!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	human
!drug_name	Pimecrolimus
!smiles	CCC1C=C(CC(CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC1=O)O)C)C(=CC4CCC(C(C4)OC)Cl)C)O)C)OC)OC)C)C
!drugbank_id	DB00337
!pubchem_cid	17753757
!cell_type	skin
!organism	human
!end_metadata
S100A7	-0.243200
COX1	-0.182330
RPS14P3	0.176601
SERPINB4	-0.173182
S100A8	-0.167163
KRT6B	0.162828
GJB2	-0.147187
SBSN	0.135206
SERPINB3	-0.129538
FLG2	0.125835
SFN	-0.122300
CA2	-0.115212
DMKN	0.114395
HLA-DRA	0.111507
AQP3	-0.109992
PTMA	-0.108179
KRT14	-0.106160
NACAP1	-0.104040
FTL	0.100749
LGALS1	0.097074
KRT17	0.096564
RPS26	0.096480
IVL	-0.087986
CEBPB	-0.086763
PIP	0.082249
ND2	-0.080299
MMP12	-0.079950
HLA-DRB1	0.079153
RPS4X	-0.076131
GAPDH	0.075788
SPRR1B	0.075228
SPRR1A	0.074832
COL6A3	0.070222
RPL36A	0.069737
FGFBP1	-0.069560
SPRR2G	-0.069322
KRT5	-0.069080
TUBB2A	-0.068315
NDRG1	-0.067695
HLA-A	-0.065876
KRT2	-0.065421
LCE2B	0.063196
HLA-DPB1	0.063115
TUBA1C	-0.062586
SNRPD2	0.060206
KRT10	-0.059626
KRT1	-0.058840
SERPINB5	-0.058672
PDLIM1	-0.058502
RHOA	0.057369
CALML5	0.056953
S100A6	0.056875
S100A4	0.056540
SPARC	0.056458
SNHG5	0.055474
CCL18	0.055393
RPS18	-0.054629
RPS29	-0.054301
TCHH	0.052219
RPL29	0.051125
KRT15	0.050965
GSTP1	0.050772
VIM	0.050739
PRDX1	0.050437
DSG1	0.050161
TXNIP	0.050090
S100A10	0.050054
ODC1	-0.049249
DAPL1	0.049196
COL1A2	0.048252
SLPI	0.047883
TUBA1A	-0.047769
CXCL14	0.047435
ACTG1	-0.046877
HIF1A	-0.046842
GJA1	-0.044970
UBC	0.044939
ASPRV1	0.044872
RPS4Y1	0.044716
CD99	0.044694
MMP1	0.044630
DCN	0.044368
TUBA1B	-0.043878
DEGS1	0.043735
RPS19	0.043464
RPS3	0.043165
RPL27	-0.043078
KRTDAP	0.042995
ATP1B3	-0.042230
PLP2	0.042135
S100A2	0.041906
IRF2BPL	-0.041132
CFL1	-0.041095
SLC38A2	0.040835
KRT25	0.040654
CFD	-0.040502
RPL13A	0.040474
C12orf57	0.040394
SLURP1	0.040385
HSP90AB1	0.040178
EIF4A3	-0.039786
MKNK2	-0.039404
RPL12	0.039359
DEFB4A	-0.039319
EMP2	-0.039198
LYPD3	-0.039114
FAM213A	0.038371
NDEL1	-0.038368
SPINK5	0.038141
FAU	-0.037992
MALAT1	-0.037875
MIF	0.037788
ENO1	0.037675
S100A9	-0.037259
IER2	-0.037177
TMSB10	0.037091
PI3	0.036792
LCE1B	0.036721
GLO1	0.036694
CDH3	-0.036530
RPL26	0.036058
SLC16A14	-0.035728
VDAC2	-0.035689
KLF10	-0.035663
RPL8	0.035640
MRFAP1	-0.035604
RPS5	0.035197
SRSF2	-0.034807
IGFBP3	-0.034273
OAZ1	0.034246
RPLP0	-0.033943
UFC1	0.033759
CLIC3	0.033738
PPIB	0.033671
ATP6	-0.033646
RPL21	-0.033615
SGK1	-0.033314
CSTB	0.033163
SEPW1	0.033147
DBI	-0.032646
APOD	0.032418
HAS3	-0.032308
COL17A1	0.032263
CNFN	0.032119
MT1HL1	0.032089
COX2	-0.032089
FTH1	0.032013
ALDH9A1	-0.031941
KLK5	0.031627
RPL4	0.031461
TAGLN2	0.031444
PDZK1IP1	-0.031399
KTN1	-0.031330
NOP58	-0.031207
YBX3	-0.031027
JUND	-0.030707
FLG	0.030654
RPS14	0.030620
NELL2	-0.030555
ADIRF	0.030503
RPS25	-0.030480
DYNLL1	-0.030088
ARG1	0.029932
VAMP8	0.029920
IGFBP4	0.029790
H1F0	0.029624
ZNF721	-0.029550
CCL2	-0.029521
ANXA5	0.029412
GPNMB	0.029403
XIST	-0.029318
THBS2	0.028708
S100A7A	-0.028484
DDX21	-0.028483
NMU	0.028424
ATP5I	-0.028371
CHSY1	-0.028309
DSG3	-0.028282
TYRP1	-0.028258
IL36G	-0.028230
DCD	-0.028174
CD63	0.028138
RTN4	-0.028040
YBX1	0.028032
SPARCL1	0.027993
PHB2	0.027928
PPP1R3C	-0.027905
ZG16B	-0.027665
GGCT	-0.027637
RPL35A	0.027609
CTSV	0.027521
RPS16	-0.027513
SCGB2A2	0.027431
ZFP36	-0.027312
SERINC5	-0.027163
HBB	0.027157
LDHB	0.027005
CRYAB	0.026898
SCO2	-0.026892
BLMH	0.026868
CAPN2	0.026851
RPL37A	-0.026839
RPL30	0.026716
HLA-DMB	0.026669
INPP1	-0.026566
NNMT	-0.026447
ACTB	0.026405
EIF4A1	0.026353
WFDC12	-0.026344
IER3	-0.026331
CXADR	-0.026301
METRNL	-0.026163
PFDN5	0.026115
SCGB1D2	0.025933
TUBB4B	-0.025909
FAM110C	-0.025908
GLTP	0.025756
PIM3	-0.025694
ELOVL1	0.025475
CTSK	0.025348
CFH	0.025311
RARS	-0.025281
B2M	-0.025138
PMS2P9	-0.025099
RPL23A	-0.025022
MYADM	-0.024955
IL20RB	0.024875
C10orf99	0.024835
ALDOA	0.024725
RPL7L1	-0.024633
ZDHHC11	-0.024424
FKBP5	0.024293
DSTN	0.024259
EPPK1	-0.024250
AHNAK2	0.023918
CRCT1	0.023912
PRR9	0.023905
RPL39	-0.023873
DHCR24	0.023872
HSPA1A	-0.023867
EEF1D	-0.023822
ATP5E	-0.023822
LAPTM5	0.023765
RASGRP1	-0.023696
HLA-B	0.023635
CTHRC1	0.023472
PRPF8	0.023404
LINC00341	0.023387
GLTSCR2	-0.023330
CHP2	0.023307
GABARAPL2	0.023306
POLR2J	0.023230
LAPTM4A	0.023154
PSMC3	0.023104
RPL36	0.022864
TMA7	0.022842
RPS17	0.022804
HLA-C	-0.022683
PPP4R1	-0.022665
NDUFS6	-0.022488
SH3BGRL3	0.022323
ZFP36L2	-0.022122
JUP	-0.022092
SPRR2B	-0.022088
TNFSF10	-0.022017
COL4A1	0.021942
COL15A1	0.021906
OLFM4	-0.021900
KIAA0247	-0.021878
ARL6IP5	0.021816
GDI2	0.021608
UAP1	-0.021570
APP	0.021520
RNASEK	0.021463
WBP5	0.021455
SFRP2	0.021426
ANXA2P2	0.021281
KRT9	0.021259
P4HB	0.021136
CTSC	-0.020988
AKR1C2	0.020977
EEF1G	0.020934
GABARAP	0.020910
NGFRAP1	0.020888
COL6A6	0.020873
GTF2H3	-0.020833
KLK10	0.020821
DCTN3	0.020697
CHCHD2	0.020653
CMBL	-0.020595
PITPNB	-0.020574
RPS2	-0.020573
SDR16C5	-0.020424
SOX7	-0.020359
RPL35	0.020259
ATP5A1	-0.020033
CXCL10	-0.020033
RPS11	-0.019985
IFITM3	-0.019953
RNF144B	-0.019857
ID2	0.019856
VPS51	-0.019835
RPS6	0.019829
ARPC2	0.019725
LUM	-0.019716
EEF1B2	-0.019685
DSC1	-0.019671
GNG12	-0.019619
NAA50	-0.019596
TGM1	0.019493
ARHGDIB	0.019452
RPL41	-0.019431
PMP22	-0.019427
KRT77	0.019423
MALL	0.019398
PABPC3	0.019378
AQP1	0.019370
GNA15	-0.019358
CD24	-0.019308
KRT23	0.019240
IFI27	0.019204
C3	-0.019202
TACSTD2	-0.019183
PPL	0.019164
PARK7	0.019114
RPL7A	0.019111
YWHAG	-0.019054
TXN	-0.019032
SNX3	0.018998
CD55	-0.018998
FAM214A	0.018827
OAT	-0.018797
ALDH2	-0.018791
PSMA1	0.018782
EMP1	-0.018764
TNFRSF1A	-0.018676
WFDC5	0.018655
MYL12B	-0.018616
RPL17	0.018615
BZW2	-0.018577
CDIPT	-0.018555
BPIFC	0.018509
HMGCR	-0.018468
CD74	0.018445
ACADVL	0.018445
PRR11	-0.018405
EHF	-0.018398
MT1E	-0.018386
CAPNS1	0.018374
FIS1	0.018358
TPPP3	0.018311
COX6C	0.018291
C15orf48	-0.018216
LRRFIP1	-0.018206
RPS3A	0.018182
CDK2AP1	-0.018169
MAPK6	-0.018165
TPSB2	0.018142
KRT16	-0.018130
SERPINF1	0.018122
IFI16	-0.018076
GNB2L1	0.018045
MYCBP2	0.017962
SARAF	-0.017947
CSNK1A1	-0.017868
TRIM28	-0.017841
C1orf198	0.017742
CD47	-0.017700
CEBPD	-0.017597
KLF4	-0.017592
KRT6A	0.017552
DUOX1	-0.017527
LTF	-0.017514
HOPX	0.017423
EMB	-0.017420
DSC3	-0.017351
ARPC1A	0.017308
HSP90AA1	-0.017288
PTTG1	0.017236
TSTA3	-0.017171
PAM	0.017028
RPL15	0.017017
RNF19A	-0.016989
HNRNPA1	-0.016987
JUNB	-0.016963
PSME2	-0.016890
RAB10	-0.016820
STAT3	-0.016753
TMBIM6	0.016740
DUSP7	-0.016738
MAFB	0.016732
TAGLN	0.016727
CAV1	0.016719
PSMC5	0.016712
RPL6	0.016653
NAMPT	-0.016647
CRABP2	-0.016619
GOLGA8B	0.016497
RNF149	-0.016440
UBA52	0.016406
CCL19	-0.016347
PLS3	0.016328
VCAN	0.016284
RPLP1	-0.016253
CYBRD1	0.016244
SNHG8	0.016083
FCER1A	0.016059
ALDH3A2	0.016046
F13A1	0.015978
SERPINE2	0.015967
TUBB6	-0.015966
SULF2	0.015946
RAP1B	-0.015898
PTTG1IP	0.015871
RRAGC	-0.015863
CCDC152	-0.015835
BCL6	0.015818
PLIN3	-0.015796
DSC2	0.015790
POLB	-0.015781
RAN	-0.015772
CRIP1	0.015751
DUSP1	-0.015735
CBR3	-0.015727
ASS1	0.015722
IDE	0.015719
TUBB	0.015686
S100A16	-0.015670
SEPT9	-0.015654
RAB24	-0.015648
ISG15	-0.015605
CEBPA	-0.015600
SF3B1	0.015542
FOLR1	0.015529
GOLPH3	-0.015513
TSPO	0.015451
GGH	-0.015403
NPM1	0.015323
PPAP2B	0.015319
SERPINB13	-0.015309
TMBIM1	-0.015304
SEMA4B	-0.015301
KRT27	0.015291
TGM3	-0.015213
PRRX1	0.015205
PSAP	0.015179
OGT	0.015155
SERF2	0.015138
PLBD1	0.015125
MIR22HG	-0.015115
UQCRFS1	-0.015098
ADAR	-0.015084
CPVL	0.015036
NMI	-0.015026
MIR21	-0.014943
RPL31	0.014920
PAK6	-0.014898
KLK7	0.014857
AHR	-0.014820
BNIP3L	0.014805
MAMDC2	0.014783
SLC25A3	0.014727
TSC22D3	0.014629
AP2S1	0.014616
ROBO1	0.014580
WIF1	0.014551
LIMA1	-0.014538
MAT2A	-0.014506
ZNF160	-0.014502
ARPC5L	-0.014485
CKB	-0.014434
RPL10	0.014403
ECM1	0.014355
SEC11A	0.014290
SYTL1	-0.014264
CD44	-0.014215
KRT31	0.014214
IGFBP6	0.014190
SNHG6	0.014156
C1S	0.014148
ORMDL2	0.014139
FSTL1	0.014121
NSA2	0.014101
LAMC1	0.014094
PSAT1	0.014093
ENDOU	-0.014092
APEX1	0.014068
DDR1	-0.014055
NCL	-0.014054
PUF60	-0.014053
HINT3	-0.014039
PAIP2	0.014036
EGR1	-0.014021
DDX17	0.014014
CALM2	0.013972
CHI3L2	-0.013951
LAMTOR4	0.013941
TIAM1	-0.013897
SDC1	-0.013892
PKM	0.013841