!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	mouse
!drug_name	Heroin
!smiles	CC(=O)OC1C=CC2C3CC4=C5C2(C1OC5=C(C=C4)OC(=O)C)CCN3C
!drugbank_id	DB01452
!pubchem_cid	5462328
!cell_type	striatum, day 15 withdrawal
!organism	mouse
!end_metadata
TTR	-0.864982
SLC17A7	-0.142175
C2orf40	-0.084386
C8orf46	-0.082589
MYL4	-0.082530
CCK	-0.082232
NRN1	-0.079239
SLC30A3	-0.073489
GBX2	0.071259
TBR1	-0.067335
C1QL2	0.065589
SLC17A6	0.063630
CDHR1	-0.063411
WFDC2	-0.062920
NTN5	-0.060297
SOSTDC1	-0.059975
ARC	0.055354
NEUROD2	-0.049439
STMN1	-0.048554
STX1A	-0.047098
CSHL1	-0.045939
NR4A2	-0.044505
FEZF2	-0.043902
KCNE2	-0.039805
FOLR1	-0.037216
FOS	0.036238
TMEM178A	-0.036191
OXT	0.035847
EGR2	0.035845
KL	-0.035449
ND4L	0.034151
RPRM	-0.033820
TNNC1	-0.033661
SPINK8	0.033480
PRL	-0.032724
PTPN5	0.032295
CALB2	0.031599
GAL	0.031397
C17orf96	-0.031365
CCDC3	-0.029869
IPCEF1	-0.029459
CNIH3	-0.029218
CORT	-0.029049
SOWAHB	-0.028939
OLFM1	-0.028697
TNNT1	0.028572
VIP	-0.028305
CLDN2	-0.028180
NPTX1	-0.028058
PRKCD	0.027433
GALNT9	-0.026600
HSPB3	-0.026574
DKKL1	-0.026466
S100A5	-0.026288
STK32C	0.026221
AQP1	-0.026113
IGFBP2	-0.025700
HKDC1	-0.025621
TEX40	-0.025396
CCKBR	-0.024875
CCL21	-0.024834
RASL10A	-0.024831
NECAB3	-0.024811
PENK	0.024661
RASL11B	-0.024213
CTGF	-0.024041
STAC2	-0.023486
WNT10A	-0.023353
KIAA1239	-0.022970
CARTPT	0.022565
TOMM70A	0.022268
SLC26A4	-0.022127
CBLN1	0.021797
ISL1	0.021497
EGR4	0.021053
MPPED1	-0.020247
SLC13A4	-0.020123
GRP	-0.020019
NPAS4	0.019995
PDYN	0.019965
MEDAG	-0.019821
TCAP	-0.019654
IGFN1	-0.019626
MAS1	-0.019624
ENPP2	-0.019318
DRD1	0.019297
TSHZ3	-0.019244
KIAA1462	0.019002
MAF	-0.018987
PPP1R1B	0.018869
FAM81A	-0.018847
LINGO1	-0.018652
BHLHE22	-0.018598
FAM19A1	-0.018459
ARHGAP15	-0.018403
NCALD	-0.018368
IGSF21	-0.018347
CRHBP	-0.018209
HLA-DRB5	-0.018046
SLC4A1	0.017953
PRSS12	-0.017859
KLHL13	0.017832
SSTR2	-0.017784
CD74	-0.017518
S100A10	-0.017459
FAM171A1	0.017414
IGFBP6	-0.017220
ZIC1	0.017143
HOMER2	-0.017098
SLC35D3	0.017041
TSPYL4	-0.016599
NTNG1	0.016586
SLC16A8	-0.016465
AGT	0.016413
ST8SIA5	-0.016409
ENC1	-0.016399
TTC9B	-0.016181
RGS16	0.015907
SEPT9	-0.015884
GLUL	-0.015720
JUNB	0.015669
SERPINI1	-0.015665
FRZB	-0.015665
OTX1	-0.015593
SYT13	-0.015533
ADCYAP1	-0.015273
RSPO3	-0.015145
ND5	-0.015083
KCNA5	0.015031
KLF2	0.014778
ADORA2A	0.014751
NDRG4	0.014736
RAPGEFL1	-0.014716
MAPK11	-0.014626
FHL2	-0.014550
CRLF1	0.014512
PER1	0.014479
NUPR1	-0.014448
RRAS2	-0.014414
IDO1	0.014333
UNC13B	-0.014218
KRT12	-0.014192
CRTAC1	-0.014077
DLK1	0.014066
ARG2	0.013976
HBB	0.013884
MLIP	-0.013712
TBC1D8	0.013649
RASD2	0.013479
RARB	0.013351
GARNL3	-0.013303
HLA-DQA1	-0.013264
HS3ST2	-0.013243
IL22RA1	-0.013163
REM2	0.013088
NLGN1	0.013080
MEF2C	-0.013079
SYNDIG1L	0.012996
SIDT1	-0.012992
GNG4	-0.012960
DUSP1	0.012874
EID1	-0.012814
TATDN2	0.012790
GCA	-0.012684
NECAB1	0.012640
RGS9	0.012630
SPARC	0.012566
PDZRN3	-0.012508
DKK3	-0.012445
OMP	-0.012408
PRR7	0.012394
OTX2	-0.012382
CPNE9	-0.012297
GBP4	0.012257
CADPS2	-0.012202
EXT1	-0.012195
ATP2A1	0.012168
LGALS1	-0.012166
BMP3	-0.012132
ITIH3	0.012115
SLC5A7	0.012113
TNFRSF25	0.012088
FREM3	0.011990
GPR6	0.011990
HIGD1A	0.011962
PDE1A	-0.011936
PLIN4	-0.011683
NRN1L	0.011643
FOXA1	0.011508
TANC1	0.011495
ISG15	0.011466
CHGB	-0.011454
UBE2QL1	-0.011439
LYPD6B	-0.011412
PKP2	0.011306
PTPRT	-0.011302
CCL17	-0.011270
SHB	0.011262
GPR88	0.011223
R3HDM2	-0.011174
NTS	0.011119
CBLN2	-0.011109
TCF7L2	0.011055
GPR83	0.011014
COL24A1	-0.011006
FAM131A	-0.010985
CALML4	-0.010974
SOX18	-0.010903
PAM16	0.010896
OVOL2	-0.010887
SATB1	-0.010810
HLA-DQB1	-0.010809
HS3ST1	-0.010784
FAAH	-0.010778
ZCCHC12	0.010726
PAMR1	-0.010681
HIST1H2BD	0.010673
COX2	0.010616
KCNC4	-0.010610
STARD8	-0.010607
TUBA8	-0.010541
FXYD7	-0.010523
DOC2A	-0.010512
PRSS35	-0.010482
TPPP	-0.010462
IGF2	-0.010462
DUSP5	0.010443
SOX5	-0.010434
ZFHX3	0.010378
SLC10A4	0.010362
TRIM54	-0.010353
ALOX12B	-0.010351
RSAD2	0.010266
DLGAP1	-0.010236
RSPO2	-0.010157
LIN7C	0.010144
SIK2	0.010141
AMOTL1	0.010107
RASGEF1C	-0.010099
COL5A1	-0.010067
TRHDE	-0.010040
ECEL1	0.010002
SV2B	-0.009971
SOBP	-0.009866
ARNT2	-0.009846
MKX	-0.009835
FIG4	0.009765
CPNE4	-0.009763
NSUN7	0.009732
CPNE7	0.009693
B4GALT4	-0.009638
HIST1H3I	0.009636
ACER2	0.009597
COL8A1	-0.009526
GPR22	-0.009521
HAPLN4	-0.009502
PDLIM1	-0.009457
CHRD	-0.009381
OTOP2	-0.009367
BTBD10	-0.009300
SERPINB13	0.009225
VSNL1	-0.009205
MSX1	-0.009197
SERINC2	-0.009194
HIST1H4K	0.009186
DZANK1	0.009178
S100A8	0.009163
CPLX2	-0.009074
ID2	-0.009073
FDX1L	0.009068
C3orf83	0.009066
ADAMTSL2	-0.009055
CD6	-0.009036
DOC2B	0.008972
TMEM108	-0.008968
KCNV1	-0.008957
DDT	0.008956
GCLC	0.008936
LDB2	-0.008922
GOPC	-0.008917
LCT	0.008916
RWDD4	0.008914
IFIT3	0.008875
WFS1	0.008869
ZNF442	0.008868
PTPRU	-0.008848
KLHL40	-0.008846
MYOZ1	0.008846
FBLIM1	0.008844
LHFPL5	0.008835
NR1D2	0.008831
GOLGA7B	-0.008806
CRYBG3	0.008778
RNF115	-0.008769
GATM	0.008732
F2R	0.008714
DIO2	-0.008655
GPR151	0.008648
S100A9	0.008644
DOK3	0.008619
TAC1	0.008611
ALDH3A1	-0.008593
SH3RF2	0.008576
SLC2A5	0.008535
UTP15	0.008510
SLC17A8	0.008500
ND6	0.008479
CACNA2D1	-0.008478
SLC39A10	-0.008475
VPS26B	-0.008464
DBP	0.008445
RXRG	0.008391
E2F1	-0.008385
USP18	0.008315
KHDRBS3	-0.008309
SERPING1	-0.008302
C2orf82	-0.008258
SLC6A7	-0.008233
SCHIP1	-0.008224
AVP	0.008203
TSHZ2	0.008160
WIPF3	0.008122
CA10	-0.008093
RESP18	0.008088
GDI2	0.008087
PDE1B	0.008085
CDC42EP3	0.008079
CHMP4B	-0.008067
CIART	0.008041
TMEM255A	0.008020
AMIGO2	0.008011
SLC23A3	-0.007993
KCNMB4	-0.007983
MICU3	-0.007941
NDUFB5	0.007939
LRFN2	-0.007936
AEBP1	-0.007920
THBD	-0.007878
VAT1L	0.007876
OR5AC2	-0.007859
IFITM3	0.007843
GNG7	0.007824
RSPRY1	0.007813
NFIX	-0.007801
H3F3C	0.007792
ETNPPL	0.007764
PHEX	0.007742
CFP	0.007724
S1PR1	0.007706
APBA2	-0.007684
PNMT	-0.007676
CD28	0.007662
IGSF1	0.007641
OR5D18	0.007625
COL4A1	-0.007609
TMEM114	0.007605
VAPB	0.007604
BCKDHB	0.007604
PRKCH	0.007588
STEAP1	-0.007582
BOK	-0.007578
CYFIP2	-0.007574
PER2	0.007572
SLC25A25	0.007564
ASPG	-0.007548
TSPAN17	-0.007544
FXYD5	-0.007541
PLS3	-0.007528
RAD51AP2	-0.007526
ACTN2	0.007518
SNX1	0.007484
RGS8	0.007478
IRF9	0.007455
SHOX2	0.007447
HCRT	0.007431
AKR1C3	-0.007430
PGM2L1	-0.007412
SNTG2	0.007375
CRYM	0.007372
PDIA4	-0.007308
CPSF2	0.007303
PAK1	-0.007280
ACTA2	0.007274
KLK6	-0.007252
SCUBE1	-0.007248
PIN4	0.007243
CETN2	0.007217
UBE2S	0.007212
OLFM2	-0.007212
DDB1	0.007208
MESDC1	0.007176
CA4	-0.007168
HK1	-0.007147
PRKAR1B	-0.007141
PRKCG	-0.007118
TUBB4A	-0.007117
OR9G4	0.007116
GPX2	-0.007111
TMEM125	-0.007095
SLC6A3	-0.007093
SEC11C	0.007083
NTNG2	-0.007081
DGKK	0.007066
PCBD1	0.007043
RDH5	-0.007041
GNG2	-0.007041
GPR68	0.007039
SNAPC1	0.007033
NLRC5	0.006998
TFAP2D	-0.006992
CAPN6	-0.006980
FBXW7	-0.006976
LTK	-0.006971
SCGN	-0.006939
PCOLCE	-0.006908
CELSR1	-0.006907
CCND1	-0.006904
PLEKHA2	-0.006892
ANO2	0.006845
LGR5	-0.006844
CDYL2	-0.006821
FOXG1	0.006819
NOP9	0.006819
SOCS3	-0.006815
SYTL4	0.006799
CIRBP	-0.006796
SMIM3	0.006789
ALKBH5	0.006788
CDKN1A	-0.006787
PLEKHD1	0.006777
TEKT1	-0.006772
GPX3	0.006770
TAC3	0.006757
RAB37	0.006750
PPM1E	-0.006741
RSU1	-0.006726
CORO1A	-0.006712
NEUROD1	-0.006708
SPRN	-0.006705
NRSN2	0.006701
RASL11A	0.006697
DRD2	0.006696
TMEM145	-0.006690
CRABP1	0.006686
EVL	0.006680
P2RY1	0.006662
KCTD12	0.006662
PLEKHH2	0.006659
DHCR24	-0.006652
PHLDA1	0.006630
KIAA1549L	-0.006627
FGF3	-0.006624
WISP1	-0.006623
ST6GALNAC2	0.006611
PCP2	-0.006606
ENTPD3	0.006600
ENDOU	0.006594
C6orf222	-0.006590
TCF23	0.006576
LLGL2	-0.006560
KLHL14	-0.006539
PRICKLE1	-0.006535
SHISA4	-0.006531
POC1A	-0.006530
SPATA2L	0.006525
C1orf115	-0.006524
ARID3B	0.006523
FKBP14	0.006512
HSPA4L	0.006512
TMEM50A	0.006493
C6orf15	-0.006485
TCF19	-0.006485
STK38L	0.006473
BDNF	-0.006472
MAPRE3	-0.006472
SERTAD4	0.006438
COX7A1	-0.006433
VAV3	0.006419
ZBTB7A	-0.006415
ZBTB7C	0.006414
FOXO1	0.006403
KCNE1L	0.006390
TMEM184C	-0.006390
B9D2	0.006388
PROX1	0.006386
MYT1	0.006379
PIK3CA	0.006375
RASGRP2	0.006366
EXTL1	-0.006363
CHST8	-0.006352
TNR	-0.006350
FGF5	-0.006346
KIAA0922	0.006344
RIC8B	0.006343
AK5	-0.006341
PRPSAP1	0.006340
PHOSPHO1	-0.006329
ARPC2	0.006310
OVOS2	-0.006306
CGA	0.006298