.025982
ARL6IP5	0.025979
IER5	-0.025950
SGK223	0.025927
SPRY2	-0.025919
C16orf54	-0.025910
SCD	-0.025879
SRRM1	-0.025875
HMGCS1	0.025798
ADORA2B	-0.025787
SFN	0.025766
SLC1A3	0.025732
RANBP1	-0.025705
RFWD3	-0.025648
PBK	-0.025643
PLS1	-0.025589
ABHD3	-0.025518
PARP4	-0.025459
KRTAP3-1	0.025454
E2F7	-0.025390
SH3BP5	0.025372
APOBEC3G	-0.025340
RNF11	0.025300
AJUBA	0.025298
MRPS6	0.025292
RPL41	0.025290
NPC2	0.025198
DDX5	-0.025109
POMP	-0.025058
HSD17B11	-0.025025
EIF4A3	-0.024936
CCNG1	-0.024915
CDKN2B	0.024881
EXOSC8	-0.024833
SLC25A32	-0.024793
DCBLD2	-0.024741
RBP7	0.024736
CRIM1	0.024729
LOC100130468	-0.024695
SLC30A1	0.024682
NAA20	-0.024653
DUSP14	0.024643
DNAJB6	-0.024585
SKA2	-0.024564
IFITM3	0.024538
FUT1	0.024494
MAFF	-0.024493
RRM1	-0.024434
COA6	-0.024387
HN1	0.024299
MSH2	-0.024245
SLC44A2	0.024154
UBR7	-0.024143
CDCA5	-0.024120
EZR	0.024014
PMAIP1	-0.024014
HSPH1	-0.023990
RPS7	-0.023975
EIF4B	-0.023958
HLA-C	0.023905
FBXO5	-0.023899
ILF2	-0.023887
CDC42EP3	0.023863
RNF167	0.023854
VRK1	-0.023812
ACTG1	0.023772
RFC3	-0.023765
ATOX1	-0.023744
CAV2	0.023721
ASS1	0.023676
MAGOH	-0.023666
TRIP13	-0.023655
TMEM47	-0.023603
NCAPG	-0.023580
ETV4	-0.023578
AATF	-0.023386
HSPA5	0.023385
POLR2I	0.023375
ACTB	0.023362
TMC4	0.023313
TIPARP	-0.023313
NUAK1	0.023306
DPY30	-0.023275
RPL26	0.023267
RHNO1	-0.023263
NXT1	-0.023221
MYADM	0.023199
PTBP3	0.023135
SAA4	0.023114
SEPW1	0.023082
NUP107	-0.023049
TPST1	-0.023024
ORMDL2	0.023000
CCDC43	-0.022913
MCM3	-0.022908
TPM4	0.022894
HIST1H3C	-0.022892
TBCB	0.022886
TP53I3	0.022865
OPTN	0.022839
MND1	-0.022756
DTX3L	0.022730
TNIP1	0.022727
ATF1	-0.022721
LSM4	-0.022665
LSM12	-0.022663
SLC38A2	-0.022661
MT1G	0.022618
SPRY4	-0.022608
NIP7	-0.022534
BNIP3L	-0.022530
TGFB1I1	0.022528
SEC31A	0.022495
L1CAM	0.022475
NOTCH2NL	0.022471
SUCO	0.022454
UQCRH	-0.022393
MB21D2	0.022351
SNRPG	-0.022336
DYNC1I2	0.022307
PTMA	-0.022271
NME1	-0.022252
ECH1	0.022228
CELSR3	0.022228
DYNLL1	0.022164
REEP5	0.022105
FAM60A	-0.022068
PRKCI	-0.022031
NCAPH	-0.022017
RPL26L1	0.022012
ACTN4	0.022011
FOXO3	0.021969
MTCH1	0.021889
GSTP1	0.021887
GLTP	0.021866
ANP32B	-0.021855
SLC35F2	-0.021783
PCBP1	-0.021730
PFN2	0.021637
COX20	-0.021633
ASAP2	-0.021632
IFITM2	0.021623
ANXA2	0.021583
CST2	0.021570
MYL12B	0.021568
SEPT10	-0.021557
CHEK1	-0.021539
TUBB2A	0.021536
NMT2	0.021470
CDK8	-0.021461
CALM3	0.021460
BUB1B	-0.021384
JUP	0.021359
CUL4B	0.021355
EGR3	-0.021339
JUN	0.021307
CKAP4	0.021222
ADNP	-0.021155
DSTN	0.021154
GSTO1	-0.021143
PIGF	0.021109
TMEM139	0.021104
RFC5	-0.021052
CST7	0.021014
SDCBP	-0.020987
TOP2A	-0.020987
YWHAQ	0.020977
MT1H	0.020975
HSP90AB1	-0.020973
KIAA1524	-0.020973
UBA2	-0.020935
TMEM243	-0.020908
C2CD3	0.020879
PIH1D1	-0.020846
BTBD11	-0.020828
PKIG	-0.020790
GPR137B	-0.020771
TP53INP2	0.020768
PPP2R3A	0.020768
CAPG	0.020756
SCRN1	0.020726
TAX1BP1	0.020717
SPANXC	0.020704
ERH	-0.020635
ARMCX6	0.020581
VAT1	0.020553
SLBP	-0.020529
EZH2	-0.020522
COMMD8	0.020507
SUDS3	-0.020492
PNMA1	0.020470
CRELD2	0.020464
CDKN1A	0.020434
ASNS	0.020414
CBFB	-0.020370
NUP35	-0.020361
ARHGAP12	-0.020358
NDC80	-0.020337
CCP110	-0.020318
HJURP	-0.020275
MSX1	0.020263
AP3S1	0.020251
CST1	0.020229
MCAM	0.020226
PNPO	0.020223
C6orf211	-0.020205
AHCY	-0.020188
HIST1H2BJ	-0.020179
GABPA	-0.020161
SAV1	-0.020144
GLI3	-0.020130
MISP	0.020095
TVP23B	0.020083
GADD45B	0.020057
CEP78	-0.020039
EHD2	0.020022
NGFRAP1	0.019992