!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	human
!drug_name	actinomycin D
!smiles	CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)N)C
!pubchem_cid	2019
!cell_type	A549 lung cancer cells
!organism	human
!end_metadata
UBC	-0.338846
SLC38A2	-0.247670
DKK1	-0.240458
ND2	-0.187946
ID1	-0.166218
DDIT4	-0.164273
AMIGO2	-0.162785
MIR21	-0.127964
COX2	-0.116427
TUBA1C	-0.107034
CEBPB	-0.099032
IRS2	-0.098740
ERRFI1	-0.094205
UBB	-0.088456
MAT2A	-0.085771
HERPUD1	-0.081697
C8orf4	-0.078213
RPL4	0.076528
TUBA1B	-0.075495
BTG1	-0.070327
IER3	-0.069444
TOB1	-0.068945
DUSP4	-0.066661
IRF2BPL	-0.065784
MTUS1	-0.063341
MAPK6	-0.063126
RPS25	0.062296
GCNT3	-0.062255
UQCRFS1	-0.062048
ALDH3A1	0.055516
APEX1	-0.055081
TMSB10	0.054966
TNFRSF1A	-0.052842
RPL39	-0.052309
KCNJ2	-0.052078
NTS	-0.052030
TRIB3	-0.051098
RPS14P3	0.050192
RPL14	0.050063
PKDCC	-0.048671
NRIP1	-0.048579
RPL3	0.048432
PKM	0.047858
TSC22D1	-0.047040
BANF1	0.046772
DUSP1	-0.045802
SLC25A6	0.045651
SIK1	-0.045635
SRXN1	-0.044637
SRP14	0.044203
SLC7A5	-0.043538
RPL8	0.043338
IER2	-0.042800
PARK7	0.042770
CDKN1B	-0.042669
IGFBP4	0.042639
EPHX1	0.042568
EIF3I	0.042513
RPS4Y1	0.042362
RPL17	0.042003
GARS	-0.041966
GPI	0.041962
GPX4	0.041380
BASP1	-0.041288
RPL9	0.040468
NDUFA1	0.040051
PLK2	-0.039882
ALX1	-0.039737
ALDOA	0.039102
FLRT3	-0.038994
CFL1	0.038893
GAPDH	0.038695
ATF4	-0.038560
RHPN2	-0.038417
EIF1	-0.038213
RPS3	0.038092
KRT81	0.038003
RPL29	0.037627
RPS8	0.037503
YBX1	0.037397
SNHG6	0.037271
FTL	-0.037071
USMG5	0.036297
BAMBI	-0.035763
DDOST	0.035425
PFDN5	0.034598
BSG	0.034435
EIF3H	0.034413
ZFAND5	-0.034345
ACTB	0.034224
GNB2L1	0.034041
SGK223	-0.033977
FTH1	0.033864
RGS2	-0.033173
H3F3B	-0.033063
FAM107B	-0.032946
COX6B1	0.032609
EDN1	-0.032532
ID3	-0.032513
CHMP2A	0.032488
GLTSCR2	0.032441
EEF1D	0.032226
SNRPD2	0.032192
NET1	-0.032191
CBX4	-0.032015
AHR	-0.031648
UQCRH	0.031521
CYP24A1	0.031507
EEF1B2	0.031353
PTRH2	-0.031307
CCT2	-0.031275
TGFBI	0.031182
PDK4	-0.031162
YWHAG	-0.031001
COX5B	0.030710
UQCRC1	0.030686
DDX5	-0.030680
RND3	-0.030608
PCBP1	-0.030578
RPL23A	0.030501
RPL22	0.030486
NEDD8	0.030261
IMP3	-0.030157
PRDX1	0.029964
PDE4B	-0.029919
ZNF146	-0.029898
CEACAM6	0.029762
LTA4H	0.029635
GPCPD1	-0.029632
C19orf33	0.029439
YTHDF1	-0.029344
RPL36A	0.029286
C1orf106	-0.029258
G6PD	0.029209
TUBA1A	-0.029066
RPL21	0.028793
PSMD8	0.028729
TAF7	-0.028727
ADM	-0.028667
GOLPH3	-0.028627
PPP1R15B	-0.028248
PUM1	-0.028183
SAT1	0.028164
RPS7	0.028066
RPL11	0.027932
SEC24B	-0.027871
HSPA8	-0.027697
OAZ1	0.027498
RPLP0	0.027485
MMADHC	-0.027460
CCNB1IP1	0.027364
C14orf2	0.027252
PPP1CC	-0.027080
PFKFB3	-0.027078
HEXB	0.027028
PCNA	-0.026963
NFKBIA	-0.026957
ELF3	-0.026915
CCT3	0.026887
PSME2	0.026859
SRP68	-0.026843
CHCHD2	0.026819
FADS1	0.026793
RAN	-0.026776
TM4SF4	0.026531
BHLHE40	-0.026509
TXNRD1	-0.026473
RNASEK	0.026378
RPL13	0.026091
TRAPPC1	0.026083
RPS15	0.025983
FAU	0.025818
LRRC75A-AS1	0.025792
PSMC6	-0.025743
IRF2BP2	-0.025730
TALDO1	0.025634
KLF10	-0.025517
GNL3	-0.025516
NOL11	-0.025443
EIF3E	0.025434
CEBPZ	-0.025321
METTL23	-0.025296
CAPNS1	0.025296
RAB13	0.025273
NQO1	0.025269
NOB1	-0.025252
RPL7A	0.025219
IER5	-0.025165
TMED2	0.025132
RNF139	-0.025110
C14orf119	-0.025058
NDUFAB1	-0.024975
LINC00473	-0.024814
FGL1	0.024747
XBP1	-0.024699
MRPL15	-0.024680
MRPL51	0.024626
SOD1	0.024609
UFC1	0.024592
NDUFV2	0.024487
ZNF217	-0.024468
FAM46A	-0.024455
MRPL10	-0.024437
RARS	-0.024419
NEDD9	-0.024385
SRP19	-0.024308
RNF4	-0.024190
TMEM147	0.024187
HSPB1	0.024174
PTGS2	-0.024135
SSR2	-0.024125
ATP5G2	0.024105
SGK1	-0.023947
UXT	0.023917
CHP1	0.023856
EIF2S2	-0.023758
DAD1	0.023705
NOP58	-0.023675
TRIM16	-0.023616
ALDH2	0.023609
HSBP1	0.023522
NR3C1	-0.023459
LGALS1	0.023439
TGFBR2	-0.023389
PNRC1	-0.023378
POLR2J	0.023344
NDUFA13	0.023319
ETFB	0.023287
RPL12	0.023287
DDX47	-0.023273
QARS	0.023148
SEPHS2	-0.023028
TNS3	-0.022982
DBI	0.022923
NDUFS6	0.022752
ARF6	-0.022749
LHX8	-0.022695
IFITM2	0.022651
DHX32	-0.022603
CDK7	-0.022572
DNAJB1	-0.022564
BCAP31	0.022555
AIMP2	-0.022526
RHOBTB1	-0.022504
HIF1A	-0.022476
POLR2I	0.022438
MID1	-0.022403
RPS13	0.022328
LAPTM4B	0.022319
CYSTM1	0.022277
PDIA6	0.022265
ZNRF3	-0.022212
MYC	-0.022164
XPOT	-0.022107
ODC1	-0.022010
CS	0.021998
EEF2	0.021958
RPL31	0.021937
BLVRB	0.021930
CHCHD10	0.021859
PTPRO	-0.021859
TOMM20	0.021849
EIF3K	0.021837
MYL12B	0.021743
TMEM205	0.021705
GDF15	-0.021705
YTHDF2	-0.021696
RPL24	0.021677
AKR1B1	0.021657
RPL32	0.021605
NNMT	-0.021530
SCAF8	-0.021493
NDUFB10	0.021487
MUC5B	0.021471
PHYH	0.021466
RRS1	-0.021350
LINC00657	-0.021293
WAC	-0.021287
GABARAPL2	0.021275
ABCC3	0.021249
CFD	0.021236
INSL4	0.021227
DNTTIP2	-0.021178
ZCCHC8	-0.021176
ADNP	-0.021117
PFN1	0.021078
AHCY	0.021066
PPIB	0.021065
PSMA6	0.021006
ACADVL	0.020937
COX1	-0.020889
DNAJB9	-0.020863
TUBB4B	-0.020805
COX7A2	0.020754
ZNF281	-0.020715
BTF3	0.020612
EEF1A2	0.020556
ARPC1A	0.020554
MFHAS1	-0.020545
RSL24D1	-0.020544
NAP1L1	0.020456
GOLGA5	-0.020315
HADHB	0.020306
HSD17B11	0.020216
CTSL	0.020160
PRDX6	0.020068
TXN	0.020055
RNASE4	0.020044
TRMT10C	-0.020033
MIS12	-0.020024
DDIT3	-0.019981
GNG11	0.019921
HNRNPC	0.019907
MRFAP1L1	-0.019907
RPS27L	0.019906
PLA2G4A	-0.019821
TUBB	-0.019800
SHOC2	-0.019792
NCOA7	-0.019781
PGRMC1	0.019774
PSMA1	0.019756
CREG1	0.019732
TSKU	-0.019611
GDI2	0.019575
S100A4	0.019513
RPS3A	0.019496
HNRNPA1	-0.019422
ARL6IP1	0.019362
ARL6IP5	0.019342
ATP5J	0.019297
MRPS21	0.019296
HDAC1	0.019260
PHB2	0.019231
KPNA2	-0.018995
HLA-DMB	0.018983
KDELR1	0.018968
NDUFA3	0.018875
RRAGA	-0.018861
PSMG2	-0.018858
SNHG16	0.018831
CKS1B	0.018778
COPZ1	0.018777
ANXA4	0.018749
RPL23	0.018737
NACA	0.018704
NME1	0.018678
SRPX	0.018675
IGBP1	0.018653
LGMN	0.018644
NXT1	-0.018599
EMP3	0.018576
APOA1BP	0.018562
CCNI	0.018537
RNF19A	-0.018536
CTCF	-0.018522
VEZF1	-0.018492
ENO1	0.018463
ZNHIT1	0.018441
RNF111	-0.018425
ATP5I	0.018412
FAM220A	-0.018412
EIF4A3	-0.018407
RPN1	0.018357
PTPLAD1	0.018331
TXNIP	-0.018330
EIF3G	0.018330
TUBB2A	-0.018296
CEBPG	-0.018289
TIPARP	-0.018278
EIF3L	0.018261
ANXA5	0.018245
KLHDC2	-0.018199
GRAMD1B	-0.018159
RNF145	-0.018129
ZSWIM6	-0.018127
PSAP	0.018099
RTN3	0.018098
MMP7	0.018090
APOH	0.018079
CD99	0.018072
STOML2	0.018065
TJP1	-0.018059
ETFA	0.018050
AVPI1	-0.018048
NDUFB11	0.018016
SIRT1	-0.017993
PRSS23	0.017936
GHITM	0.017930
PTRHD1	0.017865
CDC25B	-0.017864
GRN	0.017861
RCN1	0.017857
TMEM256	0.017842
PSMD12	-0.017794
PEBP1	0.017793
HILPDA	-0.017788
ATP5B	0.017599
TBK1	-0.017597
NDEL1	-0.017489
RBX1	0.017420
FUCA2	0.017403
WDR82	-0.017330
DSTN	0.017315
C1orf131	-0.017290
PDZD11	0.017263
TUBB3	-0.017246
RNF113A	-0.017206
FAM214A	-0.017199
COX14	0.017148
LAMB1	0.017145
SLC30A1	-0.017118
CDK5RAP3	0.017102
PSMB6	0.017071
MLPH	-0.017042
RIN2	-0.017039
RPS9	0.017017
HHEX	-0.017004
RPS5	0.016975
WBSCR22	0.016933
TSPAN4	0.016890
SOX4	-0.016876
PSMB3	0.016795
AP2M1	0.016791
OST4	0.016770
NFE2L2	-0.016760
ZFP36	-0.016747
GADD45A	-0.016733
CHSY1	-0.016731
ETF1	-0.016724
NPM1	-0.016688
TRAPPC6A	0.016649
NONO	0.016613
FKBP1A	0.016577
MISP	-0.016575
HADHA	0.016557
PSME1	0.016556
ECH1	0.016551
SRSF7	-0.016524
PUM2	-0.016522
CDIPT	0.016511
EMC4	0.016489
RPL26	0.016484
LINC00493	-0.016457
TCEB2	0.016436
KANSL1	-0.016435
LDOC1L	-0.016416
PHF23	-0.016410
RPL6	0.016391
TRA2B	-0.016362
TSPYL5	-0.016350
IER5L	-0.016346
DNAJA1	-0.016345
SLIRP	0.016330
SCP2	0.016319
GLO1	0.016312
KLF5	-0.016302
KARS	0.016289
TOX3	-0.016275
RPL30	-0.016245
COX7C	0.016231
YTHDF3	-0.016202
MMGT1	0.016161
WDR83OS	0.016113
RPL27	-0.016110
KRCC1	-0.016075
BIRC2	-0.016069
ITM2B	0.016063
MYL6	0.016060
RSRC2	-0.016047
NME7	0.016029
TM4SF20	0.016028
GTF2B	-0.016026
ID2	-0.016005
NUP35	-0.015985
ATP5H	0.015984
ARCN1	-0.015978
ARF4	-0.015973
PLCXD1	-0.015956
DEDD2	-0.015941
NUFIP2	-0.015926
GNA13	-0.015900
FNDC3B	-0.015825
SLC3A2	-0.015798
EIF3A	-0.015785
CCDC12	-0.015760
KIAA0907	0.015755
SCD	0.015708
NIT2	0.015705
SRP9	-0.015672
FADD	-0.015662
FCGBP	0.015651
MEIS2	-0.015650
EIF4A2	-0.015648
ACBD3	-0.015630
GOLPH3L	-0.015605
UQCRQ	0.015595
LYSMD3	-0.015576
PPP1R8	-0.015540
SMNDC1	-0.015526
MPHOSPH10	-0.015496