!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Mus musculus
!drug_name	Estradiol
!smiles	CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O
!drugbank_id	DB00783
!pubchem_cid	5757
!cell_type	Thymus (of ovariectomized C57BL/6) - 3 Days
!organism	mouse
!end_metadata
OAZ1	0.144060
RPS12	0.128342
RPS28	0.126726
RPL7A	0.125831
RPL8	0.125643
EEF1A1	0.116226
TUBA1B	0.115316
RPS5	0.110902
RPL10A	0.108006
CTSV	0.107792
RPL6	0.107264
PAIP2	0.106818
RBM3	0.105886
SEPP1	0.103652
RPL19	0.101738
RPS14	0.100978
RPS15	0.098273
LCK	0.098041
PFN1	0.096335
NPC2	0.094681
RPL26	0.094136
RPS3	0.090099
PPIA	0.086927
RPS24	0.086021
RPL38	0.085735
RPS27A	0.085451
RPL35	0.084573
RPL4	0.083294
SNX17	0.081572
ITM2A	0.080221
RPS17	0.079856
CST3	0.078454
THY1	0.077892
PTPRC	0.076773
RPL23	0.071393
RPS4Y1	0.070816
RCSD1	0.070102
RPSA	0.069081
RPS7	0.068668
EEF2	0.068213
TPT1	0.068130
DYNLL1	-0.068081
ARHGDIB	0.068074
CFL1	0.066147
GNB2L1	0.065094
ACTB	0.064920
RPS2	0.063425
HSP90AA1	-0.061680
EIF4H	0.060492
SEPW1	0.059907
DDIT4	0.059788
RPL15	0.059580
RPS10	0.059508
RPL7	0.059451
FAU	0.058580
ACTG1	0.058415
RPS13	0.057625
LDHA	-0.057622
RPL3	0.057568
PRSS16	0.057526
CYTIP	0.057301
SATB1	0.057261
SH2D1A	0.056980
TXNIP	0.056530
CHCHD2	0.056264
COX4I1	0.055229
AKR1A1	0.055138
LSP1	0.054798
RPS26	0.054696
HSPD1	-0.054678
RPS29	0.054273
DNAJA1	-0.053952
PDCD4	0.053722
RPLP2	0.053505
RPL28	0.053298
CD3D	0.053131
LAPTM4A	0.051937
CCL25	0.051129
PSMB7	-0.050341
JUND	-0.049965
RPL27A	0.049895
PPIB	0.049561
FKBP5	0.048843
MYB	0.048832
RNF145	0.048051
CD8B	0.047930
CYBA	0.047876
ENDOU	0.047818
RPL11	0.047276
CAPZA2	0.046776
HNRNPK	0.045622
PSMA4	0.045591
CDK9	0.045184
RPL18	0.044886
XRCC6	0.044706
RMND5A	0.044644
C11orf31	-0.044292
SLBP	-0.044056
MBNL1	0.043698
RPS21	0.043108
MDH2	0.042731
SLC25A3	0.042677
TUBB	0.041646
SARAF	0.041627
HSPH1	-0.041494
RRM2	-0.040838
FTH1	0.040635
RAG1	0.040613
ARPC5	0.040362
LIMD2	0.040336
RPS23	0.039961
HECTD1	0.039891
BTG2	0.039474
MORF4L2	0.039195
RBM38	-0.038985
KIAA0101	-0.038927
EIF3E	0.038917
CORO1A	0.038711
RPL13A	0.038680
CSDE1	0.038622
NDUFA4	0.038539
CNBP	0.038270
TBATA	0.037978
P4HB	0.037773
SF3B3	-0.037540
VPS4B	0.037063
FAM213B	0.036734
CIC	-0.036671
ATP5A1	0.036553
U2AF2	-0.036459
RPS19	0.036438
ZNF22	0.036048
HLA-DQB1	0.035439
CCT6A	-0.035439
APOE	0.035349
TMED2	0.035143
NDUFV2	0.034973
CD3G	0.034964
GNG10	0.034925
S100A8	0.034891
CDCA7	-0.034665
SP3	0.034538
CYB5A	0.034389
TMA7	0.034328
CSTB	0.034128
SPO11	0.033947
BCL11B	-0.033816
RPL21	0.033538
PSMA3	0.033320
PCNA	-0.033280
TNKS2	0.033280
RPS11	0.033272
UBE2C	-0.033183
SAT1	0.033159
NDUFB11	0.033070
STK17B	0.033014
ETS1	0.032701
GZMA	0.032657
DESI1	0.032542
RPS20	0.032471
CD83	0.032433
TFDP1	-0.032376
SHISA5	0.032349
EIF2S3	0.032340
PBK	-0.032146
ITM2B	0.032114
BTG1	0.031913
CD74	0.031911
GDI2	0.031839
RPS18	0.031641
IPO7	-0.031600
HDAC7	-0.031581
MRPS36	-0.031251
WASF2	0.031152
RPL9	0.031151
GPI	0.031056
MYL12A	0.030864
BANF1	-0.030553
RAMP1	0.030542
EMC3	0.030479
PYCARD	0.030408
GMFG	0.030236
ACTN4	-0.030194
HSP90AB1	-0.029913
EEF1G	0.029832
GLCCI1	0.029772
EMG1	0.029707
PCBP2	0.029507
ELK4	0.029447
CHORDC1	-0.029397
ARPC4	0.029254
EEF1E1	-0.029209
ELF1	0.029159
PTPN18	0.029150
RAC2	-0.029135
NME2	0.029014
GSK3A	-0.028987
DDX39B	0.028910
CSNK2B	-0.028872
PSMB2	0.028764
NACA	0.028762
CCND3	-0.028667
RRM1	-0.028621
HEXA	0.028555
PGK1	0.028408
PPM1G	-0.028297
EZH2	-0.028228
CTSD	0.028201
MPND	0.028175
H2AFV	0.028152
SPINT2	0.028128
RPL13	0.028114
CTSC	0.027734
ISG20	0.027564
POLR2B	0.027561
HMGCS1	-0.027544
TYROBP	0.027490
STIP1	-0.027326
RPL36AL	-0.027321
PGLS	0.027172
STMN1	0.027168
GRN	0.027146
ADCY6	-0.027061
CASP2	-0.027051
C1QA	0.026682
ABRACL	0.026671
INPP5J	-0.026651
RPL14	0.026582
SQLE	-0.026142
MYL12B	0.026109
PANK3	-0.026087
COX6B1	0.026086
SUMO2	0.026071
LDHB	-0.026055
CAPZA1	0.026038
NDUFV3	0.026015
COX7A2L	0.025965
ASF1B	-0.025868
CCR9	0.025852
LARP4B	0.025824
CTSS	0.025755
SERPINB6	0.025723
LY6D	0.025670
SLC25A5	0.025555
KRT18	0.025365
CPNE1	-0.025352
COX6A1	0.025349
POLR2K	-0.025312
STARD7	0.025180
TRIM59	-0.025152
ATP6AP2	0.025087
SIN3B	0.024983
RPL5	0.024706
C14orf166	0.024633
RAP1B	0.024550
VPS26A	0.024494
MAN2A1	0.024453
CLK3	0.024363
DRG1	0.024360
MAN1A1	0.024299
DNAJC8	0.024246
UBALD1	-0.024124
SLC9A3R1	0.023980
SLC38A2	-0.023907
DNTT	0.023897
ARHGEF18	0.023807
ARPC2	0.023734
LGALS9B	-0.023698
SRM	-0.023659
CD3E	0.023647
H2AFY	-0.023541
SNRPD2	0.023541
TP53INP1	0.023533
FASN	-0.023474
SWI5	-0.023457
MRPS21	-0.023389
SRSF2	-0.023182
MPEG1	0.023166
DDAH2	-0.023087
MBTPS1	0.023072
TSC22D3	0.023060
DBI	-0.023051
HIBADH	-0.023029
SYVN1	-0.022995
SREBF1	0.022929
ARSI	0.022872
ROMO1	0.022825
ATP6V0C	0.022784
CLPTM1L	0.022730
IFNGR1	0.022695
RAB1A	0.022680
C1QB	0.022679
NCAPH	-0.022643
EMB	0.022642
YPEL3	0.022619
SLC16A1	0.022618
ILK	0.022594
DGKZ	0.022589
ACTR3	0.022469
NFKBIA	0.022461
CCL5	0.022445
ACOT9	0.022425
GIMAP6	0.022416
SEP15	0.022415
SPTSSA	0.022346
HMGN1	0.022333
NAP1L1	-0.022312
PDCD6	0.022291
EIF4A2	0.022267
ARHGDIA	0.022267
MCL1	0.022137
RPL10	0.022104
BUB1B	-0.022089
ADA	0.022022
ZFP36L2	0.021987
ANAPC5	0.021957
MAZ	-0.021947
CD2	0.021884
CCNT1	-0.021823
HMGB2	0.021823
CTSA	0.021774
PARK7	0.021689
SRSF6	0.021685
MORF4L1	0.021657
SRRT	-0.021622
GAPDH	-0.021590
HSCB	-0.021427
ZDHHC8	-0.021418
PRC1	-0.021390
MCM4	-0.021345
ZMPSTE24	0.021308
NDUFB10	0.021286
UCP2	-0.021267
RPL22	-0.021163
HLA-DRB5	-0.021125
RGS10	0.021047
USO1	0.020989
MFHAS1	0.020963
VPS72	-0.020881
ATP5G3	0.020876
SUMO1	0.020871
SLC25A4	0.020849
ARF6	0.020821
RHEB	0.020619
PPP1CA	0.020607
HNRNPAB	-0.020572
HEXB	0.020563
PLTP	0.020543
CD5	0.020484
EIF3F	0.020421
CTSB	0.020402
CDK2AP1	-0.020375
UBALD2	-0.020293
CCNA2	-0.020227
JTB	0.020201
EIF4G2	0.020175
SAMM50	0.020169
HP1BP3	0.020031
HSPA5	0.019993
INMT	0.019966
ABCG1	0.019961
COPA	-0.019904
ATP5D	0.019902
PBDC1	-0.019876
C1QC	0.019830
C6orf62	0.019763
DBNL	-0.019737
IDI1	-0.019716
UQCRFS1	0.019709
PRDX1	0.019638
S100A10	0.019594
GOLGA7	0.019568
RPL12	0.019566
MATR3	0.019530
SFT2D1	-0.019472
SYTL3	0.019246
SNRNP70	-0.019235
STK38	-0.019208
TUBA1A	0.019194
API5	0.019191
CNN3	0.019060
COX5A	0.019004
PSMD14	0.018987
UBC	0.018884
IRF1	-0.018869
TMBIM6	0.018779
FNTA	0.018727
SCD	-0.018720
RPL27	0.018675
MAP1LC3B	0.018636
CA3	-0.018618
LIFR	0.018603
PSMB9	0.018601
CPSF4	-0.018574
SMC4	0.018563
VDAC2	0.018504
MCM5	-0.018504
EIF3G	0.018495
MRPL27	0.018488
CACYBP	-0.018419
VDAC3	-0.018376
SIRT7	0.018356
TOP1	-0.018333
SRP14	0.018322
C2CD2L	-0.018207
CTSH	0.018200
CD96	0.018142
USMG5	-0.018141
NT5C	0.018069
DGKA	0.018061
TAF10	0.018036
CEPT1	0.017999
IER2	0.017941
ATP5J2	0.017919
SGTA	-0.017852
CCT5	0.017851
ACIN1	-0.017814
TMEM184C	0.017791
CNOT6	-0.017777
HLA-G	0.017743
MNS1	-0.017668
ZBTB18	0.017589
C14orf2	-0.017575
HSPA14	0.017544
SCARB2	0.017524
CSNK1A1	0.017478
NAGA	0.017441
NDUFA2	0.017419
PSMD1	-0.017402
UBA1	-0.017369
SUPT16H	0.017359
MLF2	-0.017358
ATP11B	-0.017331
ANKRD44	0.017308
KIAA0922	0.017255
PHF10	0.017255
SNRNP27	0.017254
ELOF1	-0.017213
SERINC3	0.017192
CFP	0.017182
APOA1BP	0.017151
ATP5F1	0.017109
CCT8	-0.017100
TMEM147	0.017098
MRPL18	-0.017089
NT5DC2	-0.017075
UPF3B	0.017044
MAF1	0.016947
MRPS31	-0.016936
ECI2	0.016924
ATP5C1	0.016921
EP400	-0.016918
PNP	-0.016851
CRIP3	0.016849
ERCC2	-0.016839
IFI30	0.016787
SPATA13	0.016760
ZDHHC6	0.016747
NDUFA3	0.016740
UQCRHL	-0.016697
PRRC2A	-0.016663
CLUAP1	0.016633
AURKA	-0.016592
OXR1	0.016580
CLINT1	0.016559
UBAC1	-0.016544
HDAC3	0.016541
GPR162	-0.016525
C11orf74	0.016518
C20orf24	0.016514
NDUFA11	0.016485
KIAA1109	0.016471
NDUFA13	0.016452
TMEM160	0.016436
E2F4	-0.016429
TERF2	0.016426
IL2RG	0.016423
FCGBP	0.016369
MFGE8	-0.016324
TNIP1	0.016291
ARHGEF1	-0.016279
ADIPOR2	-0.016276
SNRPD1	-0.016264
TDP2	0.016260
CGGBP1	0.016260
HSPA8	-0.016250
ANXA1	0.016183
SMIM14	0.016176
PSMA5	0.016167
ANKRD46	-0.016162
CLTC	0.016157
LAMP1	0.016145
TIPIN	-0.016144
TCF12	-0.016139
NARS	-0.016102
ATP6V0E1	0.016084
OAT	0.016029
MTX1	-0.016012
NCAPD2	-0.016008
MANF	-0.015988