!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	human
!drug_name	Morphine
!smiles	CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(C=C4)O
!drugbank_id	DB00295
!pubchem_cid	5288826
!cell_type	Striatum
!organism	human
!end_metadata
TTR	-0.286019
CCDC14	0.158830
PTGDS	0.148220
CTRB2	-0.113151
RPS12	-0.089751
TSC22D3	0.083372
HTRA1	0.083315
ZBTB16	0.079686
SLC2A1	0.079201
TMA7	-0.078570
WFIKKN1	-0.072139
SEPP1	0.069312
COX4I1	0.064809
RPS27A	-0.062406
RPS14	0.060241
RPS11	-0.059507
ADORA2A	-0.059302
MFSD2A	0.059265
CKB	-0.058255
PENK	-0.058048
RNF145	-0.057212
SQSTM1	0.057077
DDN	-0.055718
NAP1L5	0.054931
CA2	-0.054621
GJB6	0.054585
PGK1	0.053942
PRICKLE2	0.053819
SYNPR	-0.053677
WIPF3	0.053037
SEPW1	-0.051340
CD81	0.049182
SLC22A17	0.049122
STK32C	-0.049073
SARAF	0.048662
MGP	0.048516
FAM107A	0.048036
UQCRC1	0.047843
RPS8	-0.047156
CAMK2N2	0.046991
OSBPL8	-0.046573
PDE10A	-0.046347
CHGB	0.046037
PEBP1	0.045959
RTN1	-0.045821
PHYHIP	-0.045763
RPS28	-0.045679
PPP3CA	-0.044873
LAMP1	0.044823
IMP4	-0.044635
RPL6	0.044596
DBP	-0.044571
CLK1	0.044486
FOXG1	-0.044264
HSPA8	-0.043930
STRIP2	-0.043797
PPP1CA	-0.043382
CAMK1G	0.043095
NTSR2	0.042870
RPL3	0.042811
LAPTM4A	0.042743
ANKRD63	-0.042464
SCG3	0.042081
ATP5A1	0.042079
PDE1B	-0.041560
PPP1CB	-0.041428
USP54	0.041221
FBXO11	-0.040914
YWHAH	0.040914
GOT1	0.040790
RESP18	0.040776
UBC	0.040273
SCG5	0.040264
PXDN	0.040042
FKBP5	0.039979
MAT2A	0.039245
APOD	0.039230
PLIN4	0.039173
SNAP47	0.039121
ATP6V1G2	0.038879
DLGAP3	-0.038820
GNG3	0.038441
TSPYL4	0.038435
ACTG1	0.038055
PBX3	-0.038032
CADM4	-0.037949
ADIPOR2	0.037386
WASF1	-0.037209
CLIP3	0.037199
STMN2	0.036831
NDRG2	0.036819
FAM98B	0.036315
ZSCAN26	0.036215
MAL	0.036092
ISCU	0.036042
PTPRN	0.036027
RCAN2	0.035375
ATP6AP1	0.035310
RPS19	-0.035280
TSC22D1	0.035210
PPP2R1A	0.035081
RPS21	-0.034977
CHCHD2	-0.034838
SRSF6	0.034680
ATP5J2	-0.034513
BSG	-0.034432
RASD2	-0.034403
GALNT16	0.034376
CRYM	0.034316
NDUFC1	-0.034119
FABP7	-0.034063
ID4	-0.034046
UNC80	0.033851
DSTN	0.033801
PPIA	0.033766
PRKAR2B	-0.033740
PRKAR1B	0.033585
POLR2M	0.033500
CAMK2B	-0.033470
PLTP	-0.033414
TMEM130	0.033396
RPL27	-0.033155
IQSEC3	0.032983
CPLX1	0.032886
MBOAT2	-0.032776
ITIH3	0.032666
SLC3A2	0.032599
CNBP	-0.032589
ZIC1	0.032471
SYNDIG1L	-0.032471
GNG7	-0.032453
TTYH3	0.032442
LDHB	0.032149
ATP1A3	-0.032141
FTH1	0.032135
EIF4A2	-0.032030
KLHL2	-0.031999
MAGED1	0.031965
PKM	0.031822
LOC728392	0.031735
GSTM3	0.031668
SERPINE2	0.031596
CLEC2L	0.031483
MLC1	0.031337
CLU	0.031329
WDFY2	-0.031253
FAM71F1	-0.031203
RPS20	-0.031176
ADAM21	-0.030951
GPR6	-0.030911
FARP1	-0.030779
HEXB	-0.030761
ACTB	-0.030706
RAB5C	-0.030695
ECI1	-0.030621
RAB31	0.030616
LZTS3	-0.030601
DRD2	-0.030584
SIRT2	0.030338
TECR	0.030193
VSNL1	0.030188
ELMOD1	-0.030162
PLP1	-0.030022
SPTBN4	-0.029925
LRTM2	-0.029921
ATP6V1A	0.029882
TSPYL1	-0.029882
UBR4	0.029758
IVNS1ABP	-0.029720
RXRG	-0.029698
NDUFA8	0.029673
RPL18A	0.029639
NDUFS1	0.029517
ATP5F1	-0.029500
PFDN6	-0.029419
PAM	0.029415
ALDOC	0.029375
RPL11	-0.029336
NAA60	0.029333
ITM2C	0.029233
GRIPAP1	0.029225
PNCK	0.029222
CCDC136	0.029211
TUBB3	-0.029105
AKR1A1	0.029063
BCL11B	-0.029000
AES	-0.028935
LAMP5	0.028933
CDH2	-0.028707
SPHKAP	0.028664
SUCLG1	0.028651
HRAS	-0.028648
ADCY2	0.028642
GAD1	-0.028571
PFKM	0.028506
NGEF	-0.028482
GPR88	-0.028432
ZNF483	0.028411
UNK	0.028338
HNRNPH1	-0.028281
RGS7BP	-0.028253
UPK2	-0.028221
RBBP7	0.028093
GLRB	-0.028061
NEFL	0.028015
CDKN1A	0.027903
FAU	-0.027873
DTX3	-0.027842
CIRBP	0.027823
TPPP3	0.027798
RASGRF1	0.027784
BAIAP3	0.027634
COX8A	0.027587
PSAP	0.027586
NSG1	0.027458
GAA	0.027426
KCNJ10	0.027401
KCNJ4	-0.027399
USMG5	0.027348
SNCB	0.027265
RPS13	-0.027255
VPS28	0.027165
FAM168B	0.027119
EGLN2	0.027032
CHGA	0.026990
DDX5	-0.026948
MRFAP1	0.026937
KLHL9	-0.026742
ENPP2	-0.026734
LRRC4C	-0.026699
VBP1	0.026668
DYNC1LI2	0.026619
DZANK1	0.026601
NDUFB6	-0.026586
NACA	-0.026576
PEA15	0.026563
HCN2	-0.026264
LACE1	-0.026241
TBXAS1	-0.026128
WDR7	0.026047
C8orf46	0.026030
ALDH5A1	0.025954
SLC4A10	0.025903
ZNF559-ZNF177	-0.025894
TMEM88B	-0.025875
JUNB	-0.025837
RERE	0.025825
ATP5B	0.025702
P2RY12	-0.025619
CELSR3	0.025578
PHACTR3	0.025537
TRO	0.025522
DNAJC7	0.025433
SIRT3	0.025363
UGT8	-0.025328
GPM6A	-0.025285
CAMK2A	-0.025269
FABP5	-0.025231
NDUFA1	-0.025191
SYNE1	0.025174
RPS18	-0.025135
RELL2	0.025093
HSD3B1	-0.025080
RBM3	0.025018
AXIN1	0.024904
ATP6V1D	-0.024784
PPP5C	0.024772
HDAC11	0.024746
NDUFA7	0.024704
MORF4L1	0.024653
PISD	-0.024532
MAP7D2	0.024516
HSP90AB1	0.024446
UQCRB	0.024418
MEIS2	-0.024365
POLR2G	0.024333
SCAMP1	0.024272
SLC35D3	-0.024259
MRPL41	0.024258
TMEM59L	0.024235
EEF1B2	-0.024220
OCIAD1	0.024213
TIMM23	0.024112
PSMD14	0.024108
HNRNPU	0.024083
ATP6V0E1	0.024057
HNRNPA0	0.023978
GRIA2	-0.023970
STMN4	0.023966
SETD7	0.023853
CCT6A	0.023816
PLEKHB2	0.023732
GLYR1	-0.023709
RAP1GAP	0.023646
GGT7	0.023625
SPARC	0.023618
WDR6	0.023613
MPP2	-0.023592
COX14	0.023539
TVP23B	0.023461
APLP2	0.023419
ABCA2	0.023400
CCNL1	0.023282
UBE2V1	0.023272
ARPC2	-0.023237
SF3B1	0.023221
RAB3GAP1	0.023199
ARL3	-0.023184
ACOT7	0.023179
SPOCK1	0.023175
PHYHD1	0.023167
RBM7	0.023158
TMEM160	0.023132
SLC6A20	0.023104
PRPS1	0.023089
TOMM7	-0.023028
GPM6B	-0.022986
MYO18A	-0.022970
FMNL2	0.022905
ARPP21	-0.022879
TAC3	0.022806
SEPT7	-0.022793
GPRIN3	-0.022772
POLDIP3	0.022750
CST3	-0.022744
CNIH2	-0.022713
HPCAL1	0.022699
TMEM158	-0.022669
IDH3G	0.022629
ATP6V1F	0.022614
RAB3A	0.022608
BTF3	-0.022591
SPNS2	0.022585
RETN	-0.022584
C6orf57	0.022537
TMEM8B	0.022531
RPL13	0.022501
ELOVL2	-0.022493
PPP1R1B	-0.022482
TUBB2B	-0.022477
VDAC1	0.022476
ATXN7L3	0.022386
FAM53C	0.022361
P4HTM	0.022349
TPRG1L	0.022329
TRIM32	0.022326
RPS24	-0.022323
ASTN1	0.022288
LHFP	0.022285
PDK4	0.022251
CALB2	0.022225
UBR5	0.022190
RPS17	0.022126
FNTA	0.022050
ENC1	0.022023
KCTD12	-0.022008
CTNNB1	0.021987
LRP12	-0.021983
GPI	0.021903
PCNP	0.021892
COL6A1	0.021886
CHST1	-0.021863
RPS7	-0.021840
RPL27A	-0.021749
GRIP2	0.021723
TRNP1	0.021715
PDP1	-0.021705
NT5DC3	0.021698
EPAS1	0.021693
COL4A2	0.021679
NSFL1C	0.021671
VSTM2L	0.021636
ELOVL5	0.021622
MSANTD4	0.021599
TOLLIP	0.021596
VPS26A	0.021571
UBA1	0.021525
GET4	0.021455
PITPNA	0.021399
ACO2	0.021368
ACSBG1	0.021284
EGR1	0.021266
SPARCL1	0.021227
ATP2A2	0.021211
HAGHL	0.021204
PRNP	0.021172
MN1	-0.021138
KCNC2	0.021108
PPM1E	0.021071
NDUFB10	-0.021066
DRD1	-0.021051
CLIC4	0.020996
NDN	0.020968
STARD10	-0.020914
DAP3	0.020888
MGLL	0.020858
MERTK	0.020857
PURB	0.020842
MARCH6	0.020841
SMIM3	0.020787
LRRC19	-0.020786
ABHD4	0.020780
SNRPF	-0.020732
TOMM20	-0.020686
SLC24A3	0.020673
MPPED1	0.020664
RAPGEF2	0.020652
PRPF8	0.020648
EZH2	-0.020632
GUK1	0.020616
KCTD1	-0.020580
AKAP5	-0.020568
PJA2	-0.020527
TESC	-0.020361
RAC1	0.020334
CRY2	0.020304
ARHGAP44	0.020293
USP22	0.020280
LRRC8A	0.020279
LDHA	0.020278
MMADHC	0.020269
TRANK1	0.020261
REEP2	-0.020248
CAPN11	0.020238
PALM	-0.020230
GIT1	0.020217
PITPNM1	0.020207
FRRS1L	-0.020199
SNX1	0.020128
C18orf32	0.020104
NDRG1	0.020094
BABAM1	0.020060
RGMA	-0.020015
PSMA2	0.020014
ACHE	0.020003
PKIG	-0.019988
GABRB1	0.019943
MOBP	0.019918
NDUFA4	0.019912
TRAPPC3	0.019905
BRINP1	-0.019889
RNF34	0.019867
NDUFV3	0.019796
RNF44	0.019793
NMNAT2	0.019763
C14orf1	0.019704
TRRAP	0.019699
WDR83OS	-0.019698
RSL24D1	0.019634
MAN1A1	-0.019625
MKL1	0.019575
CASC3	0.019572
HAX1	0.019544
FHL1	0.019524
CACHD1	-0.019509
ACSL3	0.019502
PTPLAD1	0.019495
SLC25A22	0.019492
LRRC4B	-0.019487
ALAS2	0.019432
EEF1A2	0.019395
ST8SIA3	-0.019386
RPL14	-0.019377
SPTAN1	0.019373
SNRPN	0.019369
EMC4	0.019364
UPF3B	0.019293
RPL4	0.019272
KIFC2	0.019268
DOCK9	0.019256
AMFR	0.019234
TSPAN13	-0.019209
FAM169A	0.019197
RABAC1	-0.019169
TMBIM6	0.019150
OCIAD2	0.019148
EMC3	0.019086
ACD	0.019060
RALYL	0.019058
ATP6V0E2	0.019012
ID3	0.019011
VDAC2	0.019006
RPS29	-0.018987
UQCR11	0.018908
RTN3	0.018897
CALR	-0.018825
SYT13	0.018818
C11orf87	-0.018813
SNX24	0.018807
ATP1B3	0.018775
DCLK3	-0.018772
SBK1	-0.018758
ITM2B	0.018731
ANKRD13A	0.018729
NARS	0.018699
TNS3	0.018690
RHOB	-0.018673
GPR34	-0.018659
PSMC5	-0.018635
FAM19A5	0.018635