!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	mouse
!drug_name	Heroin
!smiles	CC(=O)OC1C=CC2C3CC4=C5C2(C1OC5=C(C=C4)OC(=O)C)CCN3C
!drugbank_id	DB01452
!pubchem_cid	5462328
!cell_type	striatum, day 1 treatment
!organism	mouse
!end_metadata
TTR	0.667922
S100A5	-0.298164
OMP	-0.132686
CDHR1	-0.119630
ND6	-0.108205
STK32C	0.091212
NRN1	0.075678
NTN5	0.073916
C8orf46	0.064422
ND4L	0.060742
SLC6A13	-0.057768
CALB2	-0.057649
LCN2	0.056630
PMCH	-0.053376
ARC	-0.052066
TBR1	0.050775
TH	-0.048571
SLC17A7	0.048352
MYL4	0.046639
BHLHE22	0.045976
WFDC2	0.044337
SPINK8	0.043368
SLC6A3	-0.041340
TRH	-0.040415
SP8	-0.039449
NEUROD2	0.039218
PCMTD2	0.039189
HEBP1	0.037868
TOMM70A	0.037532
PRKCD	-0.037468
AEBP1	-0.036647
PCP2	-0.036280
NDUFB9	0.036236
SLC30A3	0.035688
MAF	0.035512
GRP	0.035076
KPNA3	0.034689
ISLR2	0.034227
GNG4	-0.034201
TMEM178A	0.034056
UBE2J1	0.032900
SDHD	0.032620
HSPA5	-0.032565
EGR2	-0.032397
NPAS4	-0.031616
CCK	0.031046
ADAM9	0.030868
PCP4	-0.030641
CNIH3	0.030566
R3HDM2	0.030411
OTX1	0.030144
CORT	0.030021
TMEM203	0.029402
PLIN4	0.029207
GBX2	0.029154
AVP	0.028944
ATRNL1	0.028609
SLC17A6	0.028577
H3F3C	0.027958
ARNT2	0.027349
ND1	-0.027241
MAS1	0.027207
IDH2	0.027202
RPRM	0.027115
EMP2	-0.027114
GABRA3	0.027058
MAP2K1	0.026819
VAPA	0.026736
TMEM184C	0.026643
TTC9B	0.026395
RTN4	0.026221
VAPB	0.026211
JUNB	-0.026097
FAM19A1	0.025971
CRHBP	0.025965
CCNG2	0.025409
PRMT8	0.025232
VPS26B	0.024168
XDH	0.024092
ACADSB	0.024002
HLA-DRB5	-0.023907
RPL18A	0.023905
TSHZ3	0.023770
SLC13A4	-0.023720
RSAD2	0.023701
S100A9	0.023447
S100A6	-0.023398
TEX40	0.023392
HPRT1	0.023380
BGN	-0.023308
DDT	0.023205
KPNB1	0.023113
GRAMD4	0.022987
ZIC1	-0.022806
REC8	-0.022580
STAC2	0.022568
DRD2	-0.022564
NFU1	0.022478
HSPB3	0.022447
FRZB	-0.022369
ARHGAP33	-0.022270
NPPA	-0.022189
CRTC2	-0.022124
ECEL1	-0.022085
PFKFB3	-0.022075
SMARCA5	-0.022064
OLFML2B	0.021983
HIGD1A	0.021981
PSMD14	0.021859
NPTX1	0.021840
DDB1	-0.021799
DCN	-0.021768
STMN1	0.021594
ND5	-0.021513
LMBR1L	0.021409
CACYBP	-0.021320
TOP2B	-0.021293
HKDC1	0.021135
CYFIP2	0.021052
CADPS2	0.021017
BTBD10	0.020954
SOWAHB	0.020917
SERPING1	-0.020877
GCLC	0.020814
DLX1	-0.020733
ITGB4	-0.020714
KCNE2	-0.020517
MEDAG	0.020442
GATA4	-0.020234
RWDD4	0.020087
SLC26A4	0.020074
PRR7	0.019974
MAPRE3	0.019938
RGMA	0.019879
SLC8A2	0.019710
ME1	0.019692
SCGN	-0.019637
SHB	-0.019540
RAPGEF3	-0.019409
CBLN1	0.019374
NECAB1	0.019280
TPPP	0.019252
OLAH	-0.019207
KL	0.019167
TATDN2	0.019041
RASL10A	0.018938
HLA-DQA1	-0.018936
GATA2	0.018855
PRKRIR	-0.018717
SPTSSA	0.018700
C14orf80	-0.018669
TRIM37	0.018620
SLC6A12	-0.018588
MAGOHB	0.018575
DOK3	-0.018572
GPD2	0.018511
CD74	-0.018508
MLIP	0.018419
TANC1	0.018361
HMGB4	-0.018319
NDUFA5	0.018315
HSPE1	0.018279
FAM131A	0.018264
STX1A	0.018205
PLEKHD1	-0.018181
ARL6IP5	0.018166
SIX6	-0.018068
FAM19A2	0.018037
DCT	0.018026
COX11	0.017956
C11orf74	-0.017944
HNRNPA0	0.017864
CCKBR	0.017837
KLK6	-0.017743
ACTB	0.017732
SARNP	0.017669
TROAP	-0.017664
YWHAQ	-0.017622
CTSD	-0.017582
WIPF2	-0.017557
OPALIN	-0.017543
HAPLN4	0.017527
NKAIN4	-0.017526
SLC39A10	0.017524
PIGT	0.017447
TMED9	0.017367
SATB1	0.017202
SLC22A7	-0.017196
FRMD7	-0.017196
SERPINB8	-0.017155
S100A8	0.017125
GALNT9	0.017068
ARHGAP15	0.017056
C15orf61	0.017026
TNNT1	-0.017020
C17orf70	-0.016962
OTOS	-0.016959
OTOP2	-0.016937
AMT	-0.016902
GFAP	-0.016845
TMEFF1	0.016835
ANKRD46	0.016800
TSPAN13	-0.016689
GPR68	-0.016533
OVOL2	0.016504
SOX8	-0.016497
NMBR	0.016489
CCDC3	0.016488
SFTPC	0.016430
IDH3A	0.016417
C11orf84	0.016411
PLOD1	-0.016389
POLR2G	0.016351
TMEM158	0.016316
MPPED1	0.016307
NUDCD2	0.016282
FAM81A	0.016267
GPR153	-0.016188
FGF23	-0.016181
CPNE9	0.016149
BSX	-0.016144
HCRT	0.016061
SLC38A5	0.016044
SERTM1	0.016035
ATP2B3	0.015997
DLX2	-0.015986
RSPO2	0.015965
OGN	-0.015963
ST6GALNAC2	-0.015889
LRG1	0.015814
LZTS1	-0.015759
CCL21	0.015692
SEPHS2	0.015613
SPARCL1	0.015525
FNDC4	-0.015475
NECAB3	0.015466
ZBTB18	0.015464
FPR2	-0.015455
FAM101B	-0.015454
TPT1	-0.015444
C5AR1	0.015435
ZDHHC5	-0.015422
KCNA5	0.015379
ITPRIP	0.015368
IGSF1	-0.015355
CNP	-0.015324
SNAI3	-0.015304
WASF3	0.015295
KRT14	0.015287
SPRTN	-0.015197
IGFBP6	0.015076
KCNC4	0.015042
LZIC	-0.015029
ADORA2A	0.015020
TCTA	-0.014985
GATAD2B	0.014970
HRH3	0.014935
FOXA1	-0.014917
FAM216B	-0.014915
GLTP	-0.014886
EEF1B2	0.014763
EGR4	-0.014708
SYNDIG1L	-0.014692
NDRG4	-0.014688
UBE2B	-0.014667
NDNF	0.014656
PRL	-0.014646
PRPSAP1	-0.014643
KLHL36	-0.014639
AMN	0.014622
EOMES	-0.014576
LMO1	0.014533
GAMT	-0.014530
IGSF8	0.014489
PCNA	0.014478
ZNF14	-0.014473
C1QL3	0.014456
CMBL	-0.014420
RASSF3	0.014417
RAB37	-0.014417
CTGF	0.014398
SERPINB13	-0.014393
ARID3B	-0.014327
FOS	-0.014318
RGS14	-0.014304
RAD21	-0.014301
ZNF319	-0.014291
TNFSF11	-0.014282
CRYAB	-0.014278
KCNJ2	-0.014262
VIP	0.014259
ITGAL	-0.014244
COPB1	-0.014234
C3orf83	-0.014199
USP28	-0.014162
GNG11	-0.014157
SYT13	0.014120
TSPAN3	0.014115
SLC23A2	0.014081
ALDH3A1	0.014049
FDXACB1	-0.014041
WNT10A	0.014007
CARTPT	0.013993
DIO2	-0.013976
LAG3	-0.013938
SCN1A	-0.013925
SNAPC1	-0.013889
EBF3	-0.013872
SOCS1	-0.013840
SPNS1	-0.013798
TMEM50A	-0.013795
AQP1	-0.013730
HIST1H4K	-0.013712
DKKL1	0.013688
RGS5	0.013677
AGPAT3	0.013670
LIMK1	0.013669
FREM3	-0.013593
CACNA2D1	-0.013592
C3AR1	0.013583
OLFM3	0.013580
IL33	-0.013569
CHI3L1	-0.013567
TFAP4	-0.013562
JUND	-0.013559
COL4A2	0.013514
HSDL1	0.013511
ATF5	-0.013493
CYP2S1	-0.013491
LYPD6B	0.013485
CNTFR	0.013473
PAM	-0.013452
PBK	-0.013440
CRLF1	0.013434
C9orf16	0.013427
DDAH2	-0.013420
ZNF93	0.013396
CHRM3	0.013368
PRSS12	0.013359
PTPN5	-0.013341
RIBC1	-0.013326
KRT12	0.013319
EIF1AY	-0.013284
GPR101	0.013261
OVOS2	0.013245
DCTN1	0.013242
ARG2	-0.013232
FITM1	0.013220
SSTR2	0.013197
FHL2	0.013184
ARPC2	0.013181
TSHB	0.013163
OR6C74	-0.013152
JAM3	-0.013135
BDH2	-0.013127
PLA2G2D	-0.013114
TJP1	-0.013104
C2orf74	-0.013079
FIBCD1	-0.013062
KCNB1	-0.013042
RAB5C	0.012984
RIN3	-0.012978
RHBDL2	-0.012967
COQ2	0.012946
SCN4B	-0.012926
URB2	-0.012916
PI15	-0.012891
ALAS2	0.012881
KLHL13	-0.012880
FABP7	-0.012878
RGS8	-0.012865
TRIM59	-0.012848
SLC6A7	0.012847
BOK	0.012796
ATP1B1	0.012795
FOXD3	0.012764
BECN1	0.012746
FAM64A	-0.012739
AKAP8	-0.012738
PRRC2A	0.012728
SERPINH1	-0.012708
ARL4D	-0.012688
CDC37	-0.012682
MICU3	-0.012669
SERPINI1	0.012655
NDP	-0.012634
TAC1	0.012604
SPHKAP	0.012604
AP5B1	0.012594
MMP7	0.012591
GIGYF2	0.012591
MYO7A	-0.012589
SLC26A1	-0.012580
SDF2L1	-0.012576
CCL17	0.012568
FEZF2	0.012568
CHCHD7	0.012566
MTX2	0.012552
ADPRHL2	0.012545
NAT14	0.012538
C21orf91	-0.012513
LECT1	-0.012511
ZBTB7A	-0.012482
DUSP1	-0.012471
LIN7C	-0.012471
ZFP1	-0.012470
GLP2R	0.012461
DYNLRB2	-0.012441
TMEM52	0.012413
ATP13A5	-0.012412
EPHA4	-0.012408
CFP	-0.012406
OGFOD3	-0.012404
NPM3	0.012396
PAM16	-0.012395
TGFB2	0.012383
DGAT1	-0.012380
CCT5	-0.012377
PCYT1A	-0.012358
EFNB2	0.012324
C2	-0.012299
C1QTNF6	0.012267
COL9A2	-0.012256
PRRG3	-0.012240
EFNA2	-0.012209
PPP1CB	0.012196
LAP3	-0.012183
ALDH1A2	-0.012159
BHLHE40	0.012142
C3	-0.012141
STON2	-0.012138
ATP5A1	0.012128
SIL1	-0.012112
MCCC1	0.012087
LPHN1	0.012080
GLUL	0.012068
WDR73	0.012056
ICOS	-0.012039
TMEM262	-0.012038
KRT26	-0.012037
GCA	0.012013
PER2	-0.012012
RBM24	-0.012009
CHAC1	0.012006
NFAM1	-0.011999
PWP1	0.011993
KCNJ11	-0.011992
PLEKHA3	0.011974
GNB2L1	-0.011961
LIPT1	-0.011959
PHYHIP	0.011940
TREML2	-0.011933
KCNE1L	-0.011931
PDHB	0.011915
EMD	0.011912
SALL3	-0.011907
SAMD8	0.011892
C16orf59	0.011870
PSMA3	-0.011862
GDI2	0.011850
SEMA4G	-0.011829
DYNLT3	0.011829
C1orf185	0.011818
EFNB1	-0.011789
TCF23	-0.011770
GPR21	0.011769
GOLGA4	0.011760
KPNA2	0.011743
E2F1	0.011719
GATM	-0.011713
CAPZA1	-0.011706
RHCG	-0.011693
TNS1	-0.011685
TRRAP	0.011680
MS4A15	-0.011667
PAX6	-0.011665
CDCA5	0.011657
RASD1	-0.011654
TEKT1	-0.011632
SLIRP	0.011607
RBBP8NL	-0.011602
C11orf58	0.011596
LRRC10B	0.011583
OR1J2	0.011558
FOXB1	-0.011556
MOG	-0.011555
TAS2R41	-0.011552
MYH14	-0.011546
RASD2	-0.011539
GPX6	-0.011535
WBP4	0.011527
GTSF1	-0.011520
ST8SIA5	0.011516
SOSTDC1	0.011462
C8B	-0.011452
FAM196B	-0.011450
OLFM2	0.011445
ZNF462	-0.011445
PLEKHO1	-0.011440
WFDC8	-0.011371