!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!ligand_name	estradiol
!ligand_id	PubChemCID:5757
!cell_type	MCF7cells
!organism	human
!end_metadata
VIP	0.169693
SLC2A3	-0.132827
MGP	0.126561
KRT13	0.106980
CDH10	-0.099070
PLEKHS1	-0.098286
VTCN1	-0.095239
SGCE	-0.094627
SHISA2	0.093839
GJA1	-0.088988
NDRG1	-0.086386
MUCL1	0.085325
GFRA1	0.083753
BST2	0.074692
KIAA1324	0.074080
LCP1	0.073204
SIGLEC6	-0.072982
TSKU	0.072784
ZNF175	-0.072672
EPAS1	-0.067224
C9orf152	0.060774
SPNS2	-0.059075
PAPSS2	-0.058800
BCAS1	-0.058589
RERG	0.058150
SLC26A2	0.058046
TENM3	0.056858
INHBB	-0.056417
SERPINE2	-0.055920
CEMIP	-0.055912
S100A9	-0.055132
MMP10	-0.055030
ELF3	-0.053588
ACTA2	-0.052651
HSPB8	0.052294
BCL2	0.051177
PYGL	-0.050884
SPATS2L	-0.050878
CELSR2	0.049427
NTN4	-0.049149
LAMB1	-0.049079
IFITM1	0.048640
CTGF	-0.048376
DCDC2	0.047942
VGLL1	-0.047518
SELENBP1	0.047489
RDX	-0.046422
CLDN1	0.046133
KIF12	0.046055
RNF150	0.045637
PDZK1	0.045559
TEAD2	0.045530
CLPSL2	0.045324
STC1	-0.044823
ACOX2	0.044681
AOX1	0.044341
SGCG	0.043414
TMEM45B	-0.043179
RASL11B	0.042968
DNAJA4	0.042145
CYP26B1	0.042008
IFI6	0.041914
MESP1	0.041875
TARP	0.041841
LIMCH1	-0.041670
NPHP3	-0.041140
S100P	-0.041028
THBS1	0.040849
ADM	-0.040695
CMBL	0.040637
KRT24	-0.040328
S1PR3	0.040158
TNFRSF21	-0.039975
WNT10B	-0.039730
HEY1	-0.039523
CALML5	0.039165
IFI27	0.038925
EFHD1	-0.038884
GDF15	-0.038847
RFTN1	-0.038518
FAM198B	0.038500
SNORD13	0.038284
JPH1	0.038121
SUSD2	0.037847
DIRC3	-0.037216
ISG15	0.037123
LINC00294	-0.037082
CAV1	-0.036884
ACTG2	0.036725
KIAA1147	-0.036696
HMGCS2	0.036316
ZNF91	-0.036309
GGT6	0.036308
MIR21	-0.036179
DNASE1	-0.036081
CA12	0.036023
NELL2	-0.036005
NMU	0.035663
SAT1	-0.035613
CKMT1A	0.035404
MFSD6	-0.035205
EFNB2	0.035177
ANKRD37	-0.035119
CREB3L2	-0.035070
ACAD11	-0.034957
BMP7	0.034931
NT5C2	-0.034794
SHC4	0.034743
IRF1	-0.034707
TPD52L1	0.034619
GHDC	0.034072
CRABP1	0.033933
CDK6	-0.033793
KITLG	0.033773
RNF43	0.033747
SLC24A3	0.033685
PXDN	-0.033543
GABRP	-0.033464
ALDH3B2	0.033408
CKMT1B	0.033406
ATP1B1	-0.033336
FAM214A	-0.033182
PRKCA	-0.033174
DRAM1	-0.032983
PRICKLE2	-0.032930
MT1X	-0.032842
UBA5	-0.032772
GABBR2	-0.032744
FAM46C	0.032683
SCARNA13	0.032292
MOB3B	-0.032265
MICB	0.032260
PKIA	-0.032226
RAB32	0.032098
TSPAN3	-0.031791
DHRS3	-0.031751
NXPH1	-0.031456
DNAJC12	0.031455
LHFP	-0.031265
LYN	-0.031201
STAMBPL1	-0.031083
SPINK4	0.030987
TMEM123	-0.030937
GHR	0.030929
NRCAM	0.030854
ITPK1	0.030662
PLGRKT	0.030631
IRF9	0.030589
ACACB	0.030428
CAV2	-0.030220
IRS1	-0.030218
S100A4	-0.030183
PMEL	0.030140
CLSTN2	0.030038
PROM1	-0.029990
IRX3	0.029614
HIST1H4H	0.029486
MAN1A1	-0.029482
TM4SF1	0.029468
CITED2	-0.029399
PALLD	0.029370
MALL	-0.029217
TPBG	-0.029171
PSMB10	-0.029134
HENMT1	0.028850
DOK7	0.028838
ASPH	-0.028782
GALNT12	-0.028770
SLC39A6	0.028668
APOA1	0.028661
TGFBI	-0.028410
CYP1B1	-0.028326
MYB	0.028227
ERO1L	-0.028141
ASS1	0.028106
H19	0.028049
PGM1	-0.028038
LMO2	-0.028031
LXN	-0.028005
GBP2	0.027900
CCDC83	0.027723
AGMAT	0.027675
GCNT1	-0.027665
S100A14	0.027654
PRSS23	0.027602
OLFML3	-0.027592
DEGS2	0.027437
PCDH19	0.027389
PAM	-0.027297
NBL1	0.027196
NFIA	0.027146
TIGD2	-0.027084
IL17RB	0.027026
MAB21L3	-0.026966
METTL7A	0.026898
AKR1C3	0.026871
LURAP1L	0.026713
DOCK11	-0.026626
ZFP36L2	-0.026481
FURIN	-0.026457
NR4A2	-0.026355
SALL4	0.026343
MIR503HG	0.026327
UGDH	-0.026117
METTL7B	0.026062
BNIP3L	-0.025952
SHROOM3	0.025916
PCP4	0.025823
NETO2	0.025756
KRT15	0.025754
ST3GAL4	-0.025600
DAB2	0.025517
ST6GALNAC2	0.025320
C6orf211	0.025277
RHOBTB3	0.025252
TMC4	-0.025163
TMEM150C	0.025151
PMEPA1	-0.025120
IFIT1	0.025105
FOSB	-0.024756
PKP2	-0.024754
ALDOC	-0.024680
PAQR7	0.024655
PCGF5	-0.024638
CAMK2N1	-0.024627
LARP6	-0.024606
IFI30	0.024598
ACSS1	0.024557
TEX19	0.024501
HBEGF	-0.024469
ATXN1	-0.024434
SH3YL1	-0.024414
C3orf52	0.024412
MPZL2	-0.024385
CDH3	-0.024304
MAP7D2	-0.024279
KCNS3	-0.024276
JAK2	0.024192
ESR1	0.024014
TSPAN5	-0.023920
FAM13A	-0.023856
VASN	-0.023806
GPR126	-0.023798
RTN4RL1	0.023668
UNC5A	0.023629
BBX	-0.023594
FAIM3	0.023592
DDAH1	0.023470
KCNK5	0.023375
FGFBP2	0.023355
EDARADD	-0.023294
CAP2	0.023273
ELOVL5	0.023232
PLOD2	-0.023115
TTC31	-0.023107
SH3GL3	-0.022988
HES2	-0.022978
PTGFRN	-0.022955
DUSP16	0.022846
HMCN1	-0.022805
TPM2	-0.022796
MT1A	-0.022699
STC2	0.022693
MSI2	0.022681
ADORA1	0.022587
INHA	-0.022582
PTGR1	0.022511
EGLN3	-0.022482
MBNL2	-0.022478
ZNF324	0.022451
ABHD3	0.022441
RCL1	0.022380
PPP2R2A	-0.022376
FAM189A1	-0.022375
BAIAP2L1	-0.022367
FGD3	-0.022301
C8orf4	-0.022289
RPP25	0.022286
IGFBP5	-0.022284
WNT5A	-0.022258
EVL	0.022252
ARNT2	-0.022246
QSOX1	-0.022240
IRX5	0.022237
IGFBP3	-0.022221
SDSL	0.022138
RPL29	0.022097
HES6	0.022056
HK2	-0.022014
PRPS1	-0.021921
DPYSL4	0.021905
GOLM1	-0.021902
GPR160	-0.021899
LAGE3	0.021891
FAM105A	-0.021868
IGF2BP2	-0.021852
COBLL1	-0.021822
ERC2	-0.021809
LPP	-0.021799
CRAT	0.021788
LIN7A	-0.021774
RAP2C	0.021753
SLC16A6	0.021731
AUTS2	0.021719
VSIG10L	-0.021676
CTNND2	-0.021648
TBC1D9	0.021567
LRIG1	0.021548
APOBEC3B	0.021537
SERPINA3	0.021536
GLRX	-0.021508
PDLIM5	-0.021507
SASH1	-0.021497
TFAP2A	-0.021399
RHOB	0.021397
PCGF1	-0.021351
DIO1	0.021334
RAPGEF4	-0.021331
PEG10	-0.021284
TCP11L1	-0.021256
SNORD12C	-0.021216
PARVA	0.021216
VWF	0.021140
VAMP8	-0.021135
BCAS3	-0.021072
SLC41A2	-0.021051
MT2A	-0.021047
NUAK2	0.021004
CUEDC1	-0.020986
CKB	0.020962
STK39	-0.020932
GLA	0.020910
COPS7B	-0.020842
CYSRT1	-0.020808
MYEOV	0.020808
NMI	-0.020794
TRIP10	-0.020790
DDB2	-0.020784
WBP1	-0.020783
LY6G5C	0.020696
PDE6A	0.020642
MLPH	-0.020600
TSPAN9	-0.020594
KIAA1467	0.020499
TMPRSS2	-0.020499
CCNO	-0.020496
SLC39A8	0.020485
ABHD14A	0.020416
LINC01293	-0.020403
ZNF185	-0.020361
SSFA2	-0.020344
SLC2A14	-0.020335
ALDH1A3	-0.020328
TSPAN15	-0.020305
FHL2	-0.020265
SH3BP4	-0.020260
SESTD1	-0.020229
IDH1	-0.020195
PRR7	0.020160
RET	0.020102
NFIB	0.020045
ITPRIPL2	-0.020032
TBC1D16	0.020011
RRAGD	-0.019974
BCL6	-0.019966
POLR2L	0.019961
SNORD89	-0.019937
BACE2	-0.019933
BASP1	-0.019931
PODXL2	0.019917
IGFBP2	0.019886
IFIT2	0.019883
UPK2	-0.019879
CEBPA	0.019842
LAPTM4A	-0.019796
IL12A	-0.019791
TANC2	-0.019763
RNF145	-0.019761
PPP1R3C	0.019744
RILPL2	-0.019727
MCCC2	0.019711
KIAA1210	-0.019698
ENPP1	-0.019676
SOCS2	0.019654
KREMEN2	0.019600
RAPGEF6	0.019515
PFKFB3	-0.019465
METTL22	-0.019457
FNDC3B	-0.019452
COL12A1	0.019419
SPIRE2	-0.019415
SCRN1	-0.019392
TGFB3	0.019359
UNC13D	-0.019331
CCNYL1	-0.019291
CYB5A	-0.019263
IL1R1	-0.019256
NRIP1	0.019207
SPATA18	-0.019070
FADS1	0.019053
MARCKS	-0.019003
CIR1	-0.019001
FFAR2	0.018995
FZD2	-0.018971
GNG4	-0.018969
RAB31	0.018949
MTURN	-0.018944
EFEMP1	0.018932
MOCS2	0.018930
SPRED1	-0.018924
COL5A2	-0.018852
ITGB6	-0.018843
CXCR4	-0.018836
ATP8B4	-0.018817
VGF	0.018792
PLAC1	0.018781
LOC100129550	-0.018754
SLC27A2	0.018749
AFAP1L2	0.018714
NDRG2	-0.018701
ZKSCAN1	-0.018661
CABLES1	-0.018632
NAB2	0.018625
FTH1	-0.018566
SYT12	0.018565
TRIP12	-0.018503
NPNT	-0.018433
RRAS	-0.018432
RAPGEFL1	0.018412
SCUBE2	-0.018334
TMEM131	-0.018301
KCNK2	-0.018291
MT1F	-0.018290
VEGFC	-0.018279
DIO2	-0.018274
B4GALT5	-0.018260
ANKRD13A	-0.018253
MAP6D1	0.018238
ACOT4	0.018232
SERPINA11	-0.018227
PTMA	-0.018208
AUP1	-0.018190
KCNK15	0.018190
PROM2	-0.018188
FBP1	0.018180
TRPC1	-0.018180
LYPD6B	-0.018172
MAP3K1	0.018155
ITGA5	-0.018147
FOXRED2	0.018145
CCDC115	-0.018136
F2RL1	-0.018114
HIPK2	0.018102
SDCBP	-0.018060
PARP4	-0.018041
ANXA1	-0.018039
MEIS1	-0.018034
IFT122	0.018028
PDE4D	-0.018021
YPEL3	-0.018016
P2RX4	0.018012
PRCP	-0.017997
ELL2	-0.017995
SH2D4A	-0.017915
NEURL1B	0.017879
ERGIC1	0.017837
SYCP2	0.017822
SLC9A3R1	0.017816
IL20	0.017804
SORL1	-0.017788
FZD4	0.017784
EPT1	0.017777
MDK	0.017757
KCTD15	0.017745
SPACA6P	-0.017730
KLHL35	0.017721
NDUFAF6	0.017713
MYO10	0.017697
GLIPR2	-0.017695
XPOT	0.017688
LRRC26	0.017595
NKD2	0.017592
ABCA4	-0.017589
ADA	-0.017588
YPEL2	-0.017588
ST3GAL1	-0.017577
NBEA	-0.017541
NAV2	-0.017537
KIAA0020	0.017524
ACSL3	-0.017524
ACOT2	0.017510
WWC2	-0.017491
WDR62	0.017459
FAM72D	0.017455
ABCC3	-0.017433
SCARNA14	0.017422
SMCO4	-0.017380
HDHD1	-0.017379
PLCB1	-0.017379
GTF2H3	0.017375